Indapamide - magani ne da aka tabbatar don hawan jini

Indapamide ya kasance na biyu, mafi zamani, ƙarni na thiazide-kamar diuretics. Babban tasirin miyagun ƙwayoyi shine raguwa mai sauri, tsayayye da tsawaita tsawan jini. Zai fara aiki bayan rabin sa'a, bayan awanni 2 sakamakon ya zama mafi girman kuma ya kasance a cikin babban matakin akalla awanni 24. Muhimman fa'idodin wannan magani shine rashin sakamako akan metabolism, ikon inganta yanayin kodan da zuciya. Kamar kowane diuretics, Indapamide za'a iya haɗe shi da mafi kyawun hanyar aminci mai haɗari: sartans da masu hana ACE.

Wanda aka wajabta wa indapamide

Dukkanin marasa lafiya da ke fama da hauhawar jini suna buƙatar magani na tsawon rai, wanda ya ƙunshi magungunan yau da kullun. Ba a dade da tambayar wannan magana ba a da'irar likitocin kwararru. An gano cewa kulawar matsa lamba na kwayoyi a kalla sau 2 yana rage yiwuwar cututtukan zuciya, gami da wadanda suka mutu. Babu wata muhawara game da matsin lambar da za'a fara shan kwayoyin. A duk duniya, matakin mahimmanci ga yawancin marasa lafiya ana la'akari da 140/90, koda kuwa matsin lamba ya hau asymptomatally kuma baya haifar da matsala. Guji shan magungunan kawai tare da hauhawar jini. Don yin wannan, za ku rasa nauyi, daina shan taba da barasa, canza abinci mai gina jiki.

Iyakar abin da kawai kawai don amfani da Indapamide da aka nuna a cikin umarnin shine hauhawar jini. Haɗu da hawan jini sau da yawa ana haɗuwa da cututtukan zuciya, kodan, tasoshin jini, saboda haka, magungunan da aka tsara don rage shi, dole ne a gwada lafiya da tasiri a cikin waɗannan rukunin marasa lafiya.

Abinda ke taimakawa Indapamide:

1. Matsakaicin matsin lamba yayin shan Indapamide shine: babba - 25, ƙaramin - 13 mm Hg
2. Nazarin ya nuna cewa aikin antihypertensive na 1.5 g na indapamide daidai yake da 20 mg na enalapril.
3. Yawan matsin lamba na lokaci mai tsawo yana haifar da karuwa a cikin hagu na ventricle na zuciya. Irin waɗannan canje-canje na ilimin halittu suna cike da damuwa da rudani, bugun jini, gazawar zuciya. Allunan indapamide suna ba da gudummawa ga raguwa a cikin adadin ventricular myocardial taro, fiye da enalapril.
4. Don cututtukan koda, Indapamide ba shi da tasiri. Ana iya yanke hukunci game da tasirin sa ta hanyar faɗuwar 46% cikin matakin albumin a cikin fitsari, wanda aka ɗauka ɗayan farkon alamun alamun rashin nasara na koda.
5. Magungunan ba shi da mummunar tasiri a kan sukari, potassium da cholesterol, saboda haka, ana iya amfani da shi sosai don ciwon sukari. Don lura da hauhawar jini a cikin masu ciwon sukari, an wajabta diuretics a cikin ƙaramin kashi, hade tare da masu hana ACE ko Losartan.
6. Abubuwan da keɓaɓɓe na Indapamide tsakanin diuretics shine haɓakawa na matakin "kyakkyawa" HDL cholesterol ta ƙarancin kashi 5.5%.

Yaya maganin yake aiki?

Babban kayan mallakar diure shine haɓakar fitarwar fitsari. A lokaci guda, yawan ruwa a cikin kyallen da jijiyoyin jini ke sauka, kuma matsi yana raguwa. A cikin watan jiyya, yawan ƙwayar extracellular ta zama ƙasa da 10-15%, nauyi saboda asarar ruwa yana raguwa da kusan kilogiram 1.5.

Indapamide a cikin rukunin rukunin shi ya mamaye wani wuri na musamman, likitoci sun kira shi da diuretic ba tare da tasirin diuretic ba. Wannan bayani yana aiki ne kawai don ƙananan allurai. Wannan magani ba ya tasiri da yawan fitsari, amma yana da tasirin natsuwa kai tsaye a kan magudanar jini kawai lokacin amfani dashi a cikin kashi ≤ 2.5 MG. Idan ka dauki 5 MG, fitowar fitsari zai karu da kashi 20%.

Sakamakon abin da matsin lamba ke raguwa:

1. Ana katange tashoshi na Calcium, wanda ke haifar da raguwa a cikin yawan ƙwayar alli a cikin bangon tsokoki, sannan kuma ga yaduwar tasoshin jini.
2. Ana kunna tashoshi na potassium, sabili da haka, shigarwar alli a cikin sel yana raguwa, aikin sinadarin nitric oxide a cikin ganuwar jijiyoyin jiki yana ƙaruwa, kuma tasoshin suna shakata.
3. Samuwar prostacyclin yana kara motsawa, saboda wanda karfin platelet ya samar ya zama kwayar jini kuma ya haɗu da bangon jijiyoyin jini yana raguwa, sautin tsokoki na jijiyoyin jijiya yana raguwa.

Fitar saki da sashi

Magungunan asali suna dauke da indapamide ne kamfanin samar da magunguna na Servier ya kera shi a jikin sunan Arifon. Baya ga asalin Arifon, ana yin rijista da yawa game da indapamide a Rasha, gami da ƙarƙashin Indapamide iri ɗaya. Ana sanya alamun ana amfani da Arifon a cikin nau'in capsules ko allunan da aka saka fim. Kwanan nan, kwayoyi tare da ingantaccen saki na indapamide daga Allunan sun shahara.

Hawan jini da hauhawar jini za su kasance abubuwan da suka gabata - kyauta

Cutar zuciya da bugun jini sune sanadin kusan kashi 70% na duk mutuwar a duniya. Bakwai daga cikin mutane goma suna mutuwa saboda toshewar hanyoyin zuciya ko kwakwalwa. A kusan dukkanin lokuta, dalilin irin wannan mummunan ƙarshen shine guda ɗaya - matsin lamba akan hauhawar jini.

Yana yiwuwa kuma dole don sauƙaƙe matsi, in ba haka ba komai. Amma wannan ba ya warkar da cutar da kanta, amma kawai tana taimakawa wajen magance bincike, kuma ba dalilin cutar ba.

• Normalization na matsa lamba - 97%
• Cirewa kan jijiyoyin mara wuya - 80%
• Cire zuciyar mai karfin zuciya - 99%
• Cire ciwon kai - 92%
• Increasearuwar kuzarin rana, inganta bacci da dare - 97%

Ta yaya ake samar da Indapamide kuma nawa:

A cewar masana ilimin zuciya, ya fi kyau a sayi talakawa Indapamide a cikin capsules. Ana adana maganin a cikin capsules tsawon lokaci, yana da mafi girman bioavailability, yana karɓa da sauri, yana ƙunshe da ƙananan kayan taimako, wanda ke nufin yana haifar da rashin lafiyan ƙasa sau da yawa.

Mafi kyawun nau'in zamani na indapamide shine allunan aiki masu tsayi. Abubuwan da ke aiki daga garesu an saki su a hankali saboda wata fasaha ta musamman: adadi kaɗan na indapamide ana rarraba su a cikin cellulose. Da zarar cikin narkewar abinci, sannu a hankali cellulose ya zama gel. Yana ɗaukar kimanin awanni 16 don warware kwamfutar hannu.

Idan aka kwatanta da allunan al'ada, indapamide mai aiki na dogon lokaci yana ba da kwanciyar hankali da ƙarfin sakamako mai tasiri, ƙwanƙwasawa na yau da kullun lokacin shan shi ƙasa. Dangane da ƙarfin aiki, 2.5 mg na Indapamide na yau da kullun shine 1.5 MG. Yawancin sakamako masu illa suna dogara da kashi, wato, yawan su da tsananin ƙaruwa da ƙaruwa da yawa. Shan allunan Indapamide mai tsawo yana rage haɗarin sakamako masu illa, da farko raguwa a cikin matakan potassium.

Rarraba madaidaicin indapamide na iya zama a kashi 1.5 na MG. A kan kunshin ya kamata alama ce ta "tsawaita aiki", "sakin gyare-gyare", "sakin sarrafawa", sunan na iya ƙunsar "retard", "MV", "dogon", "SR", "CP".

Yadda ake ɗauka

Yin amfani da indapamide don rage matsin lamba baya buƙatar haɓakar digiri a hankali. Allunan nan da nan suka fara sha cikin sigar daidaitacce. Magungunan yana tarawa a cikin jini a hankali, saboda haka yana yiwuwa a yanke hukunci game da tasirin sa kawai bayan mako 1 na magani.

Dokokin shiga daga umarnin don amfani:

Da fatan za a kula: kafin a fara jiyya tare da kowane maganin hanawa, yana da kyau a lura da wasu sigogin jini: potassium, sugar, creatinine, urea. Idan sakamakon gwajin ya bambanta da na al'ada, nemi likita, tunda shan diuretics na iya zama haɗari.

Yaya zan iya ɗaukar indapamide ba tare da hutu ba

Arearancin matsi na indapamide an ba shi damar shan lokacin da ba a iyakance ba, muddin sun ba da matakan matsin lamba kuma an yarda da su sosai, wato, ba sa haifar da sakamako masu illa ga lafiyar. Ka daina shan maganin, koda kuwa matsi ya koma al'ada.

A cikin ƙasa da 0.01% na marasa lafiya masu hauhawar jini tare da kulawa na dogon lokaci tare da allunan Indapamide da analogues, canje-canje a cikin abubuwan da ke cikin jini ya bayyana: rashi na leukocytes, platelet, hemolytic ko aplastic anemia. Don gano abubuwan da suka faru na lokacin, koyarwar ta ba da shawarar yin gwajin jini a kowane watanni shida.

Indapamide, zuwa ƙarancin ƙayyadaddun abubuwa fiye da sauran diuretics, yana haɓaka kawar da potassium daga jiki. Kodayake, marasa lafiya masu haɗari a cikin haɗari don amfani da allunan na dogon lokaci na iya haifar da hypokalemia. Abubuwan haɗari sun haɗa da tsufa, cirrhosis, edema, cututtukan zuciya. Alamomin hypokalemia sune gajiya, raɗaɗin tsoka. A cikin sake dubawar marasa lafiya masu kara kuzari wadanda suka ci karo da wannan yanayin, sun kuma ce game da rauni mai rauni - "kada ku riƙe ƙafafunsu", maƙarƙashiya a kai a kai. Yin rigakafin hypokalemia shine yawan cin abinci mai dauke da sinadarin potassium: kayan kiwo, kayan lambu, kifi, 'ya'yan itatuwa da aka bushe.

M sakamako masu illa

Ayyukan da ba sa so na Indapamide da yawan aukuwar su:

Umarnin don amfani yana nuna cewa yuwuwar halayen masu illa sun fi girma tare da ƙarin yawan allunan Indapamide, ƙananan cikin batun amfani da tsawan tsari.

Contraindications

Jerin abubuwan da suka saba wa Indapamide ya takaice. Ba za a iya sha miyagun ƙwayoyi ba:

• idan aƙalla ɗayan kayan aikinta ya tsokani halayen rashin lafiyan cuta;
• tare da rashin lafiyan ga abubuwan samo asali na sulfonamide - nimesulide (Nise, Nimesil, da dai sauransu), celecoxib (Celebrex);
• tare da matsanancin na koda ko rashin hepatic;
• idan akwai wani hypokalemia da aka kafa;
• tare da hypolactasia - Allunan suna dauke da lactose.

Ba a daukar ciki, yara, shayarwa ba tsauraran matakan hana haihuwa ba. A cikin waɗannan halayen, shan Indapamide ba a ke so ba, amma zai yiwu ta hanyar ganawa kuma yana ƙarƙashin ƙoshin lafiya na likita.

Umarnin amfani da Indapamide baya nuna yiwuwar shan shi tare da giya. Koyaya, a cikin nazarin likitoci, an tantance daidaituwa da barasa tare da miyagun ƙwayoyi a matsayin mai haɗari ga lafiyar. Amfani guda na ethanol na iya haifar da raguwa cikin matsin lamba. Zagi na yau da kullun yana kara haɗarin haɗarin hypokalemia, yana lalata tasirin sakamako na Indapamide.

Analogs da wasu abubuwa

An sake maimaita miyagun ƙwayoyi a cikin kayan aiki da sashi, wato, magungunan masu zuwa da aka yiwa rajista a cikin Federationungiyar Tarayya suna cike analogues na Indapamide:

Ana iya maye gurbinsu ta hanyar Indapamide ba tare da ƙarin shawarar likita mai halartar ba. Dangane da sake dubawar marasa lafiya da ke shan magungunan, mafi ingancin wannan jerin sune allunan Arifon da Indap.

Kwatantawa da irin kwayoyi

Daga cikin thiazide da thiazide-kamar diuretics, indapamide na iya gasa tare da hydrochlorothiazide (kwayoyi Hydrochlorothiazide, Hypothiazide, Enap bangaren, Lorista da sauran magungunan antihypertensive da yawa) da chlortalidone (Allunan Oxodoline, ɗayan abubuwan Tenorik da Tenoretik).

Kwatanta halaye na waɗannan kwayoyi:

• ƙarfin aikin 2,5 MG na indapamide daidai yake da 25 MG na hydrochlorothiazide da chlortalidone;
• hydrochlorothiazide da chlortalidone ba zasu iya maye gurbin indapamide a cutar koda ba. Ana cire su ta hanyar kodan ba canzawa, sabili da haka, tare da gazawar renal, yawan haɗuwa yana faruwa sosai. Indapamide hanta yana aiki da ita, koda fiye da 5% an keɓe shi a cikin tsari mai aiki, saboda haka ana iya bugu har zuwa wani mummunan rauni na koda;
• Idan aka kwatanta da hydrochlorothiazide, indapamide yana da tasiri mai ƙarfi na kariya akan kodan. Fiye da shekaru 2 na cinsa, GFR yana ƙaruwa da matsakaicin 28%. Lokacin ɗaukar hydrochlorothiazide - rage ta 17%;
• chlortalidone yana aiki har zuwa kwanaki 3, don haka ana iya amfani dashi a cikin marasa lafiyar da basu sami damar ɗaukar maganin akan nasu ba;
• Allunan Indapamide ba su shafar metabolism na metabolism, sabili da haka, ana iya amfani dasu don ciwon sukari. Hydrochlorothiazide yana haɓaka juriya insulin.

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