Onglisa - magani ne don kamuwa da cutar sabon zamani

Onglisa yana ɗaya daga cikin wakilan sabon rukuni na wakilai na hypoglycemic, Dhib-4 inhibitors. A miyagun ƙwayoyi yana da asali daban-daban tsarin aikin aiki daga wasu alluran maganin cututtukan ƙwayoyin cuta. Dangane da tasiri, Ongliza yana iya kama da hanyoyin gargajiya, dangane da amincin amfani, ya fi su yawa. Bugu da ƙari, ƙwayar tana da tasiri mai kyau akan abubuwan da suka shafi, rage jinkirin ciwan sukari da haɓaka rikice-rikice.

Masana ilimin kimiyya sunyi imanin cewa halittar waɗannan masu hana ruwa katuwa ne babban mataki na gaba game da magance cutar sankara. Ana tsammanin cewa gano na gaba zai zama magunguna waɗanda zasu iya dawo da dogon lokaci su dawo da aikin ƙwaƙwalwar da ya ɓace.

Me maganin Onglisa yake nufi?

Wani nau'in ciwon sukari na 2 ana nuna shi ta hanyar raunin jijiyoyin ƙwayoyin ƙwayar ƙwayar cuta zuwa glucose, jinkirta a farkon matakin insulin kira (a cikin martanin abinci na carbohydrate). Tare da karuwa a cikin tsawon lokacin cutar, kashi na biyu na samar da kwayoyin halitta a hankali ya ɓace. An yi imanin cewa babban dalilin rashin kyawun ƙwayoyin beta wanda ke haifar da insulin shine rashin ɗaukar ciki. Wadannan sune peptides wanda ke motsa sirrin kwayoyin, ana samar dasu ne domin mayar da martani ga kwararar glucose a cikin jini.

Onglisa ya jinkirta aiwatar da aikin enzyme na DPP-4, wanda ya zama dole don rushewar abubuwan incretins. Sakamakon haka, suna kasancewa cikin jini ya fi tsayi, wanda ke nufin cewa ana samar da insulin a cikin girma fiye da yadda aka saba. Wannan tasirin yana taimakawa wajen daidaita cututtukan ƙwayar cuta da a kan komai a ciki, kuma bayan cin abinci, sai ku kawo matsanancin ƙwayar cuta kusa da ilimin ɗan adam. Bayan alƙawarin Onglisa, haemoglobin mai glycated a cikin marasa lafiya an rage shi da 1.7%.

Aikin Onglises ya danganta ne da fadada aikin nasa kwayoyin halittun, magani yana kara maida hankali a cikin jini kasa da sau 2. Yayinda glycemia ke gabatowa al'ada, abubuwan da ake lalata sun daina yin tasiri a cikin kwayar insulin. A wannan batun, kusan babu haɗarin cutar hawan jini a cikin masu ciwon suga da shan miyagun ƙwayoyi. Hakanan, rashin tabbas na Onglisa shine rashin tasirinsa akan nauyi da kuma yiwuwar ɗauka tare da wasu allunan na sukari.

Ciwon sukari da hauhawar jini zai zama abin da ya wuce

• Normalization na sukari -95%
• Cirewa kan jijiyoyin mara wuya - 70%
• Cire zuciyar mai karfin zuciya -90%
• Rabu da cutar hawan jini - 92%
• Increasearuwar kuzarin rana, inganta bacci da dare -97%

Baya ga babban aiki, Onglisa shima yana da wani tasiri mai kyau a jiki:

1. Magungunan yana rage yawan glucose daga cikin hanji zuwa cikin jini, ta haka yana ba da gudummawa ga rage karfin jure insulin da sukari bayan cin abinci.
2. Yana shiga cikin ka'idar halayen cin abinci. Dangane da marasa lafiya, Onglisa yana kara karfin ji, wanda yake da matukar mahimmanci ga masu ciwon sukari da kiba.
3. Ba kamar shirye-shiryen sulfonylurea ba, wanda kuma yana haɓaka aikin insulin, Onglisa baya cutarwa ga ƙwayoyin beta. Nazarin sun bayyana cewa ba wai kawai yana lalata ƙwayoyin ƙwayar ƙwayar ƙwayar cuta ba, amma, akasin haka, yana kare har ma da ƙara adadin su.

Abun ciki da nau'i na saki

Kamfanin magungunan an samar da shi ne a cikin Amurka ta kamfanin Angra-Sweden AstraZeneca. Allunan da aka shirya za'a iya shirya su a Italiya ko Burtaniya. A cikin kunshin 3 murƙushe blister na allunan 10 kowannensu da umarnin don amfani.

Abubuwan da ke aiki na miyagun ƙwayoyi shine saxagliptin. Wannan shine mafi sabuwa na abubuwan DPP-4 wanda aka hana amfani dasu a halin yanzu; ya shiga kasuwa a cikin 2009. Kamar yadda aka haɗa abubuwan taimako, lactose, cellulose, magnesium stearate, croscarmellose sodium, ana amfani da dyes.

Onglisa yana da digo 2 - 2.5; 5 MG Allunan 2.5m rawaya, asalin maganin za'a iya bambanta shi da rubutun 2.5 da 4214 a kowane gefen kwamfutar. Onglisa 5 MG tana canza launin ruwan hoda, mai alama tare da lambobi 5 da 4215.

Dole ne a sami magungunan don siyarwa ta takardar sayan magani, amma ba a lura da wannan yanayin a cikin dukkanin kantin magani ba. Farashin Onglizu yayi matukar girma - kusan 1900 rubles. kowace fakiti. A cikin 2015, an saka saxagliptin a cikin jerin magungunan Mahimmanci da Mahimmanci, don haka masu ciwon sukari da ke rajista na iya ƙoƙarin samun waɗannan magungunan kyauta. Ongliza ba shi da ƙwayar cuta, don haka dole ne su bayar da maganin na asali.

Yadda ake ɗauka

Onglisa ya wajabta maganin ciwon sukari na 2. Jiyya ba tare da gazawa ya kamata ya haɗa da abinci da motsa jiki. Kar ka manta cewa kwayoyi suna aiki a hankali. Tare da amfani da carbohydrates mara amfani da salon rayuwa mai rai, baya samun damar biyan diyya da ake buƙata don ciwon sukari.

A bioavailability na saxagliptin shine 75%, ana lura da mafi girman abubuwan da ke cikin jini bayan minti 150. Tasirin miyagun ƙwayoyi ya kasance aƙalla awanni 24, don haka ba lallai ba ne don ɗaukar abincinsa. Allunan suna cikin kwandon fim, ba za a iya kakkarye su ba.

Shawarar da aka bada shawarar yau da kullun shine 5 MG. Ga tsofaffi marasa lafiya da keɓaɓɓen renal da hepatic kasawa, ba a buƙatar daidaita sashi.

Lowerarancin kashi (2.5 MG) ba da wuya a wajabta shi:

• tare da gazawar koda tare da GFR <50. Idan ana zargin cutar koda, ana ba da shawarar yin binciken aikinsu;
• na ɗan lokaci, idan ya cancanta, shan wasu ƙwayoyin rigakafi, maganin rigakafi, masu hana ƙwayar cuta, an nuna cikakken jerin abubuwan su a cikin umarnin.

Nazarin Gwanaye

Arkady Alexandrovich

Endocrinologist tare da gwaninta

Tambaye gwani a tambaya

Idan mai ciwon sukari ya rasa shan kwayoyin, zaka iya sha shi a lokacin. Damuwa da kashi na gaba washegari haramun ne daga umarnin. Yawan abin sama da ya kamata ba ya inganta kula da cutar siga, amma ba ya haifar da babban hadari. Ba a sami sakamako mai guba ba koda tare da amfani guda ɗaya na 400 MG na saxagliptin.

Contraindications da cutar

Ongliz bai nada ba:

1. A lokacin daukar ciki, lactation. Sakamakon magani a kan haɓakar tayi, yiwuwar shigar ciki cikin madara ba tukuna karatu.
2. Idan mara lafiya yana kasa da shekara 18. Babu bayanan tsaro saboda karancin bincike da ya shafi yara.
3. Idan maganganun hypersensitivity ga saxagliptin ya faru a baya, wasu kwayoyi daga wannan rukuni, abubuwan taimako na kwamfutar hannu. A cewar masana'anta, hadarin irin wannan halayen shine 1.5%. Dukkanin basu buƙatar sanya haƙuri a cikin ma'aikata ba kuma ba su da barazanar rayuwa.
4. Tare da rashin yarda da lactose.
5. Marasa lafiya waɗanda suka dakatar da aikin insulin ɗin su gaba ɗaya (nau'in 1 na ciwon sukari, tiyata na huhu).

A ɗan lokaci, an maye gurbin maganin tare da maganin insulin don ketoacidosis mai tsanani, tiyata mai tsanani da raunin da ya faru.

Onglisa yana da babban matakin tsaro. Wannan shi ne ɗayan drugsan magungunan maganin cututtukan cututtukan cututtukan da ba su da wata illa. Dangane da sakamakon binciken mummunan sakamako a cikin marasa lafiya tare da saxagliptin, akwai da yawa kamar yadda suke cikin ƙungiyar kulawa. Koyaya, umarnin don amfani ya nuna duk matsalolin da aka fuskanta a cikin marasa lafiya: cututtukan numfashi da urinary fili, amai, gudawa, amai, ciwon ciki, raɗa, itching, gajiya.

Yi amfani da wasu magunguna

Don hana rikice-rikice masu yawa na ciwon sukari a cikin miliyoyin marasa lafiya, ana shigar da sabbin magunguna da tsarin kulawa akai-akai cikin aikin asibiti. A halin yanzu ana amfani da magani na yau da kullun metformin + salon rayuwa. Idan wannan kit ɗin bai isa ba, fara maganin haɗuwa: ƙara ɗayan magunguna da aka yarda da su don maganin da ake akwai.

Abin takaici, ba dukkan su suna da aminci da ingancin isa:

Onglisa dangane da inganci ya yi daidai da magungunan da ke sama, kuma cikin sharuddan aminci da ƙarancin contraindications, ya fi su girma, don haka ana ɗaukar cewa za a ƙara rubuta shi ga marasa lafiya.

Endungiyar Endocrinologists ta Rasha ta amince da amfani da masu hana DPP-4 inhibitors tare da metformin a matsayin layin farko na jiyya ga masu ciwon sukari. Duk waɗannan magungunan ba sa ba da gudummawa ga hypoglycemia, suna shafar sanadin ƙwayar sukari daga kusurwa daban-daban: suna shafar juriya na insulin da lalata ƙwayoyin beta.

Don sauƙaƙe tsarin kulawa, wannan masana'anta ta ƙirƙiri Combogliz Prolong. Allunan suna dauke da 500 ko 1000 mg na metformin tsawaitawa da kuma 2.5 ko 5 mg na saxagliptin. Farashin kunshin kowane wata kusan 3300 rubles. Cikakken analog na miyagun ƙwayoyi haɗuwa ne na Ongliza da Glucofage Long, zaiyi tsada dubu rubles mai rahusa.

Idan duka magunguna biyu a iyakar adadin ba su bayar da tasirin da ake buƙata ba don maganin ciwon sukari, an yarda da shi don ƙara sulfonylureas, glitazones, insulin zuwa tsarin kulawa.

Shin zai yiwu a maye gurbin wani abu

Onglisa shine kawai magani na saxagliptin zuwa yau. Yayi wuri da wuri don magana game da bayyanar analogues mara tsada, tunda kariyar mallaka tana aiki don sababbin kwayoyi, waɗanda suka haramta kwafin asalin. Don haka, an baiwa mai ba da damar damar sake binciken bincike mai tsada, daɗaɗa ci gaba game da magunguna. Yi tsammanin rage farashin Ongliza bai dace ba.

A cikin kantin magunguna na Rasha, ban da Onglisa, zaku iya siyan allunan daga rukuni guda na Galvus da Januvius. Wadannan kwayoyi suna da irin wannan tasirin kan cutar sankarar bargo, kwatankwacin sharuddan aminci da inganci bai bayyana bambance-bambance tsakanin su ba. Dangane da sake dubawa game da masu ciwon sukari, zaku iya samun su kyauta ba a duk yankuna ba, duk da cewa dukkaninsu suna cikin shekara a cikin jerin mahimman magunguna.

Sayar da kai na waɗannan magunguna masu zaman kansu zai biya mai yawa:

Kuna iya ba da izinin rahusa waɗannan kwayoyin a cikin kantin magani na kan layi. A cikin mafi girma daga cikinsu akwai yiwuwar ɗaukar hoto na kyauta daga kantin magani daga kusa da gidan.

A cikin 2017, an ba da sanarwar sakin magunguna hade da saxagliptin da dapagliflozin da ake kira Qtern. Ya haɗu da fa'idodin ɗayan cututtukan cututtukan cututtukan ƙwayar cuta - Forsigi da Onglisa. A Rasha, har yanzu ba a yi rajista da sababbin allunan ba.

Nasiha