Babban sashin magunguna da babban aiki shine metformin. A cikin kwamfutar hannu, yana nan a cikin nau'in hydrochloride.
Magunguna suna samar da maganin ta hanyar kwamfutar hannu. Allunan an cakuda su a blisters na musamman kuma an rufe su da tsare-tsaren aluminum. An rufe kowane giro tare da allunan 15 na miyagun ƙwayoyi.
A cikin kantin magunguna, aiwatar da miyagun ƙwayoyi Glucofage mai tsawo ana aiwatar dashi a cikin kwantena na kwalliya dauke da blister 2 ko 4. Kowace kunshin na miyagun ƙwayoyi Glucofage tsawon 750 yana da koyarwa don amfani, wanda ke bayyana dalla-dalla game da dukkanin rashin amfani da magunguna yayin maganin ciwon sukari mellitus.
Abun da maganin ya haifar da tasirin sa a jikin mai cutar siga
Babban sinadari mai aiki - metformin, wani fili ne na ƙungiyar biguanide.
Bungiyar biguanide tana da tasirin sakamako na hypoglycemic.
Baya ga metformin hydrochloride, a matsayin babban bangaren aiki mai aiki, allunan maganin suna dauke da sinadarai wadanda ke yin aikin taimako.
Abubuwa masu taimako sun hada da wadannan abubuwan:
- Carmlolose sodium;
- hypromellose 2910 da 2208;
- MCC;
- magnesium stearate.
Allunan waɗanda ke cikin babban sinadaran aiki suna da milligrams 750.
Lokacin da ake shigar da ƙwayar cuta mai suna Glucofage Long, bangaren da yake aiki ana ɗaukar shi gaba ɗaya daga ƙwayar ƙwayar gastrointestinal zuwa jini. Idan an sha magani a lokaci guda yayin cin abinci, tsarin sha zai rage gudu.
Bayan sha, bioavailability na fili shine kimanin kashi 50-60%. Shiga cikin kasusuwa na jikin, metformin yana yin saurin rarraba cikin kyallen. A yayin jigilar abubuwa, kwayar aiki mai aiki da kullun ba ta samar da hadaddun ƙwayoyin cuta tare da sunadaran dake cikin jini na jini.
Metformin baya motsawar insulin a cikin ƙwayoyin beta na pancreas, saboda wannan, gabatarwar wani magani a cikin jiki baya tsoratar da haɓakar bayyanar cututtuka na hypoglycemic.
Metformin yana da tasiri mai ban sha'awa a cikin sel mai dogaro da ƙwayoyin sel. Sakamakon tasirin ƙwayoyi masu aiki a sel, akwai haɓakar haɓakar masu karɓar sel zuwa insulin, wanda ke ƙara ɗaukar glucose daga jini.
Bugu da ƙari, akwai raguwa da haɗarin glucose ta ƙwayoyin hanta. Rage ƙirar glucose yana faruwa ne saboda hanawar glycogenolysis da gluconeogenesis.
Abubuwan da ke aiki suna haɓaka ayyukan glycogen synthetase.
Yin amfani da Glucofage mai tsawo a cikin ciwon sukari mellitus yana ba da gudummawa ga kiyaye nauyin jiki ko rage girmanta.
Metformin yana kunna metabolism na lipid. Kunna aikin metabolism yana haifar da raguwa a cikin abubuwan da ke cikin cholesterol, triglycerides da LDL a cikin jiki.
Allunan suna dauke da allunan-suna dauke dasu ta hanyar jinkiri daga abubuwanda suke aiki, wannan tasirin yana haifar da gaskiyar cewa tasirin maganin yana kasancewa tsawon awanni 7 bayan shan maganin.
Manuniya da contraindications
Shan glucophage na sha ya kamata ya kasance a gaban nau'in ciwon sukari na 2 na marasa lafiya a cikin marasa lafiya da ke fama da kiba a cikin rashin inganci akan amfani da abinci na abinci da kuma motsa jiki na musamman.
Za'a iya amfani da takardar sayen magani lokacin da ake yin maganin ƙwaƙwalwar ƙwaƙwalwa ko lokacin gudanar da wani magani gaba ɗaya game da amfani da wasu wakilai na hypoglycemic, gami da kwayoyi masu ɗauke da insulin.
Kamar sauran magunguna da yawa, Glucophage 850 na aikin da aka saba ko Glucofage 750 na tsawan aikin yana da wasu abubuwan contraindications.
Babban sabbin magunguna wadanda basuda daraja shan magunguna sune:
- Kasancewar rashin damuwa ga babban bangaren miyagun ƙwayoyi ko zuwa wasu sassan magunguna.
- Kasancewar a jikin alamun alamun ci gaban ketoacidosis, precoma ko coma.
- Rashin hankali a cikin aikin kodan da hanta, yana haifar da abin da ya faru na raunin aiki.
- Wasu cututtuka a cikin m ko m siffan.
- Samun marasa lafiya da raunin da ya faru da kuma lokacin tiyata.
- Marasa lafiya suna da yanayin maye na maye da maye.
- Bayyanar alamun alamun lactic acidosis.
- Lokacin amfani da abincin da ke motsa jini ko yayin gudanar da bincike ta amfani da contrastin kwamin-kwamin cike da aidin.
- Shekarun mai haƙuri da ciwon sukari bai wuce shekara 18 ba.
Ba da shawarar amfani da miyagun ƙwayoyi ba bayan ɗaukar ciki da kuma kan aiwatar da ɗa.
Dole ne a yi taka tsantsan da kulawa yayin rubuta takaddun magani don warkarwa a cikin tsofaffi marasa lafiya waɗanda ke aiki a cikin ƙwaƙwalwar ƙwaƙwalwar jiki, wannan saboda babban yuwuwar ci gaban alamun lactocytosis a cikin jiki.
Bugu da kari, ana buƙatar taka tsantsan yayin shan magani don kula da mata masu shayarwa.
Side effects da yawan abin sama da ya kamata
Lokacin gudanar da aikin likita, sakamako masu illa na iya faruwa a jikin mai haƙuri.
Yawancin sakamako masu illa daga amfani da miyagun ƙwayoyi sune lactic acidosis, megaloblastic anemia da raguwa a cikin darajar shan ƙwayar bitamin B12.
Bugu da kari, bayyanar da damuwa a cikin aiki na juyayi baya yanke hukunci. Wadannan rikice-rikice ana bayyana su ta hanyar canji na dandano.
A wani ɓangare na gastrointestinal fili, tasirin sakamako masu zuwa na iya faruwa:
- tashin zuciya
- amai
- zafi a ciki;
- zawo
- asarar ci.
Mafi yawan lokuta, sakamako masu illa daga aikin gastrointestinal fili suna bayyana a farkon lokacin aikin jiyya kuma ƙarshe ya ɓace akan lokaci.
Don rage yiwuwar tasirin sakamako daga cututtukan hanji, ana bada shawara don ɗaukar magunguna tare da abinci ko kuma nan da nan bayan shan shi.
A cikin lokuta mafi ƙarancin yanayi, za'a iya samun karkacewa a cikin aiki na hanta da kuma bayyanar bayyanar cututtuka na rashin lafiyan fata.
Shan Metformin a allurai bai wuce 85 g ba cutarwa ne ga mutane kuma baya tsoratar da ci gaban alamun cutar rashin jini a cikin jiki, yayin da mai haƙuri ya iya nuna alamun lactocytosis.
A yayin bayyanar alamun farko na lactocytosis, kuna buƙatar dakatar da shan magunguna kuma ku nemi taimako daga asibiti a cikin cibiyar likitanci don fayyace bayyanar cututtuka da kuma tantance taro na lactate a jikin mai haƙuri. Idan ya cancanta, a asibiti, ana yin aikin hemodialysis da warkewar cututtukan alamomi.
Don rage yiwuwar tasirin sakamako, ana ba da shawarar sau da yawa cewa ku ɗauki allunan Xenical a lokaci guda kamar Glucofage Long. Wannan magani yana aiki tare da haɗin gwiwa tare da metformin.
Kafin ka fara ɗaukar Glucofage a cikin sashi na 750 MG ko kwatancinsa, yakamata ka yi nazarin bayanin maganin kamar yadda aka haɗa da umarnin don amfani.
Umarnin don amfani da miyagun ƙwayoyi
Umarnin don yin amfani da magani yana tsara yadda ake buƙatar magani a kowane yanayi. Amma kafin amfani da maganin, kuna buƙatar tuntuɓi likitanku game da shan maganin.
Daidai da umarnin, suna shan allunan a ciki baki ɗaya, ba tare da tauna ba. Shan magungunan yakamata ya kasance tare da wanke maganin kwaya da ruwa kadan.
Mafi kyawun lokacin don shan maganin shine amfani dashi yayin abincin yamma.
Dangane da umarnin, ana zaɓin sashi ne ta hanyar halartar likitan mata masu yin la’akari da sakamakon binciken da kuma halayen mutum na jiki. Lokacin zabar wani abu don shan maganin, likitan da ke gudanar da aikin kulawa yana la'akari da alamun abubuwan da ke cikin carbohydrate a cikin jini mai haƙuri.
Glucophage tsawon 750 MG an wajabta duka lokacin guda-da lokacin amfani da maganin warkewa. Lokacin amfani da maganin, ya kamata a lura da matakan da likitan halartar ya kamata kuma a lura da sigogi na abubuwan sukari a cikin jini na jini akai-akai.
Yawancin lokaci, miyagun ƙwayoyi suna farawa da kashi na 500 MG, ba sau da yawa, magani yana farawa da sashi na 850 MG
Ana shan miyagun ƙwayoyi sau 2-3 a rana yayin abinci. Za a iya ƙara yawan sashi idan ya cancanta.
Yawan maganin da aka yi amfani da shi don kula da lafiyar jiki shine 1500-2000 MG kowace rana.
A cikin taron cewa an shirya shi don canja wurin mai haƙuri zuwa shan Glucofage, to, ya kamata a watsar da sauran wakilai na hypoglycemic.
Haɗin Glucophage Long tare da wasu magunguna
Ana iya amfani da Glucophage Long azaman kayan haɗin magani tare da magunguna masu ɗauke da insulin. Lokacin amfani da miyagun ƙwayoyi tare da allurar insulin, yakamata a zaɓi sashi na ƙarshe gwargwadon tattarawar glucose da haɓakar sa.
Ba'a ba da shawarar yin amfani da miyagun ƙwayoyi ba yayin gudanar da nazarin jikin mutum ta amfani da mahallin kwatancen da ke ƙunsar aidin. Kafin irin wannan karatun, ya kamata a dakatar da gudanar da aikin Glucofage awanni 48 kafin a aiwatar da aikin sannan kuma a ci gaba da daukar kwanaki biyu bayan jarrabawar.
Lokacin yin haƙuri da mai haƙuri tare da Glucophagem Long yayin ɗaukar magunguna tare da tasirin hypoglycemic kai tsaye, ya zama dole don auna yawan sukari a cikin jini na jini.
Wadannan kwayoyi sune:
- Magungunan cututtukan ciki.
- Tetracosactide.
- Beta -2-adrenergic agonists.
- Danazole
- Chlorpromazine.
- Diuretics.
Yin amfani da waɗannan magunguna yana buƙatar saka idanu akai-akai game da yadda yawan alamu na glucose a cikin jiki ke canzawa, kuma idan mai nuna alama ya faɗi ƙasa da matakin da aka yarda, kashi na Glucofage ya kamata a daidaita.
Bugu da kari, shan diuretics a hade tare da Glucophage na iya tsokani cigaban lactic acidosis a jiki.
Lokacin amfani da magani tare da kwayoyi irin su abubuwan da ke haifar da maganin sulfonylurea, acarbose, insulin, salicylates, abin da ya faru da haɓaka alamun hypoglycemia a cikin jiki mai yiwuwa ne.
Lokacin da kwayoyi irin su Amiloride, Digoxin, Morphine, Procainamide, Quinidine, Quinine, Ranitidine da wasu sauransu ana amfani da su a far, akwai gasa tsakanin metformin da waɗannan magunguna don jigilar tubular, wanda ke haifar da karuwar taro na Metformin.
Kudin maganin, maganinsa da kuma sake dubawa game da maganin
Sayar da maganin yana gudana ne a cikin kantin magunguna na musamman gwargwadon takardar sayen magani na likitocin da ke halartar.
Don adana magani, kuna buƙatar amfani da wuri mai duhu da sanyi, wanda ba a samun yara. Rayuwar shelf shine shekaru uku.
Bayan ƙarewar lokacin ajiyar magani, an hana shi amfani dashi don warkarwa. Bayan karewar lokacin ajiya, miyagun ƙwayoyi suna yin aikin zubar dashi.
Magungunan yana da duka yanayin analogues. Magungunan analog iri ɗaya ne a cikin tsarin aikinsu ga jiki.
Wadannan magunguna masu zuwa analog ne na maganin:
- Bagomet;
- Glycon;
- Glyformin;
- Glyminfor;
- Langerine;
- Metospanin;
- Methadiene;
- Metformin;
- Siafor da wasu.
Farashin Glucofage Long 750 ya dogara kacokam kan yawan kayan ɗakunan ajiya da kuma yankin Federationungiyar Tarayyar Rasha wanda yankuna suke sayar da maganin.
Kudin kunshin wanda ya ƙunshi allunan 30 na magani a cikin blisters biyu sun bambanta dangane da yankin ƙasar a cikin kewayon daga 260 zuwa 320 rubles.
Farashin kayan haɗi, wanda ya ƙunshi allunan 60 a cikin blisters huɗu, ya bambanta dangane da yankin na Federationungiyar Tarayyar Rasha, a cikin abin da aka sayar a cikin kewayon daga 380 zuwa 590 rubles.
Mafi sau da yawa, marasa lafiya suna barin sake dubawa game da Glucofage tsawon 750 MG. Wannan ya faru ne saboda gaskiyar cewa wannan maganin shine yafi shahara yayin jiyya na nau'in ciwon sukari na 2 na mellitus. Mafi sau da yawa, mafi girman tasirin warkewa, yin hukunci ta hanyar sake dubawa na marasa lafiya, ana samun su ta hanyar amfani da miyagun ƙwayoyi a matakin farko na cutar. Sau da yawa zaka iya samun sake dubawa cewa shan magani na iya rage nauyin jikin mutum ga masu kiba da masu ciwon sukari na 2.
Idan kuna shirin yin amfani da Glucophage na tsawon lokaci don magance cututtukan cututtukan ƙwayar cuta, to, kafin amfani da miyagun ƙwayoyi, ya kamata ku nemi shawarar likitan ku kuma bincika jikin. Dangane da sakamakon gwaje-gwajen, likitocin da ke halartar za su yanke shawara cewa yana da kyau a yi amfani da maganin na tsawan lokacin aiki.
Gwanaye game da bidiyon a cikin wannan labarin zai faɗi game da ka'idodin aikin Glucophage.
