Don cimma diyya na dogon lokaci don ciwon sukari, ana amfani da analogues na insulin daban-daban. Insulin Lizpro shine mafi inganci na zamani mai lafiya mai kariya na gajere-mai amfani da jiki wanda ke daidaita metabolism.
Ana iya nuna wannan kayan aikin don masu amfani da masu ciwon sukari na kungiyoyin shekaru daban-daban. Ana iya ba da insulin Lizpro don yara masu ciwon sukari.
Idan aka kwatanta da insulins na gajere, insulin Lizpro yana aiki da sauri, saboda yawan ɗimbin sha.
Aikin magunguna da alamomi
Lizpro biphasic insulin an kirkireshi ne ta amfani da fasahar DNA. Akwai hulɗa tare da mai karɓar ƙwayoyin cytoplasmic ƙwayoyin sel, an samar da hadadden insulin-receptor, wanda ke motsa ayyukan a cikin sel, gami da haɗakar enzymes masu mahimmanci.
An yi bayanin raguwar yawan sukarin jini cikin jini ta hanyar karuwa a cikin jijiyarsa, har da kara yawan abubuwa da sha daga sel. Suga na iya raguwa saboda raguwa a cikin yawan aikinta ta hanta ko ta hanyar glycogenogenesis da lipogenesis.
Lyspro insulin shine kwayoyin halittar DNA wanda ya bambanta a cikin jerin abubuwan lysine da ƙirar amino acid a matsayi na 28 da 29 na sarkar insulin B. Magungunan ya ƙunshi dakatarwar protamine 75% da insulin lispro 25%.
Magungunan suna da tasirin anabolic da kuma tsarin metabolism na glucose. A cikin kyallen takarda (ban da ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwa), sauyawa na glucose da amino acid a cikin sel yana hanzarta, wanda ke ba da gudummawa ga samuwar glycogen daga glucose a cikin hanta.
Wannan magani ya bambanta da insulins na al'ada a cikin farawa da sauri na aiki akan jiki da ƙananan sakamako masu illa.
Magungunan yana fara aiki bayan mintina 15, wanda aka bayyana shi ta hanyar babban sha. Don haka, ana iya gudanar da shi na mintina 10-15 kafin cin abinci. Ana yin insulin na yau da kullun cikin ƙasa da rabin sa'a.
Yawan sha yana shafar wurin allurar da sauran dalilai. Ana lura da matakin ganiya a cikin kewayon 0.5 - 2.5. Insulin Lizpro yana aiki tsawon awa hudu.
Madadin aikin insulin na Lizpro an nuna shi ga mutanen da ke fama da ciwon sukari na 1 na sukari guda 1, musamman idan akwai haƙuri da sauran insulin. Bugu da kari, ana amfani dashi a irin waɗannan halaye:
- maganin ciwon kai,
- subulinaneous insulin juriya a cikin nau'i mai nauyi.
Hakanan ana amfani da miyagun ƙwayoyi don nau'in ciwon sukari na 2 na ciwon sukari tare da jure magungunan baka na hypoglycemic.
Ana iya ba da maganin insulin na Lizpro don maganin cututtukan mahaifa.
Umarnin don amfani da miyagun ƙwayoyi
Umarnin yin amfani da miyagun ƙwayoyi ya nuna cewa ya kamata a ƙididdige allurai gwargwadon matakin ƙwayar cuta. Idan ya cancanta, ana gudanar da maganin tare da insulins masu ɗaukar dogon lokaci, ko tare da magunguna na maganin sulfonylurea na baka.
Ana yin allurar da ƙananan abubuwa a irin waɗannan wuraren jikin mai haƙuri:
- kwatangwalo
- ciki
- gindi
- kafadu.
Ya kamata a sauya wuraren allurar don kada a yi amfani da su fiye da 1 lokaci na wata daya. Kada ku bayar da allura a wuraren da akwai hanyoyin jini kusa da juna.
Mutanen da ke fama da hepatic da na ƙarancin ƙwayar cuta na iya samun wadataccen insulin abun ciki da rage buƙatarta. Wannan yana buƙatar saka idanu akai-akai game da glycemia da gyara na lokaci akan sashi na miyagun ƙwayoyi.
Yanzu ana iya amfani da alkalami na Humalog (Humapen); ya fi dacewa don amfani. Akwai zaɓuɓɓuka da yawa don wannan rukunin, mafi ƙarancin sikelin an sauke shi a raka'a 0.5.
Wadannan hanyoyin suna kan siyarwa:
- "Humapen Luxura". Samfurin yana sanye da allon lantarki wanda ke nuna lokacin allura ta ƙarshe da girman girman sigar sarrafawa.
- Humapen Ergo. Pen tare da mafi kyawun darajar don kuɗi.
Ana sayar da insulin Lizpro, da alkalami na syria na Humapen a farashi mai ƙima kuma suna da kyakkyawan bita.
Side effects da contraindications
Insulin Lizpro yana da wadannan abubuwan:
- mutum rashin haƙuri,
- hawan jini,
- insulinoma.
An bayyana rashin jituwa a cikin irin wannan halayen rashin lafiyan:
- cututtukan mahaifa
- zazzabin cizon sauro
- karancin numfashi
- rage karfin jini.
Bayyanar cututtukan cututtukan ƙwayar cuta yana nuna cewa an zaɓi sashi na miyagun ƙwayoyi ne ba daidai ba ko kuskuren shine zaɓi mara kyau na wuri ko hanyar yin allura. Wannan nau'in insulin bai kamata a gudanar dashi ba, amma a kasa.
A cikin yanayin da ba kasafai yake faruwa ba, cutar sikila na iya faruwa.
Lipodystrophy an yi shi idan an yi allurar subcutaneous ba daidai ba.
Ana rarrabe alamun dake nuna yawan shaye-shayen ƙwayoyi:
- bari
- gumi
- karfin zuciya
- yunwa
- damuwa
- paresthesia a baki,
- pallor na fata,
- ciwon kai
- rawar jiki
- amai
- matsala barci
- rashin bacci
- Damuwa
- haushi
- hali da bai dace ba
- matsalar gani da magana,
- glycemic coma
- katsewa.
Idan mutum yana da hankali, to lallai ne bayyanar cikin ciki. Glucagon ana iya gudanar dashi ta hanyar ciki, subcutaneously da intramuscularly. Lokacin da aka kirkiro coma na hypoglycemic, har zuwa 40 ml na dextrose 40% ana sarrafawa ta hanyar jijiya. Jiyya yana ci gaba har sai mai haƙuri ya fito daga rashin lafiya.
Mafi sau da yawa, mutane suna yin haƙuri da insulin Lizpro ba tare da sakamako mara kyau ba.
A wasu halaye, liyafar na iya bambanta cikin rage aiki.
Siffofin hulɗa tare da wasu kwayoyi
Bai kamata a yi amfani da insulin na Lizpro tare da wasu hanyoyin magunguna ba. An inganta tasirin hypoglycemic na miyagun ƙwayoyi:
- MAO masu hanawa
- androgens
- ACE
- mebendazole,
- sulfonamides,
- carbonic anhydrase,
- akarijin
- magungunan anabolic steroid
- shirye-shiryen lithium
- NSAIDs
- chloroquinine,
- bromocriptine
- karafarini
- ketoconazole,
- Clofibrate
- fenfluramine,
- quinine
- karafarini
- ethanol
- pyridoxine
- quinidine.
Rinjawar jini yana rauni ta:
- estrogens
- glucagon,
- heparin
- somatropin,
- danazol
- GKS,
- maganin hana haihuwa
- kamuwa da cuta
- cututtukan mahaifa
- masu maganin tashin zuciya
- tausayawa
- ƙwayar cuta
- clonidine
- tricyclic maganin rigakafin,
- diazoxide
- marijuana
- nicotine
- phenytoin
- BMKK.
Wannan aikin zai iya raunana biyu da haɓakawa:
- Octreotide
- beta hanawa,
- madarar ruwa
- pentamidine.
Bayani na Musamman
Wajibi ne a tsaurara matakan lura da magungunan da likita ya kafa.
Lokacin canja wurin marasa lafiya zuwa insulin Lizpro tare da insulin aiki mai sauri, ana iya buƙatar daidaita sashi. Lokacin da kashi na mutum na yau da kullun ya wuce raka'a 100, canja wuri daga wani nau'in insulin zuwa wani yana gudana ne a ƙarƙashin yanayin wurare.
Ana buƙatar gyara ƙarin buƙatar insulin saboda saboda:
- cututtuka
- damuwar damuwa
- da kara adadin carbohydrates a abinci,
- lokacin shan magunguna tare da aikin hyperglycemic: hormones na thyroid, thiazide diuretics da sauran kwayoyi.
Rage buƙatar insulin na iya zama tare da hanta ko gazawar koda, ƙara yawan aiki na jiki, ko yayin shan magunguna tare da aikin hypoglycemic. Irin wadannan kudade sun hada da:
- ba zaɓin beta-blockers ba,
- MAO masu hanawa
- sulfonamides.
Hadarin cututtukan jini na rage karfin mutum ya fitar da motoci da kuma kiyaye hanyoyin da yawa.
Mutanen da ke da ciwon sukari na iya kawar da ƙwayar cutar hypoglycemia mai sauƙi ta hanyar cin sukari ko abinci masu girma a cikin carbohydrates.
Dole ne a sanar da likitan halartar game da gaskiyar cutar yawan kumburi, tunda dole ne a daidaita sashi.
Cost da analogues na miyagun ƙwayoyi
A halin yanzu, ana siyar da insulin Lizpro a farashin 1800 zuwa 2000 rubles.
Analogues na miyagun ƙwayoyi Insulin Lizpro sune:
- Insulin Humalog Mix 25.
- Mix Humalog Mix 50.
Wani nau'in insulin na exogenous shine aspar insulin kashi biyu.
Yana da mahimmanci a tuna cewa baza ku iya amfani da Insulin Lizpro ba bisa shawarar yanke hukunci. Ya kamata a sha miyagun ƙwayoyi kawai bayan alƙawarin da mai halartar likitan ya gabatar. Dos din ma alhakin likitan ne.
Bayanin da dokoki don amfani da insulin Lizpro ana bayar dasu a cikin bidiyon a wannan labarin.
