Marasa lafiya waɗanda ke fama da rikice-rikice na ƙwayar ƙwayar cuta sau da yawa suna da zaɓi, wanne ya fi kyau - Atorvastatin ko Rosuvastatin? Kodayake an ƙara amfani da Rosuvastatin kwanan nan, ba shi yiwuwa a ba da daidai amsar wannan tambayar, saboda kowane magani yana da fa'idodi da rashin amfani.
Dole ne a dauki magunguna biyu don maganganun cuta kamar cakuda cuta mai haɗaka ko homozygous hypercholesterolemia (ƙara yawan LDL), hypertriglyceridemia (triglycerol mai wuce kima) da atherosclerosis (ɓoyewar ƙwayar katako na jijiyoyin jini a sakamakon ƙarancin ƙwayoyin cuta na cholesterol). An kuma yi amfani dasu don hana rikicewar cututtukan atherosclerosis - hauhawar jini, cututtukan zuciya, bugun jini da bugun zuciya.
Tunda akwai bambanci tsakanin contraindications, halayen da ba a yarda da su ba, magunguna da magunguna, ya zama dole a gano wane magani ne mafi inganci kuma mai lafiya.
Menene statins?
Statins sun hada da babban rukuni na kwayoyi da aka yi amfani da su don rage yawan LDL da VLDL a cikin jini.
A cikin aikin likita na yau da kullun, ba za a iya rarraba statins tare da yin rigakafi da magani na atherosclerosis, hypercholisterinemia (hade ko haɗuwa da juna), da cututtukan zuciya.
Gabaɗaya, magunguna na wannan rukunin suna da tasirin warkewa iri ɗaya, i.e. ƙananan matakan LDL da VLDL. Koyaya, saboda nau'ikan kayan aiki masu ƙarfi da na taimako, akwai wasu bambance-bambance waɗanda dole ne a la'akari da su don guje wa halayen da ba su da kyau.
Yawancin lokaci ana rarraba Statins zuwa I (Cardiostatin, Lovastatin), II (Pravastatin, Fluvastatin), III (Atorvastatin, Cerivastatin) da kuma tsararraki na IV (Pitavastatin, Rosuvastatin).
Statins na iya zama na asali da na roba. Ga ƙwararren masani, zaɓin ƙananan ƙananan, na matsakaita, ko kuma ƙwararrun magunguna yana da mahimmanci ga mai haƙuri.
Rosuvastatin da Atorvastatin galibi ana amfani dasu don rage ƙwayar cholesterol. Kowane ɗayan magungunan yana da fasali:
Rosuvastatin yana nufin statins na ƙarni na huɗu. Wakili mai saurin rage yawan sinadarai yana da cikakken aiki tare da matsakaicin sashi na kayan aiki mai aiki. An ƙirƙira shi a ƙarƙashin alamun kasuwanci daban-daban, alal misali, Krestor, Mertenil, Rosucard, Rosart, da dai sauransu.
Atorvastatin yana nufin siffofin mutanen ƙarni na uku. Kamar misalin analog ɗin, yana da asalin halitta, amma yana ɗauke da babban adadin kayan aiki.
Akwai irin waɗannan maganganun na maganin kamar Atoris, Liprimar, Toovacard, Vazator, da dai sauransu.
Abubuwan sunadarai na magungunan
Duk magungunan suna cikin nau'in kwamfutar hannu. Ana samar da Rosuvastatin a sigogi dayawa - 5, 10 da 20 na ƙwayoyin guda ɗaya na aiki mai aiki. Atorvastatin an saki shi a cikin sashi na 10,20,40 da 80 MG na kayan aiki mai aiki. Da ke ƙasa akwai tebur mai kwatanta abubuwan taimako na sanannun wakilai biyu na gumaka.
| Rosuvastatin | Gagarinka (Atorvastatin) |
| Hypromellose, sitaci, titanium dioxide, crospovidone, microcrystalline cellulose, triacetin, magnesium stearate, silicon dioxide, titanium dioxide, daskararren carmine. | Lactose monohydrate, sodium croscarmellose, titanium dioxide, hypromellose 2910, hypromellose 2910, talc, stearate alli, polysorbate 80, celclosese microcrystalline, |
Babban bambanci tsakanin Rosuvastatin da Atorvastatin sune kayan aikin kimiyyar halayyar su. Amfanin rosuvastatin shi ne cewa yana da sauƙin rushewa cikin jini na jini da sauran ruwaye, i.e. shine hydrophilic. Atorvastatin yana da wani fasalin: yana narkewa a cikin mai, i.e. lipophilic ne.
Dangane da waɗannan fasalulluka, sakamakon Rosuvastatin an karkatar da shi ne gaba ɗaya zuwa ƙwayoyin hanta parenchyma, da Atorvastatin - ga tsarin kwakwalwa.
Pharmacokinetics da pharmacodynamics - bambance-bambance
Tuni a matakin shan allunan, akwai bambance-bambance a cikin shan su. Don haka, amfanin Rosuvastatin bai dogara da lokacin rana ko abinci ba. Kada a cinye Atorvastatin lokaci guda tare da abinci, kamar yadda wannan barnatacce yana shafar ɓangaren aiki mai aiki. Matsakaicin abun ciki na Atorvastatin ana samun shi ne bayan sa'o'i 1-2, da Rosuvastatin - bayan awa 5.
Wani bambanci tsakanin statins shine metabolism din su. A jikin mutum, Atorvastatin an canza shi zuwa wani tsari mara amfani ta amfani da enzymes hanta. Don haka, ayyukan miyagun ƙwayoyi yana da alaƙa kai tsaye da aikin hanta.
Hakanan ana shafa shi da kwayoyi waɗanda ake amfani dasu lokaci guda tare da atorvastatin. Analog ɗin sa, akasin haka, saboda ƙananan sashi, kusan ba ya amsawa da wasu kwayoyi. Kodayake wannan bai kubutar da shi daga gaban halayen halayen ba.
Atorvastatin an keɓe shi musamman da bile.
Ba kamar yawancin statins ba, Rosuvastatin kusan ba metabolized a cikin hanta ba: fiye da 90% na kayan ana cire su ba tare da hanjinsu ba kuma kawai 5-10% ta hanta.
Contraindications da m halayen
Kasancewar contraindications da ayyuka marasa kyau sune abubuwan mahimmanci yayin zaɓin mafi kyawun magani. Waɗannan masu biyowa sune manyan cututtuka da halaye waɗanda aka haramta amfani da kwayoyi, gami da sakamako masu illa.
| Contraindications | |
| Rosuvastatin | Atorvastatin |
| Mai hankali daya-daya. Haihuwa da lactation. Lalacewa zuwa hepatocytes da tsofaffin hanta na hanta. Yara da matasa a cikin shekaru 18. Myopathy ko tsinkayar da shi. M cikakkiyar jiyya tare da cyclosporine da fibrates. Rashin datti. Al'adun shan giya Myotoxicity yayin ɗaukar sauran HMG-CoA reductase inhibitors. Amfani da masu kariya daga kwayar cutar kanjamau. Wakilan tsere na Mongoloid (kawai an ba da izinin sigogi kaɗan). | Rashin hankali ga abubuwan da aka gyara. Activityara ayyukan hanta enzymes. Rashin haihuwa da lokacin lactation. Yara da matasa da ke ƙasa da shekara 18, ban da farfaɗo don maganin heterozygous na heperrolesterolemia. Rashin isasshen rigakafi. Amfani da masu kariya daga kwayar cutar kanjamau. Cutar hanta mai aiki. |
| M halayen | |
| Ciwon kai, matsalolin daidaitawa, malalar gaba daya. Haɓaka furotin da hematuria. Fata na ciki, amya, itching. Rashin daidaituwa na tsarin musculoskeletal. Dyspepsia, matsi mai rauni, kumburi da farji (pancreatitis). Mellitus na rashin insulin-da ke fama da cutar sankara. Ci gaban nono a cikin maza. A gaban bushe tari, shortness na numfashi. Stevens-Johnson Syndrome. | Ci gaban nasopharyngitis, cututtukan urinary tract. Abinda ya faru na thrombocytopenia. Hypo- da hyperglycemia, anorexia. Jin zafi a cikin kai, paresthesia, ci gaban neuropathy na yanki, hypesthesia, amnesia, dizziness, dysgeusia. Rashin ƙarfiwar ji, tinnitus, raunin gani. Ciwon makoji, hanci. Dyspeptic cuta, belching, epigastric zafi, ci gaba da pancreatitis. Urticaria, rashes na fata, ederan Quincke. Bayyanar gynecomastia. Rarraba da yawa na tsarin musculoskeletal. Cututtukan zuciya, gazawar hanta, cholestasis. Hyperthermia, asthenia, malaise. Ara ayyukan enzymes na hanta, QC da ingantaccen bincike don leukocytes a cikin fitsari. |
Inganci da Ra'ayin Kasuwanci
Babban aikin magungunan statin shine rage yawan taro na LDL a cikin jini da kuma ƙara matakin HDL.
Saboda haka, zaɓa tsakanin Atorvastatin da Rosuvastatin, dole ne mu kwatanta yadda yakamata su rage ƙwayar cholesterol.
Binciken kimiyya na kwanan nan ya tabbatar da cewa rosuvastatin magani ne mafi inganci.
Sakamakon gwaji na asibiti an gabatar da shi a ƙasa:
- Tare da daidai allurai na kwayoyi, Rosuvastatin rage rage ƙwayar LDL da 10% fiye da yadda ake magana da ita. Wannan fa'idar ta ba da damar yin amfani da magani ga marasa lafiya da ke fama da matsanancin rashin ƙarfi.
- Mitar ci gaban rikicewar zuciya da farawar sakamako mai muni ya fi girma a Atorvastatin.
- Halin rashin halayen guda ɗaya ne duka magungunan biyu.
Kwatanta tasirin rage rage tasirin cholesterol "mara kyau" yana tabbatar da gaskiyar cewa Rosuvastatin shine magani mafi inganci. Koyaya, mutum ya kamata ya manta game da irin waɗannan abubuwan kamar kasancewar contraindications, sakamako masu illa da farashi. An gabatar da kwatancen farashin magungunan guda biyu a cikin tebur.
| Sashi, yawan allunan | Rosuvastatin | Atorvastatin |
| 5mg No. 30 | 335 rub | - |
| 10mg No. 30 | 360 rubles | 125 rub |
| 20mg No. 30 | 485 RUB | 150 rub |
| 40mg No. 30 | - | 245 RUB |
| 80mg No. 30 | - | 490 rub |
Don haka, atorvastatin analog ne mai rahusa wanda mutane masu karamin karfi zasu iya samarwa.
Wannan shine abin da marasa lafiya suke tunani game da kwayoyi - An yarda da Rosuvastatin da kyau kuma ba tare da matsaloli ba. Lokacin da aka ci shi, ana rage ƙiba
Kwatanta kwayoyi na taimaka wa yanke hukuncin cewa a halin yanzu na ci gaban magani, matsayi na farko a cikin mafi kyawun allunan kwayar cholesterol an dauke ta da siffofin mutanen ƙarni na huɗu, ciki har da Rosuvastatin.
Game da miyagun ƙwayoyi Rosuvastatin da analogues an bayyana su a cikin bidiyo a wannan labarin.
