Abin baƙin ciki, koyaushe ba zai yiwu a sarrafa matakan sukari tare da motsa jiki na motsa jiki da abinci mai dacewa ba. Don haka dole ne ku yi amfani da, alal misali, Galvus, analogues na gida, farashin abin da yake ƙasa da magungunan da aka shigo da su, wanda ke da alaƙa da rage farashin sufuri, inshora, marufi.
Sakamakon tsadarsa mai yawa, yawancin lokuta marasa lafiya da ke da ƙananan rago da na matsakaita dole su canza zuwa jiyya tare da analogues. Amma menene mafi kyawun zaɓi? Za a tattauna wannan a gaba, amma da farko, ya kamata ku fahimci kanku da miyagun ƙwayoyi Galvus.
Abubuwan da ke aiki na wakilin maganin hypoglycemic shine vildagliptinum, amma akwai zaɓuɓɓuka don haɗuwa tare da metformin. Lokacin sayen magani a kantin magani, mai kantin yana bayar da magunguna daban-daban - 50 mg, haka kuma a hade tare da metformin 50/500 mg, 50/850 mg da 50/1000 mg.
Vildagliptin rukuni ne na abubuwa wanda ke haɓaka aikin alpha da beta beta waɗanda ke haifar da tsibirin na Langerhans a cikin ƙwayar cuta da hana aikin dipeptidyl peptidase-4. Wannan enzyme na musamman yana lalata nau'in glucagon-kamar 1 peptide (GLP-1) da polypeptide-insulinotropic-glucose-glucose-HIP.
Janar halaye na miyagun ƙwayoyi
Godiya ga vildagliptin, mummunan tasirin dipeptidyl peptidase-4 an rage shi, kuma samar da GLP-1 da HIP, akasin haka, yana haɓaka. Lokacin da matakan waɗannan abubuwan da ke cikin jini ya tashi, vildagliptin yana iya inganta yiwuwar ƙwayoyin beta zuwa ga glucose ɗin da aka samar, ta haka ne yake haɓaka samar da ƙwayar suga. Ya kamata a lura cewa ƙimar haɓaka aikin beta sel ya dogara da matakin lalacewarsu. Sabili da haka, a cikin mutane masu matakan sukari na yau da kullun, vildagliptin ba ya shafar samar da insulin kuma ba shakka, samar da glucose.
Bangaren mai aiki yana kara yawan GLP-1 kuma nan da nan yana kara karfin jijiyoyin sel na islet din kayan aiki zuwa glucose. Sakamakon haka, samar da glucagon yana ƙaruwa. Decreasearin raguwa a cikin matakin ƙaruwa yayin cin abinci yana haifar da karuwa a cikin ƙwayar jijiyoyin sel zuwa haɓakar ƙwayar sukari.
A yayin haɓaka mai sauri cikin matakan sukari, glucagon da matakan insulin suna ƙaruwa, wanda kai tsaye ya dogara da yawan haɓaka GLP-1 da HIP, kuma aiwatar da samar da glucose a cikin hanta yana rage gudu duka a lokacin abinci da bayan shi, wanda ke haifar da raguwar tarin glucose a cikin jini. Ya kamata a sani cewa daɗaɗaɗɗen abin da ke ƙaruwa a cikin GLP-1 na iya rage aiwatar da ɓacin rai, kodayake a aikace maganin bai tsokani cigaban irin wannan sabon abu ba.
Cikakken amfani da abubuwa guda biyu - metformin da vildagliptin, har ma sun fi dacewa a sarrafa matakin glycemia a cikin masu ciwon suga na tsawon awanni 24.
Umarnin don amfani da allunan
Cin abinci ba ya shafar amfani da miyagun ƙwayoyi Galvus ko Galvus Met.
Kafin amfani da maganin, ya zama dole a nemi taimakon ƙwararrun masani waɗanda za su ƙayyade sashi daban.
A cikin umarnin da aka haɗe don maganin Galvus 50 MG, ana nuna ƙarancin likita wanda halayen likita zai iya daidaitawa:
- Tare da monotherapy ko a hade tare da maganin insulin, thiazolidinedione, metformin - 50-100 mg.
- Masu fama da cutar sikari wadanda suka kamu da cutar siga suna daukar 100 MG kowace rana.
- Amincewa da vildagliptin, abubuwan asali na sulfonylurea da metformin - 100 MG kowace rana.
- Hadaddun amfani da sulfonylurea da kayan aikin Galvus suna ba da shawarar kashi 50 na MG kowace rana.
- Idan mai ciwon sukari yana da daskararwa na matsakaici da kuma cutar haɓaka na koda, kashi ɗaya na rana shine 50 MG.
Saka ya ƙunshi bayanin cewa yakamata a ɗauki allurai 50 a lokaci da safe, kuma ya kamata a raba 100 MG zuwa allurai biyu - da safe da maraice.
Dos na miyagun ƙwayoyi Galvus Met shi ma likita ya ƙaddara shi, la'akari da matakin sukari da haƙuri da abubuwan da miyagun ƙwayoyi ke ba wa mara haƙuri. Jagorar tana ba da shawarar matsakaita masu zuwa:
- tare da amfani mara amfani da vildagliptin an bada shawarar shan 50/500 mg sau biyu a rana;
- idan amfani da metformin ba shi da tasiri, ɗauki 50/500 mg, 50/850 mg ko 50/1000 mg sau biyu a rana, dangane da metformin da aka yi amfani da shi a baya;
- tare da haɗuwa mara amfani na vildagliptin da metformin, 50/500 mg, 50/850 mg ko 50/1000 MG sau biyu a rana ana amfani da su, gwargwadon abubuwan da aka yi amfani da su;
- yayin farkon magani tare da miyagun ƙwayoyi saboda rashin daidaituwa na abinci da motsa jiki, ɗauki 50/500 mg sau ɗaya a rana;
- a hade tare da maganin insulin da abubuwan asali na sulfonylurea, sashi na vildagliptin shine 50 MG sau biyu a rana, kuma metformin iri ɗaya ne kamar yadda yake tare da monotherapy.
Yin amfani da miyagun ƙwayoyi an haramta shi sosai ga masu ciwon sukari da ke fama da gazawar koda da sauran cututtukan wannan sashin. Bugu da kari, an wajabta kulawa ta musamman ga marasa lafiya na nau'in tsufa (sama da shekaru 65), tunda galibi suna da raguwa a aikin koda.
Likita na iya kara yawan maganin, kodayake, haramun ne a shiga cikin jinyar da kanka, wannan na iya haifar da sakamako da ba za a iya jurewa ba.
Contraindications da yiwuwar lahani
Magunguna suna da contraindications da yawa, har ma da sauran magunguna.
Ainihin, contraindications suna haɗuwa da ikon wasu gabobin ɗan adam don cire abubuwa masu aiki daga jiki.
Haramun ne a yi amfani da hanyar Galvus da Galvus Met don masu ciwon suga da ke fama da wahala ko kuma fama da wasu cututtuka:
- Rashin ƙoshin Rashin ƙira ko gazawar renal (ƙirar creatinine ya fi 135 /mol / L a cikin namiji, fiye da 110 μmol / L a cikin mace).
- Abubuwan cututtukan ƙwaƙwalwa waɗanda ke haɓaka yiwuwar haɓakar ƙirar koda. Waɗannan sun haɗa da rashin ruwa (amai ko gudawa), zazzabi, kamuwa da cuta, da kuma yanayin hypoxia.
- Dysfunction hanta.
- Na farko na lactic acidosis.
- A ci gaba da na numfashi gazawar.
- Haɓaka bugun zuciya a cikin m da na kullum, kazalika da m infarin ɓoyewar zuciya.
- Metabolic acidosis, gami da farawar ketoacidosis, coma, precoma.
- A lokacin haihuwar yaro da shayarwa.
- Ciwon insulin da ke fama da cutar siga.
- Turewa.
- Ba za ku iya amfani da miyagun ƙwayoyi kwana biyu kafin da kuma bayan gwajin rediyo da radioisotope tare da gabatarwar wani ɓangaren iodine.
- Shiga ciki tare da barasa ko kamanninsa.
- Abincin mai-kalori (kasa da 1000 kcal a kowace rana).
- Ba a kasa da shekara 18 ba.
- Rashin haƙuri na mutum zuwa vildagliptin, metformin da sauran abubuwan haɗin.
Idan ana amfani da miyagun ƙwayoyi ta hanyar da ba ta dace ba ko don dalilai da suka wuce ikon haƙuri, halayen da ba su dace ba na iya faruwa, misali:
- ciwon kai da danshi;
- karancin rauni na tsoka (rawar jiki) da jin sanyi;
- gastroesophageal reflux;
- yawan tashin zuciya da amai;
- zawo ko maƙarƙashiya;
- ƙara haɓakar gas a cikin hanji;
- canza a dandano
- hypoglycemia;
- gajiya;
- hyperhidrosis;
- rashes a kan fata, itching, urticaria;
- tsagewar yanki;
- arthralgia (ciwon gwiwa);
- exfoliation na fata;
- bayyanar blister;
- lactic acidosis;
- karancin bitamin B12;
- maganin ciwon huhu
Bugu da kari, hepatitis na iya ci gaba a jiki.
Kudin, sake dubawa da kuma daidaitawa
Wanda ya kirkiro maganin shine kamfanin samar da magunguna na Switzerland Novartis, wanda ke samar da kwayoyi tare da vildagliptin ko tare da hade da vildagliptin tare da metformin.
Ana iya ba da umarnin magunguna ta hanyar kan layi ko kawai zuwa kantin magani mafi kusa. Farashin magani ya dogara da irin sakinsa. Matsakaicin farashi kamar haka:
- Galvus 50 MG (Allunan 28) - 765 rubles.
- M Galvus Met 50/500 MG (Allunan 30) - 1298 rubles.
- M Galvus Met 50/850 MG (Allunan 30) - 1380 rubles.
- Galvus Met 50/1000 MG (Allunan 30) - 1398 rubles.
Kamar yadda kake gani, miyagun ƙwayoyi basu da arha. Ba kowa ba ne zai iya samun wadatar magani koyaushe tare da waɗannan kwayoyi, don haka akwai buƙatar zaɓi irin kwayoyi, waɗanda za a tattauna daga baya.
Amma game da ra'ayi a kan miyagun ƙwayoyi Galvus, galibi suna da inganci. Binciken yawancin marasa lafiya da ke shan magani ya nuna cewa bayan watanni 1-2 na ɗaukar Galvus, alamu na glucose sun koma al'ada. Bugu da kari, masu ciwon sukari suna son hakan yayin amfani da miyagun ƙwayoyi kuna iya cin abinci da aka haramta a baya. Galvus Met, godiya ga metformin, yana taimakawa rasa karin fam miliyan 3-4 a cikin marasa lafiya tare da kiba. Ko da yake, maganin yana da babbar hasara guda daya - yana da hauhawar farashin sa.
Idan an hana mai haƙuri yin amfani da Galvus saboda contraindications ko sakamako na gefen, likita ya tsara wani magani. Wadannan na iya zama alamu, watau wadancan samfuran wadanda ke dauke da abu guda mai aiki, bambanci shine kawai a cikin wasu abubuwan hadewa. Galvus Met shine kawai ma'anar Galvus; waɗannan shirye-shirye biyu ne waɗanda ke ɗauke da vildagliptin.
Koyaya, waɗannan magunguna suna da magunguna masu kama da yawa masu yawa tare da tasirin warkewa, wanda za'a tattauna daga baya.
Analogs na miyagun ƙwayoyi Galvus
Wannan rukuni na kwayoyi sun hada da sashi mai aiki - vildagliptin. Wadannan sun hada da kudaden Vipidia, Onglisa, Januvius da Trazent. A cikin Russia, ba a samar da shirye-shiryen da ke kunshe da vildagliptin ba, don haka za mu yi magana game da magunguna da aka shigo da su.
Vipidia magani ne mai rage sukari wanda aka yi niyya don monotherapy ko magani hade da ciwon sukari na 2. An fito dashi a cikin nau'in kwamfutar hannu, mafi girman kullun shine 25 MG kuma baya dogara da abincin. Ma'aikatan hypoglycemic ba za su iya ɗaukar masu ciwon sukari tare da koda ba, hepatic, gazawar zuciya, tare da ketoacidosis masu ciwon sukari da kuma nau'in insulin-mai ciwon sukari. Sakamakon sakamako yana kama da mummunan sakamako na miyagun ƙwayoyi Galvus. Sakamakon karancin bayanai kan illolin da kwayoyi ke haifarwa ga yara ‘yan kasa da shekaru 18 da mata masu juna biyu, ba a sanya wa irin wadannan nau’ikan marasa lafiya. Matsakaicin farashin Vipidia (25 mg 28 Allunan) shine 1239 rubles.
Onglisa shiri ne mai kyau don kiyaye matakan glucose na jini akan komai a ciki kuma bayan cin abinci. Godiya ga babban abu saxagliptin, har ila yau, maganin yana sarrafa abubuwan glucagon. Ana iya amfani dashi duka biyu azaman kadara ingantacciya kuma a hade tare da wasu magunguna. Magungunan Onglis yana contraindicated a cikin ilimin insulin, nau'in ciwon sukari na 1 da ketoacidosis. Babban halayen halayen sune ciwon kai, kumburi, makogwaro. Matsakaicin farashin maganin (5 MG 30 Allunan) shine 1936 rubles.
Januvia wakili ne na jini, wanda ya haɗa da sitagliptin mai aiki. Yin amfani da miyagun ƙwayoyi yana taimakawa wajen daidaita matakan glycemia da glucagon. Dosages an ƙaddara ta mai halartar likitan mata, wanda ke yin la'akari da abubuwan sukari, lafiyar gaba ɗaya da sauran abubuwan. Magungunan Janavia an contraindicated idan akwai wani ciwon sukari-dogara da ciwon sukari da kuma mutum rashin yarda da aka gyara. Yayin amfani, ciwon kai, raunin narkewa, raunin haɗin gwiwa, da cututtukan numfashi na iya faruwa. A matsakaici, farashin magani (100 MG guda 200 kwalaji) shine 1666 rubles.
Trazhenta magani ne wanda aka samar dashi a cikin nau'ikan allunan tare da abu mai aiki lignagliptin. Yana raunana gluconeogenesis kuma yana daidaita matakan sukari. Likita ya zabi kashi-kashi daban-daban ga kowane mara lafiya.
Ba za a iya amfani da shi ba don ketoacidosis, nau'in ciwon sukari na 1 da rashin haƙuri ga abubuwan da ke ciki. Matsakaicin matsakaici (5 MG 30 Allunan) shine 1769 rubles.
Analogs na miyagun ƙwayoyi Galvus Met
A cikin miyagun ƙwayoyi Galvus Met, analogues sune Avandamet, Glimecomb, Combogliz Prolong na samarwa na Rasha, dauke da galibi manyan abubuwa guda biyu don tasirin hypoglycemic mafi inganci.
Avandamet wakili ne na haɗin gwiwa wanda ke ɗauke da manyan abubuwan biyu - rosiglitazone da metformin. Ana amfani da miyagun ƙwayoyi a cikin maganin cututtukan da ba su da insulin-da ke fama da ciwon sukari. Ayyukan rosiglitazone an yi niyya don haɓaka hankalin masu karɓar sel zuwa insulin, da metformin - a raunana samar da glucose ta hanta. Matsakaicin farashin maganin (500/2 mg 56 Allunan) shine 210 rubles, saboda haka analog ne mai ƙima sosai.
Glimecomb wani magani ne mai inganci wanda ke daidaita matakin glucose na masu ciwon sukari. Ya ƙunshi manyan abubuwa guda biyu - gliclazide da metformin. Contraindications don yin amfani da wannan magani sune cututtukan da suka dogara da insulin, coma da precoma, hypoglycemia, ciki, shayarwa da sauran cututtukan. Matsakaicin matsakaici (40/500 mg 60 Allunan 60) 440 rubles ne.
Combogliz Prolong ya haɗa da irin waɗannan abubuwan asali kamar metformin da saxagliptin. Ana amfani dashi don nau'in ciwon sukari na 2, lokacin da aiki na jiki da abinci na musamman ba zai iya samar da raguwar glucose ba. Magungunan yana taimakawa insulin daga sel beta kuma yana inganta yiwuwar ƙwayoyin sel a ciki. Contraindications don yin amfani da miyagun ƙwayoyi sune hankalin mutum ga abubuwan da ke cikin miyagun ƙwayoyi, ciwon sukari-dogaro da kansa, yara, haihuwar yara, lactation, koda mai rauni, hanta, acidosis metabolic da sauransu. Matsakaicin farashin maganin (1000/5 mg 28 Allunan) shine 2941 rubles.
Dangane da contraindications, m cutar da babban farashin magani, ana iya maye gurbin shi da wani. Kamar yadda kake gani, magunguna a cikin wannan jerin kusan duk tsada ne sosai. Daga cikinsu, ana iya rarrabe analogues guda biyu - Glimecomb da Avandamet, waɗanda sune mafi arha a tsakanin sauran magungunan cututtukan jini. Lokacin zabar mafi kyawun zaɓi, duka likita da mai haƙuri suna yin la’akari da mahimman abubuwa guda biyu - farashi da tasirin magani.
Ana ba da bayani game da mafi kyawun magungunan cututtukan ƙwayar cuta a cikin bidiyo a cikin wannan labarin.
