Yankunan magungunan da ake amfani da su a cikin ciwon sukari basu da iyaka ga insulin na dogon lokaci.
Pharmacology a yau yana ba da kayan aikin da yawa don taimakawa rage ƙananan sukari a cikin nau'in ciwon sukari na 2. Muhimmin sashi daga cikinsu yana hade da wucin gadi, kamar yadda Pioglitazone (Pioglitazone).
Abun ciki, sakin saki
Magungunan suna kan sayarwa cike da kwali na kwali na 3 ko faranti 10, dauke da allunan dozin mai zagaye da kuma farin launi. Za'a iya samun ƙunshin mai aiki mai mahimmanci a cikin su a taro na 15, 30 ko 45 MG.
Tushen magungunan shine pioglitazone hydrochloride, wanda ke rage haɓakar hanta da kyallen takura zuwa aikin horon, sakamakon wanda glucose yake kashewa, kuma yawan aikinsa a hanta yana raguwa.
Baya ga babban kwaya, sun kuma ƙunshi ƙarin kayan haɗin ciki:
- lactose monohydrate;
- magnesium stearate;
- hydroxypropyl cellulose;
- alli carboxymethyl cellulose.
Aikin magunguna
Pioglitazone yana nufin wakilan hypoglycemic na bakin da ke kan thiazolidindine. Abun yana shiga cikin sarrafawar glucose na jini da metabolism na lipid. Rage juriya da tsoka da kyallen hanta zuwa insulin, hakan yana haifar da hauhawa wajen kashe kuzarin insulin-insulin rage-jini da rage raguwa daga hancinsa daga hanta.
Koyaya, baya fallasa ƙarin kara kuzarin sel-ƙwayoyin hanji, wanda ke kuɓutar da su daga tsufa cikin sauri. Sakamakon magani a cikin nau'in 2 na ciwon sukari yana haifar da raguwa a cikin matakan jini na glucose da gemocosylated haemoglobin. Za'a iya amfani da samfurin kawai ko a hade tare da sauran magunguna masu rage sukari.
Yin amfani da miyagun ƙwayoyi yana taimakawa ga daidaita yawan ƙwayar lipid, yana haifar da raguwa a cikin matakan TG da haɓaka a cikin HDL ba tare da rinjayar jimlar cholesterol da LDL ba.
Pharmacokinetics
Shaye maganin yana faruwa a cikin tsarin narkewa, wannan tsari yana faruwa da sauri, yana ba ku damar gano abu mai aiki a cikin jini rabin sa'a bayan shan maganin. Bayan sa'o'i biyu daga baya, matakinsa ya wuce kashi 80. Yarda da abinci yana rage ragewa abubuwan sha.
Inganci da maganin ya riga ya bayyana a farkon makon farko na cin abinci na yau da kullun. Yawan tara kayan magani a cikin jiki baya faruwa, bayan kwana daya an cire shi gaba daya ta hanyar narkewar abinci da hanta.
Manuniya da contraindications
Ana shawarar Pioglitazone a matsayin hanyar sarrafa nau'in ciwon sukari na 2. Ana iya amfani da shi azaman magani guda, don haka ana yin sa ne sau da yawa ga masu ciwon sukari waɗanda suke yin kiba ko kuma wanda aka hana yin Metformin.
Activelyarfafa aiki, ana amfani da miyagun ƙwayoyi a cikin hadaddun farce a cikin shirye-shiryen da ke biye:
- haɗuwa sau biyu tare da magungunan metformin ko ƙwayoyin sulfonylurea;
- sau uku tare da kungiyoyi biyu na kwayoyi
Kamar yadda contraindications suke:
- matsanancin ƙwayar hankali ga kowane ɓangaren magungunan;
- tarihin cututtukan zuciya;
- tsananin lalata hanta;
- nau'in ciwon sukari na 1;
- mai ciwon sukari mai ciwon sukari;
- kasancewar cutar kansa;
- gaban macroscopic hematuria na asalin rashin tabbas.
A cikin waɗannan halayen, ana maye gurbin miyagun ƙwayoyi tare da analogues da ke da tsari daban da tsarin aikin.
Umarnin don amfani
An saita sashi na miyagun ƙwayoyi ga kowane mai haƙuri daban-daban. Wannan shine aikin likita, wanda, bayan ganewar asali, ya kimanta matsayin lalacewar mai haƙuri kuma ya tsara tsarin kulawa.
Dangane da umarnin, ana shan maganin sau ɗaya a rana sau ɗaya, ba tare da la'akari da abincin ba. Koyaya, an fin so yin wannan da safe.
Ana ba da shawarar matakin farko a cikin 15-30 MG, yana iya ƙara ƙaruwa zuwa 45 MG a ƙwanƙwasawa, wannan shine mafi girman ƙa'ida.
Game da maganin haɗin gwiwa tare da wasu magungunan hypoglycemic, ana sanya magani zuwa 30 MG kowace rana, amma ana iya gyara shi gwargwadon karatun glucometer da yanayin haƙuri.
Yana da mahimmanci musamman a zaɓi madaidaicin kashi yayin ɗauka tare da insulin. A matsayinka na mai mulki, ana wajabta shi a 30 MG kowace rana, yayin da rage yawan insulin.
Ana bincika tasirin maganin duk wata uku ta hanyar nazari don hawan jini. Idan babu sakamako, za a dakatar da liyafar.
Marasa lafiya na musamman da kuma Jagorori
Ga tsofaffi, babu buƙatun sashi na musamman. Hakanan yana farawa da ƙima, a hankali yana ƙaruwa.
A lokacin daukar ciki, ba a yarda da miyagun ƙwayoyi don amfani ba, ba a fahimci tasirinsa ga tayin ba, saboda haka yana da wuya a iya faɗi abin da zai haifar. Yayin shayarwa, idan mace tana buƙatar yin amfani da wannan maganin, to ya kamata ta ƙi ciyar da jariri.
Marasa lafiya tare da cututtukan zuciya da na jijiyoyin jiki suna amfani da mafi ƙarancin kashi, yayin da ya zama dole don saka idanu akan yanayin gabobin matsalar lokacin gudanarwar Pioglitazone.
Shan Pioglitazone na iya kara hadarin kamuwa da cutar kansa yayin da kashi 0.06, wanda likita yakamata ya gargadi mara lafiyar tare da bayar da shawarar rage sauran abubuwan haɗari.
Ga marasa lafiya da m hanta, da miyagun ƙwayoyi ne contraindicated, kuma tare da matsakaici mai ƙarfi, amfani da hankali yana yiwuwa. A wannan yanayin, ya zama dole don sarrafa matakin enzymes hanta, idan sun wuce al'ada sau uku, an soke maganin.
Bidiyo game da illolin cututtukan cututtukan cututtukan ƙwayar cuta a jiki:
Side effects da yawan abin sama da ya kamata
Babban mummunan sakamako na shan miyagun ƙwayoyi shine hypoglycemia, amma mafi yawan lokuta yakan faru ne tare da yawan abin sama da yatsa ko rashin daidaituwa tare da wasu wakilai na hypoglycemic. Hakanan yana yiwuwa a rage haemoglobin da anemia.
An nuna yawan ƙwayar magunguna a cikin:
- kumburi, karuwar nauyi;
- tsoka da ciwon kai;
- take hakkin daidaituwa;
- glucosuria, protenuria;
- vertigo;
- rage ingancin bacci;
- erectile tabarbarewa;
- cutar lalacewar tsarin na numfashi;
- samuwar ciwace-ciwacen daji na nau'ikan yanayi;
- rashin lafiyan cuta;
- riskarin haɗarin fashewa da bayyanar jin zafi a cikin gabobi.
Yin hulɗa tare da wasu magunguna
Yin amfani da pioglitazone na iya rage tasirin maganin hana haihuwa.
Kayan aiki ba ya canza aikinsa lokacin amfani dashi tare da Digoxin, Metformin, Warfarin Ifenprokumon. A lokaci guda, halayensu ba su canzawa. Amfani da na lokaci guda na sulfonylureas tare da kayan maye shima baya canza karfin su.
Ba a gano tasirin Pioglitazone akan masu hana tashar alli ba, cyclosporins, da HMCA-CoA reductase inhibitors.
Lokacin da aka yi amfani da su tare da gemfibrozil, AUC na glitazone yana ƙaruwa, yana haɓaka alakar lokacin lokaci ta hanyar abubuwa uku. A wannan yanayin, ya zama dole don saka idanu akan yanayin haƙuri kuma, idan ya cancanta, daidaita sashi na maganin.
Yin amfani da haɗin gwiwa tare da rifampicin yana haifar da ƙara yawan aikin pioglitazone.
Shirye-shirye na irin wannan aiki
Ana gabatar da analogs na Pioglitazone a kasuwa tare da abubuwa masu yawa.
Kayan aikin da ke da irin wannan kayan sun haɗa da:
- Pioglar magungunan Indiya;
- Analogues na Rashanci na Diaglitazone, Astrozone, Diab-Norm;
- Allunan Irish Allos;
- Maganin Croatian Amalvia;
- Pyoglitis;
- Piouno da sauransu.
Duk waɗannan kudaden suna cikin rukunin shirye-shiryen glitazone, wanda ya hada da troglitazone da rosiglitazone, waɗanda suke da irin wannan hanyar aiki, amma sun bambanta da tsarin sunadarai, saboda haka ana iya amfani dasu lokacin da pioglitazone jikin ya ƙi. Hakanan suna da fa'idodi da rashin amfanin kansu, wanda za'a iya samu a cikin umarnin magunguna.
Hakanan, analogues da ke da tushe na yau da kullun na iya yin aiki azaman analogues: Glucofage, Siofor, Bagomet, NovoFormin.
Yana da kyau a sani cewa ra'ayoyin marasa lafiya da suka yi amfani da Pioglitazone da abubuwan da ke tattare da ita sun ɗan bambanta. Don haka, dangane da magungunan da kanta, marasa lafiya suna amsa mafi yawan gaske, suna karɓar ƙarancin sakamako masu illa.
Amincewa da rashin lafiyar analogues sau da yawa yana haifar da sakamako mara kyau, kamar ƙin nauyi, ƙonewa, da raguwa a cikin matakan haemoglobin.
Kamar yadda al'adar ta nuna, hakika maganin yana haifar da raguwa a cikin matakan sukari kuma ana iya amfani dashi da kyau a cikin maganin cututtukan type 2. Koyaya, yana da mahimmanci don zaɓar madaidaitan ƙwayoyi da sashi.
Ainihin farashin
Tun da za a iya samar da kayan aiki a ƙarƙashin sunaye daban-daban, dangane da masana'anta, farashinsa ya bambanta sosai. Sayi Pioglitazone a cikin magunguna na gida a cikin tsari mai kyau yana da matsala, ana aiwatar dashi ta hanyar magunguna tare da wasu sunaye. An samo shi a ƙarƙashin sunan Pioglitazone Asset, farashin abin da a cikin sashi na 45 MG daga 2 dubu rubles.
Pioglar zai biya 600 da ruan rubles don Allunan 30 tare da sashi na 15 MG da ɗan kuɗi mafi tsada fiye da dubu ɗaya don adadin daidai tare da sashi na 30 MG.
Farashin Aktos, a cikin umarnin wanda an tsara abu mai aiki iri ɗaya, bi da bi daga 800 da 3000 rubles.
Amalvia za ta kashe 900 rubles don sashi na 30 MG, da Diaglitazone - daga 300 rubles don sashi na 15 MG.
Ci gaban likitancin zamani yana ba da damar samun kyakkyawan sakamako a fannin sa ido da daidaita matakan sukari na jini. Yin amfani da magungunan zamani na iya cimma wannan da sauri kuma yadda ya kamata, kodayake ba su da matsala ba tare da ɓata lokaci ba, waɗanda kuke buƙatar sanin game da su kafin ku fara shan maganin.
