Aprovel magani ne wanda aka shirya don lura da hauhawar jini da jijiya. An ba shi izinin amfani da magani don ciwon sukari. A wannan yanayin, ƙwayar ba ta haifar da ciwon cirewa bayan dakatar da ilimin. Ana samun magungunan a cikin nau'ikan allunan, wanda ya ba likitoci damar sarrafa magunguna. Marasa lafiya da kansu zasu iya daidaita yanayin aikin magani a lokacin da ya dace dasu.
Sunan kasa da kasa mai zaman kansa
Irbesartan.
Aprovel magani ne wanda aka shirya don lura da hauhawar jini da jijiya.
ATX
C09CA04.
Saki siffofin da abun da ke ciki
Ana amfani da miyagun ƙwayoyi a cikin allunan da aka kera. Nau'in magani ya ƙunshi 150, 300 MG na kayan aiki - irbesartan. Kamar yadda aka yi amfani da kayan taimako a cikin samarwa:
- sukari madara;
- hypromellose;
- colloidal bushewar silicon dioxide;
- magnesium stearate;
- croscarmellose sodium.
Fim ɗin fim ɗin ya ƙunshi kakin carnauba, macrogol 3000, hypromellose, titanium dioxide da sukari madara. Allunan suna da launi mai kyau na biconvex kuma ana fenti da fari.
Aikin magunguna
Ayyukan Aprovel sun dogara da irbesartan, mai adawa da zaɓin karɓar angiotensin II mai karɓa. Sakamakon hanawar ayyukan mai karba, yawan aldosterone a cikin jini yana raguwa. Matsayin sodium ions a cikin jijiyoyin jini ba ya canzawa idan mai haƙuri bai yi amfani da miyagun ƙwayoyi ba kuma yana ɗaukar shawarar da aka bayar kawai na yau da kullun.
Sakamakon aikin ƙwayar sunadarai, an lura da raguwar hauhawar jini (BP). A wannan yanayin, babu raguwa a cikin yawan zuciya. Tare da kashi ɗaya na har zuwa 300 MG, raguwa cikin karfin jini kai tsaye ya dogara da sashi da aka ɗauka. Tare da karuwa a cikin tsarin yau da kullun na abubuwan da ke aiki, babu canje-canje masu ƙarfi a cikin alamomin hawan jini.
Ana lura da mafi girman tasirin sakamako 3-6 bayan shan kwayoyin. Tasirin warkewa na tsawon awanni 24. Bayan kwana ɗaya daga lokacin ɗaukar guda ɗaya, karfin jini yana raguwa kawai da kashi 60-70% na ƙimar mafi girma.
Tasirin magunguna na Aprovel sannu-sannu yana haɓaka tsawon kwanaki 7-14, yayin da ake lura da mafi girman dabi'un warkewar cutar bayan makonni 4-6. A wannan yanayin, sakamakon hypotensive ya ci gaba. Idan aka daina jiyya, saukar karfin jini a hankali zai dawo yadda yake.
Pharmacokinetics
Bayan gudanar da maganin baka, ƙwayar za ta shiga cikin hanji cikin hanzari ta hanyar 60-80% na kashi da aka ɗauka. Lokacin da ya shiga cikin jini, abu mai aiki ya ɗaura nauyin garkuwar plasma da kashi 96% kuma, godiya ga hadaddun da aka ƙirƙira, ana rarraba shi ko'ina cikin kyallen takarda.
Abubuwan da ke aiki sun isa matsakaicin ƙwayar plasma bayan 1,5-2 hours bayan gudanarwa.
Cire rabin rayuwa yana yin awoyi 11-15. Thanasa da 2% na kayan aiki mai aiki a cikin asalinsa an cire shi ta hanyar tsarin urinary.
Alamu don amfani
Magungunan an yi niyya ne don jiyya da rigakafin hawan jini kamar monotherapy ko a hade tare da wasu magunguna tare da tasirin antihypertensive (ƙungiyar beta-adrenergic blockers, thiazide diuretics). Kwararrun likitoci suna tsara Aprovel don nephropathy a gaban nau'in ciwon sukari na 2, tare da hauhawar jini. A irin wannan yanayin, ba a gudanar da maganin tauhidi, amma an tsara wani hadadden magani don rage karfin jini.
Contraindications
Ba'a ba da shawarar yin amfani da miyagun ƙwayoyi ba ko kuma an haramta amfani dashi a cikin waɗannan lambobin:
- ƙarancin ji na kyallen takarda zuwa kayan aikin magani;
- rashin haƙuri ga lactose, lactase;
- malabsorption na monosaccharides - galactose da glucose;
- mai tsananin raunin hanta.
Sakamakon rashin isassun karatun asibiti, an haramta shan magani ga mutanen da ba su kai shekara 18 ba.
Tare da kulawa
Ana bayar da shawarar yin taka tsantsan a waɗannan lamura:
- stenosis na aorta ko mitral valve, renal arteries;
- juyawar koda;
- CHD (cututtukan zuciya);
- tare da gazawar koda, ya zama dole don sarrafa matakin potassium da creatinine a cikin jini;
- cerebral arteriosclerosis;
- abinci mai gishiri-gishiri, tare da zawo, amai;
- hana ciwon zuciya;
- hypovolemia, karancin sodium a kan asalin maganin magunguna tare da diuretics.
Wajibi ne a lura da yanayin marasa lafiya akan cutar sankara.
Yadda ake ɗaukar Aprovel
Magungunan an yi niyya don gudanar da maganin baka. A lokaci guda, saurin da ƙarfin sha a cikin ƙananan hanji yana da 'yanci daga cin abinci. Allunan dole ne su bugu duka ba tare da taunawa ba. Ainihin matakin a matakin farko na magani shine 150 MG kowace rana. Marasa lafiya waɗanda hauhawar jini suna buƙatar ƙarin maganin hana ƙwaƙwalwar ƙwayar cuta suna karɓar 300 mg a rana.
Tare da ƙarancin raguwar hauhawar jini, haɗu da magani tare da Aprovel, beta-blockers, ana amfani da alli na calcium ion don cimma burin.
Yana da mahimmanci a tuna cewa sashi da tsawon lokacin likita an kafa ne kawai ta ƙwararren likita dangane da halaye na mutum na mai haƙuri, bayanan dakin gwaje-gwaje da kuma nazarin jiki.
Shan maganin don ciwon sukari
Yarda game da nau'in ciwon sukari na 1 ya kamata a tattauna tare da likitanka, wanda zai haramta amfani da Aprovel ko aiwatar da sauƙin maganin yau da kullun. A nau'in ciwon sukari guda biyu-wanda baya dogaro da insulin, shawarar da aka bada shawarar shine 300 MG kowace rana sau daya.
Marasa lafiya da ciwon sukari suna da haɗarin haɓakar haɓakar hyperkalemia.
Yadda za a ƙi karɓa
Canjin ciwo bayan an dakatar da shan iskar Aprovel. Kuna iya canzawa kai tsaye zuwa wani magani na likita ko dakatar da shan maganin.
Side effects na Aprovel
An tabbatar da amincin miyagun ƙwayoyi a gwaje-gwajen asibiti wanda marasa lafiya 5,000 suka shiga. Masu ba da agaji 1300 sun sha wahala daga hawan jini kuma sun ɗauki maganin har tsawon watanni 6. Ga marasa lafiya 400, tsawon lokacin aikin likita ya wuce shekara guda. Matsakaicin sakamako masu illa bai dogara da sashi da aka ɗauka ba, jinsi da shekarun haƙuri.
A cikin binciken da aka sarrafa-wuri, masu ba da agaji na 1965 sun karbi irbesartan far na watanni 1-3. A cikin 3.5% na lokuta, an tilasta marasa lafiya su yi watsi da magani tare da Aprovel saboda sigogi na dakin gwaje-gwaje mara kyau. 4.5% sun ƙi ɗaukar hoto, saboda ba su jin ci gaba.
Gastrointestinal fili
Bayyanannun bayyanannun abubuwa a cikin narkewa kamar fili:
- zawo, maƙarƙashiya, ƙwanƙwasa;
- tashin zuciya, amai;
- haɓaka ayyukan aminotransferases a hepatocytes;
- dyspepsia;
- ƙwannafi.
A ɓangaren hanta da ƙwayar ƙwayar cuta na biliary, hepatitis na iya faruwa, karuwa a cikin ƙwayar plasma na bilirubin, wanda ke haifar da cutar cholestatic.
Tsarin juyayi na tsakiya
Rushewar cikin sadarwar neuronal saboda yawan amfani da magungunan antihypertensive sau da yawa ana nuna su ta hanyar rashin jin daɗi da ciwon kai. A cikin lokuta mafi wuya, rikice-rikice, zazzabin gaba ɗaya, raunin ƙwayar tsoka, rauni na tsoka, da vertigo sun lura. Wasu marasa lafiya sun ji tinnitus.
Daga tsarin numfashi
Sakamakon sakamako na tsarin numfashi shine tari.
Daga tsarin kare jini
A cikin marasa lafiya da ke cikin haɗarin haɓakar gaɓar koda, lalatawar koda zai iya haɓaka.
Daga tsarin zuciya
Yawancin lokaci ana nuna bayyanar cututtukan Orthostatic.
Cutar Al'aura
Daga cikin bayyanuwar halayen rashin lafiyan, akwai:
- Harshen Quincke na edema;
- girgiza anaphylactic;
- kurji, itching, erythema;
- urticaria;
- angioedema.
Marasa lafiya suna iya motsa jiki don fuskantar gwajin ƙwayar cuta. Idan sakamakon ya kasance tabbatacce, ya kamata a maye gurbin miyagun ƙwayoyi.
Tasiri kan ikon sarrafa abubuwan inji
Magungunan ba ya shafar aikin fahimi na mutum kai tsaye. A wannan yanayin, yana yiwuwa a haɓaka mummunan aiki daga tsakiya da na waje na jijiya, saboda abin da aka ba da shawarar ka guji tuki, yin aiki tare da kayan aiki masu rikitarwa kuma daga wasu ayyukan da ke buƙatar saurin amsawa da maida hankali yayin lokacin maganin ƙwayoyi.
Umarni na musamman
Marasa lafiya marasa aiki da tsarin jijiyoyin jini ko tare da dysfunction mai kumburin ciki suna da haɗarin haɓakar haɓakar rashin ƙarfi, oliguria, da haɓaka nitrogen a cikin jini. Tare da raguwa mai ƙarfi a cikin karfin jini sakamakon ischemia, infarction na myocardial infarction ko bugun jini na jijiyoyin bugun jini na iya faruwa.
Yi amfani da lokacin daukar ciki da lactation
An haramta amfani da miyagun ƙwayoyi don amfani da lokacin haila. Kamar sauran magunguna waɗanda ke shafar tsarin renin-angiotensin-aldosterone, irbesartan da yardar rai zai shiga cikin shingen ƙwayar cuta. Bangaren da yake aiki zai iya shafar ci gaban cikin mahaifa a kowane matakin ciki. A wannan yanayin, ana amfani da irbesartan a cikin madarar nono, dangane da abin da ya wajaba a daina shayarwa.
Wa'adi na aprove ga yara
Ba'a ba da shawarar ga marasa lafiya da ke ƙasa da shekara 18 ba, saboda babu bayanai game da tasirin maganin a ci gaban ƙuruciya da samartaka.
Yi amfani da tsufa
Ba a buƙatar ƙarin gyaran halayen yau da kullun ga mutane bayan shekaru 50.
Aikace-aikacen aiki mara kyau
Kawai 2% na miyagun ƙwayoyi suna barin jiki ta cikin kodan, don haka mutanen da ke fama da cutar koda ba sa buƙatar rage sashi.
Amfani don aikin hanta mai rauni
A cikin rudani mai tsanani na hepatocytes, shan magani ba da shawarar ba.
Kawai 2% na miyagun ƙwayoyi suna barin jiki ta cikin kodan, don haka mutanen da ke fama da cutar koda ba sa buƙatar rage sashi.
Adadin yawa na Aprovel
A cikin nazarin asibiti, lokacin da aka ɗauki har zuwa 900 MG a kowace rana ta wani manya don makonni 8, babu alamun maye cikin jiki.
Idan alamun alamun asibiti na yawan zubar da jini sun fara bayyana a lokacin amfani da miyagun ƙwayoyi, to kuna buƙatar neman taimakon likita kuma ku daina shan magani. Babu takamaiman takamaiman abin da ya rage rauni, sabili da haka, an yi niyya don kawar da hoton hoton.
Yin hulɗa tare da wasu kwayoyi
Ta hanyar amfani da Aprovel na lokaci daya tare da wasu magunguna, ana lura da halayen masu zuwa:
- Synergism (haɓaka tasirin warkewa duka magunguna) a haɗe tare da magungunan antihypertensive, alluran tashar alli, thiazide diuretics, beta-adrenergic blockers.
- Cigaba da sanya sinadarin potassium a cikin jini ya hau tare da magungunan heparin da potassium.
- Irbesartan yana ƙara yawan guba na lithium.
- A hade tare da magungunan anti-inflammatory marasa steroidal, hadarin lalacewa na koda, hyperkalemia yana ƙaruwa, sabili da haka, dole ne a kula da aikin koda yayin aikin maganin.
Abunda ke aiki na Aprovel baya tasiri da warkewar cutar Digoxin.
Amfani da barasa
An hana wakili na antihypertensive lokaci guda tare da samfuran giya. Ethyl barasa na iya haifar da jujjuyawar ƙwayoyin sel jini, haɗuwa wanda zai iya ɗaukar katako na jirgin ruwa. Yawan zubar jini yana da wahala, wanda ke haifar da karuwa a cikin zuciya da kuma hauhawar matsin lamba. A waje da tushen ilimin magani, wannan yanayin zai haifar da rushewar jijiyoyin jiki.
Analogs
Daga cikin tsarin analogues, tsarin aikin wanda ya dogara da tsarin aiki na irbesartan, akwai magunguna na samarwa na Rasha da na kasashen waje. Kuna iya maye gurbin Allunan Allunan tare da magunguna masu zuwa:
- Irbesartan
- Ibertan;
- Firmastoy;
- Irsar;
- Irbesan.
Yana da mahimmanci a tuna cewa kafin canzawa zuwa sabon magani ya zama dole a nemi shawara tare da likitan ku. An hana maye gurbin kansa.
Magunguna kan bar sharuɗan
Ana sayar da maganin ta hanyar takardar sayan magani.
Farashi don aprovel
Matsakaicin farashin fakiti mai kunshe da allunan 14 na 150 MG ya bambanta daga 310 zuwa 400 rubles.
Yanayin ajiya na miyagun ƙwayoyi
Ana buƙatar containauke da miyagun ƙwayoyi a cikin busassun wurin da ba a iya isa ga haske da yara a yanayin zafi har zuwa 30 ° C.
Ranar karewa
Shekaru 3
Mai masana'anta
Masana'antar Sanofi Winthrop, Faransa.
Ra'ayoyi akan Aprovel
Bayani mai kyau game da tasirin miyagun ƙwayoyi a kan ɗakunan yanar gizo daban-daban suna taimakawa wajen ƙarfafa matsayin Aprovel a kasuwar magunguna.
Likitocin zuciya
Olga Zhikhareva, likitan zuciya, Samara
Magani mai tasiri don rage karfin hawan jini. Ina amfani da shi a cikin aikin asibiti kamar maganin monotherapy ko magani mai wahala. Ban ga jaraba ba Marasa lafiya basu da shawarar shan fiye da 1 lokaci a rana.
Antonina Ukravechinko, likitan zuciya, Ryazan
Kyakkyawan ƙimar kuɗi, amma ina bayar da shawarar yin taka tsantsan ga waɗannan marasa lafiya waɗanda ke da mitral ko aortic valve stenosis. An hana yara da mata masu juna biyu ɗaukar allunan Aprovel. Daga cikin sakamako masu illa, halayen rashin lafiyan ya faru. A lokaci guda, duk da mummunan halayen daga jiki, ƙwayar ta taimaka wajen rage hawan jini.
Idan alamun alamun asibiti na yawan ƙwayar ƙwayar cuta sun fara bayyana, to kuna buƙatar neman taimakon likita.
Marasa lafiya
Alkahira Airam, dan shekara 24, Kazan
Ina da hauhawar jini. Da safe yakan tashi zuwa 160/100 mm Hg. Art. Ya dauki kwayoyi da yawa don rage karfin jini, amma allunan Aprovel ne kawai suka taimaka. Bayan aikace-aikacen, nan da nan ya zama mafi sauƙi ga numfashi, sautin jini a cikin haikalin ya wuce. Babban abu shi ne cewa tasirin bayan cire magunguna yana ɗaukar tsawon lokaci. Kuna buƙatar sha darussan kuma ku ziyarci likitan ku a kai a kai. Ban lura da wani sakamako masu illa ba.
Anastasia Zolotnik, shekara 57, Moscow
Magungunan ba su dace da jikina ba. Bayan kwayoyin hana daukar ciki, fitsari, kumburi da matsanancin itching ya bayyana. Na yi ƙoƙari don sulhu na mako guda, saboda matsin lamba ya ragu, amma rashin lafiyan bai tafi ba. Dole ne in je wurin likita don zaɓar wani magani. Naji dadin cewa ciwon cirewar bai taso ba, sabanin wasu hanyoyin don rage karfin jini.
