Magungunan zamani suna amfani da rukuni daban-daban na magunguna don maganin cututtukan type 2.
Ofayan ɗayan waɗannan rukunin shine thiazolidinediones, waɗanda ke da irin wannan sakamako tare da metformin.
An yi imani da cewa, idan aka kwatanta da abubuwan da ke sama masu aiki, thiazolidinediones suna da aminci.
Yaya ake kula da ilimin dabbobi?
Hanyar zamani na ciwon sukari cuta ce mai ɗaukar matakai.
Matakan warkewa sun haɗa da hanyar likita, bin tsayayyen tsarin abinci, hanyoyin motsa jiki, magani mara amfani da magani da kuma amfani da girke-girke na gargajiya.
Kula da ciwon sukari ya ƙunshi yin amfani da magunguna na musamman don cim ma wasu burin warkewa.
Wadannan manufofin jiyya sune:
- rike adadin insulin na hormone a matakin da ake buƙata;
- normalization na yawan glucose a cikin jini;
- toshewar ci gaba ga cigaban cigaban cutar;
- neutralization na bayyanuwar rikitarwa da mummunan sakamakon.
Hanyar warkewa ta ƙunshi amfani da rukuni na rukuni na gaba:
- Shirye-shiryen Sulfonylurea, wanda ke haifar da kusan kashi casa'in na dukkanin magunguna masu rage sukari. Irin waɗannan allunan suna kawar da juriya insulin.
- Biguanides sune kwayoyi tare da abu mai aiki kamar metformin. Abun yana da tasiri mai amfani akan asarar nauyi, kuma yana taimakawa rage sukarin jini. A matsayinka na mai mulkin, ba a amfani da shi don lalacewa na aiki da aikin hepatic, saboda yana tarawa da sauri a cikin waɗannan gabobin.
- Ana amfani da inhibitors na Alpha-glycosidase prophylactally don hana ci gaban nau'in ciwon sukari na 2. Babban fa'idar magunguna ta wannan rukunin shine ba sa haifar da bayyanar cututtukan jini. Kwayoyin kwalabe suna da tasiri mai amfani akan daidaituwa na nauyi, musamman idan aka bi hanyoyin maganin abinci.
- Ana iya amfani da Thiazolidinediones a matsayin babban magunguna don maganin cututtukan cututtukan cuta ko kuma tare da haɗin gwiwa tare da wasu magunguna masu rage sukari. Babban tasirin allunan shine don ƙara ƙwaƙwalwar nama zuwa insulin, ta hakan ke hana juriya. Ba a amfani da magungunan a cikin ci gaban nau'in 1 na ciwon sukari na mellitus, tunda za su iya yin aiki kawai a gaban insulin, wanda ƙwayar huhu ke samar.
Bugu da ƙari, ana amfani da meglitinides - magunguna waɗanda ke haɓaka ƙwayar insulin, hakan yana shafar ƙwayoyin beta na pancreatic.
An riga an lura da raguwar matakan glucose minti goma sha biyar bayan ɗaukar kwaya.
Tasirin thiazolidinediones a jikin?
Magunguna daga rukuni na thiazolidinediones suna nufin kawar da juriya na insulin.
An yi imani cewa irin wannan kwayayen na iya hana hadarin kamuwa da ciwon sukari na 2.
Magungunan ilimin zamani suna wakiltar manyan magunguna biyu daga wannan rukuni - Rosiglitazone da Pioglitazone.
Babban tasirin kwayoyi a jikin mutum sune kamar haka:
- haɓaka matakin jijiyoyin jiki zuwa insulin;
- Taimakawa haɓaka aiki a cikin ƙwayoyin beta na pancreatic;
- yana kara tasirin metformin a hade hade.
Ana amfani da shirye-shirye daga rukuni na thiazolidinediones a cikin halayen masu zuwa:
- Don magani da rigakafin cututtukan siga na 2.
- Don daidaita nauyi lokacin da aka bi da maganin cututtukan abinci don masu ciwon sukari da motsa jiki.
- Don haɓaka tasirin kwayoyi daga ƙungiyar biguanide, idan ƙarshen ba ya bayyana cikakke.
Za a iya gabatar da magungunan thiazolidinedione na zamani na zamani a fannoni daban-daban, gwargwadon matsayin haɓakar ƙwayar cuta - goma sha biyar, talatin ko arba'in da biyar na kayan aiki mai aiki. Ana ba da shawarar hanya don farawa da mafi ƙarancin kashi kuma ana ɗaukar sau ɗaya a rana. Bayan watanni uku, idan ya cancanta, ƙara sashi.
Mafi sau da yawa, ana amfani da maganin don rage glucose jini. Haka kuma, a fannin likitanci, al'ada ce a rarraba marassa lafiya da ke shan kwayoyin magani “amsa” da “marasa-amsa” ga illolin cutar.
An yi imanin cewa tasirin amfani da thiazolidinediones yana da ƙanƙantar da ƙasa da na magunguna masu rage sukari na wasu ƙungiyoyi.
Contraindications da sakamako masu illa
Akwai magungunan hana daukar ciki da yawa na amfani da magunguna masu rage sukari.
Mafi mahimmancin contraindication shine ban a hana amfani da kwayoyi daga rukuni na thiazolidinediones yayin kulawa da nau'in insulin-dogara da tsarin cututtukan.
Kafin fara karatun warkewa, ya zama dole a duba yanayin aikin hanta da kimanta yiwuwar shan wannan magani.
Bugu da kari, an haramta amfani da magunguna na wannan rukunin:
- 'yan mata masu juna biyu da mata yayin shayarwa an haramtawa shan wadannan kwayoyin magani;
- a gaban bugun zuciya a cikin marassa lafiya;
- idan hypersensitivity ga aiki abu na wannan magani lura;
- a gaban matsaloli tare da aikin hanta na yau da kullun, kazalika da hanta cirrhosis tare da nau'in ciwon sukari na 2;
- yara ‘yan kasa da shekaru goma sha takwas;
A wasu halaye, za'a iya samun karuwa a jiki bayan an fara amfani da allunan. Haka kuma, irin wannan tasirin yana yiwuwa duka tare da maganin taɓothera kuma lokacin yin jiyya.
Babban gefen kuma mummunan bayyanar thiazolidinediones shine tara ruwa a cikin jiki da kuma bayyanar kumburi. Wannan yana da haɗari musamman ga marasa lafiya waɗanda ke haifar da cututtukan zuciya daban-daban.
Babban sakamako masu illa shine bayyanar kumburi na gefe, matsalar rashin jini, hepatotoxicity.
Bidiyo a cikin wannan labarin yana ba da bayyani game da allunan saukar da sukari.
