Godiya ga karatun da yawa da masana'antar harhada magunguna, a halin yanzu akwai magunguna masu inganci a kan cutar sankara. Tare da taimakon wasu magunguna, zaku iya kula da matakin insulin a cikin jini.
Matsayi na musamman tsakanin kwayoyi suna shaye shayen magunguna na zamani don maye gurbin insulin na ciki. Ana iya amfani da insulin Glargin azaman kayan aiki mai zaman kanta, wani lokacin yana kasancewa a cikin wasu kwayoyi, alal misali, Lantus ko Solostar. Karshen ya ƙunshi kusan 70% na insulin, Lantus - 80%.
Ba a yi nazarin sakamakon waɗannan magungunan ba a lokacin daukar ciki, sabili da haka, kawai likitan halartar ya kamata ya yanke shawara game da shigarwar. Hakanan, ya kamata a tsara kudaden tare da taka tsantsan ga yara underan shekaru bakwai.
Ma'anar ciwon sukari
Cutar sankarau cuta ce da ke haifar da ƙwayar ƙwayar ƙwayar cuta ta hanyar rashin insulin kira. Tare da wannan cutar, aikin gabobin jiki da tsarin jiki da yawa sun rushe, tunda canje-canje a cikin ma'aunin metabolic ya faru.
A cikin 90% na lokuta, cutar ba ta da alaƙa da rashi na insulin, a matsayinka na mai mulki, ana yiwa rajista irin wannan cutar a cikin mutane masu kiba. 10% na shari'o'in suna da alaƙa da rashin daidaituwa na glucose da insulin, wanda ya kasance saboda cutar cututtukan farji.
Akwai dalilai da yawa waɗanda zasu iya zama tsokanar cutar:
- kwayoyin halittar jini
- rushewa da tsarin autoimmune,
- rikice-rikice waɗanda ke haɗuwa da kiba da sauransu.
Tsarin cututtukan autoimmune yana kare jiki daga nau'ikan cututtukan ciki da waje, ƙwayoyin cuta da cututtuka. Wannan ya hada da duka sel da ƙasashen waje waɗanda ke da raunin cuta.
Magungunan zamani ba su san dalilin da yasa a wani lokaci tsarin autoimmune ba ya kuskure kuma ya fara ɗaukar ƙwayar tsoka da ƙwayoyin sel don baƙi, suna ƙoƙarin kawar da su, suna haifar da ƙwayoyin cuta na musamman.
A matsayinka na mai mulkin, ana aiwatar da irin wannan lalata cikin nasara, kuma sel waɗanda suka tsere daga kawarwa suna fara samar da kwayoyin halittun, ciki har da insulin, a cikin yanayin hanzari. Wannan tsari yana ɗaukar ɗan lokaci, sannan wani lokaci ya zo lokacin da yawan insulin ya fara faɗuwa, wanda ke nufin cewa matakin sukari ya tashi, wanda ba zai rushe ba.
Alamun sakandare na ciwon sukari:
- cututtukan cututtukan zuciya,
- rikicewar hormonal, sau da yawa yana rarraba goiter,
- amfani akai-akai na kwayoyi ko guba don magance wasu cututtuka.
Duk abin da ke haifar da ciwon sukari, hanyoyin cutar ba ta canzawa ba. Sakamakon karancin insulin, jikin baya daukar glucose kuma baya iya tarawa a cikin tsokoki da hanta. Yawancin sukari kyauta yana bayyana, ana jigilar shi da jini kuma yana wanke dukkanin gabobin, yana haifar da mummunar illa a gare su.
Glucose yana daya daga cikin masu samar da makamashi, don haka karancinsa yakan biya diyyar wani abu daban. A wannan yanayin, jiki yana fara aiwatar da kitsen, yana ɗaukar su a matsayin tushen ƙarfin.
Wannan "narkewa" na kitse yana da babban enzymes na abinci, wanda basa da hanyar warkewa daga jiki.
Enzymes waɗanda aka tsara don narke abinci a ƙarshe su narke cikin farji, hakan yana haifar da nau'in kumburi, wanda ke hade da alamomi masu yawa.
Halayen magunguna
Ka'idar aikin insulin, babban aikinta, gami da Glargin, shine daidaita tsarin metabolism. Insulin Lantus yana haɓaka ɗaukar glucose ta tsoka da tsotse kyallen takarda, sabili da haka, matakin ƙwayar plasma yana raguwa. Wannan magani kuma yana rage jinkirin samar da glucose a cikin hanta.
Wadannan magungunan sune analogues na insulin na mutum, wanda aka samo shi ta hanyar shawarar Escherichia coli kwayoyin DNA. An kwatanta shi da rashin isasshen ruwan sanyi a cikin tsaka tsaki yanayi.
Yana ɗaure wa masu karɓar insulin kuma yana tallata wani abu mai kama da insulin na ciki (endogenous).
Akwai daidaituwa na metabolism. Magungunan da analogues na ƙananan sukari na jini, suna kunna tasirin glucose ta tsokoki na yanki (musamman tsotse nama da tsokoki), kuma yana hana samuwar glucose a cikin hanta. Insulin yana hana proteinolysis da lipolysis, yayin inganta haɓakar furotin.
Bayan subcutaneous management na miyagun ƙwayoyi, sakamakon ya zama sananne bayan kimanin 40-60 minti. A matsayinka na mai mulkin, ana lura da aikin a cikin sa'o'i 24, aƙalla 29 hours. Ta hanyar allurar guda biyu, za'a lura da yawan abin da ke cikin jini bayan kwana 2-4.
Insulin Glargin Lantus na insulin ya lalace saboda matsakaiciyar acidic na musamman, kuma bayan gudanarwar subcutaneous, acid din ya lalace kuma an kirkiro microprecipitate, daga abin da aka fitar da miyagun ƙwayoyi a cikin ƙananan kima akan lokaci.
A cikin jini na jini, babu raguwa mai yawa a cikin girman insulin, komai na faruwa lami lafiya. Abubuwa na musamman suna ba da hanyar tsawaita aiki.
Insulin Glargin 300 yana da ingantaccen magunguna da tasirin magunguna. Ana iya bada shawarar wannan madadin azaman insulin basal a cikin marasa lafiya da ke da nau'in 1 da nau'in ciwon sukari na 2.
Idan kayi amfani da Insulin Glargin 300 IU / ml, wannan yana buɗe manyan damar don ingantaccen magani ga mutanen da ke fama da ciwon sukari.
Umarnin don amfani da miyagun ƙwayoyi
Dosages na miyagun ƙwayoyi ne wajabta daban. Ana gudanar da maganin a ƙarƙashin subcutaneously 1 lokaci ɗaya kowace rana a lokaci guda. Yankunan gabatarwar na iya zama:
- Kashin jikin mai kitse na ciki,
- cinya
- kafada.
M
Cin abinci don injections ya kamata koyaushe a canza tare da kowane gabatarwar miyagun ƙwayoyi.
A cikin nau'in ciwon sukari na 1, an sanya magani a matsayin babban insulin. A cikin nau'in ciwon sukari na 2, ana amfani dashi azaman monotherapy ko a hade tare da sauran wakilai na hypoglycemic.
Idan mara lafiya ya canza daga insulin matsakaici ko aiki na dogon lokaci zuwa insulin Glargin, to gyara na yau da kullun na insulin na asali ko canji a cikin concomitant treatment ya zama dole.
Lokacin da aka canza haƙuri daga insulin-isophan zuwa allura guda na miyagun ƙwayoyi, ya zama dole don rage kashi yau da kullun na insulin basal ta kashi ɗaya bisa uku a cikin makonni na farko na magani. Wannan ya zama dole don rage yiwuwar rashin bacci a cikin dare. A wannan lokacin, rage yawan sashi za'a iya kashe shi ta hanyar karuwa a cikin adadin insulin na gajeran lokaci.
Side effects
Hypoglycemia wani sakamako ne mara kyau na tsarin, kamar insulin far, yana bayyana idan yawan insulin ya wuce kima idan aka kwatanta da ainihin bukata. Sakamakon amfani da miyagun ƙwayoyi, mutum na iya fara samun hare-haren hypoglycemia, wanda galibi yakan haifar da rashin lafiyar tsarin mai juyayi.
Rashin daidaituwa na cututtukan ƙwaƙwalwar ƙwaƙwalwa saboda hypoglycemia, a matsayin mai mulkin, an riga an sami alamun bayyanar cututtukan adrenergic:
- yunwa
- haushi
- samarin
Sauye-sauye masu mahimmanci a cikin tsarin sukari na jini sau da yawa yana haifar da raunin gani na ciki saboda canje-canje a cikin ƙwayar nama da farfadowa da ruwan tabarau na ido. Tsawon lokacin daidaituwa na sukari na jini yana rage hadarin da ke haifar da ciwon sikari.
Raunin gida a yankin allura da halayen rashin lafiyan na iya faruwa:
- ja
- zafi
- itching
- cututtukan mahaifa
- kumburi.
Yawancin ƙananan halayen da ke faruwa a cikin aikin insulin yawanci yakan tafi a cikin 'yan makonni kaɗan a yawancin. Magungunan rashin kulawar jiki ga insulin yana haɓaka a cikin halayen da ba a sani ba.
Irin waɗannan halayen ga insulin ko waɗanda suka gabata na iya bayyana a cikin yanayin haɓakar halayen fata na fata. Kari akan haka, mai yiwuwa akwai abubuwa masu zuwa:
- angioedema,
- karin ƙarfe
- jijiyoyin jini ko girgiza kai.
Duk wadannan lamuran na iya yin barazana ga rayuwar mutum.
Wani lokacin kasancewar abubuwan rigakafi ga insulin na buƙatar canji a cikin kayan don kawar da halayen hauhawar jini ko hypoglycemia. Hakanan, insulin na iya haifar da jinkiri a cikin ƙwayar sodium.
Sakamakon haka, edema na faruwa, musamman idan aikin insulin na motsa jiki yana haifar da kyakkyawan tsari na tafiyar matakai na rayuwa.
Abun Harkokin Magunguna
Magungunan ba su dace da sauran hanyoyin ba. Ba ya buƙatar haɗe shi da wasu samfura ko gurɓataccen mai.
Yawancin kwayoyi suna shafar metabolism, wanda ke buƙatar canjin kashi. Irin wadannan kwayoyi sun hada da:
- na baka hypoglycemic jamiái,
- ACE masu hanawa
- rashin biyayya
- fibrates
- Fluxxine,
- MAO masu hanawa
- skwarin
- wakili
- salicylates,
- magungunan sulfa.
Hanyar da za ta iya rage tasirin insulin ɗin ya haɗa da:
- kamuwa da cuta
- estrogens
- isoniazid
- glucocorticoids,
- danazol
- diazoxide
- glucagon,
- clozapine.
- gestagens
- girma hormone,
- hodar iblis,
- epinephrine
- salbutamol,
- dabino
- masu hana masu kariya
- olanzapine.
Zai iya raunana kuma ya inganta tasirin insulin:
- beta hanawa,
- clonidine
- salts na gishiri
- barasa
Zaɓin insulin
Idan muka kwatanta magungunan magunguna na kwayoyi a karkashin kulawa, to, alƙawarin da aka nada a matsayin likita ya nuna ga masu ciwon sukari na farkon da na biyu. Abubuwan insulins na zamani ba su ba da gudummawa ga samun nauyi ba saboda amfani da kwayoyi. Yawan raguwar yawan dare a cikin tarowar jini shima yana raguwa sosai.
Akwai buqatar allura guda daya kacal a cikin yini. Ga marasa lafiya, yana da matukar dacewa. Sanannen ingantaccen sakamako na anaulin insulin ɗan adam tare da metformin ga marasa lafiya waɗanda ke fama da ciwon sukari na 2. Nazarin ilimin kimiyya ya nuna raguwa mai yawa a cikin tsalle-tsalle na dare a cikin yawan glucose. Saboda haka, ana samun daidaituwa na yau da kullun na cutar glycemia.
Zai dace a lura da haɗakar Insulin Glargin Lantus tare da magunguna na baka don rage glucose na jini a cikin waɗannan marasa lafiyar tare da rashin iya raunin ciwon sukari. Irin waɗannan marasa lafiya ya kamata a rubuta su ta insulin Glargin a farkon matakan cutar.
Ana iya ba da shawarar wannan maganin ta hanyar ilimin endocrinologist ko kuma babban likita. Kulawa mai zurfi ta amfani da Lantus yana ba da damar da za a iya magance glycemia a cikin mutanen da ke da ciwon sukari na duk rukuni.
Kudinsa
A kantin magani yana ba da shirye-shiryen insulin a farashi daban-daban. Farashin ya dogara da nau'i wanda ana gabatar da analogues na miyagun ƙwayoyi Glargin Insulin. Kudin maganin yana kama daga 2800 zuwa 4100 rubles
