Tare da ci gaban cututtukan da ba su da insulin-da ke fama da ciwon sukari, marasa lafiya koyaushe ba su iya sarrafa matakin glycemia ta amfani da abinci na musamman da aikin jiki. Onglisa magani ne mai rage sukari da ake amfani dashi a irin waɗannan lokuta don daidaita taro na glucose a cikin jini.
Kamar kowane magani, Onglisa yana da wasu contraindications, halayen cutarwa, da kuma abubuwan amfani. Sabili da haka, kafin amfani da miyagun ƙwayoyi, kuna buƙatar gano cikakken bayani game da shi.
Onglisa (a lat. Onglyza) sanannen magani ne da ake amfani dashi a duk duniya don nau'in ciwon sukari na 2. Sunan duniya mai zaman kansa (INN) na miyagun ƙwayoyi shine Saxagliptin.
Wanda ya kirkiro wannan wakili mai ma'anar jini shine kamfanin kera magunguna na Amurka Bristol-Myers Squibb. Babban ɓangaren - saxagliptin an ɗauke shi ɗayan mafi ƙarfi zaɓin sakewa masu iyawa na dipeptidyl peptidase-4 (DPP-4). Wannan yana nufin cewa lokacin da aka sha magani a baki, babban abu yana hana aikin enzyme na DPP-4 yayin rana.
Baya ga saxagliptin, allunan Ongliz sun ƙunshi ƙaramin adadin ƙarin abubuwan haɗin - lactose monohydrate, sodium croscarmellose, microcrystalline cellulose, macrogol, talc, dioxide titanium, magnesium stearate da wasu sauransu. Dogaro da nau'in sakin, kwamfutar hannu guda ɗaya na miyagun ƙwayoyi na iya ƙunsar 2.5 ko 5 mg na abu mai aiki.
Yaya mai maganin antidiabetic Onglisa yake aiki bayan ya shiga jikin mutum? Saxagliptin yana cikin hanzari a cikin narkewa, ana lura da mafi girman abubuwan da ke cikin jini jini bayan sa'o'i 2-4 bayan fitowar. Magungunan suna da irin wannan sakamako:
- Theara matakin ISU da GLP-1.
- Yana rage abun ciki na glucagon, kuma yana haɓaka amsawar sel sel, wanda ke haɓaka matakin C-peptides da insulin.
- Yana tsokani sakin hormone mai rage sukari ta hanyar sel wadanda ke cikin hanji.
- Yana hana sakin glucagon daga sel alpha na tsibirin na Langerhans.
Ta hanyar tsokane hanyoyin da ke sama a jikin mutum, maganin Onglis yana inganta dabi'un haemoglobin na glycated (HbA1c), alamomin glucose akan ciki mara nauyi kuma bayan cin abinci. Likitocin na iya ba da magani a haɗe tare da sauran wakilai na hypoglycemic (metformin, glibenclamide ko thiazolidinediones).
An cire abu mai aiki daga jiki a cikin tsari wanda ba a canzawa ba kuma a cikin hanyar metabolite tare da bile da fitsari.
A kan matsakaita, kyautar sikelin na saxagliptin shine 230 ml a minti daya, kuma adadin girman girman gidan (GFR) shine 120 ml a minti daya.
Umarnin don amfani da allunan
Kafin shan maganin, mai haƙuri yana buƙatar tattaunawa da ƙwararren ma'aikacin kiwon lafiyarsa wanda zai ƙayyade sashi ɗaya gwargwadon matakin sukari na masu ciwon sukari. Lokacin sayen magani na Onglisa, umarnin don amfani ya kamata a karanta a hankali kuma idan kuna da tambayoyi ku tambayi likitan su.
Ana amfani da Allunan ba tare da la'akari da lokacin cin abinci ba, a wanke da gilashin ruwa. Idan an dauki maganin a matsayin monotherapy, to, maganin yau da kullun shine 5 MG. Idan likita ya ba da izinin hada magani, to, an ba shi damar amfani da Ongliza 5 MG kowace rana tare da metformin, thiazolidinediones da sauran magungunan hypoglycemic.
Hada Onglisa da metformin, kuna buƙatar biye da matakin farko na 5 MG da 500 MG, bi da bi. An haramta shi sosai don ɗaukar ninki biyu a cikin shari'ar lokacin da mai haƙuri ya manta da shan maganin a kan lokaci. Da zaran ya tuna da wannan, yana buƙatar shan kwaya ɗaya.
Musamman abin lura shine marasa lafiya da ke fama da gazawar koda. Tare da wani nau'i mai laushi na lalata koda, ba lallai ba ne don daidaita adadin maganin. A cikin marasa lafiya da matsakaiciyar matsakaici ko gazawar rashin ƙarfi, kazalika da waɗanda ke fama da cutar sankara, yawan maganin yau da kullun shine 2.5 mg. Bugu da ƙari, lokacin amfani da mai ƙarfi na CYP 3A4 / 5 inhibitors, yawan maganin Onglis ya kamata ya zama kaɗan (2.5 MG).
Mai sana'anta ya nuna akan lokacin shirya kaya, wanda yawanci shekaru 3 ne. An adana magungunan daga ƙananan yara a zazzabi da bai wuce digiri 30 ba.
Contraindications da yiwu cutar
Tun da masana'anta ba su gudanar da isasshen gwaje-gwaje ba game da amfani da magani na Ongliz don kamuwa da insulin-da ke fama da cutar, da hadaddun amfani da insulin, har ma da yara da samartaka, a irin waɗannan halayen, an haramta maganin.
Bugu da kari, a hukumance da aka yarda da contraindications don amfani sune ketoacidosis na ciwon sukari, lactation da ciki, rashin kwanciyar hankali ga abubuwan da ke cikin miyagun ƙwayoyi, rashi lactase, glucose-galactose malabsorption da ƙwaƙwalwar jijiyoyin cututtukan ƙwayar cuta zuwa galactose.
Likita ya auna fa'idodi da fursunoni kafin ya tsara magungunan Onglis ga tsofaffi marassa lafiya da ƙarancin rashin ƙarfi a haɗe tare da abubuwan ƙira na sulfonylurea.
Wasu lokuta yayin aiwatar da shan magunguna, sakamakon da ba a so ya bayyana. Magungunan Onglisa yana da kaɗan daga gare su, kodayake, mai haƙuri na iya yin korafi game da:
- sinusitis (kumburi da hanci hanci);
- gagging;
- ciwon kai
- cututtukan urinary fili;
- ci gaban gastroenteritis (kumburi da ƙananan hanji da ciki);
- cututtukan mahaifa na sama;
- nasopharyngitis (hadadden amfani da Onglisa tare da metformin).
Wanda ya kera ba ya nuna alamun yawan shan kwayoyi. Koyaya, lokacin da alamun suka bayyana wanda zai iya nuna yawan zubar jini, ana amfani da hemodialysis don kawar da saxagliptin da metabolites ɗin daga jikin.
Hakanan ana yin magani na Symptomatic.
Siffofin hulɗa tare da wasu kwayoyi
Ba kamar sauran magungunan antidiabetic ba, alal misali, Metformin, ana iya amfani da maganin Onglis a hade tare da kusan dukkan hanyoyin. Koyaya, idan kowane cututtukan haɗuwa suka faru, mai ciwon sukari yakamata ya tafi ofishin likita don ware yiwuwar cutar daga irin waɗannan kwayoyi.
Wasu kwayoyi, irin su Carbamazepine, Phenytoin, Phenobarbital, Dexamethasone, Rifampicin, waɗanda ke cikin inginan na CYP 3A4 / 5, na iya rage abubuwan da ke tattare da metabolites na ainihin abubuwan da ke aiki. Saboda haka, sakamakon shan waɗannan magunguna yana haɓaka matakin glucose a cikin masu ciwon sukari.
Sakamakon gaskiyar cewa abubuwan da ke haifar da sulfonylurea suna haɓaka yiwuwar bayyanar cututtuka na hypoglycemia, sashi idan aka yi amfani da su tare da Onglisa yakamata a rage shi kaɗan.
A cikin umarnin da aka haɗe akwai umarnin ɗaukar Onglisa. Tun da wannan maganin yana haifar da tsananin damuwa a wasu yanayi, ana ba da shawarar cewa marasa lafiya waɗanda aikinsu ke da alaƙa da abubuwan hawa da sarrafa kayan injiniya ya kamata a cire su daga irin wannan aikin yayin da suke amfani da maganin.
Wannan zato ne kawai domin babu wani binciken da aka gudanar kan tasirin maganin a lokutan kulawa.
Ra'ayoyi game da miyagun ƙwayoyi da farashinsa
A yanar gizo zaka iya samun maganganu masu yawa game da wakili na hypoglycemic wakili Onglisa. Wannan magani ne mai kyau wanda ke rage matakan sukari a cikin masu ciwon sukari masu kamuwa da cuta ta 2. Daga cikin fa'idodin maganin akwai sauƙin amfani, mai saurin faruwa game da sakamako masu illa da tasirirsa.
Nazarin marasa amfani suna da alaƙa da farashin magunguna. Tunda an samar dashi kasashen waje, farashin sufuri, share kwastomomi na magunguna, da sauransu yana ƙaruwa. Manufar farashin kuɗi an yi shi ne ga marasa lafiya da ingantaccen wadata. Don haka, farashin 1 fakitin Onglisa, wanda ya ƙunshi allunan 30 na 5 MG kowane, ya tashi daga 1835 zuwa 2170 rubles. Don adana wasu kuɗi, marasa lafiya suna ba da umarni don sayan magani a kan layi. Kudin magungunan da aka saya ta hanyar yanar gizo za su ragu sosai fiye da na kantin magani na yau da kullun.
Duk da kyakkyawar ra'ayi na marasa lafiya da likitoci game da maganin antidiabetic, ga wasu bai dace ba. A yanar gizo za ku iya samun wasu lokuta maganganun cewa maganin bai da raguwar matakan glucose kwata-kwata. Sabili da haka, likitoci sun tsara Onglisa da miyagun ƙwayoyi a matsayin ƙari ga farji tare da Siofor ko Diabeton.
Kada mu manta cewa allunan da kansu ba zasu iya samun ingantaccen sakamako na rage girman cutar glycemia ba.
Kawai hadaddiyar hanyar abinci da wasanni zasu taimaka wajen cimma sakamakon da ake so.
Haka magunguna
A wasu halaye, shan miyagun ƙwayoyi Onglisa ya zama ba zai yiwu ba.
Sannan likita yana fuskantar aikin daidaita tsarin kulawa da mai haƙuri.
Kwararrun sun zaɓi magani wanda ya ƙunshi kayan aiki guda ɗaya, ko kuma yana da tasirin warkewa iri ɗaya.
Areasa da shahararrun analogues na miyagun ƙwayoyi Onglisa.
- Galvus - fili vildagliptin mai aiki, farashi 789 rubles.
- Vipidia - alogliptin fili mai aiki, farashi 1241 rubles.
- Januvia - sitoliptin fili mai aiki, farashin 1634 rubles.
- Glucovans - glibenclamide mai aiki + metformin hydrochloride, farashin 270 rubles
- Trazhenta - linagliptin mai aiki mai aiki, farashin 1711 rubles.
Analogues na miyagun ƙwayoyi Onglisa suna da tsada sosai, sai dai Glucovans da Glucofage. Abin takaici, ba a bayar da maganin kyauta ba kan sharuɗɗan zaɓe. Amma mai haƙuri yana da damar tambayar likitansa don maye gurbin Ongliz da aka tsara tare da analogues waɗanda aka bayar kyauta tare da takardar da ta dace. Don masu ciwon sukari, Metformin, Glibenclamide, Glyclazide, Glimepiride da sauran magunguna za a iya ba su ta wani fifiko.
Kowane likita da haƙuri a cikin ƙayyadaddun ƙaddara abin da zai fi dacewa da shi. Bayan haka, miyagun ƙwayoyi na iya zama mai tasiri, amma yana da tsada sosai kuma, a taƙaice, rahusa, amma baya samar da madaidaiciyar ƙwayar cutar. Mafi kyawun zaɓi shine ƙimar kuɗi.
Ciwon sukari mellitus cuta ce mai tsananin mahimmanci wacce ke buƙatar kulawa ta musamman. Don haka matakin sukari bai tashi ba, kuna buƙatar ba kawai shan kwaya bisa ga shawarar likita ba, har ma da bin wani tsayayyen abincin ku kuma jagoranci salon rayuwa mai aiki.
Wasu sun yi imani cewa Onglisa shine mafi kyawun magani wanda ya ƙunshi saxagliptin. Amma dole ne mu manta cewa kowace magani na iya ɗaukar haƙiƙa. Sabili da haka, ya kamata marasa lafiya su karanta bayanin maganin. Kawai hanyar da ta dace don gudanar da cutar sikari ce zata daidaita matakan glucose na jini.
Dr. Gorchakov zai yi magana game da ka'idodi na jiyya ga masu ciwon sukari na 2 a cikin bidiyo a cikin wannan labarin.
