Bayan bayyanar gajeren insulin analogues, ciwon sukari mellitus far ya isa da asali sabon matakin: bargawar sarrafa glycemia a cikin mafi yawan marasa lafiya ya zama mai yiwuwa, haɗarin rikicewar microvascular, hypoglycemic coma ya ragu sosai.
Apidra ita ce mafi ƙarancin wakilcin wannan rukunin, haƙƙin ƙwayoyi yana cikin damuwa game da Faransawa Sanofi, wanda ke da rassa da yawa, ɗayansu yana cikin Rasha. Apidra ya tabbatar da fa'ida akan takaitaccen ɗan adam: yana farawa yana tsayawa da sauri, ya kai kololuwa. Sakamakon haka, masu ciwon sukari na iya ƙin abun ciye-ciye, ba su da alaƙa da lokacin cin abinci, kuma an kuɓutar da su daga jiran sai lokacin aikin ya fara aiki. A wata kalma, sababbin magunguna sun keta al'ada ta dukkan fannoni. Wannan shine dalilin da ya sa adadin marasa lafiya da suke amfani da insulin analogues ke girma akai-akai.
Umarnin don amfani
| Abun ciki | Abunda yake aiki shine glulisin, kwayoyin sa sun sha bamban da endogenous (wanda yake cikin jiki) insulin ta hanyar amino acid biyu. Saboda wannan sauyawa, glulisin ba ya karkatar da samar da hadaddun mahaifa a cikin kwayar da a karkashin fata, don haka yana shiga cikin hanzarin jini nan da nan bayan allura. Abubuwa masu taimako sun hada da m-cresol, chloride da sodium hydroxide, sulfuric acid, tromethamine. An samar da kwanciyar hankali na mafita ta hanyar ƙarin polysorbate. Ba kamar sauran shirye-shiryen gajere ba, insulin Apidra baya dauke da zinc. Maganin yana da pH na tsaka tsaki (7.3), saboda haka ana iya dillen idan ana buƙatar ƙarancin allurai. |
| Pharmacodynamics | Dangane da ka’idar da karfin aiki, glulisin ya yi kama da insulin na mutum, ya zarce shi cikin sauri da lokacin aiki. Apidra yana rage haɗarin sukari a cikin tasoshin jini ta hanyar ɗaukar hankalin shi ta tsokoki da tsoput nama, yana kuma hana aikin glucose ta hanta. |
| Alamu | Anyi amfani da shi don kamuwa da sukari don rage glucose bayan cin abinci. Tare da taimakon miyagun ƙwayoyi, ana iya gyara hyperglycemia cikin sauri, tare da tare da rikitattun cututtukan ciwon sukari. Ana iya amfani dashi a cikin duk marasa lafiya daga shekaru 6, ba tare da la'akari da jinsi da nauyi ba. Dangane da umarnin, ana ba da izinin insulin cikin insidra ga tsofaffi marasa lafiya da ke fama da hepatic da na koda da kasawa. |
| Contraindications | Ba za a iya amfani da shi don hypoglycemia ba.. Idan sukari ya yi ƙarancin abinci kafin abinci, zai fi aminci idan aka gudanar da Apidra ɗan lokaci kaɗan lokacin da glycemia ya zama al'ada. Hypersensitivity zuwa gilluzin ko abubuwan taimako na maganin. |
| Umarni na musamman |
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| Sashi | An ƙaddara gwargwadon ƙwaƙwalwar da ake so gwargwadon yawan carbohydrates a cikin abinci da abubuwan canza mutum na abubuwan gurasar gurasa cikin raka'a insulin. |
| Matakan da ba a so | Abubuwan da ba su dace da Apidra sun zama ruwan dare ga kowane nau'in insulin. Umarnin don amfani da cikakken bayani game da duk ayyukan da ake so. Mafi yawancin lokuta, ana lura da hypoglycemia da ke haɗuwa da yawan ƙwayar ƙwayar cuta. Suna tare da rawar jiki, rauni, tashin hankali. Increasedara yawan zuciya yana nuna tsananin rashin lafiyar hypoglycemia. Abubuwan da ke tattare da rashin lafiyar jiki a cikin nau'i na edema, fitsari, redness mai yiwuwa ne a wurin allurar. Yawancin lokaci sukan ɓace bayan makonni biyu na amfani da Apidra. Reactionsarancin tsari na ƙarancin abu ne da ba a ɗauka, ana buƙatar maye gurbin insulin cikin gaggawa. Rashin yin aiki da dabarar gudanarwa da kuma halayen mutum na ƙarancin nama wanda zai iya haifar da lipodystrophy. |
| Ciki da GV | Insidul insidra ba ta tsoma baki tare da kyakkyawan ciki ba, ba ya shafar ci gaban ciki. An yarda da amfani da miyagun ƙwayoyi a cikin mata masu juna biyu waɗanda ke da nau'ikan 1 da 2 na ciwon sukari da cututtukan mahaifa. Ba a gudanar da bincike kan yuwuwar Apidra zuwa cikin madara ba. A matsayinka na mai mulkin, insulins sun shiga cikin madara a cikin ƙarancin adadin, bayan wannan ana narke su a cikin narkewa na yaro. Zai yiwu yiwuwar insulin shiga cikin jinin jariri an yanke hukunci, saboda haka sukarinsa ba zai ragu ba. Koyaya, akwai haɗarin ƙarancin halayen rashin lafiyan a cikin yaro don glulisin da sauran abubuwan haɗin maganin. |
| Hulɗa da ƙwayoyi | Tasirin insulin ya raunana: Danazol, Isoniazid, Clozapine, Olanzapine, Salbutamol, Somatropin, Terbutaline, Epinephrine. Saka bayani: Disopyramide, Pentoxifylline, Fluoxetine. Clonidine da reserpine - na iya rufe alamun farkon haila. Alcohol ya cutar da diyyar ciwon sukari na mellitus kuma yana iya tayar da matsanancin rashin ƙarfi, don haka ya kamata a rage amfani da shi. |
| Sakin Fom | Pharmacies galibi suna ba da Apidra a cikin alkalan sirinji na SoloStar. Akwatin katako mai dauke da maganin 3 ml da daidaitaccen taro na U100 an sanya su; ba a bayar da sauyawa a cikin katun ba. Maganin rubutu game da sihiri - 1 naúrar. A cikin kunshin 5 allon, kawai 15 ml ko raka'a 1500 na insulin. Hakanan ana samun Apidra a cikin ml 10 ml. Yawancin lokaci ana amfani dasu a cikin wuraren likita, amma kuma ana iya amfani dasu don cike tafkin insulin famfo. |
| Farashi | Kayan kwalliya tare da alkalami na syid na Apidra SoloStar yakai kimanin 2100 rubles, wanda yayi kama da kusancin analogues - NovoRapid da Humalog. |
| Adanawa | Rayuwar shiryayye na Apidra shine shekaru 2, muddin dai duk wannan lokacin an adana shi a cikin firiji. Don rage haɗarin lipodystrophy da ƙonewar injections, ana sanya insulin zuwa zafin jiki daki kafin amfani. Ba tare da samun hasken rana ba, a yanayin zafi har zuwa 25 ° C, ƙwayar da ke cikin silar sirinji tana riƙe da kaddarorinta na makonni 4. |
Bari mu zauna daki-daki daki daki game da amfanin Abidra, wanda basu cikin umarnin don amfani.
Don samun sakamako mai kyau na ciwon sukari akan Apidra, kuna buƙatar:
- Prick insulin mintina 15 kafin abinci. Dangane da umarnin, ana iya ba da maganin a lokacin abinci da kuma bayan abinci, amma a wannan yanayin za ku sami babban sukari na ɗan lokaci, wanda ke nufin haɓakar haɗarin rikitarwa.
- Aididdige ƙididdigar gurasar burodi, hana amfani da abinci mara amfani.
- Guji abinci mai yawa tare da babban glycemic index. Gina abinci mafi yawa akan jinkirin carbohydrates, haɗuwa da sauri tare da mai da furotin. A cewar masu haƙuri, tare da irin wannan abincin, yana da sauƙi a zaɓi madaidaicin sashi.
- Kula da bayanin kula kuma, gwargwadon bayanansa, daidaita yanayin insulin na Apidra.
Za'a iya amfani da maganin sosai don ramawa ga masu ciwon sukari a cikin matasa. Wannan rukunin ba shi da horo, al'adun cin abinci na musamman, salon rayuwa mai aiki. A cikin balaga, yawan buƙatar insulin sau da yawa yana canzawa, haɗarin hauhawar jini ya fi girma, kuma hauhawar jini yana tsawan lokaci bayan cin abinci. Matsakaicin glycated haemoglobin a cikin matasa a Rasha shine kashi 8.3%, wanda ya yi nisa da matakin da aka yi niyya.
Ciwon sukari da hauhawar jini zai zama abin da ya wuce
- Normalization na sukari -95%
- Cirewa kan jijiyoyin mara wuya - 70%
- Cire zuciyar mai karfin zuciya -90%
- Rabu da cutar hawan jini - 92%
- Increasearuwar kuzarin rana, inganta bacci da dare -97%
Nazarin kan amfani da Apidra a cikin yara sun nuna cewa wannan magani, har ma da Humalog tare da NovoRapid, yana rage sukari. Har ila yau hadarin dake tattare da cutar basir ya kasance iri ɗaya ne. Amfani mai mahimmanci na Apidra shine mafi kyawun kulawar glycemic a cikin marasa lafiya da sukari mai tsayi na dogon lokaci bayan cin abinci.
Bayani mai amfani game da Apidra
Apidra yana nufin insulin ultrashort. Idan aka kwatanta da gajerar ɗan adam na ɗan adam, ƙwayar tana shiga jini sau biyu cikin sauri, ana lura da rage girman sukari kwata na awa guda bayan gudanar da aikin ƙarƙashin ƙasa. Aikin yayi sauri da sauri kuma bayan awa daya da rabi ya kai kololuwa. Tsawan lokacin aikin shine kusan awanni 4, bayan wannan karamin adadin insulin ya ragu a cikin jini, wanda baya iya shafar glycemia.
Marasa lafiya a cikin Apidra suna da mafi kyaun alamun sukari, suna iya wadataccen tsarin rage cin abinci fiye da masu ciwon sukari akan gajeren insulin. A miyagun ƙwayoyi rage lokaci daga gudanarwa zuwa abinci, ba ya bukatar tsananin riko da abinci da kuma m abun ciye-ciye.
Idan mai ciwon sukari ya manne da abincin maras nauyi, to aikin insid din na insid na iya zama cikin sauri, kamar yadda jinkirin karas bashi da lokacin tayar da sukarin jini zuwa lokacin da magani ya fara aiki. A wannan yanayin, gajarta amma ba ultrashort insulins ba da shawarar: Actrapid ko Humulin Regular.
Yanayin Gudanarwa
Dangane da umarnin, ana gudanar da insulin na insidin kafin kowane abinci. Yana da kyawawa cewa tsakanin abinci ya kasance akalla 4 hours. A wannan yanayin, sakamakon allura biyu ba ya mamayewa, wanda ke ba da damar sarrafa ingantacciyar cutar kansa. Ana buƙatar auna glucose babu sama da awa 4 bayan allura, lokacin da kashi na maganin ya ƙare aikinsa. Idan bayan wannan lokacin sukari ya karu, zaku iya yin abin da ake kira poplite poprect. An ba da izini a kowane lokaci na rana.
Dogaro da matakin a kan lokacin gudanarwa:
| Lokaci Tsakanin allura da Abincin | Aiki | |
| Apidra SoloStar | Short insulin | |
| kwata na awa daya kafin abinci | rabin awa kafin abinci | Apidra yana samar da mafi kyawun sarrafa ciwon sukari. |
| Minti 2 kafin abinci | rabin awa kafin abinci | Tasirin rage yawan sukari na abubuwan insulins kusan iri daya ne, duk da cewa Apidra yana aiki kasa da lokaci. |
| kwata na awa daya bayan cin abinci | Minti 2 kafin abinci | |
Apidra ko NovoRapid
Wadannan kwayoyi iri ɗaya ne a cikin kaddarorin, halaye, farashi. Dukansu Apidra da NovoRapid samfuran sanannun masana'antun Turai ne, don haka babu shakka game da ingancin su. Dukansu insulin suna da masu sha'awar su tsakanin likitoci da masu ciwon sukari.
Bambancin magunguna:
- An fi son Apidra don amfani da pumps insulin. Hadarin toshe tsarin shine sau 2 ƙasa da na NovoRapid. Ana tsammanin cewa irin wannan bambancin yana da alaƙa da kasancewar polysorbate da rashin zinc.
- NovoRapid za'a iya siyan shi a cikin katako kuma ana amfani dashi a cikin alkalannin sirinji a cikin adadin raka'a 0.5, wanda yake da mahimmanci ga masu ciwon sukari waɗanda ke buƙatar ƙananan allurai na hormone.
- Matsakaicin adadin yau da kullun na insidin Apidra bai wuce 30% ba.
- NovoRapid yana da dan hankali.
Bayan ban da waɗannan bambance-bambance, ba matsala abin da za a yi amfani da shi - Apidra ko NovoRapid. Canza wani insulin zuwa wani shawarar don dalilai na likita kawai, yawanci waɗannan halayen rashin lafiyan halayen ne.
Apidra ko Humalog
Lokacin zabar tsakanin Humalog da Apidra, ya fi wahala a faɗi wanne ya fi kyau, tunda duka magunguna kusan iri ɗaya ne cikin lokaci da ƙarfin aiki. A cewar masu ciwon sukari, canjin daga insulin zuwa wani yana faruwa ba tare da wata wahala ba, sau da yawa ba a canza abubuwa don yin lissafi ba.
Bambancin da aka samo:
- Abun insidra yana da sauri fiye da Humalog wanda ke shiga cikin jini a cikin marasa lafiya tare da ƙwayar visceral;
- Za a iya siyan humalog ba tare da almakunan alkalami ba;
- a wasu marassa lafiya, allurai na shirye-shiryen ultrashort iri daya ne, yayin da tsawon insulin tare da Apidra yai kasa da Humalog.
