Baeta Long yana cikin rukunin wakilai na hypoglycemic don gudanar da aikin parenteral. An sanya allura a karkashin fata. Hanyar aikin ta dogara ne da kundin kayan aikin magunguna na exenatide, wanda ke aiki akan masu karɓar glucagon-like peptide-1. Abubuwan da ke aiki zasu iya haɓaka haɓakar insulin kafin glucose ya ci daga abinci. A lokaci guda, ayyukan hormonal na sel na kashin baya yana raguwa lokacin da aka cimma matakan sukari na al'ada na jini.
Sunan kasa da kasa mai zaman kansa
Exenatide.
Baeta Long yana cikin rukunin wakilai na hypoglycemic don gudanar da aikin parenteral.
ATX
A10BJ01.
Saki siffofin da abun da ke ciki
Ana yin magungunan a cikin wani nau'in farin foda don ƙirƙirar allurar subcutaneous. Magungunan suna da tasiri na tsawan lokaci. Ana sayar da foda cikakke tare da sauran ƙarfi. Na karshen shine bayyananne ruwa mai santsi tare da launin shuɗi ko launin ruwan kasa. Foda ya ƙunshi 2 MG na abu mai aiki - exenatide, wanda aka haɗu tare da sucrose da polymer azaman kayan taimako.
A sauran ƙarfi ya ƙunshi:
- croscarmellose sodium;
- sodium chloride;
- sodium dihydrogen phosphate a cikin nau'i na monohydrate;
- bakararre ruwa don allura.
Aikin magunguna
Magungunan yana cikin rukunin ƙwararrun liketine - GLP-1. Lokacin da glucagon-kamar peptide-1 aka kunna, exenatide yana haɓaka insulin hormonal na insulin ta hanyar ƙwayoyin beta na pancreatic kafin abincin da aka yi niyya. Maganin yana rage jinkirin narkewar ciki idan ya shiga cikin jini. Abunda yake aiki na Baeta yana inganta halayyar kyallen takarda zuwa aikin insulin, ta haka za'a iya sarrafa glycemic iko akan asalin cutar sankara mara nauyi. Samun insulin yana tsayawa lokacin da matakin sukari na jini ya faɗi zuwa al'ada.
Karatuttukan asibiti sun nuna cewa gudanar da abinci na rage abinci da rage cin abinci.
Exenatide a cikin tsarin sunadarai ya bambanta da tsarin kwayar halitta na insulin, abubuwan da suka samo asali na D-phenylalanine da sulfonylurea, alpha-glucosidase blockers kuma daga thiazolidinediones. Magungunan ƙwayoyi suna inganta aikin tsibirin Langerhans na ƙwayar cuta. A wannan yanayin, exenatide yana hana ɓoyewar glucagon.
A cikin karatuttukan asibiti, an gano cewa gudanar da maganin kashe wutar lantarki yana rage yawan ci da rage cin abinci, yana hana motsin ciki. Abubuwan da ke aiki suna haɓaka tasirin hypoglycemic na sauran jami'ai masu maganin cututtukan ƙwayar cuta.
Pharmacokinetics
Tare da gudanar da aikin subcutaneous, miyagun ƙwayoyi suna tarawa cikin ƙwayar jini ba tare da fuskantar biotransformation ba a cikin ƙwayoyin hanta. Matsakaicin girma na rarraba exenatide shine kimanin lita 28. Abubuwa masu aiki suna barin jiki ta amfani da gurɓataccen dunƙule ta cikin kodan, daga nan sai ya bi bayanta ta kare. Magungunan gaba daya an cire su ne sati 10 kacal bayan karshen jiyya.
Wani hypoglycemic wakili wajibi ne don rage taro taro na sukari a cikin jini tare da type 2 ciwon sukari.
Bayanai Baeta Tsayi
Wani hypoglycemic wakili wajibi ne don rage taro taro na sukari a cikin jini tare da type 2 ciwon sukari. An hana shi sosai don gudanar da maganin don kamuwa da cutar 1. Ana amfani da miyagun ƙwayoyi tare da ƙarancin tasiri na matakan don rage wuce kima: ƙarin motsa jiki, abincin abinci na musamman.
Contraindications
Magungunan yana contraindicated a cikin mutane da:
- ciwon sukari da ke dogaro da insulin;
- bayyanar sirri na mutum zuwa ƙarin abubuwa masu aiki na miyagun ƙwayoyi;
- mai rauni na koda.
- mai tsanani halayen mahaifa huhun jijiya na narkewa kamar jijiyoyi;
- mai ciwon sukari mai ciwon sukari;
- yara ‘yan kasa da shekara 18;
- mata masu juna biyu da masu shayarwa.
Yadda ake ɗaukar Baetu Long
Ana gudanar da maganin a karkashin cinya a cinya, bangon ciki da na fata a karkashin fata sama da tsoka ko a cikin goshin.
Sashi a matakin farko na farji ya kai 5 MG, mita na sarrafawa kowace rana - sau 2. Dole ne a yi amfani da miyagun ƙwayoyi a cikin mintina 60 kafin fara abincin azumi. An bada shawarar bayar da allura kafin karin kumallo da kuma abincin dare. Wata daya bayan fara maganin ƙwaƙwalwa tare da haƙuri mai kyau, ana ba da izinin ƙarawa zuwa 10 MG don gudanarwa sau 2 a rana.
Abun sakamako Baeta Long
Sakamakon sakamako na amfani da miyagun ƙwayoyi na iya lalacewa ta hanyar rashin amfani da magani ko hulɗa mara kyau da wani magani. Dole ne a sanar da halayen da ba ku da matsala ga likitanka.
Gastrointestinal fili
Lokacin amfani da Byeta azaman monotherapy, haɓakar:
- tashin zuciya
- amai
- maƙarƙashiya
- tsawan zawo;
- rage cin abinci, anorexia;
- dyspepsia.
A haɗuwa da jiyya, ƙarar da aka bayyana tana haɗuwa da haɓakar haɗarin rauni na ciki da duodenum, kumburi da farji, ƙoshin ɗanɗano, bayyanar zafin da ɗinka, ɓarna, ɓacin zuciya.
Hematopoietic gabobin
Tare da hanawa daga tsarin toshe jini, yawan tattarawar sel ya ragu.
Tsarin juyayi na tsakiya
Abubuwan da ke haifar da lalacewar tsarin juyayi suna bayyana a cikin nau'i na tsananin farin ciki, ciwon kai, rauni da kuma bayyanar rashin nutsuwa. A cikin lokuta mafi wuya, gogewar rawar jiki ta bayyana.
Daga tsarin urinary
Tare da amfani da lokaci daya tare da wasu kwayoyi, ci gaban lalacewa na koda ko kuma yanayinsa mai yiwuwa ne. Wataƙila karuwa a cikin taro maida hankali akan kwayoyin halitta.
Tsarin Endocrin
Tare da zagi da miyagun ƙwayoyi, hypoglycemia na iya haɓaka. Musamman tare da amfani da layi daya na amfani da sulfonylureas.
Tare da zagi da miyagun ƙwayoyi, hypoglycemia na iya haɓaka.
Cutar Al'aura
Allergic halayen ana halin da ci gaban fitsari fata, itching, angioedema, urticaria, gashi asarar, anaphylactic shock.
Tasiri kan ikon sarrafa abubuwan inji
Magungunan ƙwaƙwalwar ƙwayar cuta ba ta da tasiri a cikin aikin hankali, ƙwarewar motsa jiki da tsarin juyayi. Sabili da haka, yayin lokacin jiyya an ba shi izinin yin aiki tare da kayan aiki masu rikitarwa, tuki da sauran ayyukan da ke buƙatar babban saurin halayyar jiki da tunanin mutum, maida hankali.
Umarni na musamman
Ana ba da shawarar Exenatide bayan cin abinci. Haramun ne a sanya allurar ciki da ciki.
Abubuwan da ke tattare da magani suna da yuwuwar immunogenicity, saboda wanda jikin mai haƙuri, a gaban yanayin rashin hankali, na iya samar da ƙwayoyin rigakafi a kan abubuwan da ke aiki. A mafi yawancin halaye, titin na rigakafi yana da ƙanƙantar da kai kuma ba ya haifar da ci gaba da halayen anaphylactic. A cikin makonni 82 na maganin ƙwaƙwalwar ƙwayar cuta, an lura da raguwar hankali a cikin amsawar rigakafi, sabili da haka, ƙwayar ba ta haifar da barazanar rayuwa ba dangane da yiwuwar ci gaban tashin hankali na anaphylactic.
Haramun ne a sanya allurar ciki da ciki.
A cikin halayen da ba kasafai ba, exenatide na iya rage jinkirin kasalar da jijiyoyin jiki mai sanyin jijiya. Don haka, yin amfani da magungunan da ke haɗuwa da kwayoyi waɗanda ke hana motsin hanji ko kuma buƙatar ɗaukar hanzari daga hanjin narkewa ba da shawarar ba.
Bayan dakatar da ilimin magani, tasirin hypotensive na iya tsawan lokaci mai tsawo, saboda matakin exenatide a cikin plasma yana raguwa tsawon makwanni 10. Idan, bayan dakatar da maganin, likitan ya sake tsara wani magani, yana da mahimmanci a faɗakar da ƙwararrun masanan game da gwamnatin ta Baeta ta baya. Wannan ya zama dole don nisantar abin da ya faru na mummunan halayen.
A cikin aikin asibiti, akwai lokuta na asarar nauyi mai nauyi (kusan 1.5 kilogiram a mako ɗaya) yayin kulawa da exenatide. Ragewa mai nauyi a cikin nauyin jiki na iya haifar da mummunan sakamako: hawa da sauka a cikin yanayin hormonal, haɓakar haɗarin cututtukan zuciya, ci gaba, rashin ci gaba, rashin yiwuwar faduwar koda. Tare da asarar nauyi, ya zama dole don sarrafa alamun cholelithiasis.
Yi amfani da tsufa
Mutane sama da 60 da haihuwa ba sa buƙatar ƙara gyaran tsarin kulawa.
Mutane sama da 60 da haihuwa ba sa buƙatar ƙara gyaran tsarin kulawa.
Aiki yara
An haramta amfani da miyagun ƙwayoyi a cikin ƙuruciya saboda rashin bayanai game da tasirin magani a cikin ci gaban jikin mutum har zuwa shekaru 18.
Yi amfani da lokacin daukar ciki da lactation
A lokacin gwaje-gwajen daidaituwa na miyagun ƙwayoyi a cikin dabbobi, an bayyana sakamako mai guba a kan gabobin ciki na mahaifiyar da kuma tasirin teratogenic akan tayin. Lokacin amfani da miyagun ƙwayoyi ta hanyar mata masu juna biyu, rikicewar ciki, damuwa a cikin ci gaban gabobin da kyallen takarda yayin embryogenesis na iya faruwa. Don haka, haramun ne yin amfani da Baeta ga mata yayin daukar ciki.
Yayin magani tare da maganin cututtukan jini, an bada shawarar soke shayarwa saboda yuwuwar cututtukan jini a cikin yarinyar.
Aikace-aikacen aiki mara kyau
Lokacin amfani da miyagun ƙwayoyi a cikin marasa lafiya da gazawar haɓaka mai yawa, an lura da karuwar haɗarin halayen halayen ƙwayar gastrointestinal. Musamman tare da keɓantaccen creatinine a ƙasa 30 ml / min. Dangane da haka, an haramta yin amfani da yanki na Baeta ga mutanen da ke da lalata game da batun haya
Magungunan yana contraindicated don amfani da mutane tare da mummunar cutar hanta.
Amfani don aikin hanta mai rauni
Magungunan yana contraindicated don amfani da mutane tare da mummunar cutar hanta.
Yawan damuwa
A cikin aiwatar da tallan bayan-bayan, akwai lokuttan yawaitar yawan maye, hoton asibiti wanda ya kasance ci gaban tashin hankali da tashin zuciya. A wannan yanayin, an wajabta mai haƙuri magani don mayar da hankali ga kawar da bayyanar cututtuka. Don rage yiwuwar yawan shan ruwa, kar a cutar da magani. Idan babu aiwatar da aikin hypoglycemic, ya zama dole don canzawa zuwa canji na warkewa, haɓaka mai zaman kanta a cikin sashi ko tazarar sarrafawar Bayeta yana tazara. Matsakaicin yawan amfani shine sau 2 a rana.
Yin hulɗa tare da wasu kwayoyi
Exenatide, lokacin da aka ba shi hadin kai tare da Digoxin, yana rage matsakaicin adadin magudanar ta karshen ta 17%, lokacin da zai isa wurin ya karu da awa 2.5. Haka kuma, irin wannan maganin hadewar ba ya tasiri da lafiyar mutum na gaba daya kuma an ba shi izinin amfani.
Tare da gudanarwa na lokaci ɗaya na Baeta Long tare da Lovastatin, ana lura da raguwa a cikin matsakaicin matakan plavma na Lovastatin da kashi 28%, lokacin zuwa isa Cmax yana ƙaruwa da sa'o'i 4. Tare da irin wannan canji a cikin sigogin kantin magani, gyaran tsarin allurai na magunguna wajibi ne.
Exenatide, lokacin da aka ba shi hadin kai tare da Digoxin, yana rage matsakaicin adadin magudanar ta karshen ta 17%, lokacin da zai isa wurin ya karu da awa 2.5.
Shan Htr-CoA reductase inhibitors baya shafar metabolism din mai. Babu canje-canje a cikin taro na Exenatide a hade tare da Metformin, Thiazolidinedione.
A cikin marasa lafiya suna shan 5-20 MG na rana na Lisinopril don daidaita yanayin hawan jini, yayin da aka yi amfani da exantide, lokacin ya isa zuwa matakin plasma mafi girma na lisinopril. Canje-canje a cikin sigogin magunguna
Lokacin da aka haɗa shi da warfarin a cikin karatun bayan-bayan-tallace, shari'o'in haɓakawa na zubar jini na ciki da haɓaka a cikin lokacin don isa zuwa mafi yawan warfarin cikin sa'o'i 2. Ba'a bada shawarar wannan haɗin azaman magani na haɗin kai ba. Idan ya cancanta, a matakin farko na magani, mai haƙuri yana buƙatar sarrafa matakin coumarin da kuma abubuwan da aka samo daga warfarin a cikin jini.
Amfani da barasa
Ba'a yarda da maganin cututtukan hypoglycemic don amfani da alamun cirewa ba. A lokacin jiyya, an haramta shi sosai don shan giya. Ingan giya na Ethyl zai iya saurin yiwuwar haɓaka ƙarancin ƙwayar cuta da sauran halayen marasa kyau. Ethanol yana da mummunar tasiri a cikin ƙwayoyin hanta, yana kara haɗarin haɓakar mai ƙima.
Analogs
Bayetu Long tare da raunin rashin warke ko rashi mai rauni ana iya maye gurbin shi da ɗayan magungunan masu zuwa waɗanda ke da tasirin sakamako na hypoglycemic:
- Baeta;
- Exenatide;
- Victoza;
- Forsyga;
- NovoNorm.
Magunguna kan bar sharuɗan
An hana sayar da magani kyauta ba tare da shawarar likita an haramta ba.
Zan iya siye ba tare da takardar sayan magani ba
Sakamakon yiwuwar haɓakar hypoglycemia lokacin da aka ɗauka ba tare da alamun likita kai tsaye ba, ba za ku iya siyan magani ba tare da takardar izinin likita ba.
Farashi
Matsakaicin farashin maganin a cikin kasuwar magunguna ya bambanta daga 5 322 zuwa 11 000 rubles.
Yanayin ajiya na miyagun ƙwayoyi
An bada shawara don ɗaukar foda na magani a wani wuri da keɓe daga haɗuwa da hasken rana, a zazzabi na + 2 ... + 8 ° C. Bayan buɗe kunshin, ajiya a yanayin zafi har zuwa + 30 ° C don ba fiye da makonni 4 ba.
Ranar karewa
Shekaru 3
Mai masana'anta
Amilin Ohio Electric, Amurka.
Idan aka haɗu da warfarin, nazarin kan sayar da labarai sun tattara maganganu na zubar jini a ciki.
Nasiha
Miroslav Belousov, dan shekara 36, Rostov-on-Don
Ina da ciwon sukari da ba na insulin ba. Na dauki Bayetu tare da allura na insulin har kusan shekara guda. Magungunan suna tasiri sosai tare da aikinta - sukari daga 13 mmol sun daidaita zuwa 6-7 mmol. An sami cikas a cikin isar da insulin zuwa cikin garin, Dole ne kawai in sanya allurai na cutarwa na Bayeta. Suga ya kasance al'ada. Ina da cutar hanta a lokaci guda, don haka na nemi shawarata tare da likitan na kafin amfani da miyagun ƙwayoyi. Baeta bai cutar da cutar ba, saboda haka na bar kyakkyawan nazari.
Evstafy Trofimov, dan shekara 44, St. Petersburg
A wani gwajin likita na gaba ya bayyana darajar sukarin jini. Manuniya sun tashi saboda tsananin damuwa. An gano mu da ciwon sukari na 2. Anyi allurar rigakafin Baeta Long. Zai fi dacewa a sanya fata a ƙarƙashin fata tare da alƙalami na syringe. Na shafe watanni 6 ina gudanar da wannan maganin. Magungunan kanta ba ya aiki. Lokacin da ake shan magani, ana buƙatar abinci na musamman da aikin jiki. Sannan sukari ya rage zuwa al'ada. Na lura cewa a yayin jiyya na rasa kilogiram 11 na wuce haddi, hawan jini ya ragu. Yana da muhimmanci a bayar da allura gwargwadon umarnin.
Natalya Solovyova, dan shekara 34, Krasnoyarsk
Ina da ciwon sukari na 2 Exenatide injections sa kusan shekara guda. Weight bai ragu ba. Bayan allurar maraice, ci yana tashi kuma kuna son ku ci abin da bai tsaya ba. Wannan irin tasirin gefen. Idan kun mallaki kanku, to, sukari ya kasance al'ada.Ina ba da shawarar mutane masu irin wannan matsala tare da karuwa don ci don tafiya don kawar da jaraba. Da safe, sukari yana cikin kewayon 6-7.2 mmol. Kadai mai jan hankali shine babban farashin.
