Hada magungunan Amurka Combogliz Prolong

Diabetology wani yanki ne mai haɓaka sosai a cikin magani. A cikin 'yan shekarun nan, an kirkiro sababbin magunguna da yawa waɗanda suka saukaka gudanar da ciwon sukari na 2. Nasarar kimiyya na shekaru goma da suka gabata ana kiranta incretin mimetics, wanda ya rage glycated hemoglobin da kashi 1%. A wannan yanayin, nauyin jikin mai ciwon sukari shima a hankali yake raguwa; magungunan karuwa basa haifar da mummunan sakamako kamar su cututtukan jini.

Duk waɗannan halaye (tsaka tsaki dangane da nauyin jikin mutum, rashi mummunar illa mara kyau, ingantaccen tasiri da ƙari mai araha) Hakanan yana aiki ne da maganin gargajiya na gargajiya na Metformin, wanda ke ɗaukar matsayi na gaba a cikin lura da ciwon sukari na 2 na rabin ƙarni.

Hada magungunan Amurka Combogliz Prolong ya haɗu da fa'idodin metformin da incretinomimetics, kuma tsarin da aka tsawaita yana ba da sauƙin amfani da ƙarin aminci.

Abubuwan da ke tattare da magunguna na magani

Combogliz Prolong shine ingantaccen haɗin daidaitacce na saxagliptin da metformin, samar da likitoci da masu ciwon sukari tare da sababbin damar da za su iya sarrafa bayanan su na glycemic.

Saxagliptin

Saxagliptin wakilin kwayoyi ne masu lalacewa. Abun ciki shine hanjin ciki yayin da carbohydrates suka shiga shi. Akwai nau'ikan hormones na halitta guda 2: GLP-1 (peptide glucagon-like) da HIP (polypeptide glucose-glucose-glucose-glucose).

Sake shiga cikin jini, su kashi 70% suna motsa samarda insulin halittun da ins-cells sel ke da alhakin wannan aikin.

A layi daya, incretins hana glucagon kira da hana saki abubuwan da ke ciki na ciki, samar da ƙarin sakamakon jikewa.

An tabbatar da cewa a cikin masu ciwon sukari tare da nau'in cuta na 2, samar da abubuwan da suke haifar da endogenous ba su da tushe saboda gaskiyar cewa ana iya lalata hormones da enzyme DPP-4 (dipeptidyl peptidase). Agara yawan masu gwagwarmaya suna hana aikin DPP-4, yayin da suke ci gaba da aiwatar da abubuwan da suka dace. Abubuwan adawar wucin gadi na GLP-1 basu da hankali ga wannan enzyme mai zafin rai.

Saxagliptin ba wai kawai ya tsawanta rayuwar incretins ba, amma kuma yana ba da gudummawa ga ci gaban lambobin su a cikin tsarin ilimin halittar jiki (mafi yawan lokuta 2). Samun magungunan rage damuwa suna rage alamomin duka azumi da kuma glycemia postprandial. Waɗannan fasalulluka na miyagun ƙwayoyi na iya kawar da yanayin hypoglycemic.

Metformin

Maganin antihyperglycemic antiformperlylymic, kawai wakilin ƙungiyar biguanide, baya tasiri akan kwayoyin-b, sabili da haka, baya motsa ƙwayar insulin kuma baya ɗaukar ƙwayar cuta.

Yana kulawa da yanayin kwantar da hankali na glycemia ta hanyar hana sakin glycogen a cikin hanta da kashi 30%. Metformin yana toshe abubuwan da ake amfani da kwayoyin glucose a cikin hanji, yana inganta jijiyoyin masu karbar kwayoyin zuwa insulin nasu. Ta hanzarta jigilar glucose zuwa tsokoki, yana ƙaruwa da ƙarfin kuzari don bukatun jikin mutum da rage ƙimar canjin sukari da ba a bayyana ba ga mai.

Metformin tare da sakewa yana da ƙarin fa'ida - mafi ƙarancin sakamako masu illa daga ƙwayar jijiyoyi, daidaitawar nauyi. Rage ruwan 'ya'yan itace na ciki, membrane ya watsar da sauri, maganin kwalliyar ya kumbura ya zama an rufe shi da gel. Godiya ga wannan matrix na gel, ana sakin magungunan gaba ɗaya a cikin kullun, yana samar da yanayin mafi yawan sha.

Haɗarin incretinomimetic tare da metformin an gane shi ta likitoci a matsayin mafi kyau a kowane matakin sarrafa nau'in ciwon sukari na 2. Baya ga dacewa da karɓar haƙuri da biyayya ga irin wannan tsarin kulawa, babban shawarta shine ingantaccen aiki da ingantaccen tsaro. Ga masu ciwon sukari masu kiba, wannan shine mafi kyawun zabi, tunda magani baya bayar da tasirin gudummawar nauyi, haɓakar bugun zuciya, cututtukan cututtukan zuciya, da kuma oncology.

Formaddamar da tsari da abun da ke ciki Kombiglyze tsawan

Kamfanin samar da magunguna na Amurka Bristol-Myers Squibb yana samar da magungunan maganin cututtukan cututtukan cututtukan fata a cikin nau'ikan allunan da aka canza launin tare da karfin da aka daidaita.

Kowane ƙwayar capsule ya ƙunshi 500 ko 1,000 MG na abubuwan da ke aiki na Metformin da 2.5 ko 5 mg na Saxagliptin. Baya ga kayan abinci na yau da kullun, an haɗa abun ɗin tare da fillers: magnesium stearate, sodium carmellose, hypromellose. Launin harsashi na iya zama rawaya, ruwan hoda ko m, gwargwadon sashi. Ana cakuda capsules a cikin sel mai warware almara. Akwatin kwali na iya ƙunsar 4-8 irin faranti.

Saki magunguna. A Combogliz Tsawon lokaci farashin ya dogara da sashi: 1000 mg + 5 mg (Allunan 28) - har zuwa 3250 rubles .; 1000 mg + 2.5 MG (Allunan 56 a kowace fakitin) - har zuwa 3130 rubles.

Rayyan shiryayye na magani ba ya wuce shekaru 3. Dole ne a zubar da maganin da ya ƙare. Magungunan ba ya buƙatar yanayi na musamman don ajiya.

Combogliz Na Zamani: umarnin don amfani

Likita ya zaɓi jadawalin gudanarwa da kashi-kashi daban-daban, la'akari da alamun da ke nuna glucose, lafiyar gaba ɗaya, yawan masu ciwon sukari, amsawar mutum ga allunan. Gabaɗaya, koyarwar tana ba da irin waɗannan shawarwarin.

Yawancin magani ana daukar shi 1 a rana / Rana. a lokaci guda.

Sha kwamfutar hannu da safe ko da yamma, ba tare da nika ba. Don sauya fasalin fitarwa, amincin kwasfa yana taka rawa ta musamman.

Sashi na mutum ne, a matsayin farawa na monotherapy zai iya zama kwamfutar hannu 1 (500 MG na metformin + 2.5 MG na saxagliptin), idan ba a iya samun cikakken ikon sarrafa glycemic ba, ana ƙaruwa da kashi zuwa allunan 2 (1000 mg na metformin + 5 MG na saxagliptin).

Tare da yin amfani da magunguna na lokaci ɗaya don magance cututtukan haɗuwa, sakamakon hulɗa yakamata a la'akari. Musamman, tare da kulawa na lokaci daya na hana masu hana CYP3A4 / 5 isoenzymes (Indinavir, Ketoconazole, Nefazodon, Itraconazole, Atazanavir), an ƙaddara mafi ƙarancin saxagliptin - 2.5 MG.

Magunguna waɗanda suka danganta da metformin tare da tsawan tasirin sakamako mara amfani a cikin nau'in rikicewar dyspeptiki yana ƙasa da analogues tare da sakin hanzari. Saboda jiki ya saba da sabon yanayin, ba shi da ciwo mai narkewa, kashi kashi ya kamata a da za'ayi hankali, kowane 2 makonni.

Duk wani canje-canjen rayuwa dole ne a lasafta shi yayin yin daidaiton maganin, saboda haka yana da mahimmanci a sanar da likita game da su a cikin lokaci.

Analogs Kombiglyce Na Ci gaba

Don Combogliz Prolong, analog tare da wannan saitin abubuwa masu aiki guda ɗaya na iya zama Comboglis XR, wanda aka samar a Italiya da Burtaniya. Farashin analog daga 1650 rubles. (Allunan 28 na 1000 na metformin da 2.5 mg na saxagliptin).

Dukkanin tasirin warkewar cutar Avandamet, Yanumet, Glimecomb, GalvusMet da Bagomet da ƙari suna da irin tasirin warkewa.

Adana magunguna dangane da aiki guda ɗaya kamar Glyformin Prolong, Glucofage, Metadiene, Sofamet, Diaformin Od, Ongliza, Matospanin, Metfogamma, Siofora.

Wanene ya nuna maganin

An tsara Combogliz tsawan tsinkaye don ciwon sukari na 2 don daidaita tsarin glycemic a matsayin ƙari ga rage cin abinci mai ƙoshin abinci da isasshen motsa jiki, idan gyare-gyaren salon bai haifar da sakamakon da ake so ba kuma haɗakar saxagliptin tare da metformin ya dace da haƙuri.

Cikakken kuma dangi contraindications

Ko da magani tare da babban matakin aminci, wanda shine Combogliz Prolong, ba a sanya shi don rashin haƙuri da ɗaukar hankali ga abubuwan da ke cikin tsari ba.

1. Ba a nuna maganin ga mata masu juna biyu da masu shayarwa ba (an canza su zuwa ɗan insulin na ɗan lokaci), saboda ƙarancin ingantaccen shaida na inganci, ba a sanya su ga yara.
2. Magungunan ba su dace da masu ciwon sukari masu cutar ta 1 ba.
3. A cikin tabarbarewa na yara, da yanayinda yake tsokane su, haka kuma ba a sanya magani ba.
4. Kada kuyi amfani da magani don kula da marasa lafiya da cututtukan cututtukan da ke haifar da yunwar oxygen na kyallen takarda.
5. Tare da ketoacidosis (nau'in ciwon sukari) tare da ko ba tare da coma ba, ba a ɗaukar maganin na ɗan lokaci.
6. An soke magungunan ƙwayoyin cuta yayin aiki, tare da raunin raunin da ya faru, ƙonewa mai yawa. Gwajin X-ray tare da alamomin sinadarin aidin a cikin masu ciwon sukari na iya lalata kodan, don haka an canza shi zuwa insulin. A cikin duka, ana nuna ilimin insulin na awanni 48 kafin da kuma awanni 48 bayan hanyoyin, musamman, duk ya dogara da yanayin kodan da kuma lafiyar ɗan haƙuri.
7. Abubuwan cututtukan hanta, lactic acidosis da dogarawar barasa suma suna cikin jerin magungunan hana haihuwa. Ba za ku iya yin kwayar maganin ba ga marasa lafiya da ke fama da rashin haƙuri.

   
   

Ya kamata a saka kulawa ta musamman ga masu ciwon sukari na tsufa, musamman tare da rashin abinci mai narkewa, cututtukan cututtukan fata da ƙarancin motsa jiki wanda zai iya tayar da hauhawar jini.

M illa maras so illa da yawan abin sama da ya kamata

Saksagliptin tare da bambance-bambancen digiri na yuwuwar zai iya haifar da yanayi:

• Sinusitis
• Migraines
• Ciwon ciki;
• Vomiting;
• Kwayar cututtukan cututtukan hanji;
• Rashin rikicewar motsi na hanji;
• Thrombocytopenia;
• Nasopharyngitis;
• Hypoglycemia;
• Cutar Gastroenteritis;
• Kwari kan fuska;
• Kwayar cutar kansa
• Urticaria.

Nazarin dakin gwaje-gwaje sun nuna raguwa a cikin shan bitamin B12 tare da tsawaita amfani da miyagun ƙwayoyi, kazalika da raguwa a yawan adadin ƙwayoyin cuta. Magungunan cutar overdose suna guda ɗaya, mafi yawan lokuta suna faruwa tare da amfani da saxagliptin na dogon lokaci. Magungunan ba ya haifar da maye, tare da wuce haddi na miyagun ƙwayoyi, hemodialysis yana da tasiri. A layi daya, ana gudanar da cutar sikari.

Yawan maganin metformin ya zama ruwan dare, mafi haɗarin rikicewa shine lactic acidosis.. Kuna iya gane yanayin ta wadannan alamun:

1. Rushewa;
2. Rage numfashi;
3. Ciwon ciki;
4. Pressurearancin saukar karfin jini;
5. Hypothermia;
6. Muscle cramps;
7. Zuciyar bugun zuciya.

A cikin mawuyacin hali, ruhi mai rauni, fainting, precoma da coma. Wanda aka cutar ya bukaci asibiti cikin gaggawa, ba tare da isasshen kulawar likita ba, zai iya mutuwa. Hakanan an cire metformin ta hanyar hemodialysis, yana da mahimmanci a la'akari da cewa ƙirar creatinine ya kai 170 ml / min.

Mafi daidai ga masu ciwon sukari suna cika duk shawarar likita, ƙananan haɗarin mummunan rikitarwa. Game da Combogliz na tsawan lokaci, ba shi da wuya a bi jadawalin shan maganin.

Zaɓuɓɓuka don hulɗa tare da wasu magunguna

Lokacin ƙirƙirar tsarin kulawa don Combogliz Prolong, yana da mahimmanci a gargaɗin endocrinologist game da duk magungunan da mai ciwon sukari ke ɗauka don magance cututtukan haɗuwa. Wasu daga cikinsu suna iya haɓaka ƙarfin rage sukari na Comboglize, wasu suna hana aikinta.

Don ra'ayin gabaɗaya, zaku iya kewaya teburin.

Amprenavir, Diltiazem, Erythromycin, Fluconazole, Aprepitant, Verapamil, ruwan innabi, Ketoconazole, magungunan sulfonylurea, Glibenclamide, Ketoconazole, isoenzymes CYP3A 4/5, Famotidine
Wakilan cationic, Furosemide, ethanol magunguna, Nifedipine

A bayyane yake cewa gwaje-gwajen tare da gano kansa da magani na kai tare da Combogliz Prolong na iya samun babban sakamako na kiwon lafiya.

Kwayar Combogliz: sake dubawa game da masu ciwon sukari

Likitocin da ke lura da tasirin maganin tare da maganin Combogliz Prolong sun lura da bambancinsa, kuma masu ciwon sukari ba su da shakku kan iyawarsa.

Cikakken tsarin kula da ciwon sukari na buƙatar tsarin haɗa kai: ƙananan kayan abinci mai narkewa, kulawa na yau da kullun na karatun glucometer, isasshen motsa jiki da tallafin likita. Sai kawai a cikin wannan haɗin za ku iya dogara da tasirin 100% na Combogliz Prolong.

A cikin bidiyon, farfesa-endocrinologist A.S. Ametov yayi magana game da ka'idodin zamani na gudanar da ciwon sukari na 2.