Metformin Canon ga masu ciwon sukari na shekaru daban-daban

Dangane da metformin hydrochloride, ba wai kawai ana samar da Glucofage (330 rubles) na asali ba, har ma analologues masu yawa: Siofor (320 rubles), Metformin Teva (198 rubles), Metformin Canon (195 rubles). Idan likita ya ba da kowane irin magani dangane da metformin, ku ji kyauta don neman takardar sayan magani don ƙimar Metformin Canon mai araha da inganci.

Generic Glucofage na aji na biguanides na ƙarni na 3 magani ne mai inganci na maganin antidiabetic wanda ke daidaita bayanan glycemic ba tare da ƙarin kumburi ba. Tare da mafi ƙarancin sakamako masu illa, a cikinsu wanda babu ƙin jini a jiki, yana dawo da sinadarin lipid, yana taimakawa wajen sarrafa nauyin jikin mutum.

Siffofin Sashi da Tsarin Magana na Tsarin Magani

Kamfanin masana'antar cikin gida na Canonfarm Production yana samar da magani a cikin nau'ikan zagaye ko allunan kwalajin convex a cikin farin harsashi. Ya danganta da abun da ke ciki na metformin hydrochloride, ana iya siye magani tare da sashi na 1000, 850, 500 MG a cikin cibiyar sadarwa ta kantin magani.

A kan Metformin Canon, farashin zai dogara da manufar tallan kantin magani da kashi:

• 30 inji mai kwakwalwa 850 MG kowane. - 88-90 rubles .;
• 30 inji mai kwakwalwa 1000 MG kowane - 108-138 rubles;
• 60 inji mai kwakwalwa. 500 MG - 146-160 rubles;
• 60 inji mai kwakwalwa. 850 MG kowane - 167-192 rubles;
• 60 inji mai kwakwalwa. 1000 mg kowane - 248-272 rubles.

Baya ga sashin aiki mai aiki, abun da ya shafi magungunan ya kuma hada da abubuwan karawa a cikin sitaci, primogel, povidone, sodium fumarate, talc. Shell ɗin an yi shi da farin opadra II, macrogol, barasa polyvinyl, titanium dioxide da talc.

Rayuwar shiryayye na allunan shine shekaru 2, magani ba ya buƙatar yanayi na musamman don ajiya.

Pharmacology

Metformin Canon magani ne na rage sukari mai narkewa, shine kawai wakilin ajin biguanide. Tare da wuce haddi na glucose a cikin jini, yana rage matakinsa ta hanyar hana glucogenesis a cikin hanta, yana toshe abubuwan da yake sha ta hanyar bangon hanji, yana kara yiwuwar amfani da shi ta hanyar kyallen takarda, inda aka canza shi zuwa makamashi, maimakon mai, saboda karuwa a cikin hankalin masu karɓar sel zuwa insulin.

Rage juriya na insulin zuwa mafi girman takaddama tsoka, ƙashin mai ya fi wahalar metabolite.

Metformin yana ƙarfafa glycogen synthase da glycogenesis ta salula. Ba kamar shirye-shiryen rukunin sulfanyl urea ba, samar da insulin baya motsa biagunids. Wannan ba ya haifar da ƙarin nauyi a kan cututtukan ƙwayar cuta da ƙwayoyin sel, ba ya tsokani yanayi na rashin ƙarfi a cikin mutane masu lafiya waɗanda ke amfani da metformin don asarar nauyi, hana cutar oncology da cututtukan zuciya, ko don tsawaita rayuwa cikin balaga (bayan shekaru 40).

Wani muhimmin yanayi don cikakken iko na cutar glycemia a nau'in ciwon sukari na 2 shine daidaita nauyin jikin mutum. Ba kamar yawancin magungunan hypoglycemic ba, Metformin Canon yana tsaka tsaki dangane da samun nauyi, kuma tare da yin amfani da shi koyaushe har ma yana ba da gudummawa ga ɗan raguwa.

Pharmacokinetics

Rashin metformin a cikin bangon ciki ya dogara da cikarsa: idan kun ɗauki kwaya kafin abinci, yawan shan shine 48-52%, lokacin da kuka yi amfani da maganin a lokaci guda yayin abinci, tsarin yana raguwa kuma aikin yana raguwa.

Ana lura da mafi girman taro na biagunide (2 μg / l) bayan sa'o'i 2-3. Abubuwan suna yadawa da sauri ta kyallen, tare da cikakken cikakken bioavailability har zuwa 60%. Metabolite din baya shiga cikin kariyar jini, amma yana shiga cikin sel jini. Mafi yawa daga cikin magungunan suna tarawa a cikin ƙodan, hanta, da gyada mai haɓaka. Lokacin amfani da kwamfutar hannu mai nauyin 850 MG, ƙarar rarraba zai zama lita 296-1012.

Ba a sami metabolites metabolites a cikin jikin ba, kodan ya kawar da shi ta hanyar da ba ta canzawa. A cikin mutane masu daidaitaccen metabolism, tsinkayen metformin yana cikin kewayon 400 ml / min. Cire rabin rayuwar shine 6.2 hours. Tare da cututtukan koda, wannan mai nuna yana ƙaruwa, kuma tare da ita haɗarin tarin metformin, wanda ke tsokani lactic acidosis.

Alamu don nadin Metformin Canon

An wajabta Metformin Canon ga masu ciwon sukari da ke da cutar cuta ta 2 idan nau'in canjin yanayin rayuwa (ƙarancin abincin carb, isasshen aikin motsa jiki, kulawar yanayin motsa rai) bai samar da cikakkiyar iko na glycemic ba.

Ga marasa lafiya masu kiba, metformin shine mafi kyawun zaɓi. An haɗa magungunan sosai tare da magungunan ƙwayar cuta na sauran ƙungiyoyin magunguna, a cikin abin da tsarin aikin ya bambanta da biguanides. Wataƙila cikakken magani tare da insulin.

Hakanan ana nuna magungunan don maganin cututtukan type 2 na yara a cikin yara masu shekaru 10. Ana amfani dashi azaman magani na farko-layi ɗaya ko kuma a hade tare da insulin.

Jikin bodybuilders yana amfani da wannan magani don bushe tsokoki, gwaji tare da asarar nauyi da 'yan mata, amma wannan amfanin yana barata ne kawai idan matsalar wuce kima yana da nasaba da juriya ta insulin da cuta na rayuwa.

WHO ta ba da shawarar metformin ga marasa lafiya masu lafiya bayan shekaru 40 da haihuwa a 200 mg / m / day. don tsawanta rayuwa (rigakafin cutar atherosclerosis, cututtukan zuciya, oncology).

Hanyoyin aikace-aikace

Allunan tana bugu ba tare da nika ba, tare da ruwa, lokacin cin abinci ko kuma bayansa. Likita ya tsara tsarin magani da kashi bisa la’akari da sakamakon gwajin dakin gwaje-gwaje, matakin cutar, rikicewar rikice-rikice, halayen marasa lafiya ga metformin.

Majinyacin Adult

Ana amfani da miyagun ƙwayoyi don monotherapy ko a cikin hadaddun magani tare da madadin magungunan maganin cututtukan cututtukan. Matsayin farawa na Metformin Canon, bisa ga umarnin don amfani, shine 1000-1500 mg / rana. Idan ka rarraba tsarin yau da kullun ta hanyar sau 2-3, zaka iya rage sakamako a cikin nau'in rikicewar dyspeptic. Bayan sati 2, idan jiki ya daidaita, amma glucometer din ba mai karfafa gwiwa bane, sannu-sannu a hankali za'a iya amfani da sashi.

Lokacin sauya wasu analogs, mutum ya kamata ya bishe shi ta hanyar magungunan da suka gabata, da kuma lokacin kawar dasu (tsawan tsawan yana buƙatar wani ɗan hutu).

Idan an wajabta Metformin Canon ga masu ciwon sukari a hade tare da allurar insulin, yanayin farawa na allunan ba su wuce raka'a ɗaya a kowace rana ba tare da maganin 1000 MG, sau 2-3 / rana. a sashi na 500-850 MG. A wannan yanayin, an ƙayyade adadin insulin daidai da fasalin menu da alamu na glucometer.

Marasa lafiyar yara

Ciwon sukari na 2 a cikin yara ba sabon abu bane a yau, musamman a ƙasashe masu tasowa. Abinda aka tabbatar da abinci mai gina jiki, rashin aiki a jiki, yanayin damuwa mai zurfi yana haifar da yanayi don yaduwar cutar a cikin yara. An wajabta Metformin Canon ga yara sama da shekaru 10 azaman maganin layin farko ko kuma a hade da allurar insulin.

Yawan farawa, koyarwar ta bada shawarar zabar mafi ƙarancin - 500 MG / rana. Ana ba yaro kwamfutar hannu da yamma, yayin cikakken abincin dare. A cikin makonni biyu, zaku iya kimanta sakamakon magani da daidaita sashi, sannu a hankali kawo shi zuwa matsayin kulawa (1000-1500 mg / day) ko matsakaici (200 MG / rana). An rarraba maganin yau da kullum zuwa kashi 2-3.

Marasa lafiya na Balagagge

A cikin shekarun da suka gabata, a cikin masu ciwon sukari tare da gwaninta (kuma ba kawai) ba, ikon kodan ya ragu, don haka ana wajabta Metformin Canon don kula da tsarin ayyukan su a kowane wata shida. Doctor ya saita tsawon karatun, yana da kyau a sarrafa jadawalin shan magunguna don wannan rukuni na masu ciwon sukari kuma kada a katse magani ba tare da yarjejeniya da endocrinologist ba.

Recommendationsarin shawarwari

Jiyya tare da Metformin Canon yana buƙatar saka idanu na yau da kullun na glucometer da yin rikodin sakamakon a cikin bugun mai ciwon sukari. Baya ga sukari mai azumi, ya zama dole a duba kuma postprandial, sa'o'i 2 bayan cin abinci. Idan sakamakon ya wuce na baya ta fiye da 3 mmol / l, kuna buƙatar daidaita abincin.

Lokacin rubuta magani, ana gargadin mai ciwon suga game da yiwuwar abubuwan da ba a zata ba: tare da bayyanar tashin zuciya da amai, jin zafi a cikin ramin ciki, ƙwanƙwashin tsoka da raunin ƙarfi, dole ne a dakatar da amfani da maganin kuma ka faɗi matsalolin ga likita.

Disordersarancin cututtukan cututtukan dyspepti (sitati da rikicewar abinci) suna tafiya ba tare da taimakon likita ba, amma wasu alamun na iya zama kiran farko na haɓakar lactic acidosis.

Metformin, kamar sauran magungunan maganin magana na baka, ana soke shi kwana biyu kafin aikin, gwaje-gwajen X-ray (gami da kyamar hoto, iv urography), waɗanda ke amfani da alamun alamun kyamara a kan aidin. Don wannan lokacin, ana canzawa mai ciwon sukari zuwa insulin. An sake dawo da tsarin kulawar da ya gabata 2 kwanaki bayan ƙarshen hanyoyin, idan yanayin nasa baya buƙatar wasu matakan.

Ana cire ƙwayar Metformin ta hanyar kodan, sabili da haka, ya kamata a bincika sharewar creatinine kafin farkon karatun kuma yayin shan maganin: tare da aikin koda na al'ada - lokaci 1 a shekara, tare da rage KK kuma a cikin manya - sau 2-4 / shekara.

Bayyanar cututtuka na kamuwa da cutar huhu, bronchi, da spinal urogenital suma ya zama dalili na ziyartar mahaukacin endocrinologist.

Gabanin tushen ilimin tsufa na metformin, barasa yana da haɗari musamman. Haramcin ayyukan hanta, samar da glycogen endogenous, yana barazanar haɓaka yanayin hypoglycemic da disulfiram-like.

Shan isasshen bitamin B 12 ana fushi da shi ta hanyar dakatar da shan shi. Matsalar tana faruwa tare da tsawanta na yau da kullun na maganin kuma ana iya juyawa. Idan an lura da alamun hypovitaminosis B12, metformin ya kamata a maye gurbin shi da analogues.

Tasiri kan ikon sarrafa kayan aiki masu rikitarwa

Metformin Canon ba ya shafar gudanar da sufuri ko wasu hanyoyin hadaddun idan ana amfani dasu a cikin maganin monotherapy. Tare da kulawa mai rikitarwa tare da sulfonylureas da insulin, tasirin hypoglycemic mai yiwuwa ne, wanda ya lalata mummunan halayen psychomotor da maida hankali.

Sakamakon mara amfani

Metformin magani ne wanda ke da tushe mai karfi na aminci da tasiri, matsayin zinare a cikin lura da masu ciwon sukari, amma magungunan masu ciwon sukari ana fahimtar su ta hanyoyi daban-daban. Sakamakon mafi yawan abubuwan da ba a yarda da su shine dyspeptik; yayin daidaitawa, 'yan kalilan ne ke gujewa su. Idan kun ɗauki kwaya tare da abinci, sannu-sannu yana ƙaruwa sashi, zaku iya rage alamun ciwon ciki.

Sauran matsanancin shine lactic acidosis, wanda ke haɓaka tare da tarawar metformin a cikin jikin da ke haɗuwa da gazawar koda. Irin waɗannan halayen ba su da ɗanɗano, masu faɗi faɗi kuma suna buƙatar cire magani. Zai dace don kimanta yanayin yiwuwar sakamako masu illa daga gabobin da tsarin a cikin tebur.

Dukkanin sakamako masu illa suna iya juyawa kuma sun ɓace bayan soke Metformin Canon. Aikin asibiti ya nuna cewa yana da shekaru 10-16 shekaru yanayin da tasirin sakamako masu illa suna kama da na manya.

Sakamakon hulɗa tare da wasu magunguna

Tare da yawancin wakilai na hypoglycemic, Metformin an haɗa shi daidai, ana amfani dashi sosai a cikin hadaddun farji, amma, kamar kowane magani, yana da nasa iyaka.

Abubuwan haɗin gwiwa

Magungunan bambance-bambancen X-ray dangane da aidin, wanda aka yi amfani da shi a cikin karatun rediyo, na iya tsokani lactic acidosis yayin shan metformin. Saboda haka, kwanaki 2 kafin a aiwatar da kuma kwanaki 2 bayan gwajin, ana maye allunan da allurar insulin.

Ba da shawarar haɗuwa ba

Yin amfani da barasa da ethanol na kwayoyi tare da maganin metformin na iya haifar da lactic acidosis. Sakamakon haka yana yiwuwa tare da lalatawar hanta da rage-kalori.

Zaɓuɓɓuka Masu Amfani

Lokacin amfani danazol tare da metformin, yanayin hypoglycemic yana yiwuwa. Idan irin wannan haɗin yana da mahimmanci, daidaitawa kashi metformin ya zama dole.

Mahimmancin allurai na chlorpromazine yana toshewar sakin insulin, yana kara matakan sukari. Antipsychotics kuma suna buƙatar titition na kashi na metformin yayin da bayan magani na layi daya.

Glucocorticosteroids yana rage haƙuri na glucose, yayin da yake ƙaruwa da matakinsa a cikin plasma, ketosis yana yiwuwa a cikin matsanancin yanayi. Tare da nadin irin waɗannan makircin, an rage adadin metformin.

NSAIDs da madauki diuretics tare da metformin suna haifar da rikicewar koda. Wannan yanayin yana da haɗari ga haɓakar lactic acidosis.

Nifedipine yana haɓaka ɗaukar ƙwayar tsoka da mafi girman haɗari na metformin, wannan gaskiyar dole ne a la'akari da shi lokacin da aka tsara tsarin kulawa.

Suna haɓaka ƙarfin maganin ƙwayar cuta da haɗuwa tare da acarbose, insulin, magungunan sulfonylurea.

Magungunan da ake amfani da su don magance hauhawar jini suna iya haɓaka tasirin hypoglycemic kuma suna buƙatar titition na kashi na metformin.

Contraindications

Baya ga rashin hankali ga abubuwan da ke tattare da kwayoyin, ba a sanya maganin ba:

• Tare da coma mai ciwon sukari, precoma, ketoacidosis;
• Masu ciwon sukari tare da CC a ƙasa 60 ml / min.;
• Shafar mummunan yanayi (rashin ruwa, zazzabi, cututtukan fata);
• Tare da hypoxia wanda ya haifar da rawar jiki, sepsis, pathologies na kodan asalin cutar, bronchi, huhu;
• Marasa lafiya tare da m ko na kullum cuta sa tsoka hypoxia;
• Don lokacin aikin tiyata, a cikin lura da mummunan raunin da ya kone;
• Masu shan giya na yau da kullun, mutanen da ke shan maye;
• Tare da lalata cututtukan hepatic;
• A cikin yanayin lactic acidosis;
• Yara ‘yan kasa da shekara 10, masu juna biyu da masu shayarwa;
• Dan lokaci: ƙuntatawa akan lokacin aiki da karatun rediyo.

Iri yawan abin sama da ya kamata

A cikin nazarin asibiti a cikin masu ba da agaji waɗanda suka ɗauki kashi goma na metformin (85 g), hypoglycemia bai inganta ba, sun nuna alamun lactic acidosis.

Kuna iya gane yanayin ta hanyar rikicewar dyspeptik, canje-canje a cikin motsi na hanjin hanji, yanayin zafi a ƙasa da al'ada, cramps muscle da kuma ciwon ciki, gajeriyar numfashi, rashin daidaituwa da tsinkaye, fainting da coma. Halin yana buƙatar cire magungunan gaggawa da kuma asibiti. Raguna da ragowar metformin a cikin asibiti suna kwance ta hanyar amfani da shi.

Kallon Maganin Ciwon Jiki

Game da Metformin Canon, sake dubawa galibi tabbatacce ne. Da yawa suna lura da kasancewar magunguna a ɓangaren farashin farashin. Rabin marasa lafiya suna nuna tsayayyen sarrafa sukari mai tsayayye, asarar nauyi, da sarrafa abinci.

Daga cikin ƙididdigar mara kyau, gunaguni na sakamako masu illa a cikin nau'in rikicewar gastrointestinal, wanda ba ya ɓata tare da lokaci, rinjaye.Babu shakka, a cikin irin waɗannan halayen, yana da daraja a tuntuɓi likitanku, tun da ma analogues na tushen metformin suna da abubuwa na taimako iri-iri waɗanda zasu iya haifar da rashin lafiyan jiki da sauran halayen. Yana yiwuwa a maye gurbin jigon tare da asalin glucophage.

Analogues na miyagun ƙwayoyi

Don Metformin Canon, nau'ikan kwayoyi da yawa na iya zama analogues. Kwatancen magunguna tare da tasirin warkewa iri ɗaya da ainihin kayan metformin sune:

1. Glucophage - asalin magani na Faransanci na asali wanda ya kai 130 rubles .;
2. Metfogamma - Allunan Jamus a farashin har zuwa 330 rubles .;
3. Formmetin asalinsu ne na cikin gida, suna siyarwa 250 rubles .;
4. Sofamet kalma ce ta Bulgaria, za'a iya siyanta akan 109 rubles.

Dangane da rarrabuwar ATX, ana iya samun jerin abubuwan ta hanyar Siofor, Bagomet, Avandamet, Metformin Teva da sauran analogues. Wanda ya kirkiro Metformin Canon shima yana da fasali mai tasirin gaske. Ana samun magungunan sakin-sako a sigogin 500, 750 da 1000 mg. Prefix "tsawo" da sauran analogues

Kasuwancin magunguna na zamani yana cike da magungunan rigakafi, amma a cikin azuzuwan 10 na magungunan da aka tsara don sarrafa nau'in ciwon sukari na 2, metformin kadai ba shi da lafiya. Wannan shine kawai mai araha, magani mai zurfi wanda mai ciwon sukari ke buƙata a kowane mataki na cutar.

Abubuwan ban sha'awa game da metformin za'a iya samu a bidiyon.