Neurontin shiri ne mai kama da tsari a cikin jijiyoyin jiki zuwa ga GABA neurotransmitter (gamma-aminobutyric acid). Da farko, ana amfani da kayan aiki na maganin azaman anticonvulsant. Kuma kawai 'yan shekaru daga baya, da inganci a lura da da dama na kullum neurogenic zafi syndromes da aka saukar.
Sunan kasa da kasa mai zaman kansa
INN - Gabapentin.
Neurontin shiri ne mai kama da tsari a cikin jijiyoyin jiki zuwa ga GABA neurotransmitter (gamma-aminobutyric acid).
Sunan kasuwanci a Latin shine Neurontin.
ATX
Lambar ATX ita ce N03AX12.
Saki siffofin da abun da ke ciki
An samar dasu a cikin nau'ikan allunan da kawuna, sinadarin aiki wanda shine gabapentin.
Karanta kuma game da sauran sashi:
Neurontin 600 - umarnin don amfani.
Neurontin 300 - menene wajabta shi?
Kwayoyi
Ellipse-mai siffa, mai rufi tare da daraja da kuma NT zanen. A gefe guda na kwamfutar hannu, dangane da kashi na kayan aiki, lambobin suna ƙulla su:
- a kan allunan tare da adadi na 600 mg gabapentin 16;
- 800 MG - 26.
Allunan mai ruɓaɓɓen allunan.
Abun da ke ciki, ban da kayan aiki, ya ƙunshi kayan taimako:
- poloxamer-407;
- sitaci;
- E572.
Yawan su kuma ya dogara da maida hankali kan ainihin kayan.
Kafurai
Ana samar da capsules ta yawan gabapentin:
- 100 MG
- 300 MG;
- 400 MG
Capsules sun bambanta a bayyanar (launi na kwalin gelatin) da kuma yiwa alama.
Sun bambanta da bayyanar (launi na kwalliyar gelatin) da kuma yiwa alama. 100 MG capsules fararen fata ne, 300 MG mai launin rawaya ce, kuma 400 MG orange ce. Baya ga gabapentin, capsules sun hada da tsofaffi:
- madara sukari monohydrate;
- sitaci;
- magnesium hydroxylate.
Capsules kuma sun bambanta da girma - A'a. 3, 1, 0 a cikin juyawa don sashi.
Aikin magunguna
Duk da irin tsarin da yayi da GABA, gabapentin baya daurewa ga masu karbar GABAA da masu karbar GABAA. Ana yin bayanin abubuwan da ke tattare da tsinkaye ta hanyar iyawar abu don ɗaure zuwa wasu raka'o'in ions na alli na alli wanda ke cikin ƙananan ƙwayar jijiyoyin tsokoki na kashin baya.
Idan jijiyoyi masu nisa (nesa) sun lalace, adadin α2-δ subunits yana ƙaruwa sosai. Activoƙarin su yana ƙaruwa yaduwar Ca2 + zuwa cikin sel ta hanyar membrane, wanda ke haifar da rarrabuwar sa da rage damar lokacin aiki. A wannan yanayin, abubuwa masu motsa jiki masu narkewa (neurotransmitters) - glutamate da sinadaran P - ana sake su ko haɗa su, ana karɓar masu karɓar ionotropic glutamate.
Tasirin narkewar Neurontin shine saboda toshe watsa alamun alamun jin zafi a matakin kashin.
Gabapentin yana aiki ne kawai a kan masu karɓar karɓaɓɓun, ba tare da canza fasalin alli a cikin masu karɓar ba a kunna ba. Tasirin narkewar Neurontin shine saboda toshe watsa alamun alamun jin zafi a matakin kashin. Bugu da kari, miyagun ƙwayoyi suna shafar sauran tsarin:
- Masu karɓa na NMDA;
- tashoshin ion sionum;
- tsarin opioid;
- hanyoyin monoaminergic.
Bugu da ƙari ga hanawa na jijiya, an bayyana sakamako mai zurfi. Magungunan suna aiki a kan gada, cerebellum da vestibular nuclei, wanda ke bayani ba wai kawai tasirin analgesic ba, har ma da kayan anticonvulsant, suna kawar da jaraba ga opioids kuma sun riga sun sami rashin hankali.
Sabili da haka, magungunan suna da tasiri ba kawai don dakatar da ciwo na kullum ba, har ma don rage ciwo mai zafi.
Pharmacokinetics
Tasirin Neurontin ya dogara da kashi-kashi. Bayan sarrafawar bakin mutum na 300 da 600 MG na wani abu, ƙwaƙwalwar sa shine 60% da 40%, bi da bi, kuma yana raguwa da ƙaruwa mai yawa. Magungunan yana ma'amala da ɗan lokaci kaɗan tare da ƙwayoyin plasma (3-5%). Ofararrawar rarraba shine ~ 0.6-0.8 l / kg. Bayan shan 300 mg na gabapentin, mafi girman jikewa (2.7 μg / ml) na jini plasma ya isa bayan sa'o'i 2-3.
Magungunan yana ma'amala da ɗan lokaci kaɗan tare da ƙwayoyin plasma (3-5%).
Gabapentin yayi saurin wucewa shingen kwakwalwa. Ayyukanta a cikin ƙwayar cerebrospinal shine 5-35% na plasma, kuma a cikin kwakwalwa - har zuwa 80%. A cikin jikin, kayan ba ya halakar da kayan halitta kuma ƙwayayen ke canza shi. Adadin excretion ya dogara da ƙididdigar creatinine (ƙarar jini ta barkewar jini a cikin minti 1). A cikin marasa lafiya da keɓaɓɓen aikin na koda, rabin rayuwar abu bayan rashi ɗaya shine awoyi 4.7-8.7.
Menene taimaka?
Sanya don sauƙaƙa ciwo mai raɗaɗi da ciwo mai zafi tare da:
- cututtuka na rheumatic;
- postherpetic neuralgia;
- kumburi da trigeminal jijiya;
- ciwon sukari da na polyneuropathy na sana'a;
- cututtukan marassa lafiya na nakasassu tare da osteochondrosis, radiculopathy;
- carpal rami syndrome;
- increasedara yawan ƙwayoyin spasmodic na kwakwalwa;
- sirinjiyel;
- zafi bayan-bugun jini.
Lokacin ɗaukar Neurontin, ba kawai ciwo na neuropathic ya tsaya ba. Ana amfani da miyagun ƙwayoyi don maganin farfadowa na ƙwayar cuta kafin aiki mai ɗauka da aiki. Gabatarwarsa yana taimakawa rage yawan maganin hana haihuwa da ake amfani da su a cikin bayan aikin, da kuma rage tsananin zafin.
Magungunan yana da ikon dakatar da farko kawai (kai tsaye a fannin aikin tiyata) jin zafi na baya, har ma don shafar sakandare (nesa daga filin tiyata) zafin da ya haifar ta hanyar aikin injin.
Ana amfani da maganin don maganin barna a matsayin anticonvulsant. A cikin nau'i na magani ɗaya wanda aka yi amfani da shi don taimakawa raunin raunin m.
Contraindications
Contraindications don amfani da Neurontin sune:
- halayyar rashin lafiyan mutum;
- shekaru har zuwa shekaru 3.
A contraindication ga yin amfani da Neurontin ne mai hali na rashin lafiyan.
Tare da kulawa
Ya kamata a tsara masu haƙuri tare da gazawar renal tare da taka tsantsan a ƙarƙashin ikon sarrafa ayyukan. Tunda an cire shi yayin hemodialysis, ana buƙatar daidaita sashi.
Yadda ake ɗaukar neurontin?
Ana ɗaukar maganin a baka, an wanke shi da ruwa, ba tare da la'akari da cin abinci ba. Kuna iya raba kwamfutar hannu a cikin rabin, watse cikin haɗari. Ana aiwatar da jiyya a matakin farko bisa ga tsarin da aka bi:
- Ranar farko - 300 mg sau ɗaya a rana;
- Rana ta 2 - 300 MG 2 sau a rana;
- Rana ta 3 - 300 MG sau 3 a rana.
An nuna irin wannan tsarin ga marasa lafiyar manya da matasa daga shekaru 12. Idan ana buƙatar karɓar magani, to, ana aiwatar da shi a hankali, rage girman kashi na akalla kwanaki 7, ba tare da la'akari da alamu ba.
Ana ɗaukar maganin a baka, an wanke shi da ruwa, ba tare da la'akari da cin abinci ba.
A cikin wasu halaye, marasa lafiya na manya na iya fara magani tare da kashi 900 MG tare da haɓaka hankali (titration) na 300 MG kowace rana a cikin kwanaki 2-3. Matsakaicin adadin yau da kullun shine 3600 MG. An kai shi a cikin makonni 3. A cikin mummunan yanayin mai haƙuri, ana karuwa da kashi a cikin ƙananan kima ko babban gibba tsakanin tarars.
Don lura da sankara, dole ne a yi amfani da miyagun ƙwayoyi ci gaba. A wannan yanayin, ana lissafta kashi na yau da kullun ta likita.
Shan maganin don ciwon sukari
Ana amfani dashi azaman magani na zabi don taimako na jin zafi a cikin cututtukan ciwon sukari. An ba da shawarar yin amfani da maganin a 300 MG kowace rana a maraice, a hankali (kowane kwanaki 2-3) yana ƙaruwa da kashi zuwa 1800 MG kowace rana.
Ana amfani dashi azaman magani na zabi don taimako na jin zafi a cikin cututtukan ciwon sukari.
Har yaushe zan iya ɗauka?
An ba da shawarar yin amfani da miyagun ƙwayoyi ba fiye da watanni 5, saboda Ba a yi nazari a kan wani magani mai tsawo ba. Tare da tsawon lokaci, ƙwararren likita ya kamata ya auna buƙatar haɓakar bayyanar wuri.
Sakamakon sakamako na Neurotin
Mafi yawan lokuta, tsakanin abubuwan da ke tattare da shan miyagun ƙwayoyi, amai da amai da yawa ana lura dasu. Sau da yawa ba sau da yawa, ƙwayar tana da mummunan tasiri akan tsarin daban-daban.
Gastrointestinal fili
Mafi yawan lokuta lura:
- take hakkin motsi;
- bushewa da oropharynx;
- matsanancin gas;
- tashin zuciya, amai
- rikicewar dyspeptic;
- cingam cuta;
- yawan cin abinci.
A cikin bayan-warkewa, an yi rikodin rikice-rikice na cututtukan ƙwayar cuta mai daskarewa.
Hematopoietic gabobin
Sau da yawa ana samo leukopenia, hauhawar jini da kuma yawan ƙwaƙwalwar jini.
Tsarin juyayi na tsakiya
Mafi sau da yawa bayyana:
- nutsuwa
- bincike;
- rauni
- paresthesia;
- rawar jiki
- ƙwaƙwalwar ajiya
- take hakkin hankali;
- zalunci na reflexes.
Rashin shan magani da wuya yana haifar da asarar hankali, raunin tunani, kamar rashin tsoro, rashin tsoro, damuwa, yana haifar da cin zarafin tunani.
Daga tsarin urinary
Ware lokuta na hyperactivity na mafitsara, m na koda gazawar. Kwayoyin cuta, ciki harda cututtukan urinary tract, ana yawan lura da su.
Daga tsarin musculoskeletal
Galibi, magani yana tare da:
- myalgia;
- arthralgia;
- jijiyar wuya da teak.
A ɓangaren fata
Sau da yawa akwai mummunan halayen a cikin hanyar:
- 'yar tsana;
- kurma;
- kuraje
- rashes;
- itching.
Alopecia, redness, da fitsari na magani ba su zama gama gari.
Cutar Al'aura
An bayyana rashin lafiyan damuwa ta hanyar cututtukan fata, faɗuwar matsalar anaphylactic da wuya ba a lura da shi ba.
Tasiri kan ikon sarrafa abubuwan inji
Lokacin shan miyagun ƙwayoyi, ba a bada shawara ga tuki motoci ko aiki tare da ƙwararrun haɗari kafin a tabbatar cewa babu wani mummunan sakamako na miyagun ƙwayoyi akan halayen neuromuscular.
Umarni na musamman
Marasa lafiya da ke shan miyagun ƙwayoyi sun ba da rahoton sassan halayen kisan kai. Sabili da haka, ya zama dole a saka idanu a kan yanayin tunanin mutum-mai raɗaɗi tare da alƙawarin gyara ɓarna.
Idan alamun bayyanar cututtukan cututtukan cututtukan cututtukan ƙwayar cuta sun bayyana, yanke shawarar dakatar da miyagun ƙwayoyi yana da nauyi.
Tare da janyewar miyagun ƙwayoyi yayin maganin cututtukan ƙwayar cuta, raɗaɗi na iya haɓaka.
Tare da janyewar miyagun ƙwayoyi yayin maganin cututtukan ƙwayar cuta, raɗaɗi na iya haɓaka. Ana amfani da miyagun ƙwayoyi marasa inganci a cikin maganin cututtukan mahalli na farko wanda har ma yana iya haifar da ƙarfafa su. Sabili da haka, sanya wannan magani ga marasa lafiya tare da paroxysms hade da hankali.
Tare da gudanarwa na lokaci guda na opioids da Neurontin, CNS ɓacin rai na iya haɓaka - saka idanu akan yanayin mai haƙuri da daidaita sashi na lokaci ya zama dole.
Yi amfani da lokacin daukar ciki da lactation
Magunguna lokacin haihuwar ciki an wajabta amfani da shi lokacin da ake samun fa'ida game da haɗarin cutar da amfrayo. Babu buƙatar sarrafa ayyukan miyagun ƙwayoyi a cikin jini na jini.
Domin an samo maganin a asirin mammary gland shine yake, lokacin ciyarwa, ya zama dole don katse abincin da ya shafi jariri da canja shi zuwa cakuda.
Magunguna lokacin haihuwar ciki an wajabta amfani da shi lokacin da ake samun fa'ida game da haɗarin cutar da amfrayo.
Adanar Neurontin ga yara
Ba a tsara magani tare da Neurontin har zuwa shekaru 3. A shekaru 3-12 shekaru, farawa shine 10-15 mg / rana. An kasu kashi uku. Don cimma sakamako na warkewa, an ƙara haɓaka shi, yana kai 40 mg / rana. Wajibi ne a tabbatar da tsawan awanin sa'o'i 12 tsakanin liyafar.
Yi amfani da tsufa
A cikin tsohuwar ƙungiyar tsufa (> shekaru 65), lalata yanayin aikin ƙwaƙwalwa saboda ayyukan da suka shafi shekaru yawanci ana samunsa, sabili da haka, a cikin irin waɗannan marasa lafiya, ikon ƙaddamar da ikon halitta ya zama dole.
Yawan abinciki na neurotin
Tare da gudanar da aiki guda ɗaya na babban kashi, an lura da alamun masu zuwa:
- raunin gani;
- daɗaɗɗar walwala;
- dyspemia (rashin lafiyar articulation);
- rashin bacci (baccin rana);
- bari;
- take hakkin hanji.
Idan kashi ya wuce, musamman a hade tare da Neurontin da sauran magungunan neurotropic, coma na iya haɓaka.
A wani babban kaso, allurar da ta dace da kuma karin jini a mafi yawan lokuta ana wajabta wa marasa lafiya masu fama da tabin hankali.
Yin hulɗa tare da wasu kwayoyi
Lokacin da aka yi amfani da Neurontin tare da abubuwanda suka samo asali na opium poppy, ana iya lura da alamun hana tashin hankali na CNS. Canje-canje a cikin kantin magunguna na Neurontin lokacin da ba a lura da magungunan antiepileptic ba.
Haɗin kwayoyi da maganin rigakafi yana rage ƙwaƙwalwar Neurotin da kusan 1/4.
Ana haɗuwa da Venoruton da sauran ƙwayoyin cuta tare da kayan aiki na ƙwayoyi kuma ana iya tsara su don hana mummunan sakamako daga tsarin wurare dabam dabam.
Tare da bayyanar matsakaici na rashin lafiyan, ana amfani da antihistamines, kamar Cetrin a cikin layi daya tare da miyagun ƙwayoyi.
Tare da bayyanar matsakaici na rashin lafiyan, ana amfani da antihistamines, kamar Cetrin a cikin layi daya tare da miyagun ƙwayoyi.
Amfani da barasa
Ba'a ba da shawarar shan barasa da magani a lokaci guda, saboda Dukansu suna da tasiri akan tsarin juyayi na tsakiya. Koyaya, ana amfani da miyagun ƙwayoyi don maganin dogara da barasa. Yana rage sha'awar giya, yana kawar da rashin bacci da bacin rai.
Analogs
Akwai maganganu da yawa na Neurotin:
- Convalis;
- Abin fari;
- Egiptiin;
- Gabalept;
- Wimpat;
- Gabastadine
- Tebantin;
- Gabapentin;
- Katena.
Magunguna kan bar sharuɗan
Da takardar sayan magani.
Zan iya saya ba tare da takardar sayan magani ba?
Ba a ba da shawarar magungunan kan-kan-kan-kan don kauce wa yin jabu ba.
Farashin Neurontin
Kudin shine 962-1729 rubles.
Yanayin ajiya na miyagun ƙwayoyi
Adana a zazzabi da bai wuce 25 ° C ba, a cikin isar da yara.
Ba'a bada shawarar magungunan kan-sa-kai don kauce wa jabu ba.
Ranar karewa
Bai wuce shekaru 2 ba.
Mai masana'anta
Pfizer (Jamus).
Nazarin Neurontin
Alexey Yuryevich, dan shekara 53, Kaluga: "Na dade ina fama da raunin neuropathic. A shekara daya yanzu, likita ya ba da liyafar ta Neurontin 300. Da farko sakamakon ya yi kyau, amma yanzu ya ɗan raunana. Na ci gaba da shan magani, amma ina zargin cewa saboda tsawon magani ba shi da tasiri. "
Konstantin, 38 years old, Odessa: "Likita ya tsara hanya Neurontin. Ya dauki maganin da likitan ya umarta, yana bin tsarin.A wannan lokacin babu sakamako masu illa da suka firgita, kuma magungunan suna aiki da kyau. "
Olga, ɗan shekara 42, Melitopol: "Bayan shan Neurontin, sakamakon ya ci gaba na dogon lokaci, ban ji daɗi ba, ƙafafuna sun ji rauni kaɗan.
