Duloxetine magani ne mai tasiri a cikin nau'ikan raɗaɗi na cututtukan zuciya da kuma baƙin ciki iri-iri. Sakamakon ƙarfin ƙarfinsa, wannan magani ya sami aikace-aikace na asibiti da yawa.
Duloxetine magani ne mai tasiri a cikin nau'ikan raɗaɗi na cututtukan zuciya da kuma baƙin ciki iri-iri.
Sunan kasa da kasa mai zaman kansa
Nonasashen waje na ƙasa ba cikakke ba sun yi daidai da ciniki.
Sunan sunadarai na miyagun ƙwayoyi shine (γS) -N-Methyl-γ- (1-naphthyloxy) -2-thiophenpropanamine.
A cikin Latin: Duloxetine.
ATX
ATX: N06AX21.
Saki siffofin da abun da ke ciki
Ana samar da maganin a cikin kwalliyar gelatin mai wuya, murfi da jikinsa wanda aka zana shi a shuɗi. A cikin capsule akwai microgranules mai sihiri waɗanda ke da launin fari ko launin shuɗi.
Abubuwan da ke aiki suna wakiltar duloxetine. Kayan abinci masu taimako sune kamar haka:
- hypromellose;
- mannitol;
- sitaci;
- titanium dioxide;
- sucrose;
- lauryl sulfate;
- cetyl barasa
Ana sanya gelatin kwalliya daga gelatin, titanium dioxide tare da ƙari da fenti mai ruwan hoda mai haske V.
An fito da miyagun ƙwayoyi a cikin kwalliyar gelatin capsules na shuɗi mai launi.
Aikin magunguna
Abubuwan da ke aiki suna hana sake farfado da norepinephrine, serotonin da dopamine (a bangare ɗaya). Wannan yana haifar da tarawar waɗannan ƙwaƙwalwar ƙwaƙwalwa kuma ƙara haɓaka watsa su a cikin tsarin juyayi na tsakiya. Abun ya sami damar ƙara ƙararrakin zafi don jin zafi wanda ke haɓaka tare da neuropathy.
Pharmacokinetics
Bayan gudanar da maganin baka na miyagun ƙwayoyi, abubuwa masu aiki suna farawa a cikin sa'o'i 2. Bayan sa'o'i 6, ana kaiwa mafi yawan maida hankali. Adadin magani a cikin jini baya raguwa lokacin cin abinci, amma tsawon lokacin da zai kai yawan maida hankali zai iya zuwa awa 10.
Yawan magani a cikin jini baya raguwa lokacin cin abinci.
Abubuwan da ke aiki suna ɗaure su ta hanyar ƙwayoyin plasma. Ilimin ƙwaƙwalwar ƙwayar hanta da kodan ba ya shafar ayyukan wannan aikin. Ana cire maganin daga jikin mai haƙuri tare da fitsari. Cire rabin rayuwa ya kai awa goma sha biyu.
Alamu don amfani
Anyi maganin Duloxetine don:
- nau'in jin zafi na cututtukan jijiyoyin mahaifa;
- Damuwa
- syndromes na ciwo mai raɗaɗi na tsarin musculoskeletal (ana lura da irin wannan syndromes tare da fibromyalgia, osteoarthritis na gwiwa gwiwa, ciwo na baya na baya);
- na kawo damuwa damuwa.
Contraindications
Dangane da umarnin hukuma game da miyagun ƙwayoyi, daga cikin contraindications sune:
- rufaffiyar kusurwa mara iyaka;
- shekaru har zuwa shekaru 18;
- gazawar hanta (bayan shan 20 MG na miyagun ƙwayoyi, tsawon duloxetine ya karu da 15% idan aka kwatanta da bayanan gargajiya);
- rashin kwanciyar hankali ga fructose;
- rashi isomaltase da sucrase;
- glucose-galactose malabsorption;
- tashar masarafi na gazawar rashin aiki;
- saukar karfin jijiya mara jijiyoyi.
Tare da kulawa
Ana buƙatar daidaitawa da kula da likita na yau da kullun idan mai haƙuri yana da wasu maganganun:
- hauhawar cikin jini;
- babban haɗarin haɓaka kusurwa ta rufe fuska;
- rashin lafiyar bipolar cuta da ciwan ciki.
- lalacewar aikin na renal, gazawar renal (ƙaddamar da creatinine 30 ml / min), hemodialysis;
- lokacin daukar ciki a cikin marasa lafiya;
- tunanin kashe kansa ko ƙoƙarin aikata shi a cikin tarihi;
- katsewa
- haɓakar haɗarin hyponatremia (wannan rukuni ya haɗa da tsofaffi, marasa lafiya da kewaya, rashin ruwa, cututtukan rashin isasshen ƙwayar maganin antidiuretic).
Yadda ake ɗaukar duloxetine?
Capsules na miyagun ƙwayoyi an yi nufin sarrafawa na baka. An haɗiye su kuma an wanke su da gilashin ruwa.
Kada a cire manyan kwayoyin halitta a cikin kwansonsu kuma a haɗa su da samfura ko abubuwan sha don ƙirƙirar fitarwa.
Anyi bayanin wannan ta hanyar gaskiyar cewa ya kamata a narkar da miyagun ƙwayoyi kuma ya shiga cikin hanjin. Jirgin gelatin mai shiga ciki yana taimakawa sosai don cimma wannan.
Matsayi na yau da kullun na miyagun ƙwayoyi, wanda likitoci ke bi da shi sau da yawa, ya kai 30-60 mg. Ba a raba wannan adadin zuwa sassa da yawa, amma ana amfani dashi don gudanar da sabis na lokaci daya. Yin amfani da miyagun ƙwayoyi bai dogara da cin abinci ba.
Dangane da ganewar asali da yanayin jigilar mai haƙuri, ana iya daidaita sashin yau da kullun kuma ya kai 120 MG. A wannan yanayin, wannan yakamata ya kasu kashi biyu.
Ana haɗiye Capsules kuma an wanke shi da gilashin ruwa.
Shan maganin don ciwon sukari
Nazarin sun tabbatar da tasiri na miyagun ƙwayoyi a cikin nau'ikan raɗaɗi na cututtukan cututtukan zuciya. Idan babu contraindications, marasa lafiya da ciwon sukari na iya ɗaukar ma'aunin yau da kullun.
Shekaru nawa aka nuna?
Rabin rayuwar rabin abubuwan da ke aiki ya kai awa 12.
Sakamakon sakamako na Duloxetine
Daga cikin cututtukan da suka fi yawa daga shan magunguna su ake kira ciwon kai, tashin zuciya, bera, bushewar baki, hauhawar ciki, raunin nauyi.
A cikin mafi yawan marasa lafiya, waɗannan bayyanar cututtuka sun bayyana zuwa mataki mai laushi kuma kawai a farkon far. Akwai canje-canje a cikin ƙimar enzymes na hanta, a cikin mafi yawan lokuta, parasitic (naman gwari) da cututtukan cututtuka (laryngitis, otitis media) mai yiwuwa ne.
Gastrointestinal fili
Daga tsarin narkewar abinci, halaye masu zuwa ga shan maganin na iya bayyana: haushi na ciki, tashin zuciya, amai, ƙarancin bushewar ƙwayar bakin, tashin zuciya (maƙarƙashiya ko zawo), ƙwanƙwasa, dyspepsia.
Lokacin shan maganin, tashin zuciya na iya faruwa.
Wataƙila ci gaban gastritis, gastroenteritis, stomatitis, hepatitis, hanta gazawar, bayyanar belching, take hakkin dandano mai dandano.
Da wuya a gano shi: kasancewar jini a cikin kwali, numfashi mara kyau, zub da jini na ciki da kuma jaundice.
Tsarin juyayi na tsakiya
Daga cikin cututtukan da suka zama ruwan dare gama gari: yawan bacci, ciwon kai, damuwa, damuwa, bacci, bacci, damuwa, tashin hankali, tashin hankali, tashin hankali.
Lokaci-lokaci, marasa lafiya suna koka da yawan tashin hankali, dyskinesia, myoclonus, hargitsin barci, tashin hankali, bruxism, disorientation a sararin samaniya, mai rauni taro.
Wani lokaci marasa lafiya suna koka game da rikicewar bacci yayin shan maganin.
Fushi, tashin hankali, tashin zuciya, tashin hankali, son zuciya, kashe kansa, damuwar psychomotor da ciwon suga serotonin da wuya.
Daga tsarin numfashi
Sakamakon sakamako daga tsarin numfashi kaɗan ne. Mafi sau da yawa, marasa lafiya da ke shan maganin sun koka da hawan jini. A wasu halaye, ana lura da abin damuwa na matsawa na hanjin hanji da hanci.
A ɓangaren fata
Abubuwan da suka fi yawa suna haifar da gumi sosai na jiki, fatar jiki.
Diagnosedarancin da aka gano ana fama da su sune cututtukan jini da ke ƙasa, hotoensitivity (tsinkaye ga hasken rana), cututtukan ciki, bayyanar gumi mai sanyi, cututtukan cututtukan cututtukan mahaifa, cututtukan Stevens-Johnson da angioedema.
Sakamakon sakamako na yau da kullun shine gumi mai yawa na jiki.
Daga tsarin kare jini
Dangane da umarnin don miyagun ƙwayoyi, yawancin lokuta akwai rauni game da aikin erectile, matsaloli a cimma ma'anar tsinkaye, rage sha'awar jima'i.
Ba a taɓa lura da dysuria, riƙewar urinary, nocturia, urination mai saurin shiga ciki, urinary rashin daidaituwa, rikicewar ciki, cututtukan ƙwayoyin cuta, zubar jini na farji.
Da wuya, bayyanar cutar menopause da canji a cikin warin fitsari na iya faruwa.
Daga tsarin zuciya
Alamomin da suka fi yawa sun hada da fulawa da saurin bugun zuciya.
Da ɗan ƙarancin yau da kullun suna suma, alamun tachycardia, ƙarshen hutu da hawan jini.
Daga cikin abubuwan da ba a san su sosai ba wanda ake kira atrial fibrillation, arrhythmia supraventricular da rikicin hauhawar jini.
A lokacin yin jiyya tare da miyagun ƙwayoyi, marasa lafiya da wuya suna fuskantar rauni.
Tsarin Endocrin
A cikin lokuta masu rauni, hypothyroidism yana haɓaka.
Daga tsarin musculoskeletal
Sakamakon mafi yawanci gefen tsarin musculoskeletal shine bayyanar cututtukan tsokoki, jin zafi a cikin tsokoki da ƙashi, jin tsauri.
Juyawar tsoka yana bayyana sau da yawa.
Trismus yana da matukar wuya.
Cutar Al'aura
Tare da karuwar haɓakar mai haƙuri zuwa ɗaya ko ƙari a cikin abubuwan da ke cikin miyagun ƙwayoyi, bayyanar rashin lafiyan mai yiwuwa ne. A cikin mafi yawan lokuta, ana bincikar halayen anaphylactic.
Tasiri kan ikon sarrafa abubuwan inji
Lokacin da aka magance shi tare da Duloxetine, akwai haɗarin rashin barci, take hakkin halayen psychomotor, da sauran ayyukan fahimi. A saboda wannan dalili, marasa lafiya yakamata su ƙi hawa mota kuma su shiga cikin haɗari mai haɗari.
A cikin lura da Duloxetine ya kamata barin watsi da tuki.
Umarni na musamman
Ya kamata a kammala hanyar maganin a hankali ta hanyar rage kashi. In ba haka ba, ci gaban cire ciwo yana yiwuwa.
Sakamakon gaskiyar cewa ba shi yiwuwa a rage sashi zuwa 15 MG, lokacin da aka haɓaka gudanar da mulki.
Yi amfani da lokacin daukar ciki da lactation
A cikin magani, babu bayanai game da tasirin maganin a kan lafiyar da ci gaban tayin, saboda haka, ba a ba da shawarar yin amfani da Duloxetine ba. Bangaren lokuta ne wadanda amfanin mahaifiyar daga shan maganin ya wuce hadarin yiwuwar tayin. Lokacin da ake rubuta magani yayin lactation, ya kamata a dakatar da lactation.
Lokacin da yake rubuta maganin rigakafi ga mata masu haihuwa, ya kamata a faɗakar da mai haƙuri game da buƙatar ingantaccen maganin hana haihuwa.
Lokacin da ake rubuta magani yayin lactation, ya kamata a dakatar da lactation.
Adana Duloxetine ga Yara
Ba a wajabta magunguna ga yara da matasa masu shekaru 18 da haihuwa ba.
Yi amfani da tsufa
Yawan kwayoyi na Duloxetine
Magungunan warkewa na yau da kullun, waɗanda ba a ba da shawarar su wuce su ba, shine g 1.2. Haɓaka wannan sashi (duka tare da maganin taɓotra tare da wasu magunguna) yana haifar da bayyanar cututtuka:
- almubazzaranci
- nutsuwa
- cutar serotonin;
- coma
- tachycardia;
- amai
Describedaya daga cikin shari'ar yawan abin sama da ya kamata ya bayyana (kashi 3 g), wanda zai biyo baya sakamakon mummunan sakamako.
Babu takamaiman maganin rigakafi don wannan abu mai aiki, saboda haka ana ɗaukar matakai da yawa don daidaita yanayin mai haƙuri.
- Tsarkake ciki (shigo da amai) yana da ma'ana idan an dauki magani kwanan nan.
- Shan gawayi yana kunna shan maganin.
- Gudanar da cutar bayyanar cututtuka dangane da alamun.
Yawan shaye-shayen magunguna na iya haifar da nutsuwa.
Yin hulɗa tare da wasu kwayoyi
Idan aka haɗu da wasu magunguna, zaku buƙaci daidaita mita na gudanarwa ko sashi.
Tare da masu hana CYP1A2. Haɗin kai sau da yawa yana haifar da haɓaka cikin abubuwan da ke aiki a cikin plasma. Ya kamata a lura da ƙara hankali yayin da aka haɗa shi da Tolterodine da Desipramine.
Tare da sauran maganin rigakafi. Ba a ba da shawarar hadin gwiwar gudanarwa ba, gami da magungunan Paroxetine. Wannan yana haifar da raguwar sharewa.
Tare da MAO inhibitors, Moclobemide. Aikace-aikacen ba a so, saboda haɓakar ƙwaƙwalwar tsoka, hauhawar jini, ƙwayar cuta, myoclonus. A cikin mawuyacin hali, mutuwa tana yiwuwa.
Tare da benzodiazepines, ethanol, magungunan antipsychotic, phenobarbital. Ba a yaba irin waɗannan haɗuwa ba.
Tare da wakilan antiplatelet da maganin anticoagulants. A irin waɗannan halayen, zub da jini yana yiwuwa. Bayan ɗaukar maganin tare da Warfarin, karuwa a INR mai yiwuwa ne.
Yakamata a yi taka tsantsan yayin rubuta ajiyar magungunan ƙwayar cuta tare da clomipramine, St John's wort, pethidine, triptanam, Amitriptyline, Venlafaxine da Tramadol, Zinnat.
Haɗuwa da clotrimazole ba ya haifar da canje-canje da aka ambata a cikin aiki.
Amfani da barasa
Don lokacin magani tare da Duloxetine, ya kamata ku guji shan giya. In ba haka ba, akwai babban haɗarin cutarwa daban-daban.
Analogs
Magunguna iri ɗaya a cikin kayan aiki da aikin su ne Duloxetine Canon da Symbalta.
Kwayoyi masu zuwa suna da irin wannan sakamako:
- Tsage bakin ciki;
- Venlaxor;
- Hypericum Gelarium;
- Trittiko;
- Velaxin;
- Xel;
- Amitriptyline;
- Fluoxetine.
Kowane ɗayan waɗannan kwayoyi suna da alaƙa ta abubuwa masu aiki da fasalin amfani. A saboda wannan dalili, yakamata ku nemi likitan ku kafin maye gurbin magani.
Wani magani mai kama da wannan shine Symbalta.
Magunguna kan bar sharuɗan
Dangane da umarnin hukuma don amfani, ana samun wannan maganin akan takardar sayan magani.
Zan iya saya ba tare da takardar sayan magani ba?
Neman Duloxetine ba tare da takardar sayan magani ba haramun ne.
Farashin Duloxetine
Kudin maganin ya dogara da adadin capsules a cikin fakitin.
A cikin Pharmacy na Moscow, matsakaicin farashin:
- 14 capsules (30 MG) - 1000 rubles;
- 28 capsules (60 mg) - 2100 rubles.
Yanayin ajiya na miyagun ƙwayoyi
Abubuwan adanawa: zazzabi + 15 ... + 25 ° C, rashin hasken rana kai tsaye da danshi.
Ranar karewa
Magana game da dokokin ajiya, ana iya amfani da capsules har tsawon shekaru 3 daga ranar sakewa.
Mai masana'anta
Wanda ya kirkiro wannan samfurin shine Canonfarm Production CJSC. Kamfanin yana cikin yankin Moscow (Schelkovo).
Akwai wasu kamfanonin da yawa waɗanda ke samar da maganin. Daga cikinsu akwai kamfanin Glenmark.
Duloxetine Reviews
Likitoci suna ba da amsa da kyau ga wannan magani, wanda aka bayyana shi ta babban inganci da tasiri mai yawa. Yawancin marasa lafiya kuma suna farin ciki da jiyya.
Likitoci
Olga, masanin ilimin ƙwaƙwalwa, ƙwarewar likita 13 shekaru, Moscow.
Amfanin wannan magani shine tasirirsa akan mummunan ciwo na cututtukan etiologies. Ya dace da marasa lafiya da masu ciwon sukari. Ba sau da yawa ana sanya shi azaman maganin hana haifuwa, tunda akwai magunguna masu dacewa. Rashin kyau shine babban darajar kuɗi, tunda ana buƙatar dogon hanya.
Sau da yawa, marassa lafiya da ke shan maganin suna korafin shan iska.
Marasa lafiya
Nikolay, ɗan shekara 40, Tyumen
Duloxetine ya ba da magani ta likita saboda karuwar damuwa. Bayan 'yan kwanaki a farkon hanya an sami karancin tashin hankali, amma ba a dakatar da jiyya ba. Bayan wasu 'yan kwanaki, sai a daina ganin tasirin hakan gaba daya. Farashin yana da girma sosai, amma magani ya fi ƙarfin farashin ganye, don haka farashin ya halatta.
