Ana samun magungunan a cikin nau'i biyu. Kayan a cikin nau'ikan dakatarwa don gudanar da aikin karkashin kasa wanda aka samar a cikin kwalabe da gurneti ana kiranta Biosulin N.
Na biyu nau'i na miyagun ƙwayoyi ana kiran shi Biosulin P kuma shine mafita wanda aka samar a cikin kwalabe da katako.
Ana amfani da maganin a matsayin wakili na hypoglycemic kuma ana amfani dashi don kula da ciwon sukari.
Kayan magunguna na maganin
Insulin Biosulin N shine insulin na mutum wanda aka kera shi ta amfani da fasahar recombination DNA.
Biosulin N insulin ne mai matsakaici. Tasirin miyagun ƙwayoyi a jikin ɗan adam ya samo asali ne daga hulɗa da miyagun ƙwayoyi tare da takamaiman masu karɓa a kan membrane membranes of hises-dogara, wanda ke haifar da samuwar insulin-receptor.
Sakamakon hadaddun yana motsa matakai na rayuwa. Wadannan hanyoyin sun hada da hada hadadden enzymes, kamar su:
- hexokinase;
- pyruvate kinase;
- glycogen synthetases, da sauransu.
Magungunan yana samar da raguwa a cikin matakan glucose a jikin mutumin da ke fama da nau'in ciwon sukari na 1 na mellitus ta hanyar inganta tsarin jigilar shi a cikin sel da inganta haɓakawa da sha. Bugu da ƙari, hanyoyin inganta lipogenesis da glycogenogenesis suna haɓaka. Biosulin N da Biosulin P yana rage yawan samar da glucose ta hanta.
Tsawon lokacin aiwatar da magunguna ya dogara da yawan ƙwaƙwalwa. Abubuwan da suka biyo baya suna da tasiri mai mahimmanci a cikin adadin sha:
- Yawan maganin da akayi amfani dashi.
- Hanyar gudanar da magani.
- Wuraren gudanar da aikin da ke dauke da waken insulin.
- Halin jikin mai haƙuri.
Bayanan da aka yi amfani da su yayin aiwatar da miyagun ƙwayoyi sun kasance kamar haka:
- farawa na miyagun ƙwayoyi yana farawa awanni 1-2 bayan allura;
- ana lura da mafi girman tasirin ƙwayar awanni 6-12 bayan allura;
- tsawon lokacin maganin yana daga sa'o'i 18 zuwa 24.
Cikakkiyar shan ƙwayoyi da kuma saurin bayyanawa ga jiki ya dogara ne akan yankin allura, sashi da maida hankali ne akan abubuwan da ke tattare da ƙwayar. Rarraba magunguna a jiki bai yi daidai ba. Penetration na miyagun ƙwayoyi ta hanyar hanawar mahaifa baya faruwa, kuma maganin bai iya shiga cikin madarar nono ba.
Halakar ma'aikacin da aka gudanar an gudanar da shi ta hanyar insulinase galibi a cikin ƙwayoyin hanta da ƙwayar koda. Samfurin lalata kayan ana aiwatar da shi ta hanta.
Tsarin cirewa daga jiki yana cire kimanin kashi 30-80%.
Alamu, contraindications da sakamako masu illa
Alamar don amfani da samfurin magani shine kasancewar a jikin mai haƙuri na nau'in ciwon sukari na 1 na mellitus.
Ana amfani da miyagun ƙwayoyi don nau'in ciwon sukari na 2 na mellitus, wanda yake a mataki na jure magunguna na hypoglycemic da aka ɗauka na baka, a mataki na juriya ga magungunan baka yayin amfani dashi a cikin hadaddun farji, haka kuma yayin haɓaka cututtukan cututtukan cututtukan cuta na 2 na cututtukan mellitus.
Babban contraindications don amfani shine kasancewar ƙara yawan hankalin mutum ga insulin ko kuma wani sashi wanda shine ɓangaren na'urar likita da haɓaka alamun mai haƙuri yana da halin hypoglycemic.
Bayyanar sakamako masu illa daga amfani da kayan likita yana da alaƙa da tasirin ƙarshen a kan ayyukan metabolism metabolism.
Babban sakamako masu illa da ke fitowa a jikin mai haƙuri lokacin amfani da miyagun ƙwayoyi sune kamar haka:
- Haɓakawa a cikin jikin yanayin rashin lafiya, wanda ke bayyana kanta a cikin bayyanar pallor na fata, ƙara haɓaka, haɓaka ƙoshin zuciya da bayyanar tsananin ƙarfin jin yunwa. Bugu da kari, farin ciki da tsarin jijiyoyi da paresthesia a bakin ya bayyana; bugu da ƙari, zazzaɓi mai zafi ya bayyana. Mai tsananin rashin ƙarfi na haifar da mutuwa.
- Allergic halayen lokacin amfani da miyagun ƙwayoyi suna bayyana da wuya kuma galibi yakan faru ne a cikin fatar fatar kan fata, haɓakar edema na Quincke, kuma a cikin yanayi mai wuya yanayin tashin hankali anaphylactic.
- Kamar yadda raunin da ke cikin gida ya kamu, cututtukan zuciya, kumburi da itching a wurin allurar ta bayyana. Tare da tsawaita amfani da miyagun ƙwayoyi, haɓakar lipodystrophy a cikin allurar yana yiwuwa.
Bugu da ƙari, bayyanar edema, da kurakurai masu raɗaɗi. Mafi sau da yawa, sakamakon da aka nuna na ƙarshe yana faruwa a matakin farko na far.
Umarnin don amfani da miyagun ƙwayoyi
Magungunan magani hanya ce don gudanar da aiki a ƙarƙashin ƙasa. Yawan likitan da ake buƙata don allurar ya kamata ya lissafta ta likitan halartar.
Endocrinologist ne kawai zasu iya yin lissafin kashi, wanda ake buƙata ya yi la'akari da yanayin jikin mutum da sakamakon gwaje-gwaje da binciken haƙuri. Sashi da aka yi amfani dashi don magani yakamata yayi la'akari da matakin glucose a jikin mai haƙuri. Mafi sau da yawa, ana amfani da miyagun ƙwayoyi a cikin sashi na 0.5 zuwa 1 IU / kg na nauyin jikin mai haƙuri.
Yawan zafin jiki na wakili da aka yi amfani da shi don gabatarwa a cikin jiki ya kamata ya zama zafin jiki na dakin.
Dole ne ayi amfani da lissafin adadin maganin a cikin yankin cinya. Bugu da ƙari, ana iya gudanar da maganin a cikin subcutaneously a cikin yankin bango na ciki, buttock, ko kuma a yankin da ke tattare da ƙwayar tsoka.
Don hana lipodystrophy a cikin ciwon sukari na mellitus, ya zama dole don canza wurin allurar.
Ana iya amfani da biosulin N duka a matsayin kayan aiki mai zaman kanta yayin lokacin insulin da kuma azaman ɓangaren ƙwaƙwalwa mai rikitarwa a haɗaka tare da Biosulin P, wanda insulin gajere ne.
Bai kamata a yi amfani da miyagun ƙwayoyi don magani ba, bayan girgiza shi, dakatarwar ba ta sami farin tint ɗin ba kuma ya zama girgije mai ɗaukar hoto.
Game da amfani da wannan magani, ya kamata a aiwatar da saka idanu akai-akai game da matakin glucose na plasma.
Abubuwan da suka haifar da haɓakar yanayin rashin ƙarfi a cikin jikin mai haƙuri na iya zama, ban da abin sama da ya kamata, waɗannan dalilai masu zuwa:
- maye gurbin magani;
- take hakkin tsarin abinci;
- abin da ya faru na amai.
- abin da ya faru na zawo;
- tanadi kan mai haƙuri na ƙara yawan aiki na jiki;
- cututtuka na shafar jikin mutum na bukatar insulin;
- canjin yankin allura;
- hulɗa tare da wasu magunguna.
Tare da farkon insulin insulin, ba dole ne a gudanar da aikin abin hawa ba, tunda akwai yuwuwar yiwuwar raguwa a cikin yanayin mutum da raguwar ƙarancin gani.
Yanayin ajiya, farashi da kuma alamun magunguna
Ya kamata a adana miyagun ƙwayoyi a wurin da aka ba shi kariya daga haske, a zazzabi na 2 zuwa 8 digiri Celsius. Haramun ne a daskare na'urar lantarki.
Ya kamata a ajiye kwalban da aka buɗe da aka yi amfani da shi tare da na'urar likita a yanayin zafi a cikin kewayon daga digiri 15 zuwa 25 Celsius. Wannan umarnin insulin don amfani ya bayyana cewa rayuwar shiryayye na miyagun ƙwayoyi shine watanni shida. Lokacin amfani da miyagun ƙwayoyi a cikin kabad, rayuwar shiryayye daga cikin kundin da aka yi amfani da shi kada ya wuce makonni 4.
Ya kamata a adana magungunan a wani wuri wanda ba zai isa ga yara ba.
Rayuwar shiryayye na kayan aikin likita na kunshin shine shekaru 2. Bayan wannan lokacin, bai kamata a yi amfani da na'urar likita ba lokacin maganin insulin.
Ana bayar da maganin a cikin kantin magunguna ta hanyar takardar sayan magani.
Dangane da marasa lafiya da suka yi amfani da wannan nau'in insulin, hanya ce mai kyau don sarrafa matakin sukari a jikin mai haƙuri da ciwon sukari.
Analogues na miyagun ƙwayoyi sune:
- Gansulin N.
- Insuran NPH.
- Humulin NPH.
- Humodar.
- Rinsulin NPH.
Kudin kwalba ɗaya a Rasha yana kan matsakaicin 500-510 rubles, kuma katako 5 tare da ƙarar 3 ml kowane yana da farashi a cikin kewayon 1046-1158 rubles.
Bidiyo a cikin wannan labarin yayi magana game da aiki da halayen insulin.
