Galvus yana nufin magungunan kwayar halitta waɗanda ke da tasirin sakamako mai hauhawar jini. Babban abu mai amfani da maganin shine Vildagliptin.
Ana amfani da miyagun ƙwayoyi don daidaita sukarin jini kuma marasa lafiya suna dauke da cutar sukari.
Abun ciki, tsari na saki da aikin magani
Babban sashi na wannan maganin shine allunan. Sunan kasa da kasa shine Vildagliptin, sunan cinikayyar shine Galvus.
Babban nuni ga shan maganin shine kasancewar nau'in ciwon sukari na 2 a cikin mutum. Kayan aiki yana nufin magungunan hypoglycemic da masu haƙuri ke ɗauka don rage taro na sukari a cikin jini.
Babban abu na miyagun ƙwayoyi shine vildagliptin. Hankalinsa shine 50 MG. Elementsarin abubuwa sune: magnesium stearate da sitaci carboxymethyl sitaci. Wani abu mai ratsa jiki shine shima lactose anccrous lactose da microcrystalline cellulose.
Ana samun maganin ta hanyar allunan da aka sha a baka. A launi daga cikin Allunan jere daga fari zuwa kodadde rawaya. Filin allunan suna da kyau kuma sunyi laushi tare da kasancewar bevels a gefuna. A jikin bangarorin biyu a jikin kwamfutar hannu rubutun suna: "NVR", "FB".
Galvus yana samuwa a cikin nau'i na blister don 2, 4, 8 ko 12 a cikin kunshin ɗaya. 1 blister ya ƙunshi allunan 7 ko 14 na Galvus (duba hoto).
Amfanin Vildagliptin, wanda shine ɓangare na miyagun ƙwayoyi, yana tayar da kayan aiki na islet na ƙwanƙwasa, yana rage aikin aikin enzyme DPP-4 kuma yana ƙara haɓaka ƙwayoyin β-sel zuwa glucose. Wannan yana inganta kwayar cutar insulin.
Halin ƙwayoyin sel-haɓaka an inganta shi don la'akari da matsayin lalacewarsu ta farko. A cikin mutumin da bashi da ciwon suga, asirin insulin ba ya motsawa sakamakon shan maganin. Abun yana inganta tsarin glucagon.
Lokacin ɗaukar Vildagliptin, matakan lipids a cikin jini yana raguwa. Yin amfani da miyagun ƙwayoyi a matsayin wani ɓangare na monotherapy, kamar yadda a cikin haɗin tare da Metformin, don kwanaki 84-365 yana haifar da raguwa a cikin matakan glucose da haemoglobin na glycated a cikin jini.
Pharmacokinetics
Magungunan da aka ɗauka a kan komai a ciki suna tunawa cikin minti 105. Lokacin shan miyagun ƙwayoyi bayan cin abinci, shanshi ya ragu kuma yana iya kaiwa awa 2.5.
Ana amfani da Vildagliptin ta hanyar shaƙar sauri. A bioavailability na miyagun ƙwayoyi ne 85%. Cakudawa cikin abubuwan da ke tattare da magani a cikin jini ya dogara da matakin da aka dauka.
Ana amfani da miyagun ƙwayoyi ta ƙarancin digiri na ɗaukar nauyin sunadaran plasma. Matsakaicinsa shine 9.3%.
Abubuwan an cire su daga jikin mai haƙuri tare da tsarin rayuwa. An nuna mata kashi 69% na maganin da aka dauka. 4% na miyagun ƙwayoyi da aka dauka suna shiga cikin amsar hydrolysis.
Kashi 85% na miyagun ƙwayoyi an cire shi daga jiki ta hanta, sauran 15% na hanji. Rabin rayuwar miyagun ƙwayoyi ya kai kimanin sa'o'i 2-3. Magungunan magunguna na Vildagliptin ba su dogara da nauyi ba, jinsi da ƙungiyar kabilanci, wanda mutumin da yake shan maganin ya kasance.
A cikin marasa lafiya da ke fama da aikin hanta, an lura da raguwa a cikin bioavailability na miyagun ƙwayoyi. Tare da wani nau'i mai sauƙi na ƙeta, alamar bioavailability yana raguwa da kashi 8%, tare da matsakaicin sifa - by 20%.
A cikin siffofin masu tsanani, wannan alamar yana raguwa da 22%. Decreasearin raguwa ko karuwa a cikin bioavailability tsakanin 30% al'ada ne kuma baya buƙatar daidaita sashi.
A cikin marasa lafiya da ke fama da rauni na aiki a matsayin cuta mai haɗuwa, ana buƙatar daidaita sashi. A cikin mutane sama da 65, akwai karuwa a bioavailability na miyagun ƙwayoyi ta 32%, wanda aka ɗauka al'ada ne. Ba a samun bayanai game da halayen magungunan ƙwayoyi a cikin yara ba.
Manuniya da contraindications
Ana amfani da Galvus don maganin ciwon sukari na 2 a cikin waɗannan lambobin:
- tare da ƙarancin ingancin motsa jiki da abinci, ana amfani dashi a cikin haɗin gwiwa tare da Metformin;
- a hade tare da Insulin, Metformin, tare da rashin ingancin waɗannan magunguna;
- azaman magani guda, idan mai haƙuri yana da rashin haƙuri ga Metformin, idan abincin tare da motsa jiki bai haifar da sakamako ba;
- a hade tare da abubuwan Metformin da sulfonylurea, idan magani a baya tare da alamomin da aka nuna basu bada tasiri ba;
- a cikin tsarin kulawa tare da amfani da Thiazolidinedione, Sulfonylurea da ire-irensa, Metformin, Insulin, idan jiyya tare da alamomin da aka nuna sun banbanta, kamar abincin tare da motsa jiki, bai bada sakamako ba.
Contraindications zuwa shan miyagun ƙwayoyi sune:
- lactic acidosis;
- ciki
- shayarwa;
- karancin lactase;
- nau'in ciwon sukari na 1;
- take hakkin hanta;
- rashin daidaituwa na galactose;
- rashin cin nasara na zuciya na wani nau'in cuta na aji;
- rashin jituwa ga abubuwan da ke hada magunguna;
- ketoacidosis mai ciwon sukari (da m da na kullum);
- shekaru zuwa shekaru 18.
Umarnin don amfani da miyagun ƙwayoyi
Sashi na wannan magani ya dogara da halaye na jikin wani haƙuri.
Tebur na shawarar dosages na miyagun ƙwayoyi:
| Monotherapy | Insarin insulin tare da thiazolidinedione da metformin | A hade tare da abubuwan sulfonylurea da abubuwan metformin | A hade tare da sulfonylurea (Kalaminta) |
|---|---|---|---|
| 50 MG sau ɗaya ko sau biyu kowace rana (matsakaicin kashi 100 MG) | 50-100 mg sau ɗaya ko sau biyu a rana | 100 MG kowace rana | MG 50 sau ɗaya a kowace awa 24 |
Idan babu raguwa a cikin yawan sukari na jini daga matsakaicin adadin na 100 MG, an yarda da ƙarin ɗaukar sauran magungunan masu kama da cutar.
Galvus bashi da alaƙa da cin abinci. Daidaitawa likita ya zama dole ga marasa lafiya da ke fama da rauni na aiki daidai gwargwado. Matsakaicin adadin ya kamata ya zama 50 MG kowace rana. Don wasu rukunan marasa lafiya, ba a buƙatar daidaita sashi na magani ba.
Umarni na musamman
Ba a ba da shawarar Galvus ga waɗannan mutane ba:
- fama da gajiyawar zuciya a wani yanayi na aji;
- da cin zarafin hanta;
- fama da rashi aiki na na dan bambancin digiri.
An magance miyagun ƙwayoyi gaba ɗaya don:
- mata masu ciki;
- reno uwaye;
- yara ‘yan kasa da shekara 18;
- marasa lafiya tare da jaundice.
Ana amfani dashi tare da taka tsantsan a cikin marasa lafiya da alamun cututtukan cututtukan cututtukan cututtukan ƙwayar cuta, da kuma a cikin marasa lafiya waɗanda ke fama da ƙarshen ƙarancin bugun zuciya da ke gudana ta hanyar tsarkake jini.
Wajibi ne a yi amfani da magani tare da taka tsantsan a cikin marasa lafiya tare da aji na III na ciwon zuciya.
Gudanar da maganin na yau da kullun na sulfonylurea da galvusa na iya haifar da hauhawar jini. Idan ya cancanta, rage kashi.
Side effects da yawan abin sama da ya kamata
Sakamakon sakamako daga shan magani yana da wuya. Fitowarsu yayi gajere kuma yawanci baya bukatar shafewa.
Tare da monotherapy, ba a cika ganin abubuwan mamaki masu zuwa:
- Dizziness
- kumburi
- maƙarƙashiya
- ciwon kai;
- nasopharyngitis.
Idan aka haɗu da Metformin, waɗannan masu yiwuwa ne:
- gagging;
- Dizziness
- ciwon kai.
Lokacin haɗuwa da magani tare da abubuwan sulfonylurea, waɗannan masu yiwuwa ne:
- maƙarƙashiya
- Dizziness
- nasopharyngitis;
- ciwon kai.
Idan aka haɗu da insulin, waɗannan masu yiwuwa ne:
- asthenia;
- zawo
- hypoglycemia;
- jin sanyi
- ciwon kai;
- rashin tsoro;
- bege na amai.
Tare da gudanarwa na lokaci daya tare da thiazolidinedione, cututtukan mahaifa da ke haifar da nauyin jiki na iya faruwa.Da cikin lokuta masu saurin kamuwa, cututtukan ciki, cututtukan fata da ƙarancin hepatitis ana lura da su bayan gudanarwa.
Yawan shaye shaye na miyagun ƙwayoyi a wasu yanayi yana haifar da zazzabi, ciwon tsoka da kumburi.
Irin wannan alamun yana faruwa lokacin da aka lalata 400 MG na Galvus yayin rana. Mita 200 na miyagun ƙwayoyi ana haƙuri da haƙuri sau da yawa. A sashi na 600 MG, mai haƙuri yana da kumburi daga ƙarshen, yayin da matakin myoglobin da adadin wasu enzymes na jini ke ƙaruwa.
Ana samun nasarar kawar da cututtukan da ke cikin maye bayan an daina amfani da maganin.
Hadin gwiwar Magunguna da Analogs
Ana nuna maganin yana da ƙananan matakin hulɗa da miyagun ƙwayoyi, wanda ke ba ka damar ɗaukar maganin tare da enzymes da inhibitors daban-daban.
Lokacin da aka haɗu tare da Warfarin, Amlodipine, Glibenclamide, Digoxin, babu wata ma'amala mai mahimmanci a cikin asibiti da aka kafa tsakanin waɗannan kwayoyi da Galvus.
Galvus yana da misalai masu zuwa:
- Vildagliptin;
- Vipidia;
- Karfe Galvus;
- Onglisa;
- Trazenta;
- Januvius.
Galvus Met yana da alamun analogues na cikin gida, daga cikinsu akwai: Glimecomb, Combogliz Prolong, Avandamet.
Abubuwan bidiyo game da abin da ya faru, magani da rigakafin ciwon sukari:
Ra'ayin likitoci
Daga sake dubawar likitoci, ana iya kammala da cewa Galvus ya sami karbuwa sosai kusan duk marasa lafiya, amma an lura da raunirsa da kuma buƙatar ƙarin shan magunguna masu rage sukari.
Galvus yana da kwarewa sosai na aikace-aikace a Rasha. Samfurin yana da inganci kuma mai lafiya. Galvus yana da haƙuri a haƙuri ta hanyar marasa lafiya, yana da ƙananan haɗari don hypoglycemia. Ya dace sosai ga tsofaffin marasa lafiya, da aka ba da alama alamar ƙimar aikin renal a cikin manya. Nazarin ya nuna cewa Galvus za a iya ɗauka a matsayin wani ɓangare na ilimin nephroprotective.
Mikhaleva O.V., endocrinologist
Duk da kyawawan kayan Galvus, wanda ya ƙunshi rage nauyin marasa lafiya, tasirin saurin sukari yayi ƙanƙanci. Sau da yawa, maganin yana buƙatar haɗuwa tare da wasu magungunan hypoglycemic.
Shvedova A.M., endocrinologist
Farashin kudade a yankuna daban-daban sun kama daga 734-815 rubles. Babban analog na miyagun ƙwayoyi (Galvus Met) yana cikin yankin na 1417-1646 rubles.
