Glimecomb wakili ne na yawan son zuciya a cikin nau'in ciwon sukari na 2 na ciwon sukari. Magunguna a layi daya yana inganta yanayin ƙirar mai, yana rage haɗarin filayen atherosclerotic a kan bangon jijiyoyin jiki, rage nauyin jiki a cikin kiba. An tsara miyagun ƙwayoyi ne kawai in babu tasirin rage cin abinci da motsa jiki.
Sunan kasa da kasa mai zaman kansa
Glyclazide + Metformin.
Glimecomb wakili ne na yawan son zuciya a cikin nau'in ciwon sukari na 2 na ciwon sukari.
ATX
A10BD02.
Saki siffofin da abun da ke ciki
Magungunan an yi su ne da nau'ikan farin allunan don amfani da bakin, ana nuna shi da launin shuɗi ko kirim mai tsini da kuma sifa mai fasalin-silili. Unitungiyar magunguna ta haɗo mahaɗan aiki guda 2: 40 MG na gliclazide da 500 MG na metformin hydrochloride. Povidone, magnesium stearate, sorbitol da sodium sodium suna aiki azaman abubuwan taimako. Allunan suna ƙunshe cikin raka'a 10 cikin fakiti mai laushi. A cikin wani kwali yalwatacce ne 6 blisters.
Aikin magunguna
Magungunan yana nufin haɗuwa da wakilai na hypoglycemic don maganin bakin. Magungunan yana da tasirin cutar kansa.
Glyclazide shine asalin tushen sulfonylurea. Hanyar aiwatar da aiki mai sunadarai ya samo asali ne daga haɓakar ayyukan ɓangarorin ƙwayoyin beta na pancreatic. Sakamakon sakamako na hypoglycemic, mai saurin ƙwaƙwalwar ƙwayoyin jikin mutum zuwa insulin yana ƙaruwa, samar da hormone yana ƙaruwa. Abubuwa masu aiki suna maido da farkon aikin tsibirin na Langerhans kuma ya gajarta lokacin daga lokacin cin abinci zuwa asirin insulin.
Glimecomb yana haɓaka asarar nauyi yayin da suke biye da abinci akan tushen kiba.
Baya ga shiga cikin metabolism, ƙwayar ta inganta ƙwaƙwalwar ƙwaƙwalwar ƙwayar cuta, rage ƙwayar platelet, ta hana haɓakar ƙwayar jijiyoyin bugun jini. A kan tushen ɗaukar Glimecomb, permeability na bangon jijiyoyin bugun gini an daidaita shi, an dakatar da microthrombosis da atherosclerosis, kuma an sake dawo da fibrinolysis na halitta. Maganin yana nuna adawa ga karuwar jijiyoyin jiki ga adrenaline a cikin microangiopathies. Yana inganta nauyi asara yayin bin abinci a bango mai kiba.
Metformin hydrochloride rukuni ne na biguanide. Kwayar aiki mai aiki yana rage yawan ƙwayar plasma na sukari ta hanyar dakatar da gluconeogenesis a cikin hepatocytes da rage ƙimar glucose a cikin ƙananan hanji. A sunadarai dauki bangare a cikin lipid metabolism, rage matakin low yawa lipoproteins, triglycerides da cholesterol a cikin jini. Zai taimaka rage jiki, amma in babu insulin a cikin warkarwa, ba a samun sakamako na warkewa. Yayin nazarin karatun asibiti, ba a ba da rikodin maganganun hypoglycemic ba.
Pharmacokinetics
| Gliclazide | Metformin |
| Tare da gudanarwa na baka, ana lura da babban adadin sha. Lokacin amfani da 40 MG, mafi girman yawan abin da ke cikin plasma an gyara shi bayan sa'o'i 2-3. Sadarwar tare da sunadaran plasma yana da girma - 85-97%. Sakamakon ƙirƙirar hadaddun abubuwan gina jiki, ana rarraba magunguna cikin hanzari cikin kyallen takarda. Tana aiwatar da canji a hepatocytes. Cire rabin rayuwa yana sanya awanni 8-20. An cire fitsari mai aiki a cikin fitsari da kashi 70%, tare da feces ta 12%. | Microvilli yana ɗaukar hanzari a cikin ƙananan hanji ta 48-52%. A bioavailability lokacin da aka ɗauke shi a kan komai a ciki shine 50-60%. Matsakaicin maida hankali ana samun sa'o'i 1-2 bayan gudanarwa. Tabbatar da furotin na Plasma yayi kadan. Ana lura da tarin ƙwayar sel. Rabin rayuwar shine awa 6.2. Magungunan yana kwance ta hanyar kodan a cikin asalin su kuma 30% ta cikin hanji. |
Ana amfani da maganin don magance nau'in ciwon sukari na 2.
Alamu don amfani
Ana amfani da miyagun ƙwayoyi don magance cututtukan type 2, lokacin da aka sami ƙarancin ƙarfin maganin maganin motsa jiki, aikin jiki da kuma maganin ƙwaƙwalwa tare da Metformin da Gliclazide.
Ana amfani da wakili na hypoglycemic a matsayin madadin magani na miyagun ƙwayoyi tare da kwayoyi 2 a cikin marasa lafiya na marasa lafiyar insulin-da ke fama da ciwon sukari na insellus, idan har ana sarrafa glucose na jini sosai.
Contraindications
Ba a ba da shawarar maganin don amfani ba a cikin waɗannan lambobin:
- nau'in ciwon sukari na 1;
- lactic acidosis;
- ƙananan matakan potassium na plasma;
- coma mai ciwon sukari, precoma;
- mai ciwon sukari mai ciwon sukari;
- tsari mai zurfi a cikin kodan da cututtukan da ke rushe aikin gabobin (fitsari, matsanancin kamuwa da tsari, kumburi);
- porphyria;
- shan miconazole;
- ba daidai ba aikin hanta;
- bugun zuciya, matsananciyar oxygen, gazawar numfashi, karancin zuciya;
- maye giya, bayyanar cututtuka;
- yanayi wanda insulin farji ya zama dole (raunin da ya biyo bayan rauni, lokacin farfadowa bayan yawan tiyata, ƙonewa);
- kasa da awanni 48 kuma cikin kwanaki 2 bayan daukar hoto ta amfani da bambancin aidin;
- rage cin abinci mai kalori kuma idan aka dauki kasa da 1000 kcal a rana;
- rashin kulawa na jikin mai haƙuri zuwa abubuwan da ke cikin miyagun ƙwayoyi.
Bugu da ƙari, ba a ba da shawarar yin amfani da maganin don tsofaffi masu aiki a cikin yanayin tsananin ƙarfin jiki ba, saboda yuwuwar ci gaban lactic acidosis.
Dole ne a yi taka tsantsan idan akwai zazzabi, dysfunction adrenal, kuskuren aiki na kashin baya, glandon thyroid.
Yadda ake shan glimecomb
Magungunan an yi shi ne don gudanar da maganin baka a lokacin abinci ko kai tsaye bayan abinci. Jima'i na lokacin magani yana ƙaddara ta hanyar halartar likitan halartar, saita tsarin maganin mutum dangane da yawan sukari a cikin jini.
Tare da ciwon sukari
Singleari guda a matakin farko na maganin shine 540 MG na allunan tare da mitar gudanarwa kowace rana har zuwa sau 1-3. A mafi yawan lokuta, ana shan maganin sau 2 a rana - da safe da kuma kafin lokacin kwanciya. Ana zaɓi ƙimar yau da kullun a hankali har sai an ci gaba da biyan diyya na hanyoyin cututtukan.
Sakamakon sakamako na glimecomb
Abubuwan da ba su dace ba a jikin mai haƙuri suna haɓakawa tare da gudanar da maganin mara kyau ko a kan asalin cututtukan sakandare.
Magungunan an yi shi ne don gudanar da maganin baka a lokacin abinci ko kai tsaye bayan abinci.
Gastrointestinal fili
Abubuwan da ke haifar da sakamako a cikin tsarin narkewa kamar:
- dyspepsia, matsalar narkewar abinci;
- jin nauyi a cikin ciki;
- tashin zuciya, amai;
- zafin epigastric;
- bayyanar dandano na karfe akan tushen harshe;
- rage cin abinci.
A cikin mafi yawan lokuta, ayyukan hepatocytic aminotransferases, alkaline phosphatase suna haɓaka. Wataƙila ci gaban hyperbilirubinemia har zuwa abin da ya faru na cholestatic jaundice, yana buƙatar dakatar da miyagun ƙwayoyi.
Hematopoietic gabobin
A miyagun ƙwayoyi na iya haifar da hana ayyukan jan kashi, a sakamakon abin da yawan sifa abubuwa na jini suke raguwa, agranulocytosis, hemolytic anemia tasowa.
Tsarin juyayi na tsakiya
Wataƙila raguwa a cikin ƙwarewar gani, ciwon kai.
Daga tsarin zuciya
Arrhythmia, tsinkaye jini ya kwarara.
Tsarin Endocrin
Idan aka keta tsarin allurar dosing kuma ba a bi abincin ba, haɗarin hauhawar jini yana ƙaruwa, wanda ke tattare da rauni mai rauni, raunin juji na wucin gadi, ƙara yawan shaye-shaye, asarar sarrafa hankali, rikicewa da rikicewar rikicewar cuta.
Daga gefen metabolism
A ƙarshen bango na rikicewar rayuwa, lactic acidosis na iya bayyana. Ana nuna yanayin aikin jijiya ta rauni, matsanancin ciwo a cikin tsokoki, gazawar numfashi, zafi a ciki, rage zafin jiki da raguwar hauhawar jini, da bradycardia.
Cutar Al'aura
Ana bayyanar da halayen anaphylactoid zuwa abubuwan da ke haifar da maganin sulfonylurea ta hanyar rashin lafiyar cututtukan vasculitis, urticaria, macula, kurji da pruritus, cututtukan Quincke, tashin hankalin anaphylactic.
Tasiri kan ikon sarrafa abubuwan inji
A yayin jiyya tare da Glimecomb, dole ne a kula da hankali lokacin tuki, yana aiki tare da keɓaɓɓun hanyoyin da sauran ayyukan da ke buƙatar taro daga haƙuri.
Umarni na musamman
Lokacin ɗaukar magungunan sulfonylurea, akwai haɗarin haɓaka mai ƙarfi da tsawanta, wanda ke buƙatar kulawa ta musamman a cikin tsakaitattun wurare da gudanarwar cikin jijiya na 5% na glucose bayani na kwanaki 4-5.
Hadarin kamuwa da cutar ya haɓaka tare da ƙarancin abinci, da tsawan aikin jiki ko kuma tare da gudanar da magunguna na cututtukan cututtukan fata da yawa. Don rage yiwuwar hanyar cututtukan cututtukan cuta, yakamata mutum yabi shawarar shawarwarin da aka haɗa akan magungunan kuma samun cikakkun bayanai yayin tattaunawa tare da likitan halartar.
Ana buƙatar gyaran gyangya don wucewa ta jiki da ta motsa jiki ko canje-canje a cikin abinci.
Yi amfani da tsufa
Mutanen da shekarunsu suka wuce 60 bai kamata su sha maganin ba a gaban tsananin aikin jiki saboda karuwar haɗarin lactic acidosis.
Aiki yara
Ba a ba da shawarar yin amfani da maganin ba har sai da ya kai shekara 18.
Ba a ba da shawarar yin amfani da maganin ba har sai da ya kai shekara 18.
Yi amfani da lokacin daukar ciki da lactation
Lokacin da ciki ya faru, Glimecomb ya kamata a maye gurbin shi da maganin insulin, saboda tsinkaye tsinkaye na abubuwa masu aiki ta hanyar shinge yana yiwuwa. Babu bayanai game da tasirin teratogenic na mahaɗan aiki guda biyu.
Glyclazide da metformin za a iya cire su a cikin madarar uwa, sabili da haka, a yayin jiyya tare da wakili na hypoglycemic, dole ne a soke lactation.
Aikace-aikacen aiki mara kyau
An sanya maganin a cikin yanayin koda ba daidai ba ne da cutar amai da gudawa.
Amfani don aikin hanta mai rauni
An haramta magungunan tare da aikin hanta mara kyau.
Cutar Glimecomb
Tare da cin zarafin miyagun ƙwayoyi, lactic acidosis da halin hypoglycemia na iya haɓaka. Idan akwai alamun lalatattun lactic acid na kyallen takarda, dole ne a kira motar asibiti nan da nan don wanda aka azabtar. A cikin yanayin tsaye, hemodialysis yana da tasiri.
Idan akayi asarar rai, toshewar ciki na maganin 40% na glucose yana da matukar muhimmanci ko a cikin kashin kansa.
Idan akayi asarar rai, na cikin farji na maganin 40% na glucose, glucagon, intramuscularly ko subcutaneously, ya zama dole. Bayan kwanciyar hankali, mai haƙuri yana buƙatar abinci mai gina jiki na carbohydrate.
Yin hulɗa tare da wasu kwayoyi
Lokacin shan wasu kwayoyi a layi daya tare da Glimecomb, ana lura da halayen masu zuwa:
- Effectarfafa tasirin warkewa a hade tare da captopril, coumarin anticoagulants, beta-blockers, bromocriptine, antifungal jamiái, salicylates, fibrates, MAO inhibitors, maganin tetracycline, magungunan anti-mai hana kumburi da maganin tarin fuka.
- Glucocorticosteroids, barbiturates, antiepileptic kwayoyi, alluran tubule alli, thiazide, diuretics, Terbutaline, Glucagon, Morphine suna ba da gudummawa ga raguwar aikin hypoglycemic.
- Cardiac glycosides yana ƙaruwa da yiwuwar ventricular extrasystole, yayin da rage zubar jini a cikin kashi, ƙara haɗarin myelosuppression.
Magungunan yana rage ƙwayar plasma na Furosemide da kashi 31% kuma rabin rayuwarsa da kashi 42%. Nifedipine yana ƙaruwa da yawan narkewar metformin.
Magungunan yana rage ƙwayar plasma na Furosemide da kashi 31% kuma rabin rayuwarsa da kashi 42%.
Amfani da barasa
An haramtawa shan giya sosai yayin lokacin jiyya. Ethanol yana haifar da haɗarin haɗarin maye da ci gaban lactic acidosis. Ethanol yana ƙaruwa da rashin yiwuwar bunkasa haɓakar ƙwayar cuta.
Abinda za'a maye gurbin
Analogues na miyagun ƙwayoyi, mai kama da sifofin sunadarai da kaddarorin magunguna, sun haɗa da:
- Diabefarm;
- Glyformin;
- Gliclazide MV.
Canza zuwa wani magani yana yiwuwa a cikin rashin sakamako na warkewa daga shan Glimecomb kuma a ƙarƙashin tsananin kulawa daga likitan halartar.
Magunguna kan bar sharuɗan
Ana sayar da maganin ta hanyar takardar sayan magani.
Zan iya siye ba tare da takardar sayan magani ba
An haramta sayar da magani kyauta saboda karuwar haɗarin hypoglycemia lokacin ɗaukar matakin da ba daidai ba.
Farashin Glimecomb
Matsakaicin farashin kwamfutar hannu shine 567 rubles.
Yanayin ajiya na miyagun ƙwayoyi
Ya kamata a adana magungunan ta hanyar isa ga yara, a cikin bushe, wuri mai duhu a zazzabi da bai wuce + 25 ° C ba.
Ranar karewa
Shekaru 2
Mai masana'anta
Na'urar kemikal da magunguna "AKRIKHIN", Russia.
An haramta sayar da magani kyauta saboda karuwar haɗarin hypoglycemia lokacin ɗaukar matakin da ba daidai ba.
Nazarin masu ciwon sukari na Glimecomb
Arthur Kovalev, dan shekara 40, Moscow
Don nau'in ciwon sukari na 2, Ina ɗaukar allunan Glimecomb kusan shekara guda. Yawan jikin mutum bai ragu ba, saboda bayan shan magungunan da kake son ci. Amma bayan na sha kwayoyin a maraice kafin lokacin kwanciya, yanayin yakan zama daidai. Da safe, sukari ya bambanta daga 6 zuwa 7.2 bayan shan kwaya tare da karin kumallo.
Kirill Gordeev, mai shekara 29, Kazan
Magungunan suna da kyau yana rage sukarin jini. Na karba na tsawon watanni 8. Na kuma sanya allurar insulin. Bayan katsewa a cikin samar da kwayar, sai da na sha wasu kwayoyin magani na dan lokaci, amma sun nuna ingantaccen aiki. Soda ya kasance a matakin daidai, duk da aikin hanta mai rauni a cikin yanayin na.
Likitoci suna bita
Marina Shevchuk, endocrinologist, 56 years old, Astrakhan
Magungunan da ke kan asalin nau'in ciwon sukari na 2 yana biya glycemia da kyau. Sakin gyare-gyaren na iya rage haɗarin ci gaba da cututtukan cututtukan zuciya, wanda shine dalilin da ya sa tsofaffi marasa lafiya da mutanen da ke fama da cututtuka na tsarin zuciya da jijiyoyin jini na iya ɗaukar magani. Ina yin amfani da magani a kai a kai a cikin aikina na asibiti tare da zaɓin kowane ɗayan. Pricearancin farashi tare da babban aiki.
Evgenia Shishkina, endocrinologist, 45 years old, St. Petersburg
Magungunan yana da tasiri mai laushi da tasiri. Yana taimakawa rage jini. A lokacin jiyya, yana da mahimmanci a bi tsarin abinci, amma a ci a kai a kai, haka kuma motsa jiki. Ba a lura da sakamako masu illa tare da yin biyayya ga tsari irin na dosing ba. Ayyukan miyagun ƙwayoyi yana farawa a cikin gajeren lokaci. Magungunan ya kafa kansa a kasuwa don ciwon sukari.
