Metformin Canon: umarni don amfani da dalilin da yasa ake buƙata

Metformin Canon yana daya daga cikin wakilan kungiyar kunkuntar kungiyar biguanides. Yanzu kawai abu mai aiki daga wannan rukuni an yarda ya yi amfani da - metformin. A cewar likitocin, shi ne mafi yawan magunguna don maganin ciwon sukari, yana tare da shi cewa ana fara magani idan aka gano wata cuta. Zuwa yau, an sami gagarumar gogewa game da amfani da wannan magani - sama da shekaru 60. A cikin shekaru, mahimmancin metformin bai ragu ba kwata-kwata. A akasin wannan, miyagun ƙwayoyi sun bayyana yawancin kaddarorin masu amfani ga masu ciwon sukari har ma da fadada ikon yinsa.

Yadda Metformin Canon ke aiki

Metformin Canon magani ne na hypoglycemic. Wannan yana nufin cewa yana kawar da sukari yana haɓaka halayyar masu ciwon sukari kuma yana hana rikice-rikice irin na ciwon sukari. Dangane da umarnin, ƙwayar ba ta shafi matakin sukari a cikin mutane masu lafiya, ba shi da ikon haifar da cututtukan jini.

Hanyar aikinta:

1. Metformin ya mayar da hankalin insulin ga masu ciwon sukari. Yana canza tsarin masu karɓar ƙwayoyin insulin, saboda wanda insulin ya fara ɗaure wa masu karɓa da ƙwazo, wanda hakan yana inganta watsa jini daga jini zuwa mai, hanta da ƙwayoyin tsoka. Yawan cin glucose a cikin sel ba ya ninka. Idan yawan ƙwayar carbohydrate ya kasance mai yawa kuma kashe kuzari a kan aikin jiki yana da ƙima, ana adana glucose a cikin nau'in glycogen da lactate.
2. Metformin Canon yana taimakawa rage yawan sukari mai azumi. Wannan aikin yana da alaƙa da ikon metformin don hana samar da glucose a cikin ƙwayoyin hanta da kashi 30%, don haɓaka haɗarin glycogen.
3. Metformin yana aiki sosai cikin kasusuwa na hanji. A lokaci guda, yawan shan glucose a hankali yana ragewa kimanin kashi 12%. A sakamakon wannan, glycemia bayan cin abinci yayi girma a hankali, babu tsinkayen tsalle mai tsinkaye masu kamuwa da cutar sankara tare da lalacewar lokaci guda cikin walwala. Wani bangare na glucose baya shiga cikin tasoshin kwata-kwata, amma ana samin metabolized kai tsaye a cikin hanji don lactate. Hannun hanta ya tattara kuma anyi amfani da shi don cike gibinsa. A nan gaba, ana kashe waɗannan ajiyar akan rigakafin yanayin hypoglycemic.
4. Metformin yana taimakawa rage yawan ci, yana sauƙaƙa asarar nauyi a cikin marasa lafiya tare da jure ƙarfin insulin.
5. A miyagun ƙwayoyi miyagun ƙwayoyi yana shafar maganin ƙwayoyin cuta na lipid a duka masu ciwon sukari da marasa lafiya da dyslipidemia ba tare da ciwon sukari ba. Godiya ga metformin, matakin triglycerides yana raguwa da kusan 45%, jimlar cholesterol by 10%, matakin "kyau" cholesterol dan kadan yana ƙaruwa. Mai yiwuwa, wannan aikin yana da alaƙa da ikon ƙwayar don murƙushe hadawan abu da iskar shaƙa.
6. Metformin yana hana rikicewar ƙwayoyin cuta na ciwon sukari. An yi bayanin wannan sakamako ta hanyar sa hannun abu a cikin hanyoyin glycation na sunadarai tare da sukari mai yawa.
7. Magungunan yana motsa ƙwayar fibrinolytic na jini, yana rage ikon platelet don haɗuwa tare, yana rage yiwuwar ƙwanƙwasa jini. Wasu likitoci sunyi imanin cewa Metformin ya fi asfirin girma a cikin tasirin antiplatelet dinsa.

Wanene aka wajabta maganin

Ya zuwa yanzu, jerin abubuwan da ke nuna shan shan Metformin Canon yana iyakance ga nau'in ciwon sukari guda 2 kawai da kuma yanayin da ya gabata. Kwanan nan, iyakokin magunguna suna faɗaɗa. Yiwuwar amfani dashi a cikin mutane masu kiba, cututtukan jijiyoyin jiki, dyslipidemia ana la'akari.

Alamu don alƙawari daga umarnin:

Ciwon sukari da hauhawar jini zai zama abin da ya wuce

• Normalization na sukari -95%
• Cirewa kan jijiyoyin mara wuya - 70%
• Cire zuciyar mai karfin zuciya -90%
• Rabu da cutar hawan jini - 92%
• Increasearuwar kuzarin rana, inganta bacci da dare -97%

• Sakamakon ciwon sukari a cikin manya da yara daga shekaru 10. Dole ne a haɗu da miyagun ƙwayoyi tare da tsarin abinci da ilimin jiki. Yi amfani da wasu allunan hypoglycemic da insulin an yarda. Ana lura da kyakkyawan sakamako na magani a cikin masu ciwon sukari.
• Don hana haɓakar ciwon sukari a cikin mutane tare da hali don hana haɓakar metabolism. An tsara miyagun ƙwayoyi idan mai haƙuri ya kasa cimma daidaituwa na yawan ƙwayar cutar glycemia tare da abinci da wasanni, kuma an ƙayyade haɗarin ciwon sukari a matsayin mai girma. Musamman Metformin an ba da shawarar musamman ga mutanen da suka wuce 60 tare da mummunan kiba, ƙarancin gado (ciwon sukari a cikin ɗayan iyayen), raunin ƙwayar cuta ta hanta, hauhawar jini, da tarihin ciwon sukari na gestational.

Ba kamar Metformin ba

Don nuna wurin da miyagun ƙwayoyi na Metformin Canon a tsakanin sauran allunan da ake kira Metformin, za mu juya zuwa tarihin. Anyi amfani da Biguanides a cikin magani na ƙarni da yawa. Koda a lokacin Tsararru na Tsakiya, an kula da urination ta hanyar infusions daga tsire-tsire na Galega officinalis. A cikin Turai, an san shi da sunaye daban-daban - Lilac na Faransa, ciyawar farfesa, akuya (karanta game da akuya na magani), a cikin Rasha suna yawan kiran shi da Lily na Faransa.

Asirin wannan tsiron ya fito da shi a farkon karni na 20. Abun, wanda ya ba da tasirin rage sukari, an sanya shi da sunan guanidine. An ware daga tsire, guanidine a cikin ciwon sukari ya nuna sakamako mai rauni, amma mai guba. Binciken kyawawan abubuwa na sukari bai daina ba. A cikin shekarun 1950s, masana kimiyya sun yanke hukunci akan kawai biguanides - metformin. An bai wa magungunan sunan Glucophage - mai amfani da sukari.

A ƙarshen 1980s, an gano cewa ɗayan mahimman abubuwan da ke haifar da ciwon sukari shine jurewar insulin. Bayan wallafa sakamakon binciken masana kimiyya, sha'awar glucophage ya karu sosai. An gudanar da bincike sosai game da tasiri, aminci, hanyoyin magungunan, da yawa na nazarin asibiti. Tun daga 1999, alluna tare da metformin sun zama na farko a cikin jerin shawarar da aka yiwa masu ciwon sukari. Suna wanzuwa a wuri na farko har zuwa yau.

Saboda gaskiyar cewa Glucofage aka ƙirƙira shi shekaru da yawa da suka wuce, sharuɗan kariyar mallaka don shi sun daɗe. Doka ta doka, duk wani kamfanin samar da magunguna na iya samar da metformin. Yanzu a cikin duniya an samar da ɗaruruwan kwayoyin halitta na Glucophage, yawancin su a ƙarƙashin sunan Metformin. A Rasha, akwai masana'antun kwamfyutoci sama da dozin guda biyu tare da metformin. Kamfanoni waɗanda suka ci amanar marasa lafiya sau da yawa suna ƙara alamar mai ƙira ga sunan miyagun ƙwayoyi. Metformin Canon shine samfurin Canonfarm Production Kamfanin yana samar da magunguna tsawon shekaru 20. Suna cika cikakkun bukatun duniya da ka'idoji masu inganci. Shirye-shiryen Canonfarm suna shawo kan matakan da yawa, farawa daga albarkatun ƙasa da ake amfani da su, suna ƙarewa da allunan da aka shirya. Dangane da masu ciwon sukari, Metformin Canon yana kusan kusa da tasiri a cikin ingancin Glucofage na asali.

Canonpharma yana samar da metformin a fannoni da dama:

Umarnin don shan miyagun ƙwayoyi

Koyarwar ta jaddada wajabcin lura da tsarin abincin a duk tsawon lokacin kulawa tare da miyagun ƙwayoyi. Mai haƙuri yana buƙatar rage yawan ƙwayar carbohydrate (likita ya ƙayyade adadin raguwa la'akari da tsananin cutar), rarraba su a cikin sassan abinci na tsawon ranar. Idan kun kasance kiba, ana shawarar rage yawan adadin kuzari. Mafi karancin adadin kuzari lokacin shan Metformin Canon shine 1000 kcal. Abinci mai tsayayye yana ƙara haɗarin sakamako masu illa.

Idan mai ciwon sukari bai riga ya dauki metformin ba, magani yana farawa ta hanyar kashi 500-850 MG, kwamfutar hannu tana bugu a cikakkiyar ciki kafin lokacin kwanciya. A farko, haɗarin sakamako masu illa yana da yawa musamman, don haka ba a kara adadin zuwa sati 2. Bayan wannan lokacin, kimanta matakin rage yawan ƙwayar cutar glycemia kuma, idan ya cancanta, ƙara sashi. Kowane makonni 2, zaku iya ƙarawa daga 500 zuwa 850 MG.

Yawancin admission - sau 2-3 a rana, yayin da ɗayan liyafar ta kasance maraice. Dangane da sake dubawa, ga yawancin marasa lafiya, daidaituwa na glycemia ya isa 1500-2000 mg kowace rana (3x500 mg ko 2x850 mg). Matsakaicin adadin da umarnin ya bayar shine 3000 MG (3x1000 MG) ga manya, 2000 MG ga yara, 1000 MG ga marasa lafiya da gazawar renal.

Idan mai haƙuri ya bi abinci, yana ɗaukar metformin a gwargwadon ƙwayar cuta, amma ba ya gudanar da nasarar biyan diyya ga masu ciwon sukari, likitan na iya ba da shawarar raguwa mai mahimmanci a cikin kwayar insulin. Idan an tabbatar da rashi na insulin, bugu da presari yana ɗaukar magungunan hypoglycemic wanda ke motsa ƙwayar huhu.

Abin da sakamako masu illa na iya zama

A cikin mucosa na hanji, maida hankali na metformin ya ninka sau ɗari sau da yawa a cikin jini, hanta da kodan. Yawancin sakamako masu illa na miyagun ƙwayoyi suna da alaƙa da wannan. Kimanin 20% na marasa lafiya a farkon shan Metformin Canon suna da raunin narkewa: tashin zuciya da gudawa. A mafi yawan lokuta, jiki yana kulawa don daidaitawa da miyagun ƙwayoyi, kuma waɗannan alamun suna ɓacewa akan kansu a cikin makonni 2. Don rage tsananin tasirin sakamako, umarnin don amfani da shawarar shan magani tare da abinci, fara magani tare da mafi ƙarancin kashi.

Game da haƙuri mai haƙuri, an shawarci likitoci su canza zuwa allunan Metformin da aka yi ta amfani da sabuwar fasaha. Suna da tsari na musamman, godiya ga wanda abu mai aiki ya shiga jini daidai a cikin kananan rabo. A wannan yanayin, haƙurin maganin yana inganta sosai. Allunan da ake amfani da allunan na tasirin zamani ana kiransu Metformin Long Canon. Dangane da sake dubawa, sun kasance babban madadin magani na Metformin Canon tare da rashin haƙuri.

Bayani game da yawan tasirin sakamako daga umarnin:

Umarnin don amfani da mummunan sakamako masu illa shine lactic acidosis. Wannan cin zarafin yana faruwa tare da babban karuwa a cikin taro na metformin a cikin kyallen takarda saboda yawansu mai yawa ko kashi na kasa. Abubuwan da ke tattare da hadarin sun hada da cututtukan cututtukan cututtukan zuciya da ke tattare da rikice-rikice da yawa, yunwar, shan giya, hypoxia, sepsis, da cututtuka na numfashi. Alamun farawa daga lactic acidosis sune jin zafi da jijiyoyin wuya, rauni a bayyane, gajerewar numfashi. Wannan rikitarwa yana da wuya sosai (lokuta 3 cikin 100 shekaru mutum) kuma yana da haɗari sosai, mace-mace daga lactic acidosis ya kai 40%. A cikin 'yar karamar tuhuma game da ita, kuna buƙatar dakatar da shan kwayoyin, nemi likita.

Contraindications

Yawancin contraindications a cikin umarnin don amfani sune ƙoƙari ne na masana'anta don hana acidosis lactic. Ba za a iya tsara Metformin ba:

• idan mai haƙuri yana da gazawar renal da GFR tare da ƙasa da 45;
• tare da mummunan hypoxia, wanda cututtukan huhu na iya haifar, cututtukan zuciya, bugun zuciya, anemia;
• tare da gazawar hanta;
• mara lafiya tare da giya;
• idan mai ciwon sukari ya taɓa fuskantar lactic acidosis, koda kuwa sanadin nasa ba metformin bane;
• yayin daukar ciki, ana ba da izinin insulin ne kawai daga magungunan hypoglycemic a wannan lokacin.

An soke magungunan tare da ketoacidosis, yayin kulawa da cututtukan ƙwayar cuta, raunin da ya faru, kawar da rashin ruwa, kafin ayyukan tiyata. An daina amfani da Metformin kwanaki 2 kafin a yi amfani da X-ray tare da wakili na bambanci, ana sake jinyar ta kwana 2 bayan binciken.

Raunin ciwon sukari da aka dade ana fama dashi shine yawan ciwon zuciya. A cikin umarnin, wannan cutar tana nufin contraindications zuwa magani tare da metformin, amma a aikace, likitoci dole ne su ba da maganin ga irin wannan marasa lafiya. Dangane da binciken farko, metformin a cikin marasa lafiya da cututtukan zuciya ba wai kawai yana inganta diyyar ciwon sukari ba, amma yana rage mace-mace da sauƙaƙa yanayin gaba ɗaya. Hadarin lactic acidosis a wannan yanayin yana ƙaruwa kaɗan. Idan aka tabbatar da wannan matakin, to za a cire lalacewar zuciya daga cikin jerin abubuwan da ke hana haihuwa.

Canform Slimming na Metformin

Yawancin masu ciwon sukari sunada kiba kuma suna da karuwa don samun sabon fam. A hanyoyi da yawa, wannan halin yana da alaƙa da juriya na insulin, wanda yake halayyar duk matakan ciwon sukari. Don shawo kan juriya, jiki yana samar da insulin a cikin ƙara girma, tare da wadataccen wadata. Yawan wucewar hormone yana haifar da yawan ci, yana hana rushewar kitse, kuma yana ba da gudummawa ga karuwar mai mai visceral. Haka kuma, mafi muni ciwon sukari ana sarrafawa, shine mafi bayyanar da sha'awar wannan nau'in kiba.

Rage nauyi shine ɗayan mahimman abubuwan kula da ciwon sukari. Wannan burin da aka baiwa marasa lafiya ba abu bane mai sauƙi: dole ne su yanke ƙazamar ragewa a kan carbohydrates da adadin kuzari, da kuma yaƙar hare-hare masu zafi. Metformin Canon yana taimakawa sauƙaƙa asarar nauyi. Yana rage juriya ga insulin, wanda ke nufin cewa matakan insulin a hankali suna raguwa, an sauƙaƙe rushewar kitse. Dangane da sake dubawa game da asarar nauyi, sakamako masu illa na miyagun ƙwayoyi suna da amfani - tasiri akan ci.

Don asarar nauyi, ana iya tsara maganin ba kawai ga masu ciwon sukari ba, har ma ga mutanen da ke da ƙarfin jurewar insulin. A matsayinka na mai mulki, waɗannan su ne marasa lafiya da ƙurar kiba mai nauyi, kewaye da ƙafa sama da 90 cm, BMI na sama da 35. Metformin ba magani bane don kiba, lokacin da aka karɓa, matsakaicin nauyin nauyi shine kilogiram 2-3 kawai. Yana da wata hanya ce ta rage nauyi. Domin shi ya yi aiki, rage yawan caloric da aiki na jiki ya zama tilas ga marasa lafiya.

Analogs

Metformin Canon yana da yawancin analogues. Allunan da wannan abun da ke ciki za'a iya sayansu a kowace kantin magani. Wadanda suka fi fice a Rasha sune:

• Kamfanonin cikin gida na Metformin Akrikhin, Biosynthesis da Atoll;
• Rasha Gliformin, Formmetin;
• Glucophage na Faransa;
• Zepiva na Czech;
• Metformin Teva na Isra'ila;
• Siofor.

Farashin analogues na kayan aikin Rasha da na Isra’ila, da kuma Glucofage na asali, kusan iri ɗaya ne da Metformin Canon. Siofor na Jamusanci ya fi 20-50% tsada. Kudaden glucophage sun ninka 1.5-2.5 sau fiye da irin na Metformin Long Canon.

Nazarin masu ciwon sukari