Thioctic acid shine abu mai kama da bitamin, antioxidant mai karewa. Tsarin sashi shine magani na zabi a cikin jiyya na rashin lafiyar endothelioneural (lalacewa da yanayin jijiyoyin jijiyoyi saboda raguwar wadatarwar jini sakamakon tashin jijiyoyin bugun zuciya) da kuma damuwa damuwa.
Suna
Lipoic acid, alpha lipoic acid, thioctacid sune kalmomin maganin thioctic acid.
A cikin Ingilishi, kayan ana kiranta Thioctic acid. A cikin Latin - Acidum thiocticum (asalin halittar Acidi thioctici). Sunan kasuwanci na iya zama daban (Oktolipen, Berlition 600, da sauransu).
Thioctic acid shine abu mai kama da bitamin, antioxidant mai karewa.
ATX
Lambar ATX ita ce A16AX01.
Saki siffofin da abun da ke ciki
Akwai a matsayin:
- kwayoyin hana daukar ciki
- bayani don allura, 1 ml wanda ya ƙunshi 25 MG na α-lipoic acid;
- mai da hankali ga mafita don jiko.
Ana samo Thioctacid a cikin nau'i na allunan da aka rufe.
Kwayoyi
Ana samun Thioctacid a cikin nau'i na allunan mai rufi a cikin sashi na 200 da 600 MG na kayan aiki mai aiki.
Foda
A cikin nau'in foda, ba a amfani da kayan don magani, saboda mai narkewa kawai a cikin ethanol.
Aikin magunguna
Kasancewa mai maganin antioxidant na halitta, thioctacid yana hana kunna abubuwa na nukiliya kappa-bi saboda tsattsauran ra'ayi. Keta dokokin sa yana haifar da cututtukan autoimmune, murdiya sake zagayowar sel da rashin lafiyar sel.
A nosological sakamako ne saboda ta Properties:
- sa hannu cikin amsawar decarboxylation na alpha-keto acid - tabbatar da musayar kuzarin salula da hana DKA;
- ikon rage matakin kiwan acid, cholesterol;
- antioxidant - ɗaure abubuwa masu tsattsauran ra'ayi, alamu na numfashi, maido da glutathione;
- hanawa na kwayar nitric oxide ta ƙwayoyin hanta - rigakafi da taimako na phlebopathy;
- radioprotective.
Ta hanyar yin aiki da ƙwayar endothelium na jijiyoyin jini, acid na lipoic (thioctic) yana rage lalacewar ƙasan su ta ciki, yana rage lumen, kamshi da haɗarin haɗarin jini.
Godiya ga waɗannan kaddarorin na thioctacide, miyagun ƙwayoyi suna da tasiri mai yawa ga jiki:
- yana kunna guduwar jini;
- yana hana ɓarnatar da ƙwaƙwalwar ƙwaƙwalwar NO, wanda ke hana lalacewar ischemic a cikin ƙwayoyin jijiyoyi;
- yana haɓaka halayen jijiyoyin jijiyoyin jiki;
- yana daidaita ayyukan glutathione;
- yana hana lalacewar membranes cell.
Sakamakon tsarin aikin wakili sune:
- normalisation na cholesterol;
- raguwa a cikin juriya na insulin;
- karuwar iko na glycemic;
- kariya daga tsibirin huhu ta samar da insulin;
- raguwa a cikin matakan ƙwayar lipid, wanda ke bayyana kyakkyawan sakamako na lura da kiba;
- rigakafin cututtukan ƙwayar sel saboda tarin sorbitol a cikinsu;
- haɓaka kayan na roba da microcirculation na hanyoyin jini;
- rage abubuwanda ke haifar da kumburi a cikin jini;
- haɓaka aikin kawar da hanta, samar da ƙwayoyin bile da kuma kiyaye ƙwayoyin sel daga lalacewa.
Yin aiki akan endothelium na jijiyoyin jini, acid na lipoic (thioctic) yana rage lalata lalacewar cikin su, yana rage lumen, lalata da kuma haɗarin ƙwanƙwasa jini, hanyoyin kumburi.
Aciki yana sauƙin shayar da jijiyar jini, wanda ke ƙayyade tasirirsa a cikin maganin encephalopathy da cututtukan ƙwayar jijiya ta tsakiya: Alzheimer da Parkinson's.
Pharmacokinetics
Lokacin ɗauka ta baka, ƙwayar ta kusan ɓoye cikin narkewa. Gudanar da magani na abinci tare da abinci yana rage rage ƙwaƙwalwarsa. Babban aiki (Cmax) na miyagun ƙwayoyi ana lura da kwata na awa ɗaya ko awa daya bayan gudanarwa. A cikin hanta, biotransformation na alpha lipoic acid yana faruwa ne a lokacin farkon farkon ta hanyar bangon hanji, hanta, huhu, wanda ke ƙara yawan bioavailability na abu har zuwa 30-60%.
Lokacin ɗauka ta baka, ƙwayar ta kusan ɓoye cikin narkewa.
Vp ɗin sa (ƙarar rarraba) shine kusan milimita 450 / kg, wanda ke nuna yawan ƙwayar magunguna a cikin kyallen jiki. Rabin-rabi (T1 / 2), ko lokacin asarar aiki na 50%, na lipoic acid shine minti 20-50, wanda ya kasance sakamakon kawar da samfuran samfuran canji na abu wanda ke faruwa a hanta ta hanjin kodan. Adadin tsarkakewar jini na jini (Cl plasma) daga maganin shine 10-15 ml / min.
Abin da ake buƙata don
Ana amfani da Thioctacid don magance cututtukan cututtukan da ke haifar da damuwa na oxidative, hyperinsulinemia, insulin resistance, disothelial dysfunction. Amfani da magani:
- Marasa lafiya da ciwon sukari da rikitarwarsa, kamar:
- ciwon sukari polyneuropathy;
- encephalopathy mai ciwon sukari;
- kamuwa da cutar hanta a cikin marasa lafiya da juriya na insulin;
- maganin ciwon sukari;
- cututtukan zuciya na zuciya na zuciya;
- kiba
- Polycystic ovary syndrome a cikin mata.
- Cututtukan hanta da ke haifar da maye tare da barasa, karafa masu nauyi, guba; gabatarwar wani wakili ko bidiyo mai zagaya yanar gizo da sauri (hepatitis C, B).
- Cutar ƙwayar ƙwayar ƙwayar ƙwayar cuta.
- Rheumatoid Arthritis.
Ana amfani da sinadarin, tare da damar iya sarrafa carbohydrate da metabolism mai, a matsayin wani ɓangare na abinci don rage nauyi da kuma kula da kiba.
A cikin cosmetology, ana amfani da acid don:
- kawar da kumburi;
- kariya daga tasirin abubuwanda ke haifar da cutarwa, sanya fata;
- bayyanawa, kariya ta UV;
- farfadowar nama;
- hanawa glycation - aiwatar da fizgen collagen tare da glucose;
- sabuwa.
Kayan yana haɓaka sakamako akan fatar da jikin bitamin D, ascorbic acid da tocopherol.
Kayan kayan kwalliya basu da fiye da kashi 10% na lipoic acid a cewar Dokar EU. Amfani da su yana nunawa ga mata masu tsufa, tsotsar fata, yanayin motsa jiki, haushi. Hakanan, ana amfani da kayan kwalliya tare da thioctacid idan fatar tana shafa mai, tare da kara girma da kuraje.
Contraindications
Tunda acid ɗin na lipoleic a cikin adadin da ake buƙata ana iya haɗuwa dashi cikin jikin mutum, kusan ba shi da rikitarwa ga manufar. Babban contraindication shine rashin kwanciyar hankali ga abu. Yi amfani da miyagun ƙwayoyi tare da taka tsantsan tare da:
- ciki da lactation;
- shekaru na mai haƙuri har zuwa shekaru 6.
Babban contraindication shine rashin kwanciyar hankali ga abu.
Iyakancewar ya faru ne sakamakon karancin gogewar amfani da magunguna a cikin marasa lafiya na waɗannan rukunoni da kuma rashin isasshen sakamako na aminci.
A cikin maganin tari, kasancewar lactose a matsayin filler yakamata a yi la’akari. Dalilin irin waɗannan abubuwan yana cikin contraindicated a cikin marasa lafiya tare da malabsorption - rashin haƙuri na lactose.
Yadda ake ɗaukar thioctic acid
An fara amfani da warkaswa ta hanyar amfani da acid na thioctic acid ta hanyar sarrafawa ko jiko na maganin. Lokacin da yanayin ya daidaita, ana wajabta jiyya tare da allunan.
A cikin ƙirƙirar maganin jiko daga mai da hankali a cikin ampoules, abubuwan da ke ciki suna narkewa da maganin gishiri - Maganin NaCl.
Don shiga cikin mulki (ta bakin) gudanarwa, shawarwarin masu zuwa ana biye da su:
- dauka kafin abinci sau ɗaya a rana.
- kada ku tauna, hadiyewa, shan ruwa mai yawa;
- bayan rabin sa'a kuna buƙatar karin kumallo;
- matsakaicin adadin yau da kullun mafi yawan lokuta ba ya wuce milimita 600 na thioctacide;
- hanya na magani shine watanni 3, bisa ga alamu, za a iya tsawaita lokacin farjin.
An fara warkaswa ta hanyar amfani da maganin thioctic acid ta hanyar jijiya na wakili.
An wajabta jiyya tare da allunan bayan hanyar makonni 2-4 na jijiyoyin jini ko jiko na miyagun ƙwayoyi.
A cikin ciki, ana shayar da maganin a hankali don guje wa sakamako masu illa. An tsara ƙaura game da jinkirin saukar da gabatarwa. Isarar ita ce 300-600 MG.
Hakanan ana amfani da acid na Thioctic don gudanarwar intramuscular. Don kauce wa halayen da ba a sani ba, ba da shawarar yin allura fiye da 2 ml na bayani a wuri guda ba.
Acid acid na jikin jikin mutum
A cikin gina jiki, horar da karfi da kuma motsa jiki na kwararru, ana amfani da thioctacid don rage matsananciyar damuwa bayan babban motsa jiki. Thearfin rage ayyukan glucose da kuma canza shi zuwa mahaɗan makamashi kuma yana taka muhimmiyar rawa: wannan dukiyar ta likitanci tana taimakawa wajen samar da kuzari ga tsokoki masu narkewa kuma suna samun babban sakamako daga horo. Bugu da ƙari, acid yana haɓaka thermogenesis, yana taimakawa kawar da adon mai a cikin wuraren matsala, saboda haka an umurce shi ba kawai a wasanni ba, har ma don asarar nauyi.
A cikin gina jiki, horar da karfi da kuma motsa jiki na kwararru, ana amfani da thioctacid don rage matsananciyar damuwa bayan babban motsa jiki.
Ana nuna wa athletesan wasan kwatankwacin kashi 50 MG sau 3-4 a rana rabin sa'a bayan cin abinci. Tare da horo mai zurfi, adadin magunguna yana ƙaruwa zuwa 300-600 MG kowace rana.
Shan maganin don ciwon sukari
A cikin ciwon sukari na mellitus, an fara amfani da miyagun ƙwayoyi parenterally (kewaya hanji). An mai da hankali ne a cikin 100-250 MG na 0.9% sodium chloride kuma a cikin girma na 600 MG ana sarrafawa ta hanyar hankali cikin kwanaki 15. Ana gudanar da maganin a cikin hawan keke na kwanaki 5 tare da hutun kwana 2 tsakanin su. A cikin duka, ana amfani da ampoules 15 don aikin jiyya.
Bayan an kammala maganin allurar, ana tura mai haƙuri zuwa allunan thioctacid, 1 pc. kwana daya kafin karin kumallo.
A cikin ciwon sukari na mellitus, an fara amfani da miyagun ƙwayoyi parenterally (kewaya hanji).
Normalizing glucose da kunna samar da insulin dinka na iya buƙatar daidaita sashi na insulin da rage magunguna. A cikin rikitattun rikice-rikice, hanyar kulawa na iya zama watanni 3-5.
Side effects
An lura da mummunan tasiri a cikin 1 yanayi a cikin marasa lafiya 10,000. An bayyana a cikin hanyar:
- rashin lafiyan fata;
- hypoglycemia;
- tare da amfani da baki, raunin dyspeptik, bugun zuciya, raunin epigastric mai yiwuwa;
- tare da iv, rashi, hauhawar jini da hauhawar jini, hangen nesa biyu, amai, da gudawa, da basur na iya faruwa.
Bayyanannu suna ɓoye lokacin da aka rage kashi ko kuma bayan an dakatar da sarrafa abubuwan.
Umarni na musamman
Marasa lafiya masu ciwon sukari ya kamata su lura da matakan glucose akai-akai. Hanyoyin da aka shirya suna da matukar daukar hoto, saboda haka ana amfani dasu kai tsaye bayan dilution ko kariya tare da allo mai walƙiya.
Amfani da barasa
Magungunan ba su dace da barasa ba, saboda ethanol yana rage tasirin bayyanar cutar.
Tasiri kan ikon sarrafa abubuwan inji
Ba kai tsaye yana tasiri da ƙimar halayen neuromuscular ba, amma bayyanannun bayyanannun bayyanannun suna buƙatar taka tsantsan yayin aikin jiyya.
Yi amfani da lokacin daukar ciki da lactation
Yana da karɓa don rubuta magani a lokacin lokacin haihuwa idan amfanin maganin ya wuce haɗarin haɗari. A cikin batun lokacin da ake yin layya ya zama dole lokacin da ake shayarwa, ya zama dole don canja wurin jariri zuwa ciyarwar mutum.
Yana da karɓa don rubuta magani a lokacin lokacin haihuwa idan amfanin maganin ya wuce haɗarin haɗari.
Adana maganin thioctic acid ga yara
Umarnin yin amfani da miyagun ƙwayoyi bai bada shawarar amfani da shi a cikin yaran da shekarunsu basu kai shekaru 6 ba. Koyaya, bisa ga alamun, ana iya tsara maganin a cikin adadin:
- 0.012 g 2-3 sau a rana don yara 'yan shekaru 7;
- 0.012-0.024 g sau 2-3 a rana ga yaran da suka wuce shekaru 7.
Yawan damuwa
Yiwuwar yawan abin sama da ya kamata yana da karami, amma tare da hankalin mutum ko ya keta tsarin aikin gudanarwa, masu zuwa na iya faruwa:
- ciwon kai
- tashin zuciya da amai.
Game da maye, ana yin magani ne da nufin dakatar da alamun.
Tare da yawan ƙwayar magunguna, ciwon kai ya bayyana.
Yin hulɗa tare da wasu kwayoyi
Acid bai dace da:
- Maganin Ringer da sauran jami'ai waɗanda ke ɗauke da alli da magnesium;
- shirye-shiryen karfe;
- ethanol.
Magungunan yana inganta tasirin insulin da wakilai na hypoglycemic na hanji.
Analogs
Analogues na Acidum thiocticum sune magunguna:
- Alfa lipon;
- Lirƙirari;
- Thioctacid;
- Thiogamma;
- Oktolipen;
- Lipoic acid, suna gama gari shine bitamin N;
- Lipothioxone;
- Neuroleipone;
- Yin zabe.
Magunguna kan bar sharuɗan
Da takardar sayan magani.
Zan iya siye ba tare da takardar sayan magani ba
A'a.
Farashin thioctic acid
Ya danganta da mai ƙira da nau'in saki, farashin maganin ya bambanta daga 40 (Allunan 50) zuwa 2976 (Allunan 100) rubles. Thioctacid 600 a cikin ampoules farashin 1,539 rubles. don shiryawa. A cikin Ukraine, farashin ya tashi daga 92 zuwa 292 UAH.
Yanayin ajiya
Jerin B - Ajiye a cikin sanyi, wuri mai duhu.
Magungunan zazzabi ne kawai idan mai haƙuri yana da takardar sayen magani.
Ranar karewa
Shekaru 3
Nazarin Acidctic Acid
Magungunan ya dade bai haifar da muhawara ba tsakanin masu amfani da kwararru. Kuma bayyanar siffofin zamani tare da mafi ƙarancin sakamako masu illa suna haifar da sake dubawa mai kyau.
Likitoci
Elena Sergeevna, mai ilimin tauhidi, Kiev: "Ni mai ciwon sukari ne kuma na sami fa'idar thioctic acid, sabili da haka, tare da lamiri mai kyau, Ina rubuta Thioctacid BV ga marasa lafiya."
Inga Olegovna, endocrinologist, Kostroma: "A cikin aikin likita, yana da mahimmanci a tabbatar da inganci da amincin magungunan. Na kasance sau da yawa na gamsu da sakamakon sakamako na magani tare da miyagun ƙwayoyi Thioctacid BV kamar yadda aka ayyana."
Marasa lafiya
Mirra, dan shekara 45, Krivoy Rog: "Watanni shida da suka gabata, na fara jin rauni a yatsuna da hannayena. Likita ya ce sanadin cutar sankarau ce, kuma an ba ni allunan Thioctacid BV. Na sha rabin biyu, kuma lafiyar ta ta inganta sosai."
Oksana, dan shekara 31, Odessa: "Umarnin ya nuna cewa akwai yiwuwar rashin lafiyan, amma maganin bai haifar da alamun rashin lafiyan cuta ba, kodayake ni mutum ne mai rashin lafiyar da kwarewa."
Anna, mai shekara 40, Kazan: “Baya ga ciwon sukari, akwai manyan matsaloli tare da kashin baya. Ina shan magunguna sama da watanni 3. Duk da cewa na sha wasu magunguna da yawa banda shi, babu wasu sakamako masu illa, koda nauyin ya rage kadan ba tare da wani abincin abinci ba. "