Kwayar Combogliz - magani don sabon ƙarni na ciwon sukari

Haɗin maganin metformin da DPP4 inhibitors (glyptins) an gano su ta hanyar endocrinologists a matsayin mafi ma'ana ga masu ciwon sukari na 2. Abubuwan da aka yi nazari da yawa daga aji na gliptins shine saxagliptin. An sake sayar da fili na saxagliptin tare da metformin a cikin kwamfutar hannu guda daya a cikin 2013 a karkashin sunan Combogliz Prolong.

Abubuwan da ke aiki a cikin abubuwan da ke cikin su suna da tasirin gaske: suna rage juriya ga insulin kuma suna inganta haɓakar insulin. Haka kuma, ƙwayar ta tabbatar da aminci ga zuciya da jijiyoyin jini, kusan ba sa haifar da ƙin jini, ba ya ba da gudummawar ƙimar nauyi. Algorithms na gida na maganin cututtukan cikin gida suna ba da shawarar shan Combogliz Prolong na marasa lafiya da rashi insulin. Tare da glycated haemoglobin sama da 9%, ana iya rubuto shi nan da nan bayan gano ciwon sukari.

Hanyar aiwatar da aiki daidai

Combogliz Prolong magani ne na Ba'amurke, haƙƙin haƙƙin na nasa na kamfanonin Bristol Myers da Astra Zeneka ne. Allunan suna da zaɓuɓɓukan sashi guda 3, wanda ke ba da damar zaɓar madaidaitan adadin metformin da saxagliptin, gwargwadon halayen cutar:

Ciwon sukari da hauhawar jini zai zama abin da ya wuce

• Normalization na sukari -95%
• Cirewa kan jijiyoyin mara wuya - 70%
• Cire zuciyar mai karfin zuciya -90%
• Rabu da cutar hawan jini - 92%
• Increasearuwar kuzarin rana, inganta bacci da dare -97%

• 1000 MG + 2.5 MG ya dace da masu ciwon sukari tare da tsayayyar insulin, kiba, ƙarancin motsi;
• 1000 mg + 5 mg wani zaɓi ne na gama gari ga marasa lafiya da masu ciwon sukari tare da rage ƙarancin insulin da ƙaramin nauyi;
• Ana amfani da 500 + 5 MG a farkon jiyya tare da Combogliz Prolong, za'a iya amfani dashi akan ci gaba mai gudana tare da ƙarancin insulin, nauyin jiki na al'ada.

Lokacin da aka bincika daidaituwa na Comboglyz da abubuwan da ke ciki, metformin da saxagliptin, ya juya cewa babu bambance-bambance a cikin magungunan magungunan, haɗuwa da abubuwa guda biyu a cikin kwamfutar hannu guda ɗaya ba ya lalata kaddarorin kowane ɗayansu ba, tasirin cutar kansar daidai yake.

A lokaci guda, ana ɗaukar hadadden magunguna mafi inganci fiye da ɗaukar kwayoyi iri daban. Wannan ya faru ne saboda karuwa da yarda da magani, ajalin yana nufin yarda da duk magungunan likitan. A cikin cututtukan cututtukan ƙwayar cuta, irin su ciwon sukari mellitus, yana da ƙarancin al'ada: marasa lafiya sun manta da ɗaukar wani kwaya, ko kuma sun daina shan ɗayan magunguna. Karatun yana nuna cewa mafi sauƙin tsarin kulawa, mafi sauƙin likita zai iya cimma. Canjin daga metformin da saxagliptin daban zuwa Combogliz Prolong yana ba ku damar kara rage hawan jini da kashi 0,53%.

Metformin

Shekaru da yawa, yana da metformin wanda ƙungiyar masu ciwon sukari ke ba da shawarar a farkon shi. Wannan shi ne saboda gaskiyar cewa metformin yana aiki a kan babban dalilin cutar hawan jini a cikin nau'in masu ciwon sukari na 2 - juriya na insulin. Dangane da umarnin, rage yawan cutar glycemia a cikin ciwon sukari yana faruwa ne saboda:

• dakatarwar samar da glucose a cikin jiki (gluconeogenesis, zuwa ƙarancin girma - glycogenolysis);
• rage jinkirin shakar sukari a cikin narkewar abinci;
• ƙara yawan aikin insulin a cikin kyallen takarda, musamman tsoka.

Yawancin lokaci ana tantance ingancin magunguna masu rage sukari da raguwar haemoglobin idan an sha su. Don metformin, wannan alamar yana da girma sosai - 1-2%. Magungunan ba shi da tsaka tsaki dangane da nauyi; fiye da shekaru 10 na gudanarwa, matsakaicin karuwa a cikin marasa lafiya da ke fama da cutar sukari ya kasance 1 kg, wanda ba shi da ƙarancin magani tare da maganin insulin da abubuwan ƙira na sulfonylurea.

Abin takaici, yin jiyya tare da metformin ba koyaushe zai yiwu ba saboda sakamakon da ke tattare da shi - rashin jin daɗi na ciki, zawo, cutar safiya. Don haɓaka haƙuri na miyagun ƙwayoyi, an fara fito da shi a cikin nau'ikan allunan tare da gyara (tsawaita) saki. Yana da irin wannan metformin wanda yake a cikin Comboglize Prolong. Kwamfutar hannu tana da tsari na musamman: ana sanya abu mai aiki a cikin matrix wanda ya sha ruwa. Bayan gudanarwa, matrix ya juya ya zama jel, wanda ke haifar da jinkirin fitar da tsarin metformin daga ciki zuwa cikin jini. Ingancin rage karfin sukari ana tsawanta ta wannan hanyar har zuwa awanni 24, don haka umarnin yin amfani da shawarar bayar da shawarar shan Allunan sau daya a rana.

Saxagliptin

Wannan bangaren Comboglize Prolong yana da alhakin inganta aikin insulin. Hanyar aiwatar da saxagliptin shine hana enzyme DPP-4, aikin sa shine rushewar abubuwan ciki. Ana samar da tsoka ta hanyar haɓakar glycemia da kuma haɓaka haɓaka haɓakar aikin insulin. Idan kun rage tasirin DPP-4, incretins zasuyi aiki mai tsawo, aikin insulin zai karu, glucose jini zai ragu.

Amfanin maganin shine dangantakar glucose a cikin jini da samarda insulin. Abubuwan da suka samo asali na sulfonylurea basu da wannan alaƙar. Ko da a cikin babban allurai, saxagliptin ba zai iya tsawaita rayuwar mahaɗa ba fiye da sau 2, don haka tasirin rage nauyin shi a cikin lokaci kuma a zahiri ba ya haifar da hypoglycemia. Ba rage raguwa guda daya na hatsarin glucose ba yayin da aka yi amfani da shi. Halin mai hankali na saxagliptin zuwa ƙwayoyin beta waɗanda ke samar da insulin yana ba da damar tsawaita aikin su da jinkirta lokacin ba da maganin insulin, wanda ba makawa a cikin ciwon sukari mellitus.

Dukansu metformin da saxacgliptin suna rage jinkirin shigar glucose daga jijiyoyin cikin hancin. A cewar masu ciwon sukari, magungunan biyu suna rage yawan ci da haɓaka satiety, don haka Combogliz Prolong shine mafi kyawun zaɓi ga marasa lafiya da ke da nauyin wuce kima, sabanin sananniyar haɗuwa da metformin tare da sulfonylurea.

Abinda kawai ɓarkewar saxagliptin shine farashinsa, wanda yake tsari ne na girman girma fiye da shirye-shiryen sulfonylurea mai arha.

Abubuwan taimako

Baya ga abubuwa masu aiki, Allunan Combogliz Prolong suma suna dauke da wasu abubuwan da zasu inganta kayan aiki tare da samar da tsawan metformin. A matsayin ɓangare na ciki, ko matrix, magnesium stearate, hypromellose, carmellose. Allunan suna da llsa Oan Opadrai guda uku, wanda ya ofunshi talc, titanium oxide, macrogol. Babban saman ya ƙunshi rina - baƙin ƙarfe.

Dosages daban sun bambanta a launi: 2.5 + 1000 mg rawaya, 5 + 500 m, 5 + 1000 ruwan hoda. Ga kowane kwamfutar hannu, ana amfani da suturar da ta dace tare da fenti mai shuɗi.

An keɓance kayan haɗin kai tare da feces a cikin nau'i mai taushi, zai iya ɗaukar nau'in kwamfutar hannu. Babu sauran abubuwa masu aiki a wannan taro.

Rayuwar shiryayye na Comboglize Prolong shine shekaru 3. Abinda kawai masana'antun ke buƙata don yanayin ajiya shine zazzabi har zuwa digiri 30.

Farashin marufi daga 3150 zuwa 3900 rubles. ya danganta da yawan allunan a cikin fakitin (28 ko 56 inji mai kwakwalwa) da sashi.

Dokokin shan magani

Thewarin da aka bada shawarar kwayar saxagliptin ga yawancin masu ciwon sukari shine 5 MG. Smalleraramin kashi na 2.5 mg an tsara shi don gazawar renal tare da GFR ƙasa da 50, kazalika yayin ɗaukar wasu magungunan antifungal, antibacterial da antiretroviral waɗanda ke haɓaka haɗakar saxagliptin a cikin jini.

An zaɓi sashi na metformin daban-daban dangane da matakin ƙarfin insulin. A farkon rabin watan, masu fama da cutar sankara suna shan kwamfutar hannu 1 dauke da 5 + 500 MG.

A farkon farawa, hadarin sakamako na sakamako na metformin yana da girma sosai. Don rage su, ana ɗaukar maganin a hankali tare da abinci, zai fi dacewa da yamma. Idan an yarda da metformin da kyau, bayan makonni 2, ana ƙaruwa da kashi zuwa 1000 mg. Saxagliptin ya bugu daidai gwargwado. Idan akwai wani rashin jin daɗi a cikin narkewar narkewa, ya kamata a jinkirta karuwar kashi kuma a ba ƙarin lokaci don jikin don amfani dashi ga maganin. Idan glycemia al'ada ce, ana iya ɗaukar Combogliz Prolong a cikin wannan adadin don shekaru da yawa ba tare da asarar tasiri ba.

Matsakaicin iyakar izinin Comboglize shine 5 + 2000 MG. An ba da shi ta allunan 2 na 2.5 + 1000 MG, sun bugu a lokaci guda. Idan 2000 MG na metformin don ciwon sukari bai isa ba, ana iya ɗaukar 1000 mg daban, zai fi dacewa a cikin tsawan tsari guda (Glucofage Long da analogues: Formin Long, Metformin MV, da sauransu).

Don tabbatar da tsarin daidaituwa na abubuwan da ke aiki, maganin yana bugu da misalin lokaci guda. Don adana kayan da aka tsawaita na allunan ba za'a iya murƙushe su ba.

Yadda zaka maye gurbin Combogliz Prolong

Jini a cikin Combogliz Prolong ba ya nan kuma ba zai fito nan gaba ba, tunda har yanzu maganin yana dauke da shi. Rukunin analogues na rukuni suna linagliptin gliptins (an haɗa haɗuwa tare da metformin a ƙarƙashin alamar kasuwanci ta Gentadueto), vildagliptin (Galvus Met hade miyagun ƙwayoyi), sitagliptin (Velmetia, Yanumet). Sakamakonsu a cikin ciwon sukari na mellitus shine mafi kusanci ga saxagliptin, amma abubuwa sun bambanta a cikin magunguna, magunguna, contraindications, don haka canzawa zuwa sabon magani dole ne a yarda da likita.

Ta yaya zaka iya adanawa kan siyan Combogliz Na Tsawon Lokaci:

1. Combogliz na Zamani daga Onglisa da Metformin. Onglisa - magani ne na masana'anta guda, ya ƙunshi 2.5 ko 5 MG na saxagliptin. Farashinsa shine 1800 rubles. don allunan 30 na 5 MG. Don sake maimaita gaba ɗaya abun da ke ciki na Combogliz Prolong, kowane ƙaramin metformin yana ƙara zuwa Ongliz, zai biya 250-750 rubles wata daya.
2. Tambayi likitanka don neman magani kyauta don tabbatarwa. Wataƙila ba za a iya samun miyagun ƙwayoyi a duk yankuna ba, amma adadinsu yana haɓaka kowace shekara. Nunawa don alƙawarin saxagliptin - hypoglycemia mai yawa ko rashin ƙarfi a kan sulfonylurea. Tun da maganin ba shi da ilimin tsirrai masu tsada, kantin magani zai ba ku ko dai allunan asalin Combogliz Prolong na asali, ko metformin da Onglizu.
3. Idan kayi odar magani a cikin kantin magani ta kan layi ka ɗauke shi kanka daga batun batun, zaka iya ajiye kusan 10% na farashinsa.

Canzawa zuwa kayan aikin sulfonylurea abu ne wanda ba a son shi, saboda suna iya haifar da hypoglycemia. Idan babu wani madadin, zai fi kyau ɗaukar mafi kyawun glimepiride da gliclazide. Analogues na miyagun ƙwayoyi Combogliz tare da waɗannan abubuwa - Amaril M, Glimecomb.

Alamu don amfani

Dangane da umarnin, an tsara allunan Combogliz Prolong don ciwon sukari na nau'in 2, idan gyaran abinci da abinci na jiki bai isa rage rage yawan ƙwayar cuta ba. Ganin yawan farashin maganin, ƙarancinsa ya fi kaɗan. Dangane da endocrinologists, suna ba da magani a cikin halayen masu zuwa:

1. Idan haƙuri ya rage insulin kira, kuma shan sulfonylurea ne contraindicated.
2. Tare da babban haɗarin hypoglycemia: tsofaffi, masu ciwon sukari tare da cututtuka masu haɗari da ƙuntatawa na abinci, marasa lafiya tare da babban aiki na jiki, suna aiki a wurin da ke buƙatar matsanancin kulawa.
3. Marasa lafiya na masu ciwon sukari da ba sa bin shawarar likitan koyaushe na iya manta shan kwaya ko kuma a kan lokaci.
4. Masu ciwon sukari tare da neuropathy waɗanda suka share alamun hypoglycemia.
5. Idan mai ciwon sukari yayi aiki da dukkan karfinsa don kaucewa juyawa zuwa insulin. An yi imani cewa sulfonylurea na iya haɓaka halakar sel. Babu irin wannan bayanin game da sacasagliptin.

Contraindications

Jerin contraindications a cikin umarnin Combogliz Prolong yana da faɗi sosai, kamar a kowane magani:

Side effects

Saxagliptin dan kadan yana kara saurin kamuwa da ciwon kai (ta 1.5%), sinusitis, amai (1%), ciwon ciki (1.9%), gastroenteritis (1.4%), rashin lafiyan (1.1%).

Daga cikin halayen sakamako na metformin, an lura da tashin zuciya da amai yayin shan allunan Combogliz Prolong. Yawan su ya fi 5%.

Samun yawaitar saxagliptin ba mai haɗari bane kuma yana haifar da maye. Wuce kashi na metformin na iya shafar lafiyar sosai. Na uku na masu ciwon sukari waɗanda suka dauki fiye da 50 g na metformin da zarar sun fara haɓaka lactic acidosis.

Yayin ɗaukar Tsarin Tsarin Metformin, wasu kwayoyi na iya canza tasirin hypoglycemic. Ya kamata a biya kulawa ta musamman ga ƙwayoyin rigakafi, antifungal, hormonal da antihypertensive, antidepressants, cikakken jerin su yana cikin umarnin. Lokacin amfani da ketoconazole antifungal da itraconazole, maganin clarithromycin da telithromycin, nefazodone antide, magungunan rigakafin kwayar cutar HIV a rana, kawai 2.5 mg ne na saxagliptin.

Ra'ayoyi game da Haduwa