Diagninide magani ne na baki. Ayyukan miyagun ƙwayoyi ya samo asali ne daga ƙarfafawar sakin insulin daga ƙwayoyin beta na ƙwayar ƙwayar ƙwayar cuta.
Diagninide shiri ne na likitanci wanda sakamakonsa na warkewa ya danganta ne da ikon babban bangaren aiki don tasiri tasirin tashoshin da ke dogaro da ATP a cikin membranes na sel membranes na sel da ke ciki. Aiki mai aiki yana toshe tashoshin jigilar potassium kuma yana buɗe tashoshin jigilar alli.
Irin wannan tasirin akan sel yana haifar da ƙaruwa a cikin adadin ƙwayar kalsiyam, wanda ionsrsa ke kunna aikin samar da insulin.
Lokacin shan maganin ta hanyar mutumin da ke fama da ciwon sukari na 2, ana lura da insulin a cikin mintina 30 bayan an saka ƙwayar.
Wannan halayen jiki ga gabatarwar miyagun ƙwayoyi yana samar da raguwar adadin sukari a cikin jini a cikin duk lokacin cin abinci.
Yawan taro a cikin aiki na jini yana iya haɓaka da raguwa da sauri. Bayan sa'o'i 4 bayan shan miyagun ƙwayoyi, ana lura da raguwa mai yawa a cikin jikin mutum.
Magungunan suna da kusan kashi 63% na bioavailability. Ana lura da mafi girman abun ciki mai aiki a cikin jini sa'a daya bayan shan miyagun ƙwayoyi. Lokacin da aka shiga ciki, matakin garkuwar furotin ya kai kashi 98%.
Kwayar mai aiki mai aiki da ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwa tana da cikakken haɗari ƙarƙashin ikon CYP3A4 a cikin sel na hanta hanta. A cikin tsarin metabolism, fili ya zama mara amfani. Ana fitar da excittion na metabolites tare da bile kuma ta cikin tsarin motsa jiki ta hanjin kodan.
Abun da ke cikin miyagun ƙwayoyi, nau'in saki da marufi
Ana samun magungunan a cikin nau'ikan farin allunan, wanda na iya samun kirim ko launin toka mai launin shuɗi. Siffar Allunan suna da sikelin-silsila; Dogaro da adadin abu mai aiki mai karfi, launi na shiri ya bambanta da launi.
Babban sashin magunguna shine maganin disaglinide. Lokacin da abun ciki a cikin kwamfutar hannu shine 50 μg, launi na allunan suna fari.
Idan kwamfutar hannu ta ƙunshi 1 MG na kayan aiki mai aiki, launin maganin yana da haske rawaya ko rawaya.
Idan akwai kayan aiki mai aiki a cikin adadin 2 MG a cikin abun da ke cikin magungunan, allunan suna fentin farin tare da cream ko launin ruwan rawaya.
Baya ga babban abu mai aiki, an haɗa abubuwan da ke gaba cikin abubuwan da aka haɗa da kayan aikin likita:
- Poloxamer.
- Meglumine.
- Lactose Monohydrate.
- Cellulose
- Potyacryline potassium.
- Silinda Magnesium na Silinda Dioxide.
Ana amfani da wannan abun ɗin a cikin shiri tare da 500 μg na kayan mai aiki. Idan abun da ke ciki ya ƙunshi ƙwayar 1 na ƙarshe, to, an ƙara fenti zuwa kayan taimako. Ana amfani da rawaya ƙarfe baƙin ƙarfe azaman fenti.
Don siyarwa ga mai siye, duk nau'ikan magungunan suna kunshe cikin fakiti mai laushi. Kowane fakitin ya ƙunshi Allunan 10.
Sanyawar kwayar selula a cikin kwali na kwali, wanda ya hada da umarnin don amfani da miyagun ƙwayoyi.
Alamu, magungunan hana amfani da maganin
Babban nuni ga amfani da umarnin Diclinid yana nuna kasancewar nau'in ciwon sukari na 2.
Ana amfani da wannan magani don dalilai na warkewa idan amfani da abincin abinci na musamman da matakan rage nauyin jiki da matsakaiciyar aiki na jiki a jikin mai haƙuri bai bada damar cimma sakamako mai kyau da ake so ba.
Za'a iya amfani da miyagun ƙwayoyi a lokacin magani, duka biyu a matsayin babban magani yayin monotherapy, kuma azaman ɗayan abubuwan haɗin lokacin da ake amfani da su a cikin tsarin aikin magani mai rikitarwa.
Lokacin gudanar da rikicewar jiyya, ana iya amfani da maganin a cikin haɗin gwiwa tare da metformin da thiazolidinediones.
Kamar kowane magani, Diclinid yana da manyan abubuwan contraindications waɗanda zasu iya iyakance yiwuwar yin amfani da magani don maganin ciwon sukari.
Babban nau'in contraindications don amfani daidai da umarnin yin amfani da su sune kamar haka:
- kasancewar a cikin jikin mai haƙuri na nau'in 1 mellitus ciwon sukari;
- haƙuri yana da alamun cutar ketoacidosis mai ciwon sukari;
- kasancewar cikin jikin cututtukan cututtuka;
- gudanar da tiyata mai zurfi da ke buƙatar sauyawa zuwa amfani da ilimin insulin;
- matsanancin rauni na koda;
- kasancewar karancin lactose da rashin jituwarsa;
- tsawon lokacin haihuwa.
- yara da shekarun yarinta na mai haƙuri;
- kasancewar rashin lafiyar jiki ga abubuwan da ke tattare da maganin.
Tsanaki yana buƙatar yin amfani da miyagun ƙwayoyi yayin da akwai keta doka a cikin aiki na hanta.
Dole ne a yi taka tsantsan yayin amfani da miyagun ƙwayoyi, idan mara lafiyar ba shi da isasshen abinci mai gina jiki ko kuma an gano kasalar gazawar a cikin jiki, an kuma buƙatar yin amfani da magani a hankali ga marasa lafiya da ke fama da shan giya.
Umarnin don amfani da miyagun ƙwayoyi
Diagninide an yi shi ne don amfani dashi yayin aiwatar da maganin cututtukan type 2 na ciwon sukari guda 2 a hade tare da aikin jiki da abinci. Babban manufar miyagun ƙwayoyi shine don kula da ƙididdigar ƙwayar ƙwayar cuta a cikin jikin mutum a cikin iyakokin da ke kusa da ƙaddarar ilimin lissafi.
Ya kamata a sha miyagun ƙwayoyi a lokaci guda tare da abinci, ana bada shawara don shan maganin a lokacin da ake buƙata da farko, sannan ku ci abinci bayan mintina 15.
Likita ya zaɓi adadin ƙwayoyi don kowane mai haƙuri daban-daban, la'akari da halayen jikin mai haƙuri da kuma hyperglycemia index.
Mafi sau da yawa, kashi na farko da aka ba da shawarar don gudanarwa shine 0.5 MG a kowace rana, idan a baya mai haƙuri yana shan wasu wakilai na hypoglycemic, to, maganin da aka bada shawara shine 1 MG. Yakamata ayi gyaran mako ko aƙalla sau ɗaya a kowane sati biyu.
Matsakaicin matsakaicen da aka yi amfani dashi a cikin jiyya shine 4 MG kowace rana, kuma matsakaicin sashi ba ya wuce milimita 16 a rana.
Lokacin amfani da miyagun ƙwayoyi azaman kayan haɗin kai, ana iya amfani dashi a hade tare da metformin ko thiazolidinediones. Lokacin gudanar da aikin haɗin gwiwa, sigogin zai kasance iri ɗaya kamar lokacin monotherapy.
Tare da ƙarin magani, ana daidaita sashin da aka shafa.
Ana yin gyaran ne ta fuskoki ɗaya ko wata, gwargwadon matakin glycemia a jikin mai haƙuri da masu ciwon sukari na 2.
Tasirin sakamako da yawan shan ƙwayoyi
Mafi yawan tasirin gefen da aka samu yayin magani tare da magani shine bayyanar alamun hypoglycemia a cikin haƙuri mai fama da ciwon sukari mellitus. Mitar abin da ya faru na wannan sakamako ya dogara ba kawai kan sashi na miyagun ƙwayoyi ba, har ma a kan halayen mutum na jikin mai haƙuri.
Bugu da ƙari, bayyanar sakamako masu illa da ke tattare da aikin tsarin daban-daban da gabobin mutum.
Ya danganta da yawan aukuwar lamarin, ana iya raba dukkan sakamako masu illa zuwa bangarori da yawa - na maimaituwa, mara galihu, da wuya, da ba a sani ba.
Magungunan zai iya haifar da sakamako masu illa:
- Abubuwan da ke tattare da tasirin rigakafin a cikin nau'in itching, fitsari da urticaria.
- Hypoglycemic jihar da halin hypoglycemia tare da asarar sani.
- A cikin halayen da ba a sani ba, ana lura da raunin gani a cikin ciwon sukari. Ana lura da wannan sakamako a farkon farkon maganin.
- Rashin hankali a cikin aiki na tsarin zuciya.
- Jin zafi a cikin ciki, ƙarancin aikin hanta
- Activityara ayyukan hanta enzymes.
Lokacin da yawan shaye-shaye ya faru, yanayin hauhawar jini yawanci yana tasowa a cikin jiki, wanda ke haɗuwa da alamomin masu zuwa:
- bayyanar yunwar;
- karuwar gumi;
- karuwar zuciya;
- ciwon kai
- Damuwa
- karancin magana da hangen nesa.
Jiyya don yawan zubar da jini shine ƙara yawan glucose a cikin jiki ta hanyar ɗaukar dextrose da sauƙin narkewa carbohydrates.
Kudin maganin, ƙirarta da kuma sake dubawa game da miyagun ƙwayoyi
Farashin magani a kan ƙasa na Tarayyar Rasha ya dogara ne akan yankin da aka sayar da miyagun ƙwayoyi kuma matsakaita kusan 200-220 rubles kowace kunshin. A cikin kantin magunguna, ana bayar da magani ta hanyar takardar sayan magani.
Ya kamata a adana magungunan ba tare da isa ga yara ba. Ya kamata a kiyaye wurin ajiya na magunguna daga hasken rana. Yanayin zafin jiki na ajiyar magani ya zama bai wuce 25 digiri Celsius ba. Rayuwar shiryayye na miyagun ƙwayoyi shine shekaru 2.
Game da Diaglinide, zaku iya samun nau'ikan sake dubawa na marasa lafiya waɗanda suka yi amfani da wannan magani wajen aiwatar da cututtukan cututtukan type 2 na mellitus. Koyaya, yawancin bita suna da kyau.
Wannan gaskiyar tana nuna cewa miyagun ƙwayoyi suna da isa sosai don saka idanu a cikin ƙwayar cutar plasma. Kasancewar sake dubawa mara kyau game da miyagun ƙwayoyi shine mafi yawan lokuta ana dangantawa da rikice-rikice na sashi na miyagun ƙwayoyi da yanayin shan miyagun ƙwayoyi, wanda kwararrun likitocin suka ba da shawarar su.
Mafi yawan magungunan analogues na miyagun ƙwayoyi sune NovoNorm da Repaglinide.
A cikin bidiyon a cikin wannan labarin, masanin zai faɗi yadda za a rage yawan sukarin jininka.
