TRESIBA: UMARNIN DON AMFANI, SAKE DUBAWA GAME DA MASU CIWON SUKARI, FARASHI

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Tresiba shine mafi dadewa insulin basal da aka yiwa rajista har zuwa yau. Da farko, an kirkira shi ne ga marasa lafiya waɗanda har yanzu suna da nasu ƙwayar insulin, wato, don kamuwa da cutar siga 2. Yanzu an tabbatar da ingancin magungunan ga masu ciwon sukari masu cutar cuta ta 1.

Tresibu an samar da shi ta hanyar sanannen damuwar Danish NovoNordisk. Hakanan, samfuransa sune Actrapid na gargajiya da Protafan, sababbi ne na sabon analogues na insulin Levemir da NovoRapid. Masu ciwon sukari tare da gwaninta suna da'awar cewa Treshiba ba ta da ƙaranci ga magabata - Protafan na matsakaiciyar tsawon lokacin aiki da tsawon Levemir, kuma dangane da kwanciyar hankali da daidaituwa na aiki ya wuce su.

Ka'idar Treshiba

Ga masu ciwon sukari nau'in 1, sake maye gurbin insulin da ya ɓace ta allurar hormone na wucin gadi yana da izini. Tare da nau'in ciwon sukari na 2 mai tsawo, maganin insulin shine mafi inganci, jurewa mai sauƙi da magani mai tsada. Onlyayan abu mafi lalacewa kawai na shirye-shiryen insulin shine haɗarin haɗarin hauhawar jini.

Faduwa sukari yana da haɗari musamman da daddare, saboda ana iya gano latti, saboda haka buƙatun aminci na dogon insulins suna haɓaka koyaushe. A cikin ciwon sukari na mellitus, mafi tsayi kuma mafi tsayuwa, ƙarancin miƙar tasirin magani, ƙananan haɗarin hauhawar jini bayan gudanarwarsa.

Insulin Tresiba ya cika burin:

Ciwon sukari da hauhawar jini zai zama abin da ya wuce

Normalization na sukari -95%
Cirewa kan jijiyoyin mara wuya - 70%
Cire zuciyar mai karfin zuciya -90%
Rabu da cutar hawan jini - 92%
Increasearuwar kuzarin rana, inganta bacci da dare -97%

Magungunan yana cikin sabon rukuni na insulins na dogon lokaci, tunda yana aiki fiye da sauran, sa'o'i 42 ko fiye. Wannan ya faru ne saboda gaskiyar cewa kwayoyin halittun da aka gyara sun “manne tare” a karkashin fata kuma ana sakin su cikin jini a hankali.
Awanni 24 na farko, maganin yana shiga jini daidai, to kuwa sakamakon yana raguwa sosai. Kololuwar aiki gaba daya ba ya nan, bayanin martaba ya kusan lebur.
Duk allura suna aiki iri ɗaya. Kuna iya tabbata cewa ƙwayar zata yi aiki daidai kamar jiya. Sakamakon adadin allurai daidai yake a cikin marasa lafiya na shekaru daban-daban. Bambancin aiki a Tresiba sau 4 ƙasa da na Lantus.
Tresiba yana tsokanar kashi 36% na rashin ƙarfi na jini fiye da dogon lokacin insulin analogues a cikin lokaci daga 0:00 zuwa 6:00 hours tare da ciwon sukari na 2. Tare da nau'in cuta ta 1, amfanin ba a bayyane yake ba, ƙwayar ta rage haɗarin rashin jini a cikin maraba da kashi 17%, amma yana ƙaruwa da haɗarin rashin lafiyar rana da kashi 10%.

Abubuwan da ke aiki da Tresiba shine degludec (a wasu hanyoyin - degludec, Ingilishi degludec). Wannan insulin din ne dan adam yake canzawa, wanda a cikinsa ake canza tsarin kwayoyin. Kamar kwayoyin halitta, yana da ikon daure wa masu karɓar sel, ya inganta yanayin sukari daga jini zuwa kyallen, kuma yana rage jinkirin samar da glucose a cikin hanta.

Sakamakon tsarin da aka canza shi, wannan insulin din yana da yiwuwa ya samar da hadaddun hexamers a cikin kayan. Bayan gabatarwa a karkashin fata, yana samar da wani nau'in depot, wanda aka sha a hankali kuma a cikin tsawan lokaci, wanda ke tabbatar da samar da kwayar halittar hormone a cikin jini.

Nazarin Gwanaye

Arkady Alexandrovich

Endocrinologist tare da gwaninta

Tambaye gwani a tambaya

Daga ra'ayi na ilimin kimiyyar lissafi, tare da ciwon sukari, Tresiba ya fi sauran insulin basal maimaita sakewa na halitta na hormone.

Fom ɗin saki

Ana amfani da miyagun ƙwayoyi a cikin nau'i uku:

Tashanba Penfill - katuwar katako tare da mafita, maida hankali kan kwayar halittar a cikinsu ta zama daidaitacce - U za a iya buga insulin tare da sirinji ko sanya shi cikin akwatunan NovoPen da makamantansu.
Tresiba FlexTouch tare da maida hankali akan U100 - alkalami mai sirinji wanda aka ɗora kwandon shara 3 ml. Ana iya amfani da alkalami har sai insulin da ke ciki ya kare. Ba a bayar da sauyawa Cartridge. Matakan sashi - guda ɗaya, kashi mafi girma don gabatarwar 1 - raka'a 80.
Tresiba FlexTouch U200 - wanda aka kirkira don saduwa da ƙaruwar ƙwayar jijiyoyin jiki, yawanci waɗannan sune marasa lafiya masu ciwon sukari tare da juriya na insulin tsayayya. Thearfafa yawan insulin ya ninka sau biyu, don haka ƙarar mafita da aka gabatar da fata ba ta da yawa. Tare da sirinji na syringe, zaku iya shigar da sau ɗaya zuwa raka'a 160. hormone a karuwa of raka'a 2. Cartridges tare da babban taro na degludec Babu matsala zaka iya fita daga almarar sirinji na asali ka saka cikin wasu, kamar yadda wannan zai haifar da yawan yawan zubar jini da hauhawar jini.

Fom ɗin saki	Concentarfafa yawan insulin a cikin bayani, raka'a a cikin ml	Insulin a cikin katifa 1, naúra
Fom ɗin saki		ml	raka'a
Penfill	100	3	300
Fzarini	100	3	300
Fzarini	200	3	600

A cikin Rasha, dukkanin nau'ikan magungunan 3 suna rajista, amma a cikin kantunan magunguna suna ba da yawancin Tresib FlexTouch na maida hankali kamar yadda aka saba. Farashin Treshiba ya fi na sauran tsayi. Shirya tare da sikelin 5 (15 ml, raka'a 4500) farashi daga 7300 zuwa 8400 rubles.

Baya ga degludec, Tresiba ya ƙunshi glycerol, metacresol, phenol, zinc acetate. Acidity na maganin yana kusan tsaka tsaki saboda ƙari na hydrochloric acid ko sodium hydroxide.

Alamu don nadin Tresiba

Ana amfani da miyagun ƙwayoyi a hade tare da saurin insulins don maganin maye gurbin maganin cututtukan cututtukan fata don nau'ikan cututtukan guda biyu. Tare da nau'in cuta na 2, kawai ana iya yin insulin dogon magani a farkon matakin. Da farko, umarnin Rashanci don amfani dashi yana ba da izinin amfani da Treshiba na musamman ga majinyata na manya. Bayan nazarin da ke tabbatar da amincinsa ga kwayoyin masu haɓaka, an yi canje-canje ga umarnin, yanzu ya ba da damar amfani da miyagun ƙwayoyi a cikin yara daga shekara 1.

Tasirin degludec a kan ciki da ci gaban jarirai har zuwa shekara guda ba a yi nazarin ba, saboda haka, ba a sanya allurar ta Tresib ba don waɗannan nau'ikan marasa lafiya. Idan mai ciwon sukari ya lura da mummunan rashin lafiyan halayen ga degludec ko wasu abubuwan haɗin ginin, yana da kyau a nisanci jiyya tare da Tresiba.

Umarnin don amfani

Ba tare da sanin ka'idodin sarrafa insulin ba, rama mai kyau ga masu ciwon sukari ba zai yiwu ba. Rashin bin umarnin zai iya haifar da rikice-rikice: ketoacidosis da hypoglycemia mai tsanani.

Yadda ake kiyaye lafiya:

tare da nau'in ciwon sukari na 1, yakamata a zaɓi sashin da ake buƙata a cibiyar likitanci. Idan mai haƙuri ya karɓi insulin mai tsawo, lokacin da aka canza shi zuwa Tresiba, an fara barin kashi ɗin ba a canza shi ba, sannan a gyara don bayanan glycemic. Magungunan sun bayyana tasirinsa sosai cikin kwanaki 3, don haka an ba da izinin gyaran farko bayan wannan lokacin ya wuce;
tare da nau'in cutar 2, kashi na farawa shine raka'a 10, tare da babban nauyi - har zuwa raka'a 0.2. a kowace kg Sannan a hankali ana canza shi har sai cutar ta glycemia ta zama al'ada. A matsayinka na mai mulki, marasa lafiya tare da kiba, rage yawan aiki, tsayayyar insulin, da kuma rage yawan cututtukan cututtukan cututtukan mellitus na buƙatar allurai na Treshiba. Yayinda jiyya ke ci gaba, sannu a hankali suke raguwa;
duk da cewa insulin Tresiba yana aiki sama da awanni 24, suna yin allura sau ɗaya a rana a lokacin da aka ƙaddara. Ayyukan kashi na gaba ya kamata partially hade da wanda ya gabata;
za a iya gudanar da miyagun ƙwayoyi kawai a ƙarƙashin ƙasa. Abun da ke cikin kwakwalwa ba a so, saboda yana iya haifar da raguwar sukari, cikin ciki yana da haɗari ga rayuwa;
wurin allurar ba ta da mahimmanci, amma yawanci ana amfani da cinya don insulins mai tsawo, tun da an yi amfani da ɗan gajeren hormone a cikin ciki - ta yaya kuma a ina za a saka allurar;
alkalami mai sauƙi shine mai sauƙi, amma zai fi kyau idan halartar likitan halartar ku ya san ku da ƙa'idodin magance shi. Daidai ne, waɗannan ka'idojin an haɗa su cikin umarnin waɗanda aka haɗe zuwa kowane fakitin;
Kafin kowane gabatarwar, kuna buƙatar tabbatar da cewa bayyanar mafita bai canza ba, katun ɗin yana da ma'amala, kuma allurar ta zama mai iya aiki. Don bincika lafiyar tsarin, an saita sashi na raka'a 2 akan alkalami na syringe. kuma tura piston. Zaman saukar da m zai bayyana a ramin allura. Don Treshiba FlexTouch allurar asali NovoTvist, NovoFayn da analogues daga wasu masana'antun sun dace;
Bayan gabatarwar mafita, ba a cire allura daga fata a cikin dakikoki da yawa ba, domin insulin din ba ya fara fitowa ba. Kada a yi amfani da wurin da za a yi allura ko a sanyaya shi.

Ana iya amfani da Treshiba tare da duk magunguna masu rage sukari, gami da insulin mutum da analog, kazalika da allunan da aka umarta don ciwon sukari na 2.

Side sakamako

Zai yiwu sakamakon mummunan sakamako na maganin cutar sankara ta hanyar Tyariba da kimanta haɗarin su:

Side sakamako	Yiwuwar faruwa,%	Alamar halayyar mutum
Hypoglycemia	> 10	Tremor, pallor na fata, karuwar gumi, juyayi, gajiya, rashin iya maida hankali, matsananciyar yunwar.
Halin da ake ciki a fagen gudanarwa	< 10	Hemarancin basur, zafi, haushi a wurin allurar. Dangane da sake dubawa, yawanci suna faruwa ne a farkon maganin insulin, ƙarshe ya ɓace ko ya raunana. Edema yana faruwa a ƙasa da 1% na masu ciwon sukari.
Lipodystrophy	< 1	Canje-canje a cikin kauri daga cikin kasusuwa yana tare da kumburi. Don rage haɗarin lipodystrophy, canji koyaushe a yankin allura wajibi ne.
Allergic halayen	< 0,1	Mafi sau da yawa, ana nunawar rashin lafiyan kansa ta hanyar itching, amya, gudawa, amma halayen haɗari anaphylactic kuma zasu iya yiwuwa.

Hypoglycemia

Hypoglycemia shine sakamakon yawan zubar insulin na Tresib. Ana iya haifar dashi ta hanyar da aka rasa, kurakurai yayin gudanarwa, rashin glucose saboda kurakurai masu ƙoshin abinci ko ba'a san shi ba don aikin jiki.

Yawancin lokaci, alamun bayyanar cututtuka suna fara jin daɗin riga a matakin na hypoglycemia mai sauƙi. A wannan lokacin, ana iya haɓaka sukari da sauri tare da shayi mai zaki ko ruwan 'ya'yan itace, allunan glucose. Idan tare da ciwon sukari mellitus magana ko rashin daidaituwa na hankula a cikin sarari, asarar ɗan gajeren lokaci ya fara, wannan yana nuna canji na hypoglycemia zuwa mummunan mataki. A wannan lokacin, mai haƙuri ba zai iya jimre da faɗuwar sukari akan kansa ba, yana buƙatar taimakon wasu.

Dokokin ajiya

Dukkanin insulins sune shirye-shirye masu ƙaranƙushewa; a karkashin yanayin ajiya mara kyau ana rasa ingancin su. Alamomin ɓarna sune flakes, lumps, sediment, lu'ulu'u ne a cikin kabad, bayani mai hadari. Ba koyaushe suke kasancewa ba, sau da yawa ba za'a iya bambance insulin ta hanyar alamun waje.

Umarni game da amfani yana bada shawarar kayyade katako mai tsauri a yanayin zafi sama da 8 ° C. Rayuwar shelf yana iyakance ga makonni 30, idan har ana bin ka'idodin ajiya. Kada a yarda daskarewa da miyagun ƙwayoyi, saboda insulin shine furotin a yanayi kuma yana lalacewa a yanayin zafi ƙasa da sifiri.

Kafin amfani na farko, an cire Tirmanbu daga firiji don akalla awanni 2. Ana iya kiyaye alkairin sirinji tare da kicin din da aka fara dashi a zazzabi na ɗakuna tsawon makonni 8. A cewar masu ciwon sukari, ƙwayar ta zama mara amfani sosai nan da nan bayan wannan lokacin, kuma wani lokacin kaɗan. Tresiba insulin yana buƙatar samun kariya daga ultraviolet da radiation, microstveve, zazzabi mai zafi (> 30 ° C). Bayan allurar, cire allura daga sirinji mai rufi ka rufe katun tare da hula.

Reres insulin Treshiba

Arcadia, mai shekara 44 ya sake duba shi. Nau'in cuta guda 1, ina amfani da insulin Treshiba tsawon wata 1. Yanzu, a safiya da maraice, Ina da kusan guda sugar a kan komai a ciki, a kan Levemir da yamma koyaushe yana da ɗan ƙarami. A dare, glycemia gaba ɗaya cikakke ne, sauye sauƙaƙen da bai wuce 0.5 ba, an bincika musamman. Ya zama mafi sauƙi don kiyaye sukari daidai lokacin ƙoƙarin jiki, yanzu ba ya faɗuwa sosai kamar yadda ya gabata. Tsawon wata daya a cikin dakin motsa jiki babu wani ciwo guda daya. Abin ban sha'awa shine, yawan tsawon insulin na kasance iri daya, kuma NovoRapid ya rage da kashi daya bisa hudu. A bayyane yake, wani ɓangare na ayyukan Levemir an yi shi da gajeren insulin, amma ban ma san shi ba.

Polina ya bita, 51. Masana ilimin kimiya na endocrinologist sun bani shawarar Treshiba a matsayin mafi kyawun insulin da ake samu yanzu. Ba zan iya jimre da shi ba, bayan allura, matsanancin ƙoshin jiki, ƙaiƙayi, ƙwanƙwasa jini ya zama sau da yawa, a sakamakon haka na koma Lantus. Kuma farashin Treshiba ba shi da farin ciki, a gare ni ya yi tsada da yawa.

Arcadia, mai shekaru 37 ya bita. Yarinya 10 years old, tana da ciwon sukari daga watan Yunin da ya gabata. Daga farkon, sun zaɓi allurai na Tresiba da Apidra a asibiti, don haka ba zan iya kwatanta su da sauran abubuwan rashin lafiya ba. Babu wasu matsaloli na musamman da Tresiba, fata kawai ya zube da farko. Da farko, an magance matsalar tare da daskararren ruwa, to, rashin jin daɗin kansa ya lalace. Muna amfani da Dekskom, saboda haka ina da duk sukari a hannuna. Da dare, jadawalin glycemic kusan kusan a kwance yake, Tresiba yana aiwatar da ayyukanta daidai.

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