Metformin wani abu ne wanda yake mallakar biguanides. Metformin magani ne na likita da aka yi amfani da shi don kula da ciwon sukari.
Ayyukan maganin yana dogara ne akan gaskiyar cewa yana da ikon hana aiwatar da gluconeogenesis a cikin sel na hanta hanta, rage ƙimar shan glucose daga lumen hanji da haɓaka ayyukan amfani da glucose na ƙasa.
Bugu da ƙari, allunan kwayoyi masu ƙwaƙwalwar ƙwayoyin cuta na metformin 850 suna ƙaruwa da ƙwayar insulin a cikin sel da keɓaɓɓun kasusuwa na jikin mutum.
Yin amfani da miyagun ƙwayoyi ba shi da wani tasiri na musamman kan ayyukan samar da insulin a cikin ƙwayar ƙwayar cuta, baya tsokani ci gaban yanayin rashin ƙarfi a cikin jikin mutum. Shan magunguna na iya rage yawan triglycerides da lipoproteins a cikin jini.
Abun da ke tattare da magungunan da kaddarorin magungunan
Magungunan yana hana ci gaban aiki tare da abubuwa masu laushi masu kyau na ganuwar tsarin jijiyoyin jiki. An bayyana ingantaccen sakamako game da miyagun ƙwayoyi akan yanayin lafiyar zuciya da jijiyoyin bugun jini da aka hana ci gaba da ciwon sukari na hanji.
Jiyya na ciwon sukari tare da Metformin kawai likitan ku zai iya yin wasiyyarsa bayan cikakken binciken mai haƙuri. Tsawon lokacin jiyya da adadin maganin da aka yi amfani da shi an ƙaddara yin la'akari da duk abubuwan aikin cutar a jikin mai haƙuri.
Abubuwan da ke aiki da maganin shine Metformin hydrochloride. Tabletaya daga cikin kwamfutar hannu ya ƙunshi 850 MG na ƙwayar aiki mai aiki. Baya ga babban fili, abun da ke cikin magungunan ya hada da mahallin sunadarai masu taimakawa.
Abubuwan sunadarai da ke cikin na'urar likita sune masu zuwa:
- alli phosphate dibasic;
- sitaci masara;
- lactose;
- povidone;
- sodium benzoate;
- talc;
- magnesium stearate;
- sodium sitaci glycolate;
- titanium dioxide;
- hydroxypropyl methylcellulose;
- ethyl cellulose;
- prolylene glycol;
- polyethylene glycol.
Samun Metformin baya tasiri matakin hormone a jikin mutum, amma yana ba da gudummawa ga canji a cikin harhada magunguna, wanda ke faruwa sakamakon raguwa a cikin rabo tsakanin insulin da kyauta, karuwa a cikin rabo a jikin mutum tsakanin insulin da proinsulin. Ofayan mafi mahimman matakai a cikin aikin aiwatar da miyagun ƙwayoyi shine don haɓaka amfani da glucose ta ƙwayoyin tsoka.
Abunda yake aiki yana inganta hawan jini a cikin hanta kuma yana taimakawa hanzarta aiwatar da glucose a cikin glycogen. Amfani da Metformin 850 MG na inganta abubuwan da ke cikin fibrinolytic na jini. Wannan shi ne saboda hanawar ƙwaƙwalwar ƙwaƙwalwar ƙwayar plasminogen mai hanawa.
Ana ɗaukar ƙwayar abu mai aiki daga lumen ƙwayar gastrointestinal kuma alama ce da ke fitowa daga 48 zuwa 52%. Rabin rayuwar rabi mai aiki shine kimanin awa 6.5. Abubuwa masu aiki suna daga jikin mutum ta asali. Abubuwan da ke aiki basu da ma'amala da abubuwan gina jiki na plasma jini. Rarraba magungunan yana faruwa ne a cikin gland shine yake ji, ƙwayar tsoka, ƙodan hanta. Drawacewa daga jiki ta hanyar ƙodan yayin aiwatar da fitsari.
Tare da haɓaka rikice-rikice a cikin aiki na tsarin urinary, miyagun ƙwayoyi sun tara cikin kodan.
Alamu da magunguna don amfani da magani
Babban alamu don amfani sune masu zuwa:
- kasancewar nau'in ciwon sukari na 2 na cutar siga ba tare da nuna halin da ake ciki na faruwa na ketoacidosis;
- kasancewar kamuwa da cutar siga yayin rashin inganci daga hanyoyin rage cin abinci;
- lura da ciwon sukari mai nau'in 2 a hade tare da ilimin insulin, musamman tare da ƙaddarar ƙaddara mai kiba, wanda ke haɗuwa tare da bayyanar juriya na sashin insulin na hormone.
Babban contraindications ga yin amfani da miyagun ƙwayoyi a cikin lura da ciwon sukari na type 2 sune kamar haka:
- haɓakawa a cikin jikin ketoacidosis na masu ciwon sukari, precca mai ciwon sukari ko coma;
- aikin koda mai rauni;
- fitowan da ci gaba a jikin mai haƙuri na cututtukan cututtukan ƙwaƙwalwa tare da haɗarin aiki na nakasa mai rauni - ƙonewa, zazzabi, ƙwanƙwasawa, cututtuka na kodan, haɓakar cututtukan bronchopulmonary;
- da ci gaban m da na kullum cututtuka da za su iya tsokani ci gaban da hypoxia nama;
- mummunan tsoma bakin tiyata a jiki da mara lafiyar da ke karbar mummunan raunuka na jiki;
- abin da ya faru da ci gaban rikice-rikice a cikin aikin hanta;
- mara lafiya yana da yawan barasa ko shan guba;
- ci gaba a cikin jikin lactic acidosis;
- da buƙatar abinci mai gina jiki;
- tsawon lokacin haihuwa.
- lokacin lactation;
- mara lafiya yana da rashin kwanciyar hankali ga abubuwan da ke cikin miyagun ƙwayoyi.
An hana yin amfani da Metformin kwanaki 2 kafin da kwana 2 bayan binciken radioisotope na jiki ta amfani da abubuwan da ke tattare da sinadarin aidin.
Umarnin don amfani da miyagun ƙwayoyi
Domin sanin yadda ake shan magungunan daidai, yakamata ku nemi likita. Yakamata a bincika mai haƙuri umarnin yin amfani da Metformin.
An saita kashi na miyagun ƙwayoyi ta musamman daga halartar endocrinologist. Likita ya kayyade sashi don kowane mai haƙuri daban-daban, la'akari da sakamakon da aka samu yayin binciken jiki da yin la’akari da halayen jikin mai haƙuri. Yawan maganin da mai haƙuri ya kamata ya sha ya dogara da matakin glucose a cikin jini na jini a jikin mai haƙuri.
Don ɗaukar Metformin daidai, kashi na farko ya kamata ya kasance daga 500 zuwa 1000 MG kowace rana, wanda shine Allunan 1-2. Bayan kwanaki 10-15 na ɗauka, bisa ga shawarar da endocrinologist na lura da haƙuri, ƙarin haɓaka matakin zai yiwu idan an buƙaci wannan ta hanyar yawan abubuwan glucose a jikin mai haƙuri.
Umarnin don amfani yana ba da shawarar amfani da 1500-2000 MG na miyagun ƙwayoyi azaman maganin kiyayewa, wanda shine Allunan 3-4, kuma mafi girman adadin da aka ba da izinin shiga shine 3000 MG kowace rana.
Game da batun kula da cututtukan sukari na 2 na mellitus a cikin tsofaffi marasa lafiya, kashi da na'urar likita ta yi amfani da ita kada ya wuce 1 g ko allunan 2 a rana.
Allunan ya kamata a sha a baka ba tare da tauna ba lokacin ko kuma bayan abincin. Ya kamata a sha miyagun ƙwayoyi tare da ƙaramin ruwa na ruwa. Don hana haɓaka sakamako masu illa a cikin jiki, ana bada shawarar sashi na yau da kullun don kasha kashi 2-3.
Tun lokacin da kuke shan maganin, akwai babban yiwuwar haɓakar lactic acidosis, ana rage kashi da aka yi amfani da shi don maganin nau'in ciwon sukari na 2 na mellitus idan mai haƙuri yana da mummunar cuta na rayuwa.
Game da kulawa na lokaci guda tare da insulin a cikin kashi na ba fiye da raka'a 40 a kowace rana ba, sashi na magunguna yana canzawa. A cikin jiyya da ke buƙatar kashi na yau da kullun na insulin fiye da raka'a 40 a kowace rana, yakamata a ɗauki matakin sashi sosai tare da taka tsantsan. Zabi sashi ya kamata a yi a wannan yanayin a asibiti karkashin kulawar akai-akai na halartar likita.
Metformin yana rage yawan glucose kawai a cikin mutane masu ciwon sukari ba tare da nuna abubuwan da suka mallaka a cikin mutum mai lafiya ba.
Side sakamako na miyagun ƙwayoyi a jiki
Tare da tsawaita amfani da miyagun ƙwayoyi, yana yiwuwa jiki ya haɓaka rikice-rikice da ke haɗuwa da sha na bitamin B12.
Tare da tsawanta yin amfani da miyagun ƙwayoyi, ya kamata a kula da kulawa ta musamman don lura da yanayin aikin hanta da ƙodan.
Lokacin amfani da miyagun ƙwayoyi, waɗannan sakamako masu illa na iya faruwa:
- Daga aikin gastrointestinal tract, ana iya samun rikice-rikice, ana nunawa ta hanyar jin tashin zuciya, amai, jin zafi a ciki, rage ko rashin ci, bayyanar dandano mai ƙarfe a bakin.
- Daga fata akwai yiwuwar halayen rashin lafiyan ta hanyar fatar fata.
- Tsarin endocrine yana da ikon amsawa game da amfani da miyagun ƙwayoyi ta hanyar ƙirƙirar yanayin hypoglycemic. Mafi yawan lokuta, irin wannan yanayi yana faruwa ne sakamakon karancin magunguna.
- Daga gefen hanyar aiwatar da matakai na rayuwa a lokuta masu wuya, lokacin ɗaukar isasshen allurai, ci gaban lactic acidosis a cikin jiki yana yiwuwa. Idan wannan yanayin ya faru, ana buƙatar dakatar da maganin.
- Tsarin jijiyoyin jini yana da ikon amsa magunguna ta hanyar samuwar a wasu halayen cutar megaloblastic.
Sakamakon babban haɗari ga jiki, amfani da metformin a gaban raunin koda a cikin mutum ya kamata a dakatar dashi ko yakamata a ɗauka ƙarƙashin kulawar likita kuma a cikin ƙaramin sashi.
Yawancin masana ilimin halittar dabbobi a cikin wannan yanayin suna ba da shawarar dakatar da maganin gaba daya, kuma ɗaukar shi a cikin raguwa sosai, tunda sa ido akan abubuwan sukari shine mafi mahimmanci.
Gaskiyar ita ce haɓaka sukari na jini na iya haifar da ƙarin rikice-rikice a cikin jiki wanda zai haifar da karuwar yiwuwar mummunan sakamako.
Umarnin na musamman don amfanin Metformin
Lokacin da ake shirin yin ciki ko lokacin da ya faru, ya kamata a dakatar da maganin. Game da ciki, ana maye gurbin amfani da miyagun ƙwayoyi don lokacin haila ta hanyar maganin insulin.
Tunda babu bayanai game da yiwuwar shigar shigar da abubuwan da ke cikin miyagun ƙwayoyi da abu mai aiki a cikin madara, lokacin amfani da nono, ya kamata a dakatar da amfani da maganin. Idan akwai buƙatar gaggawa don amfani da Metformin yayin shayarwa, ya kamata a daina shayar da jarirai.
An haramta yin amfani da miyagun ƙwayoyi ga yara da matasa a ƙarƙashin shekara 18.
Likitoci ba su ba da shawarar yin amfani da miyagun ƙwayoyi a cikin lura da ciwon sukari a cikin tsofaffi, wanda shekarunsa ya kai shekaru 60 da yin babban aiki mai dangantaka da ƙara yawan damuwa a jiki. Wannan shawarar ta kasance saboda gaskiyar cewa irin waɗannan marasa lafiya suna da matukar yiwuwar haɓaka lactic acidosis a cikin jiki.
Game da shan Metformin, ana iya haɗe shi tare da wakilai waɗanda keɓaɓɓun abubuwan maganin sulfonylurea. Tare da irin wannan haɗin gwiwar gudanar da magunguna, ana buƙatar saka idanu musamman kan yanayin mai nuna alamar glucose a jiki.
Haramun ne a sha giya da magunguna masu dauke da ethanol a lokacin shan maganin. Shan Metformin a lokaci guda tare da barasa na iya tayar da haɓakar ci gaban lactic acidosis a cikin haƙuri tare da ciwon sukari.
Lokacin amfani da miyagun ƙwayoyi, an ba shi izinin motsa motoci da injuna, tun da yake gudanarwarsa ba ta tasiri da ikon tuki.
Kudin Metformin, analogues da nazarinsa na haƙuri game da amfani da miyagun ƙwayoyi
Kwayoyi masu zuwa sune analogues na Metformin:
- Bagomet;
- Glycon;
- Glyminfor;
- Glyformin;
- Glucophage;
- Glucophage Tsayi;
- Langerine;
- Methadiene;
- Metospanin;
- Metfogamma 500, 850, 1000
- Metformin;
- Metformin Richter;
- Metformin Teva;
- Metformin hydrochloride;
- Metva na Met;
- NovoFormin;
- Siofor 1000;
- Siofor 500;
- Siofor 850;
- Sofamet;
- Formmetin;
- Tsarin Pliva.
Nazarin game da amfani da miyagun ƙwayoyi ta hanyar marasa lafiya don magance cututtukan sukari sun nuna cewa wannan magani yana da tasiri a jikin mutum, wanda ke ba ka damar sarrafa yawan glucose a cikin jiki.
Akwai sake dubawa da yawa game da magungunan da ke nuna canji mai kyau a cikin jiki lokacin shan Metformin ko analogues da bayyanar ingantaccen kuzari a cikin maganin ciwon sukari. Mafi sau da yawa, marasa lafiya da ke fama da ciwon sukari mellitus da kiba suna nunawa a cikin sake duba su cewa yin amfani da Metformin a cikin aikin maganin ƙwaƙwalwar ƙwayar cuta ya rage nauyin jiki.
Kudin maganin a cikin magungunan ƙasar ya dogara da yankin da kuma shirya maganin.
Kudin magungunan Metformin Teva 850 MG a cikin ƙasa shine matsakaici na 100 rubles a kowane fakitin da ke ɗauke da allunan 30.
Magunguna kamar Metformin Canon 1000 MG yana da matsakaicin tsada a cikin ƙasar 270 rubles a kowane kunshin, wanda ya ƙunshi allunan 60.
Kudin magungunan sun dogara da yawancin Allunan suna cikin kunshin. Lokacin da sayen maganin, ya kamata a tuna cewa hutunsa yana gudana ne kawai a kan takardar sayan magani daga likitan halartar.
A cikin bidiyon a cikin wannan labarin, Dr. Myasnikov zai yi magana game da ka'idodin aikin Metformin a cikin ciwon sukari.
