Sakamakon magunguna dangane da maganin repaglinide (Repaglinide)

Amfani da sinadarai na hakoran kwayoyi an tabbatar da gaskiya cikin sharuddan warware matsalar ciwon sukari. Suna taimakawa kiyaye matakan sukari na jini cikin dubawa da rage tasirin cutar.

Ofaya daga cikin waɗannan abubuwa shine Repaglinide.

Fom ɗin saki

An hada da Repaglinide a cikin rukunin manya-manyan rukuni na kwayoyi tare da sunan kasuwanci:

• NovoNorm;
• Diaglinide;
• Eglinides da sauransu.

Tasirin waɗannan kwayoyi ya dogara ne akan abubuwan da ke tattare da magungunan ƙwayar cuta (repaglinide), wanda shine babban bangaren su, kuma za'a iya inganta shi ko inganta shi da taimakon abubuwa masu taimako.

Mafi yawancin lokuta, ana samun magunguna a cikin kwamfutar hannu tare da maida hankali kan abu mai aiki a cikin milligram 0.5, 1 ko 2.

Kayan magunguna na kayan magani

Babban mahimmancin abu shine ƙananan sukarin jini, yana dogara da tsarin hana ayyukan ATP-depend tubules wanda ke cikin ƙwayoyin reat-sel.

Repaglinide yana aiki akan tashoshin potassium, suna ba da gudummawa ga sakin K ion⁺ daga tantanin halitta, wanda ke taimakawa rage polarization ganuwar sa da kuma sakin tashoshi na alli. Duk wannan yana ba da gudummawa ga haɓakar samar da insulin da fitarwa cikin jini.

Cutar da sinadarin na faruwa ne da wuri-wuri, bayan awa daya ana samun fifiko a cikin jini, sannu a hankali yana raguwa kuma ya bace bayan awa 4.

A wannan yanayin, samfurin yana da alaƙa da furotin plasma, sama da kashi 90 cikin ɗari, sannan bayan hakan ana aiwatar dashi gabaɗaya tare da sakin:

• oxidized dicarboxylic acid;
• amines na amshi;
• acyl glucuronide.

Waɗannan abubuwa ba su da tasirin hypoglycemic kuma an keɓe su saboda ƙwayar ƙwayar jijiyoyin ciki kuma a wani bangare ta hanjin kodan.

Manuniya da contraindications

Magunguna waɗanda suka dogara da maganin repaglinide an ba da shawarar don haɓaka nau'in ciwon sukari na 2 na biyu, duka biyu a matsayin magani mai zaman kanta kuma a hade tare da metformin ko thiazolidinediones, an kara yayin shan magani ɗaya baya nuna cikakken sakamako.

Contraindications zuwa shan miyagun ƙwayoyi sune:

• gaban ciwon sukari nau'in farko;
• mummunan ilimin cutar hanta;
• take hakkin metabolism;
• lokacin ciki da lactation;
• yin amfani da magungunan gemfibrozil;
• cututtukan cututtukan ketoacidosis, coma ko precoma;
• kasancewar kamuwa da cututtukan fata, da bukatar yin tiyata ko wasu rikice-rikice wanda a cikin su insulin wajibi ne;
• karamin shekaru;
• wuce kima ji na ƙwarai zuwa ga babban kuma gefen aka gyara daga miyagun ƙwayoyi.

Tunda abu mai aiki ana raba shi ta hanjin kodan, marasa lafiya da ke fama da cutar a wannan yankin yakamata suyi maganin tare da taka tsantsan. Hakanan ya shafi marasa lafiya da ke fama da rashin lafiya da wahala daga halin febrile.

A yayin gudanar da maganin repaglinide, ya zama dole a sanya ido sosai kan alamu masu sukari na jini domin dakile cutar sikari da cutar kwayar cuta. Tare da raguwa mai narkewa a cikin glucose, sashi na miyagun ƙwayoyi yana raguwa.

Umarnin don amfani

Amincewa da miyagun ƙwayoyi ana aiwatar da shi bisa umarnin likitan, wanda ya haɗa da kayan. Ana samun yawancin kwayoyi a cikin nau'in kwamfutar hannu, ana ɗaukar su ta bakin mintuna 15-20 kafin cin abinci. An zabi sashi a kowane yanayi da kaina.

Zai fi kyau fara fara ma'amala tare da ƙaramin ƙa'ida: 0.5 MG. Bayan mako guda, zaku iya yin gyare-gyare ta hanyar ƙara yawan ƙwayar magani ta hanyar 0.5 mg. Matsakaicin da aka yarda da shi yakamata ya zama 4 MG a lokaci ko 16 MG kowace rana.

Idan mara lafiya a baya ya yi amfani da wani magani na daban na hypoglycemic kuma an canza shi zuwa sakewa, farawar farko a gare shi ya zama kusan 1 MG

Idan ka rasa shan allunan, kar a ninka sashi kafin na gaba, wannan na iya bayar da gudummawa ga raguwar glucose a cikin jini da farawar hypoglycemia. Duk wani canji na sashi ko canzawa a cikin miyagun ƙwayoyi ya kamata ya faru a ƙarƙashin kulawar likita kuma a ƙarƙashin kulawa da alamun sukari a cikin fitsari da jinin mai ciwon sukari.

Side effects

Mafi sau da yawa, lokacin amfani da magani dangane da farfadowa, hypoglycemia yana faruwa, wanda zai iya faruwa duka saboda rashin bin ka'idodi don amfani da miyagun ƙwayoyi, kuma saboda dalilai na mutum: ƙara yawan aiki na jiki, rashin yarda da abincin, da sauransu.

Bugu da kari, sakamako na iya faruwa a cikin hanyar:

• raunin gani;
• vasculitis;
• ci gaban cututtukan zuciya;
• wani rigakafi a cikin hanyar rashes da itching;
• ƙwayar cutar farin ciki da asarar sani;
• take hakkin hanta;
• zafi a ciki, tashin zuciya, zawo, ko maƙarƙashiya.

Lokacin da aka sanya maganin al'ada ko kuma aka sauya magunguna zuwa wani magani, alamomin sun shuɗe.

Bidiyo daga Dr. Malysheva game da alamun ciwon sukari:

Hulɗa da ƙwayoyi

Dangane da batun yin amfani da maganin repaglinide, ya zama dole la’akari da mu’amalarsa da sauran abubuwa.

Don haɓaka tasirin maganin yana iya:

• Gemfibrozil;
• magungunan anabolic steroids;
• Rifampicin;
• Trimethoprim;
• Clarithromycin;
• Itraconazole;
• Ketoconazole da sauran wakilan hypoglycemic;
• azzalumi na monoamine oxidase da angiotensin-mai canza enzyme;
• magungunan anti-mai hana kumburi;
• marasa zaɓi na beta-blockers;
• salicylates.

Amincewar amfani da kwayoyi tare da maganin disaglinide da gemfibrozil yana cikin contraindicated, tunda yana haifar da karuwa da yawa a cikin aikin abu da kuma yiwuwar samun kwaro.

A kan aikin repaglinide, irin waɗannan wakilai kamar:

• Cimetidine;
• Simvastatin;
• Estrogen;
• Nifedipine.

Saboda haka, za'a iya amfani dasu tare.

Ana ganin ɗan ƙaramin sakamako akan ɓangaren repaglinide dangane da magunguna: Warfarin, Digoxin da Theophylline.

Tasirin magunguna yana raguwa:

• maganin hana haihuwa;
• glucocorticosteroids;
• Rifampicin;
• kwayoyin hodar iblis;
• barbiturates;
• Danazole;
• m
• Carbamazepine;
• Kalaman thiazide.

Yin amfani da su ana bada shawara don haɗewa tare da daidaitawar kayan.

Shawarwarin don amfani

An wajabta Repaglinide don amfani lokacin da maganin abinci da ƙayyadaddun ƙoƙari na jiki ba su ƙyale ku don sarrafa sukari na jini.

Bayan lokaci, tasiri na miyagun ƙwayoyi yana raguwa, wanda ke da alaƙa da ci gaban cutar da raguwa a cikin ƙwaƙwalwar jiki ga aikin miyagun ƙwayoyi. Sannan likita ya sake tsara wani magani ko kuma yana aiwatar da daidaitawar sashi.

Ana saukaka tasirin magungunan koyaushe ta hanyar nazarin yawan haɗuwar glucose a cikin jini da fitsari. Mai haƙuri na iya yin binciken kwatancen kansa ta amfani da magungunan gida, amma lokaci-lokaci akwai kulawar da ke halartar mahaɗa. A gare shi, wajibi ne a dauki gwaje-gwaje a dakin gwaje-gwaje na asibiti.

Hakanan yana bincika matakin gemocosylated haemoglobin, wanda zai ba ku damar samun cikakken hoto game da tsarin aikin magani. Lokacin da alamu suka canza, ana daidaita yanayin sashi.

Ana amfani da kayan aiki da kanta tare da haɗin gwiwa tare da maganin rage cin abinci da motsa jiki na yau da kullun, wanda ya kamata likita ya haɓaka. A lokaci guda, canji a cikin kayan abinci ko abubuwan wasanni suna haifar da canji a cikin glucose da ke cikin jini, wanda ke buƙatar daidaita yanayin magani. Tun da mai haƙuri ba zai iya yin wannan da sauri ba, ana bada shawara don kauce wa canje-canje kwatsam cikin abinci da damuwa.

Ba za a iya amfani da Repaglinide lokaci guda tare da wakilai masu ɗauke da giya ba, saboda suna inganta tasirin sa. Magungunan da kanta ba ta tasiri da ikon fitar da abin hawa, amma lokacin da hypoglycemia ya faru, wannan ikon yana raguwa sosai. Sabili da haka, yayin shan magani, kuna buƙatar sarrafa matakin ƙwayar glucose da hana haɓaka ta raguwa.

Kamar yadda aka nuna, masu haƙuri da cututtukan ayyukan kodan da hanta, da wahala daga cututtukan zuciya da jijiyoyin jini, suna buƙatar amfani da miyagun ƙwayoyi musamman a hankali.

Babu wani binciken game da illar da mata masu juna biyu da masu shayarwa. Don haka, ba a tabbatar da amincin miyagun ƙwayoyi ga jariri ba kuma ba a ba da maganin ba yayin wannan lokacin. Mace da take buƙatar magani sai ta ƙi shayar da jaririnta.

Wannan ya shafi halaye na shekaru. Ba a san ainihin tasirin maganin a kan marasa lafiya da ke ƙasa da shekara 18 da bayan shekara 75 ba. A cikin irin waɗannan yanayi, ana maye gurbin Repaglinide ta hanyar analog ko kuma ana iya ci gaba da amfani da mai haƙuri a cikin tsufa, idan yana ƙarƙashin kulawar likitancin endocrinologist.

Shirye-shiryen sake fasalin

Magana game da miyagun ƙwayoyi ita ce Repaglinide-Teva, wanda aikinsa ya dogara da abin da ake tambaya.

Analogs sune:

• Kudin Diagninid daga 200 rubles don allunan 30;
• Jardins daga 200 rubles don allunan 30;
• NovoNorm daga 170 rubles don allunan 30;
• Invokana daga 2000 rubles don allunan 30 tare da sashi na 100 MG.;
• Forsiga daga 2000 rubles don allunan 30 tare da sashi na 10 MG.;

Farashin ma'amala da kuma analogues ya dogara da dalilai da yawa:

• sashi
• masana'anta;
• kasancewar abubuwanda suka dace da juna;
• farashin manufofin sarkar kantin magani da sauransu.

Shan magungunan hypoglycemic muhimmiyar mahimmanci ne ga yawancin marasa lafiya da ke fama da ciwon sukari na 2. Yana ba su damar inganta rayuwar rayuwa da rage mummunan tasirin cutar. Koyaya, duk wannan yana yiwuwa ne kawai idan an lura da buƙatun umarnin don amfani da miyagun ƙwayoyi da ikon nuna alamun jihar jikin.