Masana kimiyya a gab da ƙirƙirar magani don kamuwa da cutar 1

Masu bincike na Rasha sun haɓaka abubuwa wanda za'a iya sanya magani don mayar da kuma kula da lafiyar cututtukan fata a cikin nau'in 1 na ciwon sukari.

Wani sabon abu wanda masana kimiyya daga kasar Rasha suka kirkira yana iya yin maganin cututtukan cututtukan da suka lalace ta hanyar ciwon suga

A cikin kashin baya, akwai wasu yankuna na musamman da ake kira tsibirin Langerhans - su ne wadanda suke hada sinadarin insulin a jiki. Wannan hormone yana taimakawa sel su sha glucose daga jini, kuma rashinsa - bangare ko duka - yana haifar da haɓaka matakan glucose, wanda ke haifar da ciwon sukari.

Yawan wuce haddi a cikin jiki, ya sanya damuwa a jikin mutum, dan damuwa na faruwa a jiki, kuma yawancin sunadarai masu yawa suna fitowa a cikin sel, wanda hakan ke kawo cikar mutuncin wadannan sel, sanadiyyar lalacewa da mutuwa.

Hakanan, glycation yana faruwa a cikin jiki, wanda glucose ke haɗuwa tare da sunadarai. A cikin mutane masu lafiya, wannan aikin shima yana ci gaba, amma yafi a hankali, kuma cikin cutar siga yana hanzarta kuma yana lalata kyallen takarda.

Ana lura da wani mummunan da'irar mutane a cikin mutane masu fama da ciwon sukari na 1. Tare da shi, sel na Langerhans Islets sun fara mutuwa (likitoci sun yi imani da cewa wannan ya faru ne ta hanyar kai harin jiki da kanta), kuma kodayake suna iya rarrabawa, ba za su iya mayar da adadinsu na asali ba, saboda yawan glycation da oxidative damuwa da ke haifar da wucewar glucose. mutu da sauri.

Sauran rana, mujallar Biomedicine & Pharmacotherapy ta buga labarin a kan sakamakon sabon binciken da masana kimiyya daga Jami'ar Tarayyar Ural (Ural Federal University) da Cibiyar Nazarin Kwayar cuta da Fasaha (IIF UB RAS). Masana sun gano cewa abubuwan da aka samar a kan tushen 1,3,4-thiadiazine suna kawar da yanayin autoimmune da aka ambata a sama a cikin nau'in kumburi, wanda ke lalata ƙwayoyin insulin, kuma, a lokaci guda, kawar da tasirin glycation da damuwa na damuwa.

A cikin mice tare da nau'in 1 na ciwon sukari, wanda ya gwada asalin abubuwan 1,3,4-thiadiazine, matakan sunadarai masu kare jiki a cikin jini ya ragu sosai kuma haɓaka jini ya ragu. Amma mafi mahimmanci, a cikin dabbobi yawan ƙwayoyin insulin-synthesizing a cikin ƙwayar ƙwayar cuta ta karu sau uku kuma matakin insulin da kanta ya ƙaru, wanda ya rage taro na glucose a cikin jini.

Wataƙila sabbin magungunan da aka kirkira bisa abubuwan da aka ambata a sama zasu kawo sauyi kan lura da ciwon sukari na 1 kuma zai ba miliyoyin marasa lafiya damar da za su iya rayuwa nan gaba.