Idan babu cholesterol, jikin mutum ba zai iya rayuwa cikakke. Wannan sinadari wani bangare ne na membranes din tantanin halitta, bugu da kari, in ban da hakan, aikin jijiyoyi da sauran muhimman bangarorin jikin dan adam ba zai yuwu ba.
Ta hanyar yawan abubuwan da suka wuce haddi na wannan abun ana nufin mummunar cholesterol, wanda tare da furotin suna haifar da sabon fili - lipoprotein. Hakanan yana wanzu a cikin nau'i biyu: ƙarancin ƙima da ƙima mai yawa. Yawan lipoprotein mai yawa baya cutarwa ga jiki, sabanin nau'ikan sa na biyu. Idan yanayin bai gudana ba kuma matakin wannan lipoprotein a cikin jini ba mai mahimmanci bane, zai isa ga mai haƙuri ya canza zuwa abincin abinci kuma ya shiga aikin jiki a cikin rayuwar sa.
Amma waɗannan matakan ba koyaushe suna ba da sakamakon da ake so ba, a wasu yanayi, mai haƙuri na iya buƙatar tsabtace likita na tasoshin.
Masana kimiyya sun daɗe suna aiki don ƙirƙirar ingantaccen ƙwayar don rage cholesterol "mara kyau".
Har yanzu ba a samo mafi kyawun maganin ba, an kirkiro wasu rukunin magunguna don rage cholesterol, kowannensu yana da nasa halaye masu kyau.
Statins suna daga cikin mafi kyawun magunguna don maganin lipoproteins na hawan jini, amma saboda yawan gazawa da kuma haɗarin sakamako masu haɗari ga jikin mutum, musamman lokacin amfani da magunguna masu yawa, koyaushe ba saurin yin magani.
Halayen Inhibitors na Cholesterol
Lokacin da ake kula da cholesterol na jini, statins ba a haɗe shi da nicotinic acid da fibrates, waɗanda magunguna ne na aji daban-daban, saboda gaskiyar cewa ba shi da isasshen lafiya kuma yana iya haifar da ci gaban wasu cututtuka. Misali, hadewar fibrates da statins suna kara hadarin kamuwa da cutar sankarar mahaifa, abu iri daya na iya faruwa tare da hade sinadarin nicotinic acid da statins, kawai ban da komai za'a iya shafar hanta.
Amma masana ilimin magunguna sun sami mafita, sun haɓaka magunguna waɗanda ke haifar da tasiri ga wasu hanyoyin don ci gaban hypercholesterolemia, musamman, don ɗaukar cholesterol a cikin hanji. Daya daga cikin wadannan magungunan shine Ezithimibe ko Ezeterol.
Amfanin magani shine cewa yana da aminci sosai saboda gaskiyar cewa abubuwan da ke cikin jikin sa ba sa shiga cikin jini. Wannan yana da matukar muhimmanci saboda za a sami magunguna ga marasa lafiya da cututtukan hanta da kuma waɗanda ke contraindicated don amfani da statins saboda dalilai da yawa. Haɗin ezeterol tare da statins na iya ba da gudummawa ga haɓaka tasirin warkewa da nufin rage ƙwayar cholesterol a cikin jiki.
Dangane da rashin kyawun maganin, an bambanta babban farashi kuma, dangane da monoprint, ƙarancin amfanin yin amfani da shi, idan aka kwatanta da sakamako na lura da ƙirar mutum-mutumi.
Alamu don amfani da miyagun ƙwayoyi
Yaushe ake ba da shawarar yin wannan magani? An nuna shi don hypercholesterolemia na farko, ana amfani da Ezithimibe ko dai a cikin ƙari ban da abincin abinci, ko a hade tare da statins.
Wannan magani yana taimakawa ragewa ba kawai matakin jimlar cholesterol ba, har ma da apolipoprotein B, triglycerides, LDL cholesterol, kazalika da haɓaka HDL cholesterol.
Tare da hyzycholesterolemia na homozygous, ana amfani da miyagun ƙwayoyi azaman ƙari ga statins don rage kwafin cholesterol, duka duka kuma LDL.
An wajabta Ezeterol don homozygous sitosterolemia. Yana ba ku damar rage girman matakan campesterol da sitosterol.
Contraindications da sakamako masu illa
An haramta wannan maganin don amfani da marasa lafiya waɗanda ke da ƙaruwa mai saukin kamuwa da cututtukan tsarinta.
Mata masu juna biyu da lokacin shayarwa ba a ba da shawarar yin amfani da masu hana shan kwayar cutar cholesterol ba.
Idan akwai buƙatar yin amfani da mahaifiyar ezeterol ta mahaifiyar masu shayarwa, to, wataƙila zai zama wajibi a yanke shawara kan dakatar da shayarwa.
Sauran magungunan sun hada da:
- shekaru kasa da shekaru 18, tunda aminci da tasiri daga amfani da miyagun ƙwayoyi ba tukuna an kafa su;
- kasancewar duk wani cututtukan hanta a lokacin kara lalacewa, kazalika da karuwa a cikin ayyukan “hanta” transaminases;
- mai nauyi ko matsakaici a cikin gazawar hanta, kamar yadda aka auna ta hanyar ma'aunin Yara-Pyug;
- rashi lactose, rashin haƙuri a cikin lactose, glucose-galactose malabsorption;
- da amfani da miyagun ƙwayoyi a hade tare da fibrates;
- amfani da marasa lafiya da ke karbar cyclosporine na miyagun ƙwayoyi ya kamata a gudanar da su tare da taka tsantsan tare da saka idanu kan matakin tattarawar cyclosporin a cikin jini.
Game da monotherapy, mai hana daukar ciki na cholesterol na iya haifar da sakamako masu illa kamar azabar ciki, ciki, ciwon kai. Tare da jiyya mai rikitarwa tare da mutummutumi, ban da migraines, alamu na iya bayyana a cikin nau'i na gajiya, flatulence, matsaloli tare da matsi (haushi ko maƙarƙashiya), tashin zuciya, myalgia, ƙara yawan aiki na ALT, AST, da CPK. Hakanan ba a cire bayyanar fatar fata, angioedema, hepatitis, pancreatitis, thrombocytopenia da haɓaka enzymes hanta kuma ba a cire su a cikin aikin asibiti.
A cikin lokuta mafi wuya, haɓakar rhabdomyolysis mai yiwuwa ne.
Ka'idar aiki na mai hana
Ezetimibe shine yake hana shan kwaladi da wasu nau'ikan sa maye a cikin karamin hanji. A can, ana sanya magani a cikin karamin hanji kuma baya barin kwalakwai, don haka rage samar da cholesterol kai tsaye daga hanji zuwa wani bangare - hanta, rage girman ajiyar da ke cikin hanta da kuma kara yawan jijiyoyin jini.
Abubuwan da ke hana daukar ciki na cholesterol ba su ninka yawan acid din ba kuma kar a hana kwazon kogin cholesterol, wanda ba za a iya fada game da shi ba. Saboda bambancin ƙa'idar aiki, magunguna na waɗannan azuzuwan, yayin da ake amfani da su tare da statins, na iya ƙara rage ƙwayar cholesterol. Karatuttukan da suka gabata sun nuna cewa kwayar ta hana kuzarin 14C-cholesterol an hana shi daga ezeterol.
Cikakken bayanin kwayar halittar ezeterol ba za a iya tantance ta ba saboda wannan kwayar ta kusan maye gurbin ruwa.
Yin amfani da miyagun ƙwayoyi a cikin haɗuwa tare da cin abinci ba ya shafar yadda ake amfani da kwayoyin a cikin adadin da bai wuce 10 MG ba.
Hanyar aikace-aikacen, sashi da farashi
Kafin fara aikin jiyya, marasa lafiya suna buƙatar ci gaba da rage cin abinci mai ɗauke da ƙwayar cholesterol, dole ne a ci gaba da lura da duk tsawon lokacin shan maganin. Ya kamata a dauki Ezeterol a ko'ina cikin rana, ba tare da la'akari da yawan abinci ba. Yawanci, likitan halartar ya ba da umarnin ɗaukar magani na 10 MG ba fiye da sau ɗaya a rana ba.
Amma game da sashi tare da hadewar Ezithimibe tare da statins, ya kamata a bi doka mai zuwa don magani mai rikicewa: ɗaukar miyagun ƙwayoyi sau ɗaya a rana tare da statins, tabbatar da bin shawarwarin da aka tsara don ƙaddamarwa.
A cikin jiyya ta layi daya tare da masu bin ɗakin mai mai da Ezithimibe, yakamata a sha a ƙimar 10 MG sau ɗaya a rana, amma ba bayan sa'a biyu ba kafin ɗauka jerin abubuwa ko kuma ba sa wuce sa'o'i huɗu ba bayan.
Game da aiki na hanta mai rauni, marasa lafiya a mataki na rashin ƙarfi na hanta basa buƙatar zaɓin sashi. Kuma ga marasa lafiya da matsataccen hanta zuwa gazawar hanta, gaba ɗaya ba bu mai kyau ba ne a yi amfani da abubuwan hana ƙoshin ƙwayar cholesterol a cikin hanjin mutum.
Kamar yadda aka ambata a baya, farashin masu hana ruwa gudu ba shi da arha musamman, wanda ya danganta da raunin su.
Ezetimibe a cikin sashi na milligrams 10 (guda 28) za'a iya siye shi daga 1800 zuwa 2000 rubles.
Yawan ruwan sama na Ezithymibe da hulda
Lokacin amfani da hanyar motsa jiki tare da masu hanawa, yana da mahimmanci don bin umarnin likita wanda aka tsara. Amma idan yawan abin sama da ya kamata har yanzu yana faruwa, marasa lafiya ya kamata su san mai zuwa.
A cikin lokuta mafi wuya na yawan abin sama da ya wuce, abubuwan da suka faru marasa kyau waɗanda suka bayyana a cikin marasa lafiya ba su zama mai zurfin isa ba. Idan zamuyi magana game da gwaji na asibiti, to a ɗayansu an sanya maganin ga masu sa kai 15 tare da ingantacciyar lafiya a sashi na 50 MG kowace rana don sati biyu.
Wani binciken ya haɗa da masu ba da agaji guda 18 tare da alamun hypercholesterolemia na farko; an wajabta su 40 na Ezithimibe fiye da kwanaki 50. Dukkanin mahalarta gwaji na asibiti sun sami kyakkyawar haƙuri ga miyagun ƙwayoyi.
Haɗin Ezithimibe tare da yin amfani da antacids zai iya taimakawa rage yawan adadin abubuwan da ke cikin miyagun ƙwayoyi na farko, amma wannan bai shafi yanayin bioavinsa ba. Tare da maganin haɗin gwiwa tare da cholestyramine, matakin sha daga cikin jimlar adadin eseterol an rage shi da kusan kashi 55.
Tare da kulawa mai rikitarwa tare da fenofibrates, a sakamakon haka, jimlar yawan inhibitor yana ƙaruwa sau ɗaya da rabi. Yin amfani da eseterol tare da fibrates ba a yi nazari sosai ba, saboda haka ba a ba da shawarar amfani da su na lokaci ɗaya ta likitoci.
An bayyana haɗarin cutar cholesterol a cikin bidiyon a cikin wannan labarin.
