Sanadin karuwar glucose na iya zama tsawan tsawan steroids a cikin jini. A wannan yanayin, ana yin binciken cutar ciwon suga na steroid. Mafi sau da yawa, rashin daidaituwa yana tasowa saboda magungunan da aka tsara, amma kuma yana iya zama rikitarwa na cututtukan cututtukan da ke haifar da karuwa a cikin sakin kwayoyin. A mafi yawan lokuta, canje-canje na ilimin halittu a cikin metabolism na carbohydrates ana iya juyawa, bayan janyewar magani ko gyaran cutar-sanadin, sun ɓace, amma a wasu yanayi zasu iya dagewa bayan magani.
Abubuwan steroid masu haɗari sune ga mutanen da ke fama da ciwon sukari na 2. Dangane da ƙididdiga, 60% na marasa lafiya dole ne su maye gurbin wakilai na hypoglycemic tare da ilimin insulin.
Ciwon sukari na Steroid - menene?
Maganin steroidal, ko ƙwayar magunguna, ciwon sukari cuta ce da ke haifar da hauhawar jini. Dalilin shi shine sakamako na gefen glucocorticoid hormones, wanda aka yi amfani dashi sosai a duk rassan magunguna. Suna rage ayyukan rigakafi, suna da tasirin rigakafi. Glucocorticosteroids sun hada da Hydrocortisone, Dexamethasone, Betamethasone, Prednisolone.
Ba da daɗewa ba, bai wuce kwanaki 5 ba, an wajabta jiyya tare da waɗannan magunguna don cututtuka:
Ciwon sukari da hauhawar jini zai zama abin da ya wuce
- Normalization na sukari -95%
- Cirewa kan jijiyoyin mara wuya - 70%
- Cire zuciyar mai karfin zuciya -90%
- Rabu da cutar hawan jini - 92%
- Increasearuwar kuzarin rana, inganta bacci da dare -97%
- cutuka masu rauni
- ƙwayar cuta na ƙwayar cuta
- COPD cuta ce ta huhu
- gout a cikin m mataki.
Dogon lokacin, fiye da watanni 6, ana iya amfani da magani na steroid don cututtukan huhun ciki, cututtukan autoimmune, kumburi na hanji, matsalolin cututtukan fata, da juji na gabobin. A cewar kididdigar, yawan ciwon sukari bayan amfani da wadannan magunguna bai wuce 25% ba. Misali, a cikin lura da cututtukan huhu, ana lura da cutar hyperglycemia a cikin 13%, matsalolin fata - a cikin 23.5% na marasa lafiya.
Hadarin ciwon sukari na steroid yana ƙaruwa ta:
- tsinkayar gado zuwa nau'in ciwon sukari 2, dangi na farko-da masu ciwon suga;
- ciwon sukari a lokacin haihuwar akalla mace guda;
- ciwon suga;
- kiba, musamman na ciki;
- kwayar polycystic;
- tsufa.
Higherarin yawan maganin da aka sha, yana nunawa cutar rashin lafiyar steroid:
Kashi na hydrocortisone, mg a kowace rana | Riskarin haɗarin cutar, lokuta |
< 40 | 1,77 |
50 | 3,02 |
100 | 5,82 |
120 | 10,35 |
Idan mai haƙuri kafin maganin steroid bashi da raunin metabolic na farko na carbohydrates, glycemia yawanci yakan zama a cikin kwanaki 3 bayan sakewarsu. Tare da yin amfani da waɗannan magunguna na tsawan lokaci kuma tare da tsinkayar cutar sankara, cututtukan hyperglycemia na iya zama na kullum, suna buƙatar gyara na tsawon rai.
Irin wannan alamu na iya bayyana a cikin marassa lafiyar da ke haifar da ƙwaƙwalwar hormone. Mafi sau da yawa, ciwon sukari yana farawa da cututtukan Itsenko-Cushing, ƙasa da sau da yawa - tare da hyperthyroidism, pheochromocytoma, rauni ko ƙuƙwalwar kwakwalwa.
Dalilai na ci gaba
Akwai dangantaka ta kai-tsaye tsakanin amfani da glucocorticoid da haɓakar ciwon sukari na steroid. Magunguna suna musanya abubuwan da ke faruwa a jikin mu, yana haifar da tsayayyen hauhawar jini:
- Suna shafar aikin ƙwayoyin beta, saboda wanda aka rage aikin insulin, ƙaddamar da shi cikin jini sakamakon karuwar glucose.
- Zai iya haifar da mummunan mutuwar ƙwayoyin beta.
- Suna rage ayyukan insulin kuma, a sakamakon haka, suna hana turawar glucose zuwa kyallen.
- Rage samuwar glycogen a cikin hanta da tsokoki.
- Ayyukan hormone enteroglucagon an shafe shi, saboda wanda ake kara rage insulin.
- Suna ƙaruwa da kwantar da glucagon, hormone dake raunana tasirin insulin.
- Suna kunna gluconeogenesis, aiwatar da samuwar glucose daga mahallin yanayin rashin carbohydrate.
Don haka, haɓakar insulin ya ragu sosai, don haka sukari ba zai iya kaiwa ga cimma burinsa ba - a cikin sel jikin mutum. Yawan gudanawar glucose a cikin jini, akasin haka, yana ƙaruwa saboda gluconeogenesis da rauni na sanya sukari a cikin shagunan.
A cikin mutane tare da ingantaccen metabolism, aikin insulin yana ƙaruwa bayan kwanaki 2-5 na shan steroids don rama don rage yawan aikinsa. Bayan dakatar da miyagun ƙwayoyi, ƙwayar ƙwayar cuta ta dawo cikin tushe. A cikin marasa lafiya da ke da hatsarin kamuwa da cutar sikari steroid, rama na iya zama bai isa ba, hauhawar jini na faruwa. Wannan rukuni galibi yana da “rushewa” wanda ke haifar da cutar sankarar mahaifa.
An ba da cutar ta lambar ICD na 10 E11 idan an kiyaye aikin pancreatic, kuma E10 idan an lalata ƙwayoyin beta.
Fasali da alamomin cutar sikari
Duk marasa lafiya da ke shan steroids ya kamata su san alamun musamman ga masu ciwon sukari:
- polyuria - urination na haɓaka;
- polydipsia - ƙishirwa mai ƙarfi, kusan ba ya raunana bayan shan ruwa;
- bushewar mucous membranes, musamman a cikin bakin;
- m, fata mai laushi;
- jihar ta gaji kullum, rage aiki;
- tare da babban rashin insulin - asarar nauyi mara nauyi.
Idan waɗannan bayyanar cututtuka sun faru, ya zama dole don bincika ciwon sukari na steroid. Mafi kyawun gwaji a cikin wannan yanayin shine gwajin haƙuri haƙuri. A wasu halayen, yana iya nuna canje-canje a cikin ƙwayoyin carbohydrate a cikin awanni 8 bayan fara shan steroids. Sharuɗɗan ganewar asali iri ɗaya ne da na sauran nau'in ciwon sukari: glucose a ƙarshen gwajin kada ya kasance sama da 7.8 mmol / l. Tare da haɓakar taro zuwa raka'a 11.1, zamu iya magana game da rikicewar na rayuwa mai mahimmanci, sau da yawa ba za a iya musantawa ba.
A gida, ana iya gano ciwon sukari na steroid ta amfani da glucometer, matakin sama da 11 bayan cin abinci yana nuna farkon cutar. Yin azumi na sukari yana girma daga baya, idan yana saman raka'a 6.1, kuna buƙatar tuntuɓar likitancin endocrinologist don ƙarin jarrabawa da magani.
Bayyanar cututtukan ciwon sukari bazai zama ba, saboda haka al'ada ce don magance glucose jini a cikin kwanakin farko na farko bayan gudanarwar glucocorticoids. Tare da yin amfani da magunguna na dogon lokaci, alal misali, bayan juyawa, ana ba da gwaje-gwaje a mako a farkon watan, sannan bayan watanni 3 da watanni shida, ba tare da la'akari da kasancewar alamun ba.
Yadda za a kula da ciwon sukari na steroid
Ciwon sukari yana haifar da hauhawar yawan sukari bayan cin abinci. Dare da maraice kafin abinci, glycemia al'ada ce ta farko. Saboda haka, magani da aka yi amfani da shi ya kamata ya rage sukari a lokacin, amma kada ku tsokano cutar rashin ƙwayar cuta.
Don lura da ciwon sukari na mellitus, ana amfani da magunguna iri ɗaya don sauran nau'in cutar: wakilai na hypoglycemic da insulin. Idan glycemia ya kasance ƙasa da 15 mmol / l, magani yana farawa da magungunan da ake amfani da su don maganin ciwon sukari na 2. Lambobin sukari mafi girma suna nuna mummunar lalacewa a cikin aikin ƙwayar ƙwayar cuta, irin waɗannan marasa lafiya ana wajabta su allurar insulin.
Inganci kwayoyi:
Magunguna | Aiki |
Metformin | Yana inganta tsinkayewar insulin, yana rage gluconeogenesis. |
Abubuwan da aka samo daga sulfanylureas - glyburide, glycoslide, repaglinide | Kada a rubuto magunguna na tsawan matakin, ana buƙatar kulawa da tsarin abinci mai gina jiki na yau da kullun. |
Gzitazones | Sensara ƙwaƙwalwar insulin. |
Analogs na GLP-1 (enteroglucagon) - exenatide, liraglutide, lixisenatide | Mafi inganci fiye da masu ciwon sukari na 2, ƙara yawan sakin insulin bayan cin abinci. |
DPP-4 inhibitors - sitagliptin, saxagliptin, alogliptin | Rage matakan glucose, inganta nauyi asara. |
Harkokin insulin, dangane da matakin insulin nasu, an zaɓi tsarin gargajiya ko na araha | Matsakaitan insulin-matsakaici yawanci ana yin shi da gajere kafin abinci. |
Yin rigakafin
Yin rigakafi da gano lokaci na ciwon sukari steroid wani muhimmin ɓangare ne na magani tare da glucocorticoids, musamman idan ana tsammanin amfani da su na dogon lokaci. Duk matakan guda ɗaya da ake amfani da su don maganin ciwon sukari na 2, abinci mai ƙarancin carb da kuma ƙara yawan aiki na jiki, rage haɗarin cin zarafin metabolism.
Abin takaici, wannan prophylaxis yana da wuya, tunda steroids suna ƙaruwa da ci, kuma yawancin cututtukan da ke kula da su sun keɓe ko kuma taƙaita iyakance wasanni. Sabili da haka, a cikin rigakafin cututtukan sukari na steroid, babban aikin ya kasance ga bayyanar cututtuka na rikice-rikice da gyaran su a matakin farko tare da taimakon magunguna masu rage sukari.