Comboglyz Prolong magani ne na hypoglycemic. Ana amfani dashi ta hanyar marasa lafiya masu fama da ciwon sukari na 2, lokacin da abinci mai ƙarancin carb da aikin motsa jiki basa iya kiyaye matakan glucose na al'ada.
Cutar sankara (mellitus) cuta ce mai girman gaske wanda ke buƙatar kulawa ta musamman. Idan cutar an bar ta zuwa sa'a, to ya ƙunshi "tarin" matsala, daga sakerrakin fata zuwa gangrene, mafita wanda shine kawai yantsun hannu.
Samun ciwon sukari mai nasara ya ƙunshi manyan abubuwan guda huɗu: ingantaccen abinci, motsa jiki, kulawa akai-akai game da tattarawar sukari, magani na magani (ko maganin insulin don nau'in ciwon sukari na 1).
Haka kuma, amfani da kwayoyi dole ne a ɗauka tare da duk mahimmancin hankali da hankali: kowane magani yana da maganin kansa, kuma yana iya shafar jikin mai haƙuri ta hanyoyi daban-daban. Don haka, yadda ake ɗaukar Combogliz Prolong daidai yadda ba zai cutar da kanku ba? Me likitoci da marasa lafiya ke faɗi game da shi? Bari muyi kokarin fahimtar wadannan abubuwan.
Aikin magani na magani
Kamfanin kamfanin kera magunguna na Amurka Bristol-Myers Squibb ne ya kera shi.
Mai sana'antawa ya samar da maganin a cikin nau'ikan allunan da ke dauke da sinadarai biyu masu aiki - metformin da saxagliptin a cikin matakan da suka dace: 1000 mg da 2.5 mg, 500 mg da 5 mg, 1000 mg da 5 mg.
Kari akan haka, babban kwamfutar hannu ya hada da adadi kadan na irin wannan kayan taimako:
- magnesium stearate;
- sodium carmellose;
- maganin.
Kowane kwamfutar hannu na wannan magani an rufe shi a cikin yadudduka uku, waɗanda aka haɗa da ƙarin ƙarin abubuwa. Tun da miyagun ƙwayoyi ya haɗu da wakilai na hypoglycemic guda biyu, yana inganta rage yawan sukari a cikin marasa lafiya. Yi la'akari da fasalin tasirin tasirin tasirin glucose kowane.
Metformin, kasancewa wakilin ƙungiyar biguanide, yana haɓaka haɓakar glucose, ta hanyar rage girman matakinsa a cikin jinin masu ciwon sukari. Wannan abu ba ya haifar da ci gaban yanayin hypoglycemic da hyperinsulinemia. An aiwatar da tsarin metformin:
- Don rage samar da glucose ta hanta.
- Increaseara yawan abin da ke kewaye da glucose.
- Don amfani da glucose.
- Enhanceara haɓakar ƙwayoyin sel zuwa insulin.
- Don rage yawan motsawar hanji na hanji.
Ya kamata a lura cewa yayin amfani da Metformin babu wani canji a cikin taro na sukari mai narkewa. Koyaya, masu ciwon sukari suna buƙatar faɗakarwa da safe da kuma lokacin abinci, lokacin da matakan insulin na iya raguwa.
Saxagliptin ya tsokani sakin kwayoyin homonin, wadanda suke, HIP da GLP-1, wadanda suka shiga daga hanji zuwa cikin jini. Suna ba da gudummawa ga irin waɗannan hanyoyin:
- sakin insulin daga sel beta na kayan islet;
- raguwa a cikin aikin glucagon ta hanyar ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin cuta.
Wani fasalin saxagliptin shine cewa bangaren yana rage abun ciki na mai haƙuri a cikin komai a ciki kuma lokacin cin abinci.
Bayan mai haƙuri ya ɗauki kashi da ake buƙata na Combogliz Prolong, ana lura da mafi girman haɗarin metformin bayan awa bakwai.
Saxagliptin, a matsayinka na mai mulki, yana metabolized, yana haifar da babban metabolite, kuma metformin ba a iya daidaita shi ba. Don haka, ana cire su ta hanyar kodan.
Umarnin don amfani da miyagun ƙwayoyi
Nan da nan ya zama dole a tuna cewa ana sayar da maganin ne kawai ta hanyar takardar sayen magani. Kwararrun da suka tsara wannan magani ya kamata su zaɓa shi bisa ka'idodi kamar su glucose, kasancewar cututtukan da suka dace, da kuma lafiyar mai haƙuri gaba ɗaya.
Lokacin da mai haƙuri ya sami wannan kayan aiki, ya kamata a bincika umarnin yin amfani da shi. Idan kana da wasu tambayoyi, tabbas mai haƙuri dole ne ya duba likita.
Ana bada shawarar maganin Combogliz Prolong ya zama baki da maraice. Mai haƙuri ya haɗiye kwamfutar hannu gaba ɗaya ya sha shi da ruwa.
A farkon farawa, yawan maganin shine 500 MG + 2.5 MG kowace rana, tsawon lokaci ana iya inganta shi zuwa 1000 MG + 5 MG (Allunan 2). Tunda metformin na iya yin tasiri ga tsarin narkewa, ya kamata a ƙara yawan sashi a hankali. Irin waɗannan canje-canje a cikin jiki ba za a ji tsoron su ba: sakamakon karbuwa ga abu, an sake gina aikin maƙarƙashiyar. A sakamakon haka, mai haƙuri ya koka da tashin zuciya, amai, gudawa, ɗanɗano da ƙarfe a cikin bakin, rashin ci da ƙanshi.
Lokacin canzawa zuwa farji tare da Combogliz Prolong tare da sauran magunguna masu rage sukari, kuna buƙatar yin hankali musamman. Dole ne a yarda da irin wannan shawarar koyaushe tare da likita mai halartar. Wannan ya faru ne saboda gaskiyar cewa masana'anta ba ta gudanar da bincike na musamman ba game da inganci da lahani na magani Combogliz Prolong bayan amfani da wasu wakilai na hypoglycemic.
Koyaya, tare da yin amfani da magunguna da kuma hanawa na CYP3A4 / 5 isoenzymes, ya zama dole a sha mafi ƙarancin inganagliptin - 2.5 mg. Irin waɗannan abubuwan sun haɗa da:
- Indinavir.
- Ketoconazole
- Nefazodon.
- Itraconazole.
- Atazanavir da sauransu.
Ya kamata tsofaffi masu ciwon sukari suyi amfani da miyagun ƙwayoyi tare da taka tsantsan, kamar yadda bincike ya nuna cewa hakan na iya haifar da lalacewar aikin na yara
Dole ne a ajiye miyagun ƙwayoyi a zazzabi da ba ya wuce +30 digiri Celsius. Manya na buƙatar tabbatar cewa yara ƙanana ba su isa wurin shirya kayan don guje wa mummunan sakamako ba.
Rayuwar shelf shine shekaru 3, a lokacin karewarsa, an haramta yin amfani da miyagun ƙwayoyi.
Abubuwan kwantar da hankali don amfani da miyagun ƙwayoyi
Tunda babu wani bincike na kimiyya a fannin inganci da lahani na maganin Daidaita shi, koyarwar ta cire amfani da ita a lokacin kuruciya (kasa da shekaru 18), haka kuma a lokacin lokacin haihuwa da shayarwa. Hakanan, sakamakon maganin yana tasiri a jikin marasa lafiya da ke da nau'in ciwon sukari na 1 da kuma lura da ilimin insulin.
Baya ga contraindications na sama, masu ciwon sukari an hana shan miyagun ƙwayoyi a irin waɗannan halaye:
- tare da rashin haƙuri a cikin abubuwan da ke cikin ƙwayar;
- tare da rashin jituwa ta galactose daga haihuwa, kazalika da cutar glucose-galactose malabsorption da rashi lactase;
- a cikin mummunan halayen da ke tattare da rauni zuwa ga hanawar DPP-4 (alal misali, angioedema, anaphylaxis);
- a gaban cututtukan cututtukan ƙwayar cuta waɗanda zasu iya haifar da lalacewa na aiki na ƙwayar cuta: zazzabi, hypoxia (sepsis, gigice, cututtukan bronchopulmonary, cututtukan koda), cututtukan cututtuka daban-daban, rashin ruwa a jiki saboda gudawa ko amai;
- tare da dysfunction na koda, lokacin da kwayoyin halitta ke ƙasa da 1.4 mg / d (na mata) da ƙasa da 1.5 mg / dl (ga maza), haka kuma ƙin halittar ƙarancin ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwa a sakamakon kamuwa da cuta, ƙarancin cututtukan cututtukan zuciya;
- tare da acidosis na rayuwa, musamman ketoacidosis mai ciwon sukari;
- tare da maganin cututtukan cututtukan fata da coma;
- a gaban cututtukan cututtukan cututtukan ƙwaƙwalwa da na kullum wanda ke haɓaka dama na hypoxia nama;
- tare da gabatarwar iodine-dauke da wakilin bambanci kwana biyu kafin da bayan gwajin x-ray da gwajin radioisotope;
- lokacin zama kan abinci na musamman (kasa da 1000 kcal a kowace rana);
- tare da mummunan guba tare da ethanol ko shan barasa;
- tare da ayyukan tiyata da mummunan raunin da ke buƙatar gabatarwar insulin;
- tare da dysfunction hanta;
- tare da lactic acidosis.
Kamar yadda aka riga aka ambata, yin amfani da miyagun ƙwayoyi Combogliz Prolong ya zama dole tare da kulawa ta musamman ga tsofaffi marasa lafiya (daga shekaru 60), musamman waɗanda aikinsu yana da alaƙa da ƙwaƙwalwar jiki, da kuma waɗanda ke fama da ciwon huhu.
Marancin marna da Overarfewa
A wasu halaye, saboda rashin amfani da miyagun ƙwayoyi, bayyanar halayen da ba a ke so ba zai yiwu. Wannan tebur yana ba da sakamako masu illa na yau da kullun da ke hade da amfani da Combogliz Prolong.
Reactionsarancin halayen da ke tattare da monotherapy da magani na haɗin gwiwa | |
Saxagliptin | Migraine, sinusitis, kamuwa da cuta na tsarin jijiyoyin jiki, ciwon ciki da amai, haɓakar thrombocytopenia, zawo, hypoglycemia, nasopharyngitis, urticaria, gastroenteritis, facial fitsari, matsanancin ciwon zuciya. |
Metformin | Harkokin halayen da ke hade da daidaitawar jiki ga abu - gudawa, tashin zuciya, amai, haɓakar iskar gas, canjin canji. |
Bugu da ƙari, yayin nazarin dakin gwaje-gwaje, an gano cewa a cikin dogon lokaci na ɗaukar saxagliptin, akwai raguwa a cikin yawan ƙwayoyin cuta, da kuma bitamin B12.
Yawancin lokuta sun sami kaɗan kaɗan, duk da haka, tare da tsawanta amfani da miyagun ƙwayoyi, yana yiwuwa. Saxagliptin baya haifar da maye gawar jiki, amma idan ya kasance yawan overdose za'a iya cire shi ta amfani da hanyar maganin hemodialysis. Hakanan an wajabta maganin cututtukan mahaifa.
Akwai ƙarin rikodin lokuta na overdose na metformin. Babban bayyanar cututtuka sune cututtukan jini da lactic acidosis, wanda yawanci yana tare da lalacewa na koda. Babban alamun cututtukan lactic acidosis sune:
- Gajiya
- Kasawar numfashi.
- Ciwon ciki.
- Hypotension ko hypothermia.
- Myalgia.
- Bradyarrhythmia mai tsayayya.
A cikin mafi munin yanayi, rikicewa ya faru, wanda zai iya haifar da ci gaba da ƙwayar cuta. Babban alamun alamun rashin ƙarfi shine gajiya, farin ciki, fitsari, nutsuwa, damuwa, ƙuna. Metformin 850 shi ma an cire shi ta hanyar hemodialysis, dole ne a ɗauka a zuciyarsa cewa ɗaukar hankali ya kai miliyan 170 a minti daya.
Don guje wa yawan shaye-shaye da sakamako masu illa, mai haƙuri yana buƙatar bin duk shawarar likita kuma kada ya koma ga maganin kansa.
Waɗannan sune manyan ƙa'idodi biyu waɗanda zasu kare daga sakamako mara kyau.
Yin hulɗa tare da wasu kwayoyi
Ya kamata a tuna cewa ba kowane magunguna za'a iya amfani dashi tare da wasu ba. Tunda akwai halayen sunadarai daban-daban tsakanin abubuwan da ke tattare da magungunan, wannan na iya haifar da halayen da ba a iya tantancewa ba.
Don haka, wasu ƙwayoyi na iya rage tasirin hypoglycemic na saxagliptin da metformin, a sakamakon haka, matakin glucose a cikin jini ya hauhawa. Hakanan, wasu suna inganta tasirin rage sukari daga abubuwan, wanda ke haifar da raguwa cikin sauri na abun sukari.
Saxagliptin | Metformin |
Inganta yanayin hyperglycemic | |
Pioglitazone, rifampicin, aluminum hydroxide / magnesium hydroxide / simethicone. | GCS, thiazide diuretics, acid nakitinic Isoniazid, estrogens, hormones thyroid, jinƙai mai juyayi, phenothiazines, jinkirin tashar alli, phenytoin. |
Cutar da hauhawar jini | |
Diltiazem, Amprenavir, Erythromycin, Fluconazole, Aprepitant, Verapamil, ruwan 'ya'yan innabi, Ketoconazole, isoenzymes mai ƙarfi CYP3A4 / 5, Glibenclamide, Ketoconazole, Famotidine, sulferilurea abubuwan ƙira. | Magungunan Cationic, Furosemide, Nifedipine, magunguna dauke da ethanol. |
Don haka, haramun ne a sha magunguna da kai. Da farko kuna buƙatar ganin likita wanda zai iya zaɓar mafi dacewa da magungunan.
Kudin da sake dubawa na likitoci, marasa lafiya
A ina zaka saya Combogliz Na Tsawan Lokaci? Da kyau, ana iya siye magungunan a kantin magani na yau da kullun ko sanya oda a kan shafin yanar gizon official na mai siyar da Rasha.
Magungunan da aka zaɓa da mai haƙuri dole ne ya hadu da sigogi biyu - sakamako na warkewa da farashi.
Farashin magani ya dogara da irin sakinsa, saboda haka, ya bambanta tsakanin irin waɗannan iyakokin:
- 1000 mg + 5 MG (Allunan 28 a kowace fakitin): daga 2730 zuwa 3250 rubles;
- 1000 mg + 2.5 MG (Allunan 56 a kowace fakitin): daga 2,600 zuwa 3,130 rubles.
Kamar yadda kake gani, farashin ya yi tsada kwarai, saboda Combogliz Prolong magani ne mai shigo da shi. Wannan shine babban koma-bayan sa, tunda marassa lafiya da masu karamin karfi ba zasu iya samun irin wannan magani mai tsada ba.
Ya kamata a lura cewa babu maganganu da yawa game da amfani da maganin ta hanyar marasa lafiya. Ainihin, akan Intanet zaka iya samun bita na likitoci, wanda yawancinsu suna kiran wannan kayan aiki na musamman. A cewar su, maganin ba wai kawai ya zama daidai da matakin glucose a cikin masu ciwon suga ba, amma yana taimakawa wajen sarrafa nauyin su, godiya ga metformin da ke ciki.
Koyaya, kawai waɗannan marasa lafiya waɗanda ke bin ka'idodin maganin rage cin abinci don ciwon sukari na mellitus kuma suna shiga kullun a cikin aikin jiki suna iya rage nauyin jiki. Kamar yadda suke faɗi, kwayar sihiri daga dukkan cututtuka bata wanzu.
Don haka, yawancin marasa lafiya sun lura cewa warkewar tasirin maganin yana da tasiri sosai: bayan amfani da shi, ana kiyaye yawan abubuwan da ke tattare da sukari na yau da kullun. Amma matakinsa na iya "tsalle" lokacin da mai ciwon sukari baya bin abinci, yana barin kansa lamuran abinci da sauran abinci da aka haramta, da kuma lokacin tashin hankali na tashin hankali.
Gabaɗaya, za'a iya sanin cewa Combogliz Prolong magani ne mai amintacce mai cikakken ƙarfi. Koyaya, kuna buƙatar fara tuntuɓar likita game da amfani.
Haka magunguna
Wani lokaci mai haƙuri shan wannan magani yana da halayen da ba a so. Wannan na iya zama saboda rashin jituwa ga abubuwan da ya ƙunshi, abubuwan hana sabani da makamantansu.
A irin waɗannan halayen, likita ya fara daidaita tsarin kulawa kuma zaɓi wani magani wanda ya yi kama da tasirin warkewarta. Daga cikin mashahuran analogues na miyagun ƙwayoyi Combogliz Prolong, bari mu zaɓi:
- Yanumet - magani ne wanda ya hada da metfomin da saxagliptin. Babban bambanci shine cewa za'a iya ɗaukar Janumet tare da maganin insulin, kamar yadda kuma tare da agonists gamma receptor. Nazarin masu ciwon sukari da ke fama da nau'in cututtukan da ba su da izinin insulin suna dacewa da kyau. Matsakaicin farashin magungunan Yanumet (100 MG + 50 MG, Allunan 56) shine 2830 rubles.
- Galvus Met magani ne wanda babban kayansa shine vildagliptin da metfomin. Kodayake abun da ke ciki ya bambanta sosai da Combogliz Prolong, yana da tasirin hypoglycemic iri ɗaya. Ana iya haɗuwa dashi tare da insulin, abubuwan da suka dace na sulfonylurea, da metformin. Matsakaicin farashin 1 fakitin dauke da allunan 30 (50 mg + 1000 mg) shine 1,540 rubles.
- Xr comboglyce wani ingantaccen hypoglycemic ne. Ya ƙunshi metformin da saxagliptin. Sashin magunguna Comboglize Xr an ƙaddara ta halartar ƙwararren halartar, wanda ke la'akari da yanayin lafiyar mai haƙuri. Ba a amfani da magani Combogliz Xr, kamar Combogliz Prolong, a cikin yara da mata masu juna biyu. Daga cikin halayen da ba daidai ba tare da Combogliz Xr, ana iya lura cewa sun yi kama da Combogliz Prolong. Matsakaicin farashin Xr Comboglise (2.5 + 1000mg, Allunan 28) shine 1650 rubles.
Don haka, Combogliz Prolong shine magani mai tasiri a cikin yaki da alamun cututtukan sukari, musamman tare da hyperglycemia. Koyaya, idan ba zai yiwu ba siyan sa, zaɓi zaɓi mafi kyau wanda zai sami sakamako mai kyau.
Baya ga Combogliz Prolong, akwai wasu magunguna masu rage sukari. Kwararren zai ba ku ƙarin bayani game da su a cikin bidiyon a cikin wannan labarin.