Lozap 50 magani ne wanda aka wajabta wa marasa lafiya da cututtukan CCC.
Sunan kasa da kasa mai zaman kansa
Losartan.
ATX
Lambar ATX ita ce C09C A01.
Saki siffofin da abun da ke ciki
Ana amfani da miyagun ƙwayoyi a cikin nau'ikan allunan da aka rufe fim. Kowace kwamfutar hannu ta ƙunshi 50 MG na kayan aiki mai aiki. Babban sinadaran aiki na miyagun ƙwayoyi shine losartan.
Ana amfani da miyagun ƙwayoyi a cikin nau'ikan allunan da aka sanya fim, kowane kwamfutar hannu ta ƙunshi 50 MG na kayan aiki mai aiki.
Allunan tare da abun aiki mai aiki na 12.5 MG Har ila yau suna kan siyarwa. Allunan suna fararen launuka ne, kamannin biconvex.
Aikin magunguna
Losartan shine abu wanda ke ɗaure masu karɓa zuwa angiotensin II. Yana aiki akan nau'in mai karɓar mai karɓar AT1; ragowar masu karɓa don angiotensin basu ɗaure ba.
Abubuwan da ke aiki na miyagun ƙwayoyi ba su hana ayyukan enzymes waɗanda ke shafar juyar da angiotensin I zuwa angiotensin II. Ana kiyaye karfin karfin jini yayin rage matakan aldosterone da adrenaline a cikin tsarin jini. Babu wani canji a cikin taro na angiotensin II a cikin jini.
A ƙarƙashin rinjayar Lozap, juriya na tasoshin jini na gefe yana raguwa. Kayan aiki yana rage matsin lamba a cikin jijiyoyin bugun jini, yana ba da gudummawa ga karuwar diuresis.
Ragewa bayan saukarwa a kan tsokoki na zuciya yana hana haɓakar canje-canje na jini a cikin myocardium. Losartan yana rage nauyi a kan zuciya yayin aiki na jiki a cikin marasa lafiya da ke fama da rikice-rikice na tsarin zuciya.
Lozap 50 magani ne wanda aka wajabta wa marasa lafiya da cututtukan cututtukan zuciya.
Shan wannan magani ba ya hade da fashewar bradykinin. Abubuwan da ba a ke so waɗanda suke da alaƙa da wannan tsari ba su faruwa yayin jiyya tare da Lozap. Sakamakon gaskiyar cewa aikin hana ƙwaƙwalwar angiotensin-mai canzawa ba a hana shi ba, yanayin cutar angioedema da sauran halayen haɗari masu haɗari shine sau da yawa ragewa.
Sakamakon magungunan rigakafin ƙwayar cuta ya fi fitowa sosai a cikin sa'o'i 6 bayan ɗaukar kwaya. Ana kiyaye sakamako a washegari, a hankali yana raguwa.
Lozap yana nuna iyakar ƙarfin bayan ci gaba da gudanarwa na wata ɗaya ko fiye. A wannan yanayin, maganin yana haɗuwa tare da raguwa a cikin ƙayyadaddun ƙwayoyin plasma da immunoglobulins G a cikin fitsari a cikin marasa lafiya waɗanda ba sa fama da ciwon sukari mellitus.
Magungunan yana haifar da kwantar da hankali na maida hankali ga urea a cikin filayen. Hakan bai shafi aikin sassauci ba na tsarin juyayi na kansa. Lokacin da aka ɗauke shi cikin daidaitattun allurai, baya canza matakan sukari na jini.
Pharmacokinetics
Rashin kayan aiki na wakili yana faruwa a cikin ƙananan hanji. A lokacin farkon lokacin ta hanyar hepatobiliary fili, yana da saukin kamuwa da canji na rayuwa. Cytochrome CYP2C9 isoenzyme yana cikin wannan aikin. Sakamakon hulɗa na sinadarai, an kafa metabolite mai aiki. Har zuwa 15% na kashi da aka dauka ana canzawa.
Matsakaicin bioavailability na abu mai aiki shine dan kadan fiye da 30%. An lura da mafi girman mahimmancin plasma sa'a daya bayan gudanarwar baka. Ana samun irin wannan mai alama ga metabolite mai aiki bayan sa'o'i 3-4.
Abubuwan da ke aiki suna ɗaukar kusan gabaɗaya zuwa peptides na plasma. Penetration ta hanyar BBB a matakin kankane.
Likitoci sun rubuta Lozap 50 don maganin ciwon zuciya.
Abubuwan da ke aiki na miyagun ƙwayoyi suna keɓance duka ta hanji da kuma ta hanta. Rabin rayuwar wani abu wanda ba a canzawa ba shine kusan awanni 2, alamomi masu kama da na metabolite mai aiki daga 6 zuwa 9 hours.
Abin da ake buƙata don
An wajabta Lozap a cikin waɗannan halaye:
- tare da mahimmancin hauhawar jini;
- don rage haɗarin ci gaba da cututtukan CVD a cikin mutanen da ke fama da hauhawar jini;
- tare da nephropathy wanda ya haifar da rikicewar metabolism a cikin cututtukan cututtukan ƙwayar cuta marasa ƙarfi na insulin-insulin;
- don maganin ciwon zuciya na rashin lafiya.
Contraindications
Magungunan hana amfani da miyagun ƙwayoyi sune:
- bayyanar sirri na mutum zuwa ga aiki mai aiki ko wasu abubuwan da suka lalace;
- haɗuwa da miyagun ƙwayoyi tare da aliskiren a gaban ciwon sukari ko gazawar renal;
- tsawon lokacin haihuwa.
- lokacin lactation;
- shekarun yara har zuwa shekaru 18 (yiwu aron a wasu lokuta).
Dole a yi taka tsantsan yayin ɗaukar Lozap 50 yayin cututtukan zuciya.
Tare da kulawa
Musamman taka tsantsan yayin ɗaukar maganin ya kamata a lura da marasa lafiya tare da:
- hyperkalemia
- rashin karfin zuciya tare da tsananin lalacewa koda;
- Hatsarori na cerebrovascular;
- mummunan rauni na zuciya tare da cututtukan zuciya;
- koda na jijiyoyin bugun gini;
- cututtukan zuciya da na jijiyoyin jini;
- jijiyoyin jini;
- stenosis na mitral da aortic bawul;
- cututtukan zuciya na jini;
- raguwa a cikin yawan bugun jini;
- firamaren farko;
- rikice-rikice a cikin daidaitawar ruwa-electrolyte.
Musamman taka tsantsan lokacin ɗaukar miyagun ƙwayoyi ya kamata a lura a cikin marasa lafiya da ke fama da yaduwar ƙwayar cuta.
Yadda ake ɗaukar Lozap 50
Allunan ana daukarsu baka, ko da kuwa lokacin cin abinci. Haɗin maganin tare da wasu magunguna waɗanda ke rage matakin hawan jini yana yiwuwa.
Matsakaicin sigar magani na marasa lafiya waɗanda ba su da magungunan jituwar cuta shine 50 MG. Ana shan miyagun ƙwayoyi yau da kullun sau 1 a rana. Ana lura da tasirin sakamako mai ƙarfi tare da amfani da kullun na Lozap na kimanin wata 1.
Idan ya cancanta, yana yiwuwa a ƙara yawan yau da kullun zuwa 100 MG. Mutanen da ke da raguwa a cikin ƙwayar jini suna karɓar rabin adadin kashi. Marasa lafiya tare da rage aikin na koda suna buƙatar raguwa sashi.
A cikin rauni na zuciya, ana bada shawara don farawa tare da kashi na 12.5 MG. Tare da rashin isasshen tasiri, yana iya ƙaruwa kowane 7 bakwai. Yawan shan miyagun ƙwayoyi da aka cinye ya kamata ya kasance irin wannan cewa zai iya daidaita ma'auni tsakanin tasiri na jiyya da kuma rashin halayen halayen da ba za a rasa ba.
Allunan ana daukarsu baka, ko da kuwa lokacin cin abinci.
Shan maganin don ciwon sukari
Marasa lafiya da ke fama da rashin lafiyar insulin-insulin-mellitus na fara jiyya tare da daidaitaccen matakin. Wataƙila karuwarsa zuwa 100 MG / rana. Haɗuwa tare da insulin da sauran hanyoyi don sarrafa sukari na jini, diuretics baya kara haɗarin sakamako masu illa.
Side effects
Gastrointestinal fili
Maganin narkewa na iya amsawa ga magani:
- bayyanar jin zafi a cikin yankin epigastric;
- haushi;
- tashin zuciya
- amai
- rage cin abinci;
- gastritis;
- bloating;
- activityarin ayyukan enzymes na koda.
Hematopoietic gabobin
Wani lokacin lura:
- anemia
- raguwa a cikin haemoglobin;
- thrombocytopenia;
- eosinophilia.
Tsarin juyayi na tsakiya
Daga tsarin mai juyayi na iya faruwa:
- gajiya;
- Dizziness
- matsalar rashin bacci
- Lafiya;
- Damuwa
- paresthesia;
- tinnitus;
- asarar hankali;
- ciwon kai.
Daga tsarin urinary
Wasu lokuta abubuwanda zasu biyo baya:
- gazawar koda
- urinary fili cututtuka
Daga tsarin numfashi
Zai iya faruwa:
- kumburi da bronchi;
- pharyngitis;
- sinusitis
A ɓangaren fata
Akwai hadarin:
- erythema;
- aski;
- hankali na fitilar ultraviolet;
- bushe fata;
- rashes;
- hyperhidrosis.
Daga tsarin kare jini
Zai iya faruwa:
- erectile tabarbarewa;
- rashin ƙarfi.
Daga tsarin zuciya
Zai iya faruwa:
- karuwar zuciya;
- karuwar zuciya;
- rushewar orthostatic;
- bradycardia;
- jin zafi a bayan sternum;
- vasculitis;
- hanci.
Daga tsarin musculoskeletal
Ana iya haɗuwa da jiyya tare da waɗannan sakamakon da ba a so:
- lumbalgia;
- katsewa
- ciwon tsoka;
- hadin gwiwa zafi.
Daga gefen metabolism
Sauran sakamako masu illa na iya faruwa:
- matakan haɓaka na potassium a cikin jini na jini;
- karuwar creatinine;
- hyperbilirubinemia.
Cutar Al'aura
Zai iya faruwa:
- halayen anaphylactic;
- angioedema;
- hanawar tagulla.
Umarni na musamman
Amfani da barasa
Ba'a ba da shawarar a hada Lozap da barasa ba. Barasa na iya haifar da raguwa game da tasirin magani.
Ba'a ba da shawarar a hada Lozap da barasa ba.
Tasiri kan ikon sarrafa abubuwan inji
Ba a gudanar da bincike na musamman ba. Wajibi ne a ƙi yin ayyukan haɗari waɗanda ke buƙatar haɓakar maida hankali idan akwai sakamako masu illa daga tsarin mai juyayi.
Yi amfani da lokacin daukar ciki da lactation
Ba'a ba da shawarar yin magani ga mata masu juna biyu ba. Babu wani ingantaccen bayanai akan ko Lozap yana da tasirin teratogenic akan tayin, amma saboda karuwar haɗarin sakamako masu illa, ba a amfani dashi a wannan rukunin marasa lafiya.
Mata masu juna biyu waɗanda a da suka karɓi rigakafin ACE a can ya kamata a sauya zuwa madadin magani. Wajibi ne a sauya maganin da wuri-wuri bayan gano gaskiyar daukar ciki.
Babu wani bayani game da rarraba kayan da ke aiki da madara. Rashin bayanai shine dalilin ƙi shan nono a cikin lura da mahaifiyar Lozap. Dole ne a canza yaro zuwa abinci mai wucin gadi.
Neman Lozap ga yara 50
Ba a ba da shawarar yin magani don magance yara da ke ƙasa da shekara 18 ba. A cikin wasu halaye, yana yiwuwa a yi amfani da magani don lura da hauhawar jini a cikin yara da suka girmi shekaru 6. Wa'adin Lozap har zuwa wannan zamanin yana contraindicated sosai, tun da babu bayanai game da amincin miyagun ƙwayoyi na wannan rukuni na marasa lafiya.
Lokacin da aka wajabta wa yara masu nauyin 20-50 kilogiram, sashi na yau da kullun shine the na daidaitaccen matakin girma. Wasu lokuta yana yiwuwa a rubanya 50 MG na Lozap. Mafi sau da yawa, ana sanya irin wannan sigar don marasa lafiya tare da nauyin jiki sama da 50 kg.
Yi amfani da tsufa
Ga mutane sama da 75, ana bada shawarar rage yawan magungunan yau da kullun zuwa 25 MG. Ana cigaba da sanya ido kan tasirin magani. Idan ya cancanta, likitan yana daidaita maganin.
Aikace-aikacen aiki mara kyau
Shan angiotensin-canza masu hana enzyme na iya kara dagula alamun cutar rashin haihuwa. An bayyana wannan ta hanyar karuwa a cikin haɗuwar creatinine da urea a cikin jini.
Amfani don aikin hanta mai rauni
Tare da gazawar hanta yayin lalata, canji a cikin taro na aiki mai aiki a cikin plasma mai yiwuwa ne.
Amfani da gazawar zuciya
Rashin lafiyar zuciya na yau da kullun yana haifar da haɗarin mummunan hypotension a cikin marasa lafiya suna shan Lozap. Ya kamata a kula da kulawa ta musamman yayin rubuta magunguna ga mutanen da suke da irin wannan matsala.
Yawan damuwa
Tare da yawan yawan wucewa na Lozap, raguwar alama a cikin karfin jini, haɓaka yawan zuciya yana faruwa. Ana cire cututtukan cututtukan ne ta hanyar alƙawarin cututtukan cututtukan cututtukan cututtukan ƙwaƙwalwa, da maganin cututtukan alamomi.
Yin hulɗa tare da wasu kwayoyi
Haɗin maganin tare da wasu magungunan antihypertensive zai yiwu. Yin amfani da haɗin gwiwa tare da maganin cututtukan cututtukan ƙwayoyin cuta da maganin rigakafi yana haɓaka sakamako mai illa.
Magunguna waɗanda ke shafar ayyukan CYP2C9 isoenzyme na iya ƙaruwa ko rage tasiri na maganin. Ba'a ba da shawarar haɗakar da ayyukan Lozap tare da kwayoyi, babban aiki wanda shine mahallin potassium.
Ba'a ba da shawarar haɗakar da gwamnati tare da angiotensin-canza masu hana enzyme.
Haɗin maganin tare da wasu magungunan antihypertensive zai yiwu.
Analogs
Ana amfani da wakilai masu zuwa don maye gurbin wannan magani:
- Angizap;
- Hyperzar;
- Closart;
- Cozaar;
- Xartan
- Losartan Sandoz;
- Losex;
- Lozap Plus;
- Lozap AM;
- Lorista
- Presartan;
- Pulsar
- Cibiyar;
- Tozaar;
- Rosan;
- Erinorm.
Rikicin Rasha na maganin zuma Lozap 50 na iya zama maganin Blocktran.
Rashoocin Rashanci na miyagun ƙwayoyi:
- Blocktran;
- Losartan Canon;
- Kwayar cuta
Sharuɗɗan hutu na Lozapa 50 daga magunguna
Sanya da takardar sayan magani
Zan iya siye ba tare da takardar sayan magani ba
A'a.
Farashi
Kudin ya dogara da wurin da aka siya.
Yanayin ajiya na miyagun ƙwayoyi
Dole ne a adana shi a zazzabi da bai wuce + 30 ° C ba.
Ranar karewa
Kasancewa ga yanayin ajiya, ana iya amfani da miyagun ƙwayoyi a cikin watanni 24 daga ranar da aka fito. Ba da shawarar ƙarin amfani ba.
Don maye gurbin magani Lozap 50 yi amfani da magani Presartan.
Masana'antu Lozap 50
An samar da samfurin wannan kamfanin ta Slovak kamfanin Saneca Pharmaceuticals.
Neman bita akan Lozap 50
Likitocin zuciya
Oleg Kulagin, masanin zuciya, Moscow
Lozap magani ne mai kyau don lura da hawan jini. Saboda gaskiyar tasirinsa baya da nasaba da dakatar da ayyukan ACE, yana da karancin sakamako masu illa. Kayan aiki yana buƙatar taka tsantsan a amfani. Ya kamata a gwada marasa lafiya da ke da rauni game da aiki na lokaci-lokaci domin su lura da yanayin jikin. Karka taɓa sayan wannan magani ba tare da tuntuɓar likita ba. Don gudanar da magani ba tare da sakamako masu illa ba zai taimaka kawai zaɓin sashi na daidai, wanda dole ne a danƙa wa kwararrun likita.
Ulyana Makarova, likitan zuciya, St. Petersburg
Kayan aiki yana taimakawa kawai tare da amfani da ya dace. An fuskance ta da lamura daban-daban a aikace. Patientaya daga cikin haƙuri tare da haguwar jini ventricular hagu ya yanke shawarar maganin kansa. Daidaitaccen matakin bai taimaka wajen sarrafa matakin matsin lamba ba, don haka ya fara shan allunan 3 a kowace rana. Ya ƙare duka a cikin bugun zuciya, sake tayarwa da mutuwa. Irin waɗannan lokuta suna da wuya, amma ana iya magance matsalolin kiwon lafiya idan kun bi shawarar likita da umarnin don amfani.
Marasa lafiya
Ruslan, 57 years old, Vologda
Na kasance ina shan losartan tsawon shekaru. Ba a taɓa samun sakamako masu illa ba yayin jiyya. Ana kiyaye matsin a cikin matsakaici na al'ada, amma dole ne in kara sashi zuwa matsakaicin. A hankali jiki ya saba da kowane magani, don haka nan bada jimawa ba zaku nemi wanda zai maye gurbin ku.
Lyudmila, yana da shekara 63, Samara
Ta lura da hauhawar jini ta amfani da hanyoyi da yawa. Lozap yayi amfani da shi shekaru biyu da suka gabata. A wani lokaci, matsin lambar ya tsaya, amma daga nan ya fara tashi sama. Likita ya maye gurbin maganin tare da wasu nau'in inhibitor na ACE, wanda na ɗauka tare da diuretics. Wataƙila maganin bai dace da yanayin kawai ba saboda tsananin cutar, amma ba zan iya ba da shawarar shi ba.
