Liraglutide - magani don maganin ciwon sukari na 2: umarnin da sake dubawa

Menene liraglutide?

Liraglutide ingantacciyar analog ne na hormone kansa - glucagon-like peptide-1 (GLP-1), wanda aka samar a cikin narkewa a cikin abinci don maganin abinci kuma yana haifar da tarin insulin. GLP-1 na dabi'a yana lalacewa a cikin jiki a cikin 'yan mintoci kaɗan, ɗayan roba ya bambanta da shi a cikin abubuwa biyu na amino acid kawai a cikin haɗin sunadarai. Ba kamar ɗan adam ba (ɗan ƙasa) GLP-1, liraglutide yana kula da natsuwa a cikin rana, wanda ya ba da damar sarrafa shi sau 1 kawai a cikin sa'o'i 24.

Akwai shi ta hanyar bayyananniyar mafita, ana amfani dashi don injections na subcutaneous a cikin sashi na 6 mg / ml (jimlar 18 mg na kayan gabaɗaya). Kamfanin da ya fara kirkirar kamfanin shine kamfanin Danish Novo Nordisk. An kawo magungunan ga kantin magunguna ta hanyar katsi, wanda aka cushe a cikin alkalami, wanda ake yin allurar yau da kullun. Kowane ƙarfin yana ɗaukar 3 ml na bayani, a cikin fakitin 2 ko 5.

Aikin magani na magani

A ƙarƙashin aikin abu mai aiki - liraglutide, haɓaka ƙwaƙwalwa na insulin kansa yana faruwa, aikin β-sel yana inganta. Tare da wannan, ana taƙaddama ƙarancin kwayar glucose da ta dogara da su - glucagon -

Wannan yana nufin cewa tare da yawan sukari mai yawa na jini, samarda insulin yana ƙaruwa kuma ana lalata ƙonewar glucagon. A cikin halin da ake ciki, lokacin da haɗarin glucose ya ragu, toshewar insulin zai ragu, amma haɗin glucagon yana kasancewa a matakin ɗaya.

Kyakkyawan sakamako na liraglutide shine asarar nauyi da raguwa a cikin nama na adipose, wanda ke da alaƙa kai tsaye da inji wanda ke rage yunwa da rage yawan kuzari.

Nazarin a waje da jiki sun nuna cewa maganin yana iya yin tasiri mai ƙarfi akan β-sel, yana ƙaruwa da yawa.

Alamu don amfani

Liraglutide an yi shi ne kawai ga mutanen da shekarunsu suka wuce 18 da ke rayuwa tare da ciwon sukari na 2 Da ake bukata ake bukata shine mai kyau abinci mai gina jiki da aikin jiki.

Ana iya amfani dashi azaman:

1. Kadai magani don lura da ciwon sukari na 2 (magani na farko).
2. A haɗe tare da siffofin kwamfutar hannu (metformin, da sauransu) a cikin yanayi inda mutum ba zai iya cin nasarar sarrafa glycemic da ake so ba tare da taimakon wasu kwayoyi ba.
3. A hade tare da insulin, lokacin da haɗarin liraglutide da metformin ba su ba da sakamakon da ake so ba.

Contraindications da sakamako masu illa

Jerin yanayi idan aka hana yin amfani da abubuwan liraglutide:

• rashin haƙuri ɗaya;
• ciwan-wanda yake dogara da kwayar cutar kansa ta hanji, ko da an taɓa samun ta cikin dangi na kusa;
• neoplasms yana shafar gabobin guda biyu na tsarin endocrine;
• Nau'in cuta guda 1;
• hawan jini da jikin ketone;
• mataki na karshe na rashin cin nasara na koda;
• rauni na zuciya;
• jinkirta fitar da ciki;
• cutar kumburin ciki;
• rauni mai yawa na hanta;
• lokacin daukar ciki da shayarwa;
• shekaru zuwa shekaru 18.

Sakamakon mara kyau wanda zai iya faruwa yayin amfani da miyagun ƙwayoyi:

1. Gastrointestinal fili. Ciwon ciki, amai, rashin lafiyan ciki, zafin ciki, bloating.
2. Fata mai shiga tsakani. Itching, kurji, urticaria. Allergic halayen a wurin allura.
3. Tsarin rayuwa. Rashin abinci, ciwan ciki, rashin ruwa a jiki.
4. STS. Asedara yawan zuciya.
5. Tsarin ciki. Ciwon kai da danshi.

Idan ɗaya daga cikin alamun illa na liraglutide ya faru, ya kamata ka sanar da likitanka nan da nan. Wataƙila wannan shine ɗan gajeren lokaci na jiki, ko wataƙila haɗari ga lafiyar.

Umarnin don amfani

Ana gudanar da maganin Liraglutide ne kawai a karkashin fata. Haramun ne a yi amfani da shi cikin intramuscularly kuma musamman a cikin jijiya! Ana amfani da maganin a lokaci guda sau ɗaya a rana, ba tare da la'akari da abinci ba. Wuraren allurar da aka zaɓa sune kafada, cinya da ciki.

Minimumarancin farawa shine 0.6 MG kowace rana, yakamata a saka shi a kalla a mako, bayan hakan yana iya ƙaruwa sashi zuwa 1.2 MG. Don cimma sakamako mafi kyau, ana iya tsara maganin a cikin kashi na 1.8 MG. Mafi ingancin sashi shine 1.8 MG (a cikin yanayin Victoza). Idan ana amfani da Saksenda, to matsakaicin sashi shine 3 MG kowace rana.

Idan ka rasa kashi na gaba, ya kamata ku shigar da maganin da wuri-wuri a cikin awanni 12 masu zuwa. Idan fiye da wannan lokacin ya wuce, to, maganin ya tsallake kuma an gabatar da kashi na al'ada gobe. Gabatarwar ninki biyu baya bayar da sakamako mai kyau.

Abubuwan da ke aiki suna cikin katako na musamman, wanda aka gina a cikin alkairin sirinji. Kafin amfani, tabbatar cewa bayani a bayyane kuma mara launi. Don gudanar da magani, yana da kyau a yi amfani da allura ƙasa da mm 8 mm tsayi kuma har zuwa 32G lokacin farin ciki.

Liraglutide an hana shi daskarewa! Ya kamata a adana shi a cikin firiji idan sirinji mai sabo ne. Bayan amfani na farko, ana iya adana shi a yanayin zafi har zuwa 30 ° C, amma yana yiwuwa a barshi cikin firiji. Dole ne a yi amfani da katangar wata guda bayan buɗewa.

Abun Harkokin Magunguna

Analog na GLP-1 yana da ƙarancin iko don yin hulɗa tare da wasu kwayoyi, wanda aka bayyana shi ta hanyar metabolism na musamman a cikin hanta da kuma ɗaukar nauyin sunadaran plasma.

Saboda jinkirin narkewar gastric na jinkirta, wasu nau'ikan magunguna na baka suna sha tare da jinkirta, amma ba a buƙatar daidaita sashi a wannan yanayin.

Liraglutide yana rage yawan ƙwayoyin cuta, amma daidaita sashi shima ba lallai bane.

Liraglutide yayin daukar ciki

Ba a gudanar da bincike na musamman kan wannan rukunin marasa lafiya ba, saboda haka an haramta amfani da maganin. Gwaje-gwajen da ke kan dabbobi masu bincike sun nuna cewa sinadarin mai guba ne ga tayin. Lokacin amfani da maganin, yakamata mace tayi amfani da isasshen rigakafin haihuwa, kuma idan akwai bukatar shirin daukar ciki, dole ne ta sanar da likitocin da suka halarta game da wannan shawarar domin ta canza shi zuwa mafi lafiya.

Binciken hukuma na magani

Tsarin gwajin asibiti na LEAD ya bincika ingancin abu mai aiki. Mutane 4000 da ke da nau'in ciwon sukari guda 2 suka ba da gudummawa mai amfani a gare shi. Sakamakon binciken ya nuna cewa maganin yana da inganci kuma mai lafiya duka biyu a matsayin babban maganin, kuma a hade tare da sauran allunan rage sukari.

An lura cewa mutanen da suka daɗe suna karɓar ƙwayar liraglutide sun rage nauyin jiki da hauhawar jini. Halin hauhawar jini ya ragu sau 6, idan aka kwatanta da glimepiride (Amaril).

Sakamakon shirin ya nuna cewa matakin haemoglobin glycated da nauyin jiki ya ragu sosai akan liraglutide fiye da insulin glargine a hade tare da metformin da glimepiride. An yi rikodin cewa lambobin hawan jini ya ragu bayan mako 1 na amfani da miyagun ƙwayoyi, wanda baya dogaro da asarar nauyi.

Sakamakon bincike na ƙarshe:

• tabbatar da manufar manufa ta haemoglobin;
• rage ƙananan lambobi na hawan jini;
• asarar karin fam.

Abvantbuwan amfãni da rashin amfanin amfani

Kyakkyawan kaddarorin:

• Yana iya dushe ci da rage nauyin jiki.
• Yana rage yiwuwar barazanar mummunan rikice-rikice masu alaƙa da CVS.
• Ana amfani dashi sau 1 a rana.
• Muddin zai yiwu, yana riƙe aikin β-sel.
• Yana inganta aikin insulin.

Negative:

• Aikace-aikacen Subcutaneous.
• Waɗanda ke fama da rauni na iya fuskantar wasu matsaloli yayin amfani da maɓallin sirinji.
• Babban jerin contraindications.
• Ba za a iya amfani da shi ta hanyar masu juna biyu, masu lactating da yara masu shekaru 18 da haihuwa ba.
• Babban farashin kwayoyi.

Shin akwai wasu alamun analogues?

Magunguna waɗanda ke ƙunshe da ƙwayoyin rage ƙwayoyi kawai:

1. Victoza;
2. Saxenda.

Haɗin maganin, hade da shi da insulin degludec - Sultofay.

Me zai iya maye gurbin liraglutide

Binciken bidiyo na kwayoyi don asarar nauyi

Farashi

Idan akai la'akari da magungunan Viktoza da Saksenda daga ra'ayi na tattalin arziki, zamu iya yanke hukuncin cewa magani na farko zai rage ƙima. Kuma abu ba koda cewa shi kadai ke rage farashin ba, amma matsakaicin adadin yau da kullun shine kawai 1.8 MG, yayin da sauran ƙwayoyi suna da 3 MG. Wannan yana nufin cewa katako 1 na Victoza ya isa kwana 10, da Saxends - na tsawon 6, idan kun ɗauki iyakar adadin.

Nazarin masu ciwon sukari

Marina Ina rashin lafiya tare da nau'in ciwon sukari na 2 na kimanin shekaru 10, Ina shan metformin da insulin insulin, sukari yana ƙaruwa 9-11 mmol / l. My nauyin shine 105 kilogiram, likita ya ba da shawarar gwada Viktoza da Lantus. Bayan wata daya, ta yi asarar kilo 4 da sukari da aka ajiye a cikin 7-8 mmol / L.

Alexander Na yi imani cewa idan metformin ya taimaka, zai fi kyau a sha kwayoyin. Lokacin da kun rigaya ku canzawa zuwa insulin, to, zaku iya gwada liraglutide.