Baya ga maganin rage cin abinci, ana amfani da kwayoyi da yawa don magance irin wannan cutar ta yau da kullun kamar atherosclerosis.
Ofayansu shine fluvastatin, wanda shine abu na hypocholesterolemic don magance karuwar cholesterol a cikin jinin mutum.
Fluvastatin abu ne mai tsabta wanda yake da fari ko launin shuɗi. Da kyau narkewa cikin ruwa, wasu masu shan giya, suna da sifofin hygroscopic.
Ofaya daga cikin magungunan analogues na ƙwayar cuta (ƙwayar cuta), wanda ya haɗa da ƙwayar ƙwayar aiki mai aiki, shine Leskol Forte. Allunan aiki ne mai tsayi da aka saka. Suna da zagaye, siffar biconvex tare da gefuna gefuna. Ya ƙunshi 80 MG na Fluastastatin a cikin kwamfutar hannu 1.
Magani ne na wucin gadi. Yana hana aikin HMG-CoA reductase, ɗayan ayyukan daga cikinsu shine sauyawar HMG-CoA zuwa farkon abubuwan sterols, watau cholesterol, mevalonate. Ayyukanta suna faruwa a cikin hanta, inda akwai raguwar ƙwayar cholesterol, haɓaka a cikin aikin masu karɓa na LDL, haɓakawa na haɓaka ƙwayoyin LDL. Sakamakon haka, sakamakon aiwatar da duk waɗannan hanyoyin, akwai raguwa a cikin ƙwayoyin plasma.
Masana kimiyya sun tabbatar da cewa tare da adadin ƙwayar LDL cholesterol da triglycerides a cikin jini na jini, atherosclerosis yana haɓakawa kuma haɗarin haɓaka sauran cututtukan zuciya da jijiyoyin bugun jini yana ƙaruwa, wanda yawanci yakan haifar da mutuwa. Koyaya, haɓaka matakan lipoprotein mai yawa yana da tasirin hakan.
Kuna iya lura da tasirin asibiti lokacin shan miyagun ƙwayoyi bayan makonni 2, ana samun girman girmansa a cikin wata guda daga fara magani kuma ana kiyaye shi a duk tsawon lokacin amfani da fluvastatin.
Mafi girman hankali, tsawon lokacin aiki da rabin rayuwa kai tsaye ya dogara da:
- Nau'in sashi wanda ake amfani da maganin;
- Ingancin lokaci da cin abinci, abubuwan da ke cikin kitse;
- Lokacin tsawon lokacin amfani;
- Mutane daban-daban halaye na mutum metabolic tafiyar matakai.
Lokacin da aka yi amfani da fitsari sodium a cikin marasa lafiya tare da hypercholesterolemia ko hadewar dyslipidemia, an lura da raguwa sosai a cikin LDL da triglycerides da haɓaka HDL cholesterol.
A alƙawarin wajibi ne don bin shawarwari na musamman.
Idan mutum yana da cututtukan hanta, mai nuna damuwa ga rhabdomyolysis, yin amfani da wasu magunguna na ƙungiyar Statin ko cin zarafin giya, an wajabta maganin fluvastatin tare da taka tsantsan. Wannan na faruwa ne saboda yiwuwar rikodin hanta, sabili da haka, kafin ɗaukar shi, bayan watanni 4 ko kuma a lokacin ƙara yawan kashi, duk marasa lafiya suna buƙatar tantance yanayin hanta da gangan. Akwai tabbacin cewa a cikin lokuta masu wuya, yin amfani da sinadarin ya taimaka ga farkon cutar hepatitis, wanda aka lura kawai yayin lokacin jiyya, kuma a ƙarshen shi ya wuce;
Yin amfani da Fluvastatin a wasu yanayi na iya haifar da bayyanar myopathy, myositis da rhabdomyolysis. Dole ne marassa lafiya su sanar da likita mai halartar yanayin bayyanar raunin ƙwayar tsoka, tashin hankali ko rauni na tsoka, musamman a gaban haɓakar zazzabi;
Don hana haɓakar rhabdomyolysis kafin amfani, ana ba da shawarar yin nazarin yawan ƙwayar halittar phosphokinase a gaban cutar koda a cikin marasa lafiya; cututtukan thyroid; kowane nau'in cututtukan gado na tsarin tsoka; barasa giya.
A cikin marasa lafiya waɗanda suka girmi shekaru 70, ana buƙatar tantance buƙatar CPK a gaban sauran abubuwan da ke haifar da ci gaban rhabdomyolysis.
A duk waɗannan halayen, likitan halartar yana kimanta yiwuwar maganin da kuma haɗarin da ke tattare da shi. Marasa lafiya suna ƙarƙashin kulawa da kulawa akai-akai. Game da batun karuwa mai mahimmanci a cikin taro na CPK, an sake yanke shawara bayan mako guda. Idan an tabbatar da sakamakon, ba da shawarar magani.
Tare da ɓoye bayyanar cututtuka da kuma daidaituwa na maida hankali ne akan ƙwayar phosphokinase, sake dawo da jiyya tare da fluvastatin ko wasu gumaka ana bada shawarar farawa tare da mafi ƙarancin yiwuwar amfani kuma a ƙarƙashin kulawa akai-akai.
Muhimmiyar ma'ana shine tabbatar da rage yawan abincin da ake amfani da shi a jikin hypocholesterol duka kafin fara magani da lokacin jiyya.
Ana ɗaukarsa ta baka, ba tare da cin abincin ba. Wajibi ne a haɗiye kwamfutar hannu gaba ɗaya, an wanke shi da ruwa mai tsabta, 1 sau ɗaya kowace rana.
Tunda an lura da matsin lamba na ƙwaƙwalwar ƙwayar cuta ta mako na 4, sake dubawa game da kashi bai kamata ya faru a farkon wannan lokacin ba. Tasirin warkewa na Lescol Forte yana ci gaba kawai tare da amfani na dogon lokaci.
Don fara maganin, maganin da aka ba da shawarar shine 80 MG sau ɗaya a rana, wanda yake daidai ne da kwamfutar hannu 1 na Leskol Forte 80 MG. A gaban wani mataki mai laushi na cutar, ana iya tsara 20 MG na Fluastastatin, ko cokali 1 na Leskol 20 MG. Don zaɓar kashi na farko, likita yayi nazarin matakin farko na cholesterol a cikin jinin mai haƙuri, ya tsara makasudin kwantar da hankali kuma yayi la'akari da halaye na mutum na haƙuri.
A cikin taron cewa mai haƙuri yana fama da cututtukan zuciya da jijiyoyin jini kuma an yi masa aikin tiyata na angioneoplastic, shawarar farko da aka bayar shine amfani da 80 MG kowace rana.
Ba'a yin gyaran fuska ko haƙuri a cikin marasa lafiya da ke fama da rauni na aikin koda. Wannan kuwa saboda gaskiyar cewa hancin Fluvastatin yana fitar da hanta, kuma kaɗan daga cikin abubuwan da aka karɓa a cikin jikin mutum shine yake ficewa a cikin fitsari.
Lokacin gudanar da bincike, an tabbatar da inganci da kyakkyawan haƙuri ba kawai ga matasa marasa lafiya ba, har ma ga mutanen da suka haura shekaru 65.
A cikin rukunin shekaru sama da 65 da suka wuce, an ba da sanarwar martani ga magani, yayin da babu bayanan da ke nuna mummunan haƙuri da aka samu.
Magungunan suna da sakamako masu illa da yawa:
- A lokaci-lokaci, ana iya lura da abin da ya faru na thrombocytopenia;
- Wataƙila abin da ya faru na rikicewar bacci, ciwon kai, paresthesia, dysesthesia, hypesthesia;
- Bayyanar cututtukan vasculitis abu ne mai wuya;
- Bayyanar rikicewar cututtukan gastrointestinal - dyspepsia, ciwon ciki, tashin zuciya.
- Bayyanar da halayen fata masu rashin lafiyan jiki, eczema, dermatitis;
- Ciwon kirji, myopathy, myositis, rhabdomyolysis, da lupus-like reaction da wuya su faru.
An ba da shawarar maganin don amfani da tsofaffi marasa lafiya:
- Lokacin da aka bincika matakin haɓaka yawan ƙwayoyin cuta, triglycerides, low density lipoprotein cholesterol, apolipoprotein B, tare da babban hypercholesterolemia da hyperlipidemia;
- A gaban cututtukan zuciya na hanji don rage ci gaban atherosclerosis;
- A matsayin maganin hana daukar ciki bayan angioplasty.
Abinda aka contraindicated don amfani a gaban wani alerji zuwa aka gyara; marasa lafiya da cututtukan hanta, tare da haɓakawa a cikin matakin ƙwayar enzymes; yayin daukar ciki da lactation a cikin mata; yara 'yan kasa da shekara 10.
Tare da taka tsantsan, ya zama dole a rubuto magani don marasa lafiya masu fama da cututtukan fata, tare da shan giya, gazawar koda da kuma yaduwar myalgia.
Ba'a lura da halayen da ba daidai ba tare da kashi ɗaya na 80 MG.
Dangane da batun yin magana da magungunan marasa lafiya a cikin nau'ikan allunan tare da jinkirta saki a cikin sashi na 640 MG don kwanaki 14, bayyanar sakamako masu illa daga jijiyar ciki, karuwa a cikin matakan plasma na transaminases, ALT, AST.
Cytochrome isoenzymes suna cikin metabolism na miyagun ƙwayoyi. A cikin abin da ba zai yiwu yiwuwar ɗayan hanyoyin metabolic ya tashi ba, an rama shi da ƙima.
Ba a bada shawarar haɗakar amfani da miyagun ƙwayoyi Fluvastatin da HMG-CoA reductase inhibitors.
Substrates da inhibitors na tsarin CYP3A4, erythromycin, cyclosporin, intraconazole suna da tasirin da aka ambata a kan ilimin halittar magunguna.
Don haɓaka tasirin ƙari, ana bada shawarar yin amfani da colestyramine ba a cikin sa'o'i 4 bayan fluvastatin ba.
Babu contraindications zuwa haɗuwa da miyagun ƙwayoyi tare da digoxin, erythromycin, itraconazole, gemfibrozil.
Gudanar da haɗin gwiwa na miyagun ƙwayoyi tare da phenytoin na iya haifar da karuwa a cikin ƙwayar ƙwayar plasma na ƙarshen, saboda haka ya kamata a yi taka tsantsan yayin da yake tsara waɗannan magungunan. A wasu halaye, ana iya buƙatar daidaita sashi.
Akwai haɓakawa a cikin ƙwayar jini na jini na diclofenac lokacin ɗauka tare da fluvastatin.
Ana iya amfani da Tolbutamide da losartan lokaci guda.
A cikin yanayin da mutum ya sha wahala daga nau'in ciwon sukari na 2 na mellitus kuma yana ɗaukar futastastatin, yakamata a yi taka tsantsan kuma a kasance a ƙarƙashin kulawa na likita, musamman lokacin da ake yawan karɓar ƙwayoyin yau da kullun na fluvastatin zuwa 80 MG kowace rana.
Lokacin da aka haɗu da miyagun ƙwayoyi tare da ranitidine, cimetidine da omeprazole, an sami ƙaruwa mai girma a cikin girman ƙwayar plasma kuma ana lura da AUC na abu, yayin da ake rage ƙwayar plasma na Fluvastatin.
Tare da taka tsantsan, haɗaka wannan kayan tare da maganin cututtukan warfarin. Ana bada shawara don saka idanu akan lokaci na prothrombin, idan ya cancanta, daidaita sashi.
A halin yanzu, ana amfani da maganin ta hanyar da yawa sake dubawa daga marasa lafiya waɗanda suka dauki shi azaman likita. Ya kamata a lura cewa don cimma matsakaicin sakamako, wajibi ne a bi ingantaccen tsarin rayuwa, abinci mai dacewa da ƙoƙarin motsa jiki na matsakaici. Bugu da kari, ana bada shawarar yin amfani da doguwar amfani, tunda magani yana da sakamako na tsawan lokaci, a ciki yana da tasiri mai kyau a yawan adadin cholesterol a cikin jini.
Magungunan da ke dauke da Fluastastatin dole ne a sayo su a kantin magunguna tare da takardar sayen magani.
Masana za su yi magana game da mutummutumai a cikin bidiyo a cikin wannan labarin.
