Glurenorm magani ne mai tasirin gaske. Ciwon sukari na 2 nau'ikan wata cuta ce mai mahimmanci a likitanci saboda girmanta da kuma kusan rashin yiwuwar rikitarwa. Ko da tare da ƙananan tsalle-tsalle a cikin tattarawar glucose, da alama rashin ɗaukar hoto, bugun zuciya ko bugun jini yana ƙaruwa sosai.
Glurenorm yana daya daga cikin mafi ƙarancin haɗari dangane da tasirin sakamako na abubuwan antiglycemic, amma ba shi da ƙananan tasiri ga wasu kwayoyi a cikin wannan rukuni.
Pharmacology
Glurenorm shine wakili mai narkewa a cikin bakin mutum. Wannan magani shine asalin tushen sulfonylurea. Yana da cututtukan cututtukan cututtukan cututtukan fata da ƙari aikin cakuda. Yana haɓaka haɓakar insulin ta hanyar rinjayar ƙirar glucose-matsakaiciyar wannan hormone.
Tasirin hypoglycemic yana faruwa ne bayan sa'o'i 1.5 bayan gudanarwar maganin na cikin gida, ganuwar wannan sakamako yana faruwa bayan sa'o'i biyu zuwa uku, yana tsawan awa 10.
Pharmacokinetics
Bayan ɗaukar kashi ɗaya a cikin gida, Glyurenorm yana tunawa da sauri kuma kusan gaba ɗaya (80-95%) daga ƙwayar narkewa ta hanyar sha.
Abubuwan da ke aiki - glycidone, yana da kusanci sosai don sunadarai a cikin jini (sama da kashi 99%). Babu wani bayani game da hanyar ko wannan rashi na wannan abun ko kayan abinci na jikinsa a jikin BBB ko a cikin mahaifa, gami da batun fitar da glycidone a cikin madarar mahaifiyar mai shayarwa yayin shayarwa.
Yawancin samfuran metabolism glycidone suna barin jiki, ana fitar dasu ta cikin hanjin. Fraaramin juzu'i na samfuran fashewar abu ya fito ta cikin kodan.
Bincike ya gano cewa bayan gudanarwar cikin gida, kusan kashi 86% na magungunan da ake kira isotope mai taken an saki su ta hanjin ciki. Ba tare da la'akari da girman kashi da hanyar gudanarwa ta hanyar kodan ba, kusan 5% (a cikin nau'ikan samfuran metabolism) na ƙarar da aka yarda da maganin. Matsakaicin sakin miyagun ƙwayoyi ta hanyar kodan ya kasance aƙalla, koda kuwa a kai a kai.
Masu nuna alamun magunguna sun yi daidai da tsofaffi da marasa lafiya na tsufa.
Fiye da 50% na glycidone an saki shi ta cikin hanji. A cewar wasu bayanai, da metabolism na miyagun ƙwayoyi ba ya canza ta kowace hanya idan haƙuri yana da renal gazawar. Tunda glycidone yana barin jiki ta hanyar kodan har zuwa ƙaramin kaɗan, a cikin marasa lafiya da gazawar koda, ƙwayar ba ta tarawa a jikin.
Alamu
Nau'in ciwon sukari na 2 a tsakiya da tsufa.
Contraindications
- Type 1 ciwon sukari
- Acosis masu ciwon sukari;
- Cutar masu ciwon sukari
- Rashin aikin hanta a cikin babban mataki;
- Duk wata cuta mai kamuwa da cuta;
- Shekaru a ƙarƙashin 18 (tunda babu wani bayani game da amincin Glyurenorm don wannan rukuni na marasa lafiya);
- Kowane mai ɗorewa ga sulfonamide.
Ana buƙatar ƙarin taka tsantsan yayin ɗaukar Glyurenorm a gaban waɗannan cututtukan masu zuwa:
- Zazzaɓi
- Cutar ta thyroid;
- Al'adun shan giya
Allurai
Glurenorm an yi nufin amfani dashi na ciki. M riko da bukatun likita game da sashi da abinci ake bukata. Ba za ku iya dakatar da amfani da Glyurenorm ba tare da fara tuntuɓarku da likitan ku ba.
Maganin farko shine rabin kwayoyin da aka sha tare da karin kumallo.
Ya kamata a ƙosar da glurenorm a farkon lokacin cin abinci.
Karka tsallake abinci bayan shan magani.
Lokacin shan rabin kwayoyin yana da inganci, kuna buƙatar tuntuɓar likita wanda, mafi kusantarwa, zai ƙara yawan ƙwayar.
Game da tsara adadin da ya wuce iyakokin da ke sama, za a iya samun sakamako mai ma'ana yayin batun rarraba kashi ɗaya na yau da kullun zuwa kashi biyu ko uku. Mafi girma a cikin wannan yanayin ya kamata a cinye lokacin karin kumallo. Theara yawan kashi zuwa allunan hudu ko fiye da ɗaya a kowace rana, a matsayin mai mulkin, ba ya haifar da haɓaka tasiri.
Mafi girman kwayar kowace rana shine allunan hudu.
Ga marasa lafiya da ke fama da rauni aiki
Kusan kashi 5 cikin 100 na abubuwan haɓaka kayan abinci na Glurenorm suna barin jiki ta hanjin kodan. Idan mara lafiyar yana da nakasa aiki na renal, ba a buƙatar gyaran sashi.
Ga marasa lafiya masu fama da cutar hepatic
Lokacin amfani da miyagun ƙwayoyi a allurai sama da 75 MG don marasa lafiya da ke fama da rauni na aikin hepatic, lura da likita sosai dole ne. Bai kamata a ɗauka da glurenorm tare da raunin hepatic mai ƙarfi ba, tun da kashi 95 na kashi ana sarrafa shi a cikin hanta da kuma daga jiki ta cikin hanji.
Hada magani
Game da ingantaccen tasiri na amfanin Glyurenorm ba tare da haɗa shi da sauran magunguna ba, kawai ana nuna kulawa ta metmorphine a matsayin ƙarin wakili.
Side effects
- Metabolism: hypoglycemia;
- CNS: karin yawan bacci, ciwon kai, ciwo mai saurin kamuwa da cuta, paresthesia;
- Zuciya: hypotension;
- Gastrointestinal fili: asarar ci, amai, gudawa, rashin jin daɗi a ciki, cholestasis.
Yawan damuwa
Bayyanannun abubuwa: karin yawan gumi, yunwar, ciwon kai, haushi, rashin bacci, fitsari.
Jiyya: idan akwai alamun hypoglycemia, ƙwayar glucose na ciki ko samfuran da ke dauke da carbohydrates mai yawa ana buƙatar. A cikin matsanancin rashin ƙarfi na jini (tare da ragi ko ƙima), gudanarwar cikin ciki ya zama dole.
Hulɗa ta Pharmacological
Glurenorm na iya inganta tasirin hypoglycemic idan an dauki concomitantly tare da ACE inhibitors, allopurinol, painkillers, chloramphenicol, clofibrate, clarithromycin, sulfanilamides, sulfinpyrazone, tetracyclines, cyclophosphamides da aka dauka ta baki ta hanyar magungunan hypoglycemic.
Akwai yiwuwar raunana tasirin hypoglycemic a cikin yanayin gudanar da rikice-rikice na glycidone tare da aminoglutethimide, sympathomimetics, glucagon, thiazide diuretics, phenothiazine, diazoxide, har da kwayoyi waɗanda ke ɗauke da nicotinic acid.
Umarni na musamman
Marasa lafiya da ciwon sukari yakamata su bi umarnin likitan da ke halartar taron. Ya zama dole sosai don saka idanu akan yanayin yayin zaɓi na wani kashi ko miƙa mulki zuwa Glyrenorm daga wani wakili wanda shima yana da tasirin cutar hypoglycemic.
Magunguna tare da tasirin hypoglycemic, waɗanda aka ɗauka a baka, ba su da damar yin azaman cikakken maye gurbin abincin da zai ba ku damar sarrafa nauyin haƙuri. Sakamakon tsallake abinci ko keta umarnin magungunan likita, raguwar glucose na jini zai yuwu, yana haifar da rauni. Idan kun ɗauki kwaya kafin cin abinci, maimakon ɗaukar shi a farkon abincin, sakamakon Glyrenorm akan glucose jini yana da ƙarfi, sabili da haka, yiwuwar hauhawar jini ya karu.
Idan akwai alamun hypoglycemia, ana buƙatar samfurin abinci na gaggawa wanda ya ƙunshi sukari mai yawa. Idan jinin haila ya ci gaba, koda bayan wannan zaku nemi taimakon likita nan da nan.
Sakamakon damuwa ta jiki, tasirin hypoglycemic na iya ƙaruwa.
Sakamakon yawan barasa, karuwa ko raguwa a cikin tasirin hypoglycemic na iya faruwa.
Kwamfutar hannu ta Glyurenorm ta ƙunshi lactose a cikin adadin 134.6 mg. Wannan magani yana contraindicated ga mutanen da fama da wasu gado na gado.
Glycvidone wani abu ne wanda ya samo asali na sulfonylurea, wanda ya takaita ta hanyar takaitaccen aiki, saboda marasa lafiya suna amfani dashi da nau'in ciwon sukari na 2 kuma yana da matukar yiwuwar hawan jini.
Amincewa da Glyurenorm ta marasa lafiya masu nau'in ciwon sukari na 2 da cututtukan hanta masu lafiya bashi da wata matsala. Abunda kawai ke amfani dashi shine kawar da hankali na samfuran metabolism marasa aiki a cikin marasa lafiya na wannan rukuni. Amma a cikin marasa lafiya tare da nakasa aikin hepatic, wannan magani yana da matuƙar da ba a so.
Gwaje-gwaje sun nuna cewa shan Glyurenorm tsawon shekara daya da rabi da shekaru biyar ba ya haifar da karuwa a cikin jikin mutum, koda kuwa an rage raguwar nauyi. Nazarin kwatankwacin Glurenorm tare da wasu kwayoyi, waɗanda ke cikin abubuwan da ke haifar da sulfonylureas, sun bayyana rashi canje-canje masu nauyi a cikin marasa lafiya da ke amfani da wannan magani fiye da shekara guda.
Babu wani bayani kan tasirin Glurenorm kan iya tuki motocin. Amma dole ne a faɗakar da mai haƙuri game da alamun yiwuwar hypoglycemia. Duk waɗannan bayyanar za su iya faruwa yayin jiyya tare da wannan magani. Ana buƙatar taka tsantsan lokacin tuki.
Ciki, shan nono
Babu wani bayani game da amfani da Glenrenorm ta mata yayin daukar ciki da lactation.
Ba'a bayyana ko glycidone da samfuransa na metabolism sun shiga cikin madara ba. Mata masu juna biyu masu ciwon sukari suna buƙatar sa ido sosai game da glucose na jini.
Yin amfani da magungunan cututtukan cututtukan baka na mata masu juna biyu ba ya haifar da ingantaccen iko na metabolism metabolism. Don wannan, shan wannan magani lokacin daukar ciki da lactation an contraindicated.
Idan ciki ya faru ko kuma idan kun shirya shi yayin jiyya tare da wannan wakili, kuna buƙatar soke Glyrenorm kuma ku canza zuwa insulin.
Game da cutar koda
Tunda yawan ƙwayar Glyurenorm an keɓance ta cikin hanji, a cikin waɗancan marasa lafiya waɗanda ba su da aikin koda, rashi wannan magani ba ya faruwa. Sabili da haka, ana iya sanya shi ba tare da ƙuntatawa ga mutanen da ke iya kamuwa da cutar cutar sankara ba.
Kusan kashi 5 na samfuran metabolism na wannan magani an keɓance su ta hanyar kodan.
Nazarin da aka gudanar don kwatanta marasa lafiya da ciwon sukari da kuma raunin ƙarancin ƙwayar cuta daban-daban, tare da marasa lafiya kuma suna fama da ciwon sukari, amma ba tare da wahalar aikin renal ba, ya nuna cewa yin amfani da 50 mg na wannan ƙwayar yana da tasiri iri ɗaya a cikin glucose.
Babu alamun bayyanar cutar hypoglycemia. Yana biye daga wannan cewa ga marasa lafiya waɗanda ke da nakasa aiki na renal, daidaita sashi ba lallai ba ne.
