Ciwon sukari mellitus cuta ce wacce babbar alama ce ta cinikin insulin. Karshe yana haifar da gaskiyar cewa matakin sukari ya tashi sosai ko raguwa zuwa dabi'un cututtukan cuta. Abincin abinci mai gina jiki da kuma yarda da wasu ƙa'idodi ba koyaushe yana ba da sakamakon da ake tsammanin ba, don haka likitoci sukan ba da magunguna waɗanda suke maye gurbin hormone tare da wani abu mai kama.
Glulin insulin shine analogue na insulin na halitta wanda jikin mutum yayi. An tsara shi don ciwon sukari mellitus tare da isasshen samar da wannan hormone.
Abun ciki da ka'idodin aiki
Babban sashi mai amfani da maganin shine insulin Glargin. Wannan kayan haɗin ne wanda aka samo ta hanyar canji. A cikin aiwatar da halittar sa, an maye gurbin abubuwa 3 masu mahimmanci. Amino acid Asparagine an maye gurbinsu da Glycine a cikin sarkar A, kuma an haɗa Arginines biyu a sarkar B. Sakamakon wannan sake haɗawa shine babban inganci don allura, wanda ke da amfani mai amfani aƙalla awanni 24.
Abubuwan da ke aiki, wanda aka haɗe tare da kayan taimako, suna da amfani mai amfani a jikin mai haƙuri. Tare da amfani da insulin Glargin ta hanyar da ta dace:
- Yana rinjayar masu karɓar insulin waɗanda suke cikin ƙwaƙwalwar ƙashi da ƙirar tsoka. Godiya ga wannan, tasiri mai kama da na insulin na halitta yana motsawa.
- normalizes metabolic tafiyar matakai: carbohydrate metabolism da glucose samar.
- Yana ƙarfafa ƙwayar glucose ta mai da ƙananan ƙwayar nama, ƙwayar tsoka da ƙashin ƙashi.
- Yana rage yawan samarda glucose mai yawa a cikin hanta.
- Yana ƙarfafa kwayar furotin da ya ɓace.
Magungunan sun shiga cikin shelf na kantin magani a cikin hanyar mafita: a cikin kwalabe 10 ml ko kuma kwandon shara 3 ml. Yana šaukar sa'a guda bayan gudanarwa.
Matsakaicin lokacin aiki shine awoyi 29.
Carcinogenicity da tasiri akan ikon ɗaukar ciki
Kafin a sayar da shi, an gwada maganin don maganin cututtukan fata - ikon wasu abubuwa don ƙara yiwuwar cutar ciwace-ciwacen daji da sauran maye gurbi. An gudanar da ƙarin insulin na insulin zuwa mice da berayen. Wannan ya haifar da:
- Babban mace-mace a cikin kowace rukunin dabbobi na gwaji;
- Mummunan cutuka a cikin mace (a fagen injections);
- Rashin ciwace-ciwacen tumbi lokacin da narkar da shi cikin abubuwan da ba acidic ba.
Gwajin da aka yi ya nuna mai yawan guba da ke tattare da dogaron insulin.
Toarfin haihuwar da haihuwar lafiya yana da illa.
Contraindications
Glargin ba da shawarar don amfani dashi tare da rashin damuwa da rashin haƙuri a cikin abubuwan ba. Yana dan shekara 6, ana amfani da maganin ne saboda karancin karatun asibiti. Yi amfani da miyagun ƙwayoyi tare da taka tsantsan a waɗannan lamura:
- Mai rauni ko matsakaici na koda;
- Canji a cikin hanta;
- Tsufa tare da koda yaushe yana karawa aikin koda.
A lokacin jiyya, kula da kullun matakin sukari, lura da daidaituwa lokacin allurar insulin cikin kitse mai ƙyalƙyali. Yi la'akari da halaye na jikin mai haƙuri - a wasu lokuta, ya kamata a canza sashi na miyagun ƙwayoyi.
Amincewa a lokacin daukar ciki da lactation
Mata masu haihuwar yara, an sanya maganin ne kawai bayan shawarwarin farko. An tsara miyagun ƙwayoyi a cikin lokuta inda yiwuwar amfani ga uwa ta fi haɗari ga tayin. Idan mace mai ciki tana da ciwon sukari na ciki, ana ba da shawarar a kula da matakan magudanan ruwa koyaushe.
A cikin kashi na biyu da na uku na ciki, bukatar insulin ya karu. Bayan haihuwa, bukatar maganin ta ragu sosai.
A kowane wata na ciki, kuna buƙatar yin hankali game da sukarin jini kuma ku kula da matakinsa koyaushe.
Sauran karfin jituwa
Yawancin kwayoyi suna shafar metabolism metabolism. A cikin waɗannan halayen, ana buƙatar canza sashin insulin. Magunguna waɗanda ke rage sukari kwatankwacinsu sun hada da:
- ACE da MAO masu hanawa;
- Disopyramids;
- Salicylates da wakilan sulfanide a kan ƙananan ƙwayoyin cuta;
- Fluoxetine;
- Dabanbannun fibrates.
Wasu kwayoyi na iya rage tasirin cututtukan ƙwayar cuta: glucocorticosteroids, diuretics, danazol, glucagon, isoniazid, diazoxide, estrogens, gestagens, da dai sauransu Don cikakken jerin magunguna marasa jituwa, duba umarnin shirya kayan.
M sakamako masu illa
Insulin Glargin magani ne na tsari wanda ke ratsa dukkan jiki, yana shafar matakan glucose da kuma hanyoyin aiki. Tare da amfani da shi ba ta dace ba, tsarin garkuwar jiki mai rauni da sauran fasalolin jikin mutum, ƙwayoyi na iya haifar da tasirin da ba a ke so.
Hypoglycemia
Wannan yanayin yanayin rayuwa ne wanda rage yawan sukarin jini cikin jini (ƙasa da 3.3 mmol / l). Yana faruwa a lokuta inda aka gudanar da aikin wuce haddi na insulin ga mai haƙuri, matuƙar wuce buƙatarta. Idan hypoglycemia mai tsanani ne kuma yana faruwa tsawon lokaci, yana barazanar rayuwar mutum. Hare-hare masu maimaitawa suna shafar tsarin juyayi. Sirrin mutum ya zama girgije da rikicewa, yana da wahala ma mai haƙuri ya mai da hankali.
A cikin manyan al'amura, mutum ya rasa hankali gaba daya. Tare da matsataccen matsakaicin jini, hannun mutum yakan yi rawar jiki, yana son cin abinci koyaushe, yana jin haushi kuma yana fama da bugun zuciya. Wasu marasa lafiya sun kara yawan gumi.
Sakamakon sakamako daga tsarin gani
Tare da tsarin glucose a cikin jini, kyallen takan zama damuwa kuma a karkashin matsin lamba. Ragewa a cikin ruwan tabarau na ido shima yana canzawa, wanda ke haifar da rikicewar gani, wanda a ƙarshe ya koma al'ada ba tare da tsangwama ba daga waje.
Tare da ciwon sukari na retinopathy (lalacewa na baya), hanyar cutar na iya taɓarɓar saboda hauhawar yanayi a cikin matakan glucose na jini. Tare da farfadowa da ƙwayar cuta, ana bada shawara don shawa a kai a kai. In ba haka ba, sakamako na gefe a cikin nau'i na hypoglycemia na iya haifar da asarar hangen nesa.
Lipodystrophy
Wannan shi ne lalata fataccen mai wanda ke tasowa a wuraren allurar insulin. Ctionaukar da hankali da damuwa. Don hana irin wannan amsa, ana bada shawara don canza / koyaushe wuraren allurar insulin.
Allergic halayen
Waɗannan halaye ne na gida da yawa: maganin urtikaria, rashes daban-daban, redness da itching, jin zafi a wurin allurar. Hypersensitivity ga insulin haɓakawa: haɓaka fata na fata (kusan dukkanin fata sun shafi), bronchospasm, angioedema, shock, ko hauhawar jijiya. Irin waɗannan halayen suna haɓaka kai tsaye kuma suna haifar da barazana ga rayuwar mai haƙuri.
A cikin lokuta mafi wuya, gabatarwar hormone yana ba da ƙarin halayen - riƙewa na sodium, samuwar edema da ƙirƙirar amsawar rigakafi ga aikin insulin. A cikin waɗannan halayen, dole ne a daidaita adadin maganin.
Kariya da aminci
Ba a wajabta insulin Glargin don ketoacidosis mai ciwon sukari ba, tunda wakili ne mai dadewa. Tare da hypoglycemia, mai haƙuri yana haɓaka alamun da ke taimakawa gane ƙarancin raguwar sukari koda kafin hakan ta faru. Koyaya, suna iya zama ƙasa da bayyanawa ko gaba ɗaya ba a cikin marasa lafiya na waɗannan rukunoni:
- Tare da kiyaye al'ada na glucose jini;
- Marasa lafiya waɗanda aka bi da su da wasu kwayoyi;
- Tare da rikice-rikice a cikin aikin psyche;
- Tare da ci gaba mai sauƙi, rauni mai ci gaba na halin rashin ƙarfi na hypoglycemia;
- Tsofaffi mutane;
- Tare da neuropathy da tsawon lokaci na ciwon sukari.
A cikin waɗannan lokuta yiwuwar hauhawar jini
Idan kun bi tsarin da aka tsara, akai-akai kula da matakan sukari na jini kuma ku ci daidai, da alama an rage girman yiwuwar cutar yawan kumburi. Idan akwai ƙarin dalilai, canza kashi.
Dalilan da ke haifar da raguwar glucose sun hada da:
- Hypersensitivity ga insulin;
- Canjin yanki wanda aka gabatar da miyagun ƙwayoyi;
- Cutar cututtukan da ke fama da matsanancin matsayi (zawo) da amai, rikita yanayin cutar sankara;
- Ayyukan jiki ba sabon abu bane ga jikin mai haƙuri;
- Almubazzaranci;
- Keta cin abincin abinci da kuma haramtattun abinci;
- Kasawa a cikin glandar thyroid;
- Haɗin kai tare da kwayoyi masu jituwa.
Tare da cututtukan haɗaka da kamuwa da cuta, kulawar glucose jini ya kamata ya zama cikakke.
Sanya jini da fitsari akai-akai don gwaji na gaba daya. Idan ya cancanta, daidaita sashi na insulin (musamman ga nau'in ciwon sukari 1).
Taimako na farko don yawan shan ruwa
Ragewa mai narkewa a cikin glucose shine sakamako mai illa tare da gabatarwar ƙara yawan ƙwayoyi. Ana iya taimakon mai haƙuri kamar haka:
- Ka ba shi mai sauƙin narkewa a jikin carbohydrates (misali, confectionery);
- Introduaddamar da glucacon cikin kitse na subcutaneous ko intramuscularly;
- A yi allurar magudanar ruwa (a cikin jijiya).
An bada shawarar motsa jiki don ragewa. Tsarin maganin, har ma da abincin, yana buƙatar daidaitawa.
Insulin Glargin: umarnin don amfani
An gabatar da kayan aiki a hankali cikin jiki a cikin yankin na ciki, yanki na kwatangwalo da kafadu. Ana amfani da analog na hormone 1 sau ɗaya kowace rana a takamaiman lokaci. Madadin wuraren allurar don guje wa hatimin da sauran sakamako mara kyau. Nuna shigar da miyagun ƙwayoyi a cikin jijiya haramun ne.
Sunan kasuwanci, farashi, yanayin ajiya
Ana samun maganin a ƙarƙashin sunayen cinikin da ke gaba:
- Lantus - 3700 rubles;
- Lantus SoloStar - 3500 rubles;
- Glargin Insulin - 3535 rubles.
Adana a cikin firiji a zazzabi na 2 zuwa 8. Bayan buɗewa, ajiye a wuri mai duhu da kuma daga isar yara, da zazzabi har zuwa digiri 25 (ba a cikin firiji).
Insulin Glargin: analogues
Idan farashin insulin glargine bai dace da ku ba ko kuma idan abubuwa da yawa da ba a ke so sun ci gaba daga shan shi, maye gurbin maganin tare da ɗayan analogues ɗin da ke ƙasa:
- Humalog (Lizpro) magani ne mai kama da insulin na halitta a tsari. Humalog yana cikin sauri cikin jini. Idan kun gudanar da magani kawai a cikin lokacin da aka wajabta na rana kuma a cikin sashi guda, Humalog zai sha sau biyu da sauri kuma zai kai matakan da ake so a cikin 2 hours. Kayan aiki yana aiki har zuwa 12 hours. Kudin Humalogue daga 1600 rubles ne.
- Aspart (Novorapid Penfill) magani ne wanda ke kwaikwayon amsawar insulin game da abincin. Yana aiki da ƙarfi sosai da gajeru, wanda ke ba shi sauƙi don sarrafa matakin glucose a cikin jini. Kudin samfurin ya kasance daga 1800 rubles.
- Glulisin (Apidra) shine mafi karancin maganin kwayar cutar insulin. Ta hanyar kaddarorin magunguna ba ya bambanta da Humalog, kuma ta hanyar aiki na rayuwa - daga insulin na halitta wanda jikin ɗan adam ya samar. Kudinsa - 1908 rubles.
Lokacin zabar maganin da ya dace, mai da hankali kan nau'in ciwon sukari, cututtukan haɗin kai da halaye na mutum.
