Minirin wani magani ne wanda yake da akasin sakamako na diuretics (diuretics). Ana amfani da wannan magani sosai wurin maganin mutane masu cutar insipidus da polyuria. Magungunan ƙwayar cuta shine analog na vasopressin (hormone na hypothalamus).
Sunan kasa da kasa mai zaman kansa
Sunan kasa da kasa na miyagun ƙwayoyi a cikin Latin shine Desmopressin.
Minirin wani magani ne wanda yake da akasin sakamako na diuretics (diuretics).
ATX
Lambar Minin don ATX (tsabtace ƙwaƙwalwar ƙwaƙwalwa da warkewa) shine H01BA02.
Saki siffofin da abun da ke ciki
Ana amfani da magungunan Desmopressin a cikin nau'i na Allunan don maganin baka da kuma fesa don amfani da Topical (intranasal). Lokacin yin rajista don fesawa ya ƙare. Allunan Allirin suna da siffofin masu zuwa:
- convex;
- siffar m ko zagaye (dogara da kashi);
- tare da rubutu da haɗari;
- farin launi;
- dauke da 100 ko 200 μg na desmopressin, wanda yayi daidai da 0.1 da 0.2 MG na miyagun ƙwayoyi.
Abun da ke tattare da Allunan shima ya hada da wasu abubuwan taimako na daban kamar sitaci.
Abun da ke tattare da Allunan shima ya hada da wasu karin mahadi (Magnesium stearate, sitaci, sukari madara da povidone). Allunan suna cikawa a cikin kwalaben filastik na 30 inji mai kwakwalwa. da kwali na kwali.
Sirin jirgi na Desmopressin ya ƙunshi abu mai aiki, ruwa, sinadarin sodium da sauran abubuwan haɗin. 1 ml na feshin ya ƙunshi 0.1 μg na miyagun ƙwayoyi.
Aikin magunguna
Magungunan yana da sakamako masu zuwa:
- Yana haɓaka reabsorption (baya juyawa) na ruwa a cikin ɓangaren nesa na tubules mai rikitarwa, wanda ke ba da gudummawa ga riƙewar ruwa.
- Theara girman tasirin ƙananan tasoshin a cikin kyallen na hanta.
- Yana rage diuresis (fitowar fitsari).
- Osara osmolarity (maida hankali ne akan dukkan abubuwan da aka soke) na fitsari.
- Yana rage osmolarity na jini.
- Yana haɓaka samar da sinadarin na W Wilbrand factor (wani glycoprotein da ke da mahimmanci don kula da yanayin ruwa na jini da hana hasararsa)
- Da ɗanɗana rinjayar ƙarancin tsokoki na gabobin ciki da jijiyoyin jini.
- Yana taimakawa rage polyuria da nocturia.
- Yana haɓaka samar da sinadarin adrenal gland na ACTH a cikin mutanen da ke fama da cutar Cushing.
Mahimmin kadarorin magungunan shine cewa ba ya haɓaka hawan jini.
Mahimmin kadarorin magungunan shine cewa ba ya haɓaka hawan jini. Wannan yana da mahimmanci ga raunin zuciya. Lokacin shan Allunan, ana lura da mafi kyawun sakamako bayan sa'o'i 4-7. Tasirin warkewa yana kai tsawon awanni 4-8, gwargwadon yawan maganin.
Pharmacokinetics
Ana amfani da maganin ta hanyar ƙarancin bioavailability lokacin da aka karɓa shi a cikin nau'ikan allunan rubutu. Cin abinci yana cutar da shan wahala na desmopressin. Ana lura da mafi girman ƙwayar cuta a cikin jini sa'o'i 2 bayan shan allunan. Magungunan ba ya shiga cikin tsarin jijiya na tsakiya (kwakwalwa) kuma an cire shi a hankali idan aka kwatanta da vasopressin. Kodan yana daɗaɗɗa ƙwayar hanta tare da fitsari. Cire rabin rayuwar sa yayi sa'o'i 2-3.
Alamu don amfani
An wajabta magunguna don masu zuwa:
- Ciwon sukari na tsakiyar insipidus. Ana nuna wannan cutar ta raguwa a cikin kwayar cutar antidiuretic ta asali daga lalacewar tsarin hypothalamic-pituitary.
- Enuresis (urinary incontinence) a cikin yara bayan shekaru 5.
- Nocturia a cikin manya.
- Polydipsia (shan ruwa mai yawa a cikin tsananin ƙishirwa) bayan tiyata.
Saboda tasirin antidiuretic dinsa, ana iya amfani da desmopressin ba kawai don dalilai na likita ba, har ma don dalilai na bincike don tantance aikin koda da gano insipidus na ciwon sukari.
Contraindications
Contraindications don amfani da acetate desmopressin sune:
- rashin ƙarfi;
- kishin asalin psychogenic;
- polydipsia na cikin gida (na farko);
- cutar da take hakkin samar da maganin antidiuretic hormone;
- kasawar zuciya;
- raguwa a cikin osmolarity na jini plasma;
- gazawar koda
- tara ruwa a cikin kyallen takarda.
- tsari mara izini na angina pectoris;
- von cutar Willebrand;
- yanayin buƙatar amfani da magungunan diuretic.
A cikin gazawar koda, ya kamata a yi amfani da maganin tare da taka tsantsan.
Tare da kulawa
Ana gudanar da aikin tiyata ta cikin hankali tare da taka tsantsan a:
- gazawar koda
- maye gurbin ƙwayar cuta mai aiki na mafitsara tare da scarring;
- rashin daidaituwar lantarki;
- babban haɗarin hauhawar jini na intracranial;
- dauke da tayin.
Ana buƙatar yin taka tsan-tsan a cikin lura da yara underan ƙasa da shekara 1 da mutane masu hankali. A cikin kula da tsofaffi, ya zama dole don sarrafa abun da ke cikin sodium a cikin jini.
Ana buƙatar yin taka tsan-tsan a cikin lura da yara underan ƙasa da shekara 1 da mutane masu hankali.
Yadda ake ɗaukar Minirin
An zabi sashi daban-daban la'akari da shekaru, alamomi da concomitant pathology. Don rashin daidaituwa na urinary (rana ko da daddare), yakamata a sha maganin farko 200 mcg a lokacin kwanciya. A cikin manyan maganganu kuma yayin da ake riƙe da gunaguni, sashi yana ƙaruwa zuwa 400 mcg.
A lokacin jiyya, kuna buƙatar iyakance yawan shan ruwa da rana.
Jiyya na iya wuce watanni 3. Ya kamata a dauki allunan Desmopressin bayan abinci. Wani lokacin ana wajabta magani a cikin sashi na 60 da 120 mcg.
Jiyya na nocturnal polyuria
Tare da nocturnal polyuria, kashi na yau da kullun a farkon farawa shine 100 mcg. Idan mai haƙuri bai ji daɗi ba bayan sati ɗaya daga farkon farawa, sashi zai karu zuwa 200 mcg.
Idan babu wani tasiri har tsawon wata guda, magani ya tsaya tare da Minirin.
Ciwon sukari
A cikin ciwon sukari na mellitus, sashi shine 100-200 mcg / day. Tare da insipidus na ciwon sukari na tsakiya, ana shan maganin sau 1-3 a rana, 100 mcg. Idan ya cancanta, daidaita sashi. Maganin yau da kullun shine 0.2-1.2 mg. Don kula da yawan ƙwayar da ake so a cikin jini, kuna buƙatar ɗaukar microgram 200 na Minirin.
Sakamakon sakamako na Minirin
Abubuwan da ba a so ba suna da alaƙa da shaye-shaye marasa kyau a lokacin jiyya, raguwar sodium a cikin jini (hyponatremia), riƙe ruwa a cikin jikin mutum, da kuma rashin bin ka'idoji da sashi na Minirin.
Ciwon kai na iya faruwa wani lokaci lokacin shan Minirin.
Tsarin juyayi na tsakiya
Lokacin ɗaukar Minirin, waɗannan raunin jijiyoyin da ke gaba suna yiwuwa:
- Dizziness
- katsewa
- ciwon kai.
Gastrointestinal fili
A ɓangaren tsarin narkewa, cututtukan da ba a so na maganin suna yiwuwa, kamar bushewar baki, tashin zuciya, zafin ciki da amai.
Cutar Al'aura
Ba a samo halayen ƙwayar cuta ga wannan magani ba. An yarda da maganin sosai.
Tasiri kan ikon sarrafa abubuwan inji
Magungunan ba ya tasiri da ikon sarrafa fasaha.
Magungunan ba ya tasiri da ikon sarrafa fasaha.
Umarni na musamman
Lokacin shan Minirin, dole ne a bi umarnin mai zuwa:
- kar a sha ruwa mai yawa awa 1 kafin da 8 hours bayan shan allunan;
- gudanar da gwajin jini don tantance abun da ke cikin ionic;
- warkar da dukkan cututtuka da yanayin cututtukan daji kafin maganin, tare da ƙishirwa, raunin dysuric da matsanancin rashin lafiyar fitsari;
- sanitize foci na m da na kullum urinary fili cututtuka;
- soke magani idan akwai lalura na tsari a cikin zazzabi da ciwan ciki (kumburin ciki da ƙananan hanji).
Nadin Minirin ga yara
Allunan (tsotsa) Allunan za'a iya ba wa yara.
Yi amfani da lokacin daukar ciki da lactation
An wajabta maganin tare da taka tsantsan ga masu shayarwa da mata masu juna biyu. A cikin karatu, babu wani mummunan tasirin desmopressin akan tayi.
An wajabta maganin tare da taka tsantsan ga masu shayarwa da mata masu juna biyu.
Yi amfani da tsufa
Umarnin don amfani da Minirin yana nuna cewa marasa lafiya waɗanda suka girmi shekaru 65 sau da yawa suna haɓaka maganin hyponatremia. Sun rage sodium plasma.
Aikace-aikacen aiki mara kyau
Tare da sharewar creatinine kasa da 50 ml / min, an haramta amfani da magani.
Amfani don aikin hanta mai rauni
Wataƙila amfani da Minirin don cututtukan hanta.
Doarfe da yawa na Minirin
Ana nuna yawan ƙwayar magunguna ta hanyar alamun jinkirta cikin ƙwayar jikin mutum (ƙyallen bugun zuciya, cututtukan edematous, ƙwaƙwalwar hankali) da ƙarancin sakamako. Taimakawa ya hada da dakatar da jiyya. Idan ya cancanta, ana gabatar da mafita na lantarki. Tare da edema, an wajabta diuretic (Furosemide).
An nuna yawan maganin yana nunawa ta alamun jinkirta cikin ruwan jiki (hujin jiki, cututtukan edematous, rashin hankali).
Yin hulɗa tare da wasu kwayoyi
Ba a bada shawarar amfani da Minirin na lokaci daya da magunguna masu zuwa ba:
- Loperamide;
- NSAIDs (Indomethacin);
- kwayoyi wadanda ke rage jinkirin motsin hanji;
- dimethicone;
- tricyclic antidepressants;
- chlorpromazine;
- carbamazepine;
- serotonin reuptake inhibitors.
Tasirin Minirin yana raunana lokacin da aka hada magungunan tare da tetracyclines, shirye-shiryen lithium, norepinephrine da glibutide. Desmopressin yana haɓaka sakamako na hauhawar jini na wasu kwayoyi.
Amfani da barasa
Yin amfani da barasa yayin jiyya tare da Minirin ba a so.
Yin amfani da barasa yayin jiyya tare da Minirin ba a so.
Analogs
Magunguna masu zuwa suna da alaƙa da alamun ana nunawa na Minirin:
- Harshen.
- Nativa.
- Saurin Rawa.
- Nourem.
- Presinex (ana samunsa ta hancin feshin hanci).
- Vasomirin.
Ba a sayar da magani Minirina narke ba.
Magunguna kan bar sharuɗan
Magunguna magani ne.
Farashin Minirin
Magunguna a cikin kantin magani yana biyan kuɗi daga 1300 rubles.
Yanayin ajiya na miyagun ƙwayoyi
An adana su a yanayin zafi da ke ƙasa da 25 ° C a cikin busassun wuri mara amfani ga yara.
Yin amfani da Minirin tare da Loperamide lokaci guda ba a bada shawarar ba.
Ranar karewa
Allunan sun dace da shekara 2 daga ranar da aka ƙera su.
Mai masana'anta
Magungunan da analogues ana samarwa a cikin Rasha (Nativa), Jamus, Switzerland, Italiya (Presinex), Iceland, Norway, Georgia da Canada.
Ra'ayoyi game da Minirin
Galina, ɗan shekara 35, Moscow: "sonana dan shekara tara yana da maganin ciwon kai. Likita ya ba da magani game da maganin desmopressin. Bayan ya ɗauki kwaya na farko, sai ɗan ya daina hucin gado.
Zlata, dan shekara 38, Kirov: "Yaronmu da 'yar budurwata na da cuta iri daya - cin gado. An bincika su kuma ana bi da su. Likita ya shawarce ni da in yi amfani da Minirin.' Ya'yan namu mata ba su taimaka ba, amma muna da hanya guda 1. Yanzu dan mu Kada ku yi kwanciya a gado kuma ku jagoranci rayuwa mai kyau. "
