Gluconorm don ciwon sukari

A yau, mutane miliyan 350 a duk duniya suna fama da ciwon sukari mellitus (DM). Wannan shine 5% na yawan mutanen duniya. A Rasha, akwai kusan irin wannan marasa lafiya miliyan 12. Kuma ba gaskiyar cewa waɗannan cikakkun bayanai ba ne. Masu ciwon sukari tare da ɓoye nau'in ciwon sukari sau 2-3 fiye da rajista. Dangane da hasashen hukuma (kuma ba shine mafi tsinkaye ba!), A shekarar 2030, cutar sankarar cuta ta rigaya ta sha kashi 80% na mazaunan duniya.

Intensification of management na wani insidious cuta ne mai asali yanayin ga abin dogara diyya na glycemia. A bisa ga al'ada, ko dai metformin ko abubuwan da ake amfani da su na sulfonylurea ana amfani dasu azaman magungunan farko na maganin maye. Idan irin waɗannan matakan basu isa ba (DM - cuta mai taushi, cuta mai ci gaba), an haɗa insulin da sauran ƙwayoyin rage ƙwayar sukari.

Mafi kyawun haɗuwa tsakanin endocrinologists shine metformin tare da glibenclamide. Gluconorm - wannan magani ne mai kashi biyu wanda ke rage yawan yawan sukari a cikin jini. Yaya amfanin wannan ilimin, wa kuma ta yaya ya kamata ayi amfani dashi?

Halayen magunguna

Gluconorm magani ne wanda ya haɗu da magunguna na azuzuwan magani daban-daban dangane da tsarin aikin.

Abubuwan da ke cikin asali na yau da kullun shine metformin, wakili na biguanides, wanda ke daidaita abubuwan kwantar da hankali ta hanyar inganta juriyar sel zuwa insulin nasu da kuma haɓaka amfani da glucose ta kyallen. Bugu da kari, biguanide yana hana shaye-shayen carbohydrates kuma yana hana samar da glucose a cikin hanta. Yana haɓaka daidaiton ƙwayoyi da mai mai yawa, adana ingantaccen taro game da nau'ikan cholesterol da triglycerol.

Glibenclamide, sashi na biyu mai aiki a cikin takardar sayan magani, a matsayinta na wakilin aji na biyu na mahaukata, yana haɓaka samar da insulin tare da taimakon β-sel na fitsarin da ke da alhakin wannan aikin. Yana kare su daga glucose mai taushi, yana inganta insulin juriya da ingancin jijiyoyi tare da sel. Sakin insulin da aka saki yana raye sosai a cikin sha na glucose ta hanta da tsokoki, sabili da haka, ba a kafa ajalinsa a cikin kitse mai ba. Abubuwa suna aiki akan kashi na 2 na samar da insulin.

Fasali na pharmacokinetics

Bayan shiga cikin ciki, glibenclamide yana dauke da kashi 84%. Cmax (babban matakinsa) ya kai bayan awa 1-2. Rarraba ta girma (Vd) shine lita 9-10. Abubuwan da ke cikin sunadaran sunadarai na jini da kashi 95%.

Abun da ke cikin hanta an canza shi tare da sakin 2 metabolites na tsaka tsaki. Ofayansu yana kawar da hanji, na biyu - ƙodan. Rabin rayuwar T1 / 2 yana tsakanin awanni 3-16.

Bayan shiga tsarin narkewa, ana amfani da metformin a cikin ƙwaƙwalwa, babu abin da ya wuce 30% na kashi ya zauna a cikin stool. Ingancin biguanide bai wuce kashi 60% ba. Tare da cin abinci mai layi guda daya na abubuwan gina jiki, shan maganin yana rage gudu. An rarraba shi da sauri, baya shiga cikin sadarwa tare da kariyar plasma.

Gluconorm sashi tsari da abun da ke ciki

Gluconorm, hoto wanda za'a iya gani a wannan sashin, yana shiga cibiyar sadarwar kantin magani ta hanyar allunan zagaye na convex tare da farin harsashi. A lokacin hutu, inuwa na maganin yana da launin toka. A cikin kwamfutar hannu guda ɗaya akwai kayan abinci guda biyu a cikin waɗannan rabo: metformin - 400 MG, glibenclamide - 2.5 g. .ara tsari tare da tsofaffi: talc, cellulose, sitaci, glycerol, cellularphate, gelatin, steneste magnesium, croscarmellose sodium, sodium carboxymethyl sitaci, silic diethyl phthalate.

An tattara magungunan a cikin akwaku 10 ko 20. a cikin sel wanda aka yi da aluminium. A cikin kwali na kwali na iya zama daga faranti 2 zuwa 4. Don Gluconorm, Farashin kuɗi daidai ne: daga 230 rubles, sun saki maganin sayen magani. Rayuwar shiryayye daga allunan shine shekaru 3. Magungunan ba ya buƙatar yanayi na musamman don ajiya.

Yadda ake amfani da Gluconorm

Don Gluconorm, umarnin don amfani da rubutattun shan allunan ciki tare da abinci. Likita ya kirga kwatancen daban-daban, tare da yin la’akari da halaye na hanyar cutar, aladuwar cututtuka, shekaru da yanayin masu ciwon sukari, da kuma yadda jikin yake shan maganin. A matsayinka na mai mulkin, fara da kwamfutar hannu 1 / rana. Bayan mako daya ko biyu, zaku iya kimanta sakamakon, kuma tare da isasshen inganci, daidaita al'ada.

Idan Gluconorm ba magani bane na farawa, lokacin maye gurbin tsarin magani na baya, ana ba da allunan 1-2 tare da yin la'akari da ka'idodin magunguna na baya. Mafi girman adadin allunan da za a iya ɗauka kowace rana guda 5 ne.

Taimaka tare da yawan wuce haddi

Kasancewar metformin a cikin tsari yakan haifar da rikicewar hanji, wani lokacin kuma lactic acidosis. Tare da bayyanar cututtuka na rikitarwa (bugun tsoka, rauni, jin zafi a cikin yankin na epigastric, amai), an dakatar da maganin. Tare da lactic acidosis, wanda aka azabtar yana buƙatar asibiti mai gaggawa. Mayar da shi tare da cutar sankara.

Kasancewar glibenclamide a cikin dabara ba ya hana ci gaban hypoglycemia. Yana yiwuwa a gane yanayi mai haɗari ta hanyar ci, ba a kamewa ba, karuwar gumi, tachycardia, rawar jiki, fatar jiki, isonnia, paresthesia, dizziness da ciwon kai, damuwa. Tare da wani nau'i mai sauƙi na munafukai, idan wanda aka azabtar ba ya cikin tunani, ana ba shi glucose ko sukari. Tare da suma, glucose, dextrose, glucagon (40% rr) yana allurar iv, im ko a karkashin fata. Bayan mai haƙuri ya sake farfaɗo, ana ciyar da shi tare da samfurori tare da carbohydrates mai sauri, tun da juyawa a cikin wannan yanayin yakan faru sau da yawa.

Sakamakon Cutar Magunguna

Hadin gwiwa tare da ACE inhibitors, NSAIDs, antifungal magunguna, fibrates, salicitates, anti-tarin fuka, β-adrenergic blockers, guanethidine, MAO inhibitors, sulfonamides, chloramphenicol, tetracyrindiamine, tetracycodiaminophenide, tetrazinopyridin-tayin, tetrazinopyridin-tayin, tetrazinopyridin-tayin, tetrazinopyridin-tayin, tetrazinopyridin-tayin, tetrazinopyridin-tayin, tetrazinopyridin-tayin, tetrazinopyridin-tayin .

Ayyukan hypoglycemic na Gluconorm an rage shi daga tasirin adrenostimulant barbiturates, corticosteroids, magungunan rigakafi, diuretics (magungunan thiazide), furosemide, chlortalidone, triamteren, morphine, ritodrin, glucagon, hormones thyroid (a cikin hakan ne oestra, iodine, da sauransu).

Magungunan acid-haɓakar ƙwayar acid suna aiki a matsayin mai amfani ga inganci ta hanyar rage rarrabuwa tare da haɓaka abubuwan kwantar da hankali na gluconorm. Ethanol yana ƙaruwa da alama na lactic acidosis. Metformin yana cutar da magunguna na furosemide.

Sakamakon mara amfani

Metformin ɗayan amintaccen magani ne na lafiya, amma, kamar kowane magani na roba, yana da tasirin sakamako. Daga cikin abubuwanda suka zama ruwan dare akwai cuta, wanda ke ɓoye a cikin yawancin masu ciwon sukari bayan ƙarshen lokacin daidaitawa akan nasu. Glibenclamide shima kayan gwaji ne na lokaci-lokaci tare da babbar shaidar tabbatar da inganci da aminci. Yanayin da aka jera a cikin tebur yana da wuya, amma dole ne a yi nazarin umarnin kafin a fara jiyya.

Wanda aka nuna kuma ya baje kolin Gluconorm

Allunan ana ba da allunan ga masu ciwon sukari masu dauke da cutar ta 2, idan gyaran salon rayuwa da magani na baya bai samar da sarrafa glycemic 100% ba. Idan yin amfani da magunguna daban-daban guda biyu (Metformin da Glibenclamide) suna ba da izinin rarar masu sukari mai ɗorewa, zai kuma ba da shawarar maye gurbin hadaddun tare da magani ɗaya - Glucanorm.

Kada kayi amfani da Gluconorm tare da:

• Nau'in cuta guda 1;
• Hypoglycemia;
• Ketoacidosis na masu fama da cutar siga, coma da precoma;
• Tabarbarewar azaba da yanayin fusata su;
• Dysfunctions hanta;
• Yanayin da aka haifar dashi sakamakon yunwar oxygen na kyallen takarda (tare da bugun zuciya, bugun zuciya, rawar jiki, gazawar numfashi);
• Ciwon ciki;
• Amfani da miconazole na lokaci daya;
• Halin da ya shafi canzawa na ɗan lokaci zuwa insulin (yayin aiki, raunin da ya faru, cututtuka, wasu gwaje-gwaje ta amfani da alamomi dangane da aidin);
• Almubazzaranci;
• Lactic acidosis, gami da tarihi;
• Haihuwa da lactation;
• Hypocaloric (har zuwa 1000 kcal) abinci mai gina jiki;
• Hypersensitivity ga abubuwan da ke cikin tsari.

Recommendationsarin shawarwari

Amfani da Gluconorm ta Mahaifa da Marayu

Ko da a matakin shirin yaro, Gluconorm dole ne a maye gurbin shi da insulin, tun da contraindicated magani ne a cikin wannan yanayin. Lokacin da aka ciyar da madara nono, hane-hane ya kasance cikakke, tunda maganin yana ratsa ba kawai ta cikin mahaifa tayin ba, har ma cikin madara. Zabi tsakanin insulin da canjawa da jariri zuwa ciyarwar mutum yakamata yayi la’akari da matsayin hadarin ga uwar da kuma illar cutar ga jaririn.

Yin amfani da miyagun ƙwayoyi don lalata hanta da koda

Game da gazawar hanta (m, tsari na yau da kullun) Gluconorm ba a sanya shi ba. Tare da cututtukan koda, da kuma a cikin yanayi wanda zai iya tsokani su (tare da cututtukan da ke kama da ciki, girgiza, bushewar jiki), ba a nuna maganin ba.

Umarni na musamman

Raunin da ya faru da mummunan aiki, cututtukan cututtuka tare da zazzabi, suna ba da shawarar jigilar haƙuri na ɗan lokaci zuwa insulin.

Ya kamata a faɗakar da masu ciwon sukari game da haɗarin haɓakar ƙwayar cuta tare da yin amfani da NSAIDs, barasa, ethanol da magunguna, da rashin abinci mai gina jiki na yau da kullun.

Idan kun canza salon rayuwarku, abincinku, motsin rai da hauhawar jini, dole ne ku canza sashi na maganin.

Idan za a bincika mara lafiyar ta yin amfani da alamomin abun ciki na aidin, ana soke Gluconorm cikin kwana biyu, tare da maye shi da insulin. Kuna iya komawa zuwa tsarin kula da jinya da ya gabata ba da sa'o'i 48 ba bayan binciken.

Za a rage tasirin Gluconorm sosai idan mai haƙuri bai bi abinci mai ƙarancin abinci ba, yana jagorantar rayuwa mai tsayayye, baya sarrafa sukari a kullun.

Tasirin Gluconorm akan yiwuwar gudanar da sufuri

Tunda a cikin sakamako masu illa daga amfani da Gluconorm akwai kuma masu mahimmanci irin su hypoglycemia da lactic acidosis, mai ciwon sukari yakamata ya yi hankali musamman lokacin tuki da kuma a cikin yuwuwar wurin aiki mai haɗari (lokacin aiki a saman ko tare da keɓaɓɓun hanyoyin).

Gluconorm - analogues

Dangane da lambar ATX ta mataki na 4, sun zo daidai da Gluconorm:

• Glucovans;
• Janumet;
• Glibomet;
• Karfe Galvus;
• Amaril.

Zabi da maye gurbin miyagun ƙwayoyi suna iyakance ne a cikin ikon gwani. Gano kansa da magani kai ba tare da yin la’akari da duk halayen wani gabobin halitta na iya zama sakamakon mummunan sakamako ba.

Nazarin masu ciwon sukari

Game da sake duba cututtukan Gluconorm masu ciwon sukari galibi suna rikitarwa. Wasu suna jayayya cewa miyagun ƙwayoyi ba su taimaka ba, akwai wasu abubuwan ban mamaki a gefe, gami da samun nauyi. Wasu kuma sun ce babban wahalar magani game da maganin shine a zabin sashi, sannan sukari ya dawo daidai. Game da shayi na ganye "Altai 11 Gluconorm tare da blueberries" tabbatacce sake dubawa: yana taimakawa ci gaba da hangen nesa, inganta halayyar mutum.

Gluconorm magani ne mai sauƙin amfani tare da ingantaccen bincike da kuma aikin kayan aikin asibiti. Anyi amfani da magungunan Biguanides da magungunan sulfanilurea don maganin cututtukan type 2 na fiye da rabin ƙarni, kuma sababbin nau'ikan magungunan maganin cututtukan cutar ba suce ikonsu ba.