Ofaya daga cikin cututtukan hypoglycemic da aka wajabta yayin kula da nau'in ciwon sukari na 2 shine Bayeta. Magungunan yana taimaka wa marasa lafiya da wannan cuta don cimma ƙimar martaba na glycemic al'ada.
Bayanin miyagun ƙwayoyi, sakin saki da abun da ke ciki
Baeta yana aiki azaman agonist mai karɓar enteroglucagon (glucagon-like peptide), ana samarwa don narke abinci ta abinci. Magungunan yana taimakawa rage glucose, inganta aikin beta sel a cikin pancreas.
Duk da irin kwatankwacinsa da insulin, Baeta ya banbanta da kwayar halittar dake cikin tsarinta na sinadarai da kayan aikinta, da kuma farashinta.
Ana samun magungunan a cikin sirinji, wanda shine kwatankwacin maganin insulin wanda likitoci da yawa ke amfani da shi. Babu allura don allura a cikin kit ɗin, don haka ya kamata a saya su daban. Kunshin yana kunshe da alkalami mai sirinji tare da cajin caji wanda ke dauke da maganin a cikin girman 1.2 ko 2.4 ml.
Abun ciki (a cikin 1 ml):
- Babban bangaren shine Exenatide (250 mcg).
- Gishirin acid ɗin sodium gishiri (1.59 mg) abu ne mai taimako.
- Metacresol mai haɗin kai a cikin adadin 2.2 MG.
- Ruwa da sauran magabata (mamaye har zuwa 1 ml).
Baeta ne mai launi mara haske, bayyananniya, wari mara kyau.
Aikin magani na magani
Bayan gabatarwar mafita a cikin jini, matakan sukari ana daidaita shi saboda abubuwan da ke gaba:
- A lokacin haɓaka glucose, akwai karuwa a cikin ɓoyewar insulin hormone ɗin da ke cikin ƙwayoyin beta.
- Tare da raguwar sukari na jini, asirin hormone ya daina aiki, wanda ke ba ka damar kafa matakin glucose na al'ada, da guje wa yanayin hypoglycemia, wanda ke da haɗari ga jiki.
- Tare da raguwa mai yawa a cikin sukari, abubuwan da ke tattare da magunguna ba su shafi ɓoyewar glucagon, ba da damar hormone ya ƙara haɗuwa cikin jini zuwa dabi'un al'ada.
Bayan allura, ayyuka masu zuwa suna faruwa cikin jiki:
- Abubuwan da aka hana glucagon da yawa
- Motsa jiki na raguwa, tsari na kwashe abubuwan da ke ciki ya ragu.
- Marasa lafiya suna da alamar rage ci.
Haɗin kayan haɗin maganin Bayet tare da Thiazolidinedione ko Metformin shima yana taimakawa rage glucose na safe da ƙimarsa bayan cin abinci, gami da glycosylated hemoglobin.
Subcutaneous management na miyagun ƙwayoyi ya ba da izinin a sha shi nan da nan, har ya kai kololuwa a cikin aikinsa bayan 2 hours. Rabin rayuwar sa kusan awanni 24 ne kuma baya dogaro da maganin da mai haƙuri ya karɓa.
Pharmacokinetics
Bayan allurar da miyagun ƙwayoyi a cikin jiki, tsarin sha, yana shiga cikin sel duka, rarrabawa da fitarwar yana faruwa kamar haka:
- Damuwa. Abubuwan da ke aiki na miyagun ƙwayoyi, bayan yin allurar subcutaneous, da sauri su shiga cikin jini, za a iya samun mafi yawan taro bayan minti 120 (211 pg / ml). Wurin allurar ba ya shafar yawan sha.
- Rarraba. Thearar Vd shine lita 28.3.
- Tsarin rayuwa. An rarraba kayan aikin magani a cikin ƙwayar ƙwayar cuta, sel sel na gastrointestinal fili (gastrointestinal fili), gami da gudanawar jini.
- Kiwo. Wannan aikin yana ɗaukar kimanin sa'o'i 10, ba tare da la'akari da kashi ba. Thewayar ta fitar da ƙwayar fitsari tare da fitsari, sabili da haka, cin zarafin hanta ba ya shafar adadin fitarwar.
Alamu don amfani
Ana amfani da Baeta don magance cututtukan type 2.
2 zaɓuɓɓuka don maganin ƙwayar cuta:
- Monotherapy. Magungunan suna aiki azaman babban magani don kula da ƙimar glucose na al'ada. A hade tare da shi, ana bada shawara don bin wani tsarin abinci da aikin jiki.
- Hada magani. Baeta yana aiki azaman ƙarin magani don magunguna kamar su Metformin, abubuwan asalin sulfonylurea ko Thiazolidinedione, haɗinsu. Idan ya cancanta, za a iya tsara Byeta a haɗuwa tare da gabatarwar insulin basal da Metformin don inganta bayanan glycemic.
Magungunan yana contraindicated a cikin wadannan lokuta:
- ciki
- lokacin lactation;
- ciwon sukari mellitus (nau'in insulin-dogara 1);
- kasancewar bayyanar cututtuka na ketoacidosis masu ciwon sukari;
- gazawar koda
- yara, harma da matasa masu shekaru 18;
- cuta mai haɗari na ƙwayar gastrointestinal;
- rashin jituwa ga abubuwan da ke cikin magani.
Umarnin don amfani
Dole ne a gudanar da miyagun ƙwayoyi a ƙarƙashin ƙasa.
Wuraren yin allura na iya zama:
- yankin hip
- yankin gobara;
- yankin a kan ciki a kusa da cibiya.
Ya kamata a fara amfani da warkarwa tare da ƙaramin ƙwayar magani, daidai yake da 5 mcg. Ya kamata a gudanar da shi sau biyu a rana, ba ya wuce awa 1 kafin abinci. Bai kamata a ba da allura ba bayan karin kumallo ko abincin dare. Fitar da allura, ba tare da la'akari da dalilin ba, ba ya canza lokacin gudanar da magani na gaba a fata. Haɓakar kashi na farko zuwa 10 mcg yana yiwuwa wata daya bayan fara maganin.
Yin amfani da magunguna na Bayeta tare da abubuwan da ake amfani da su na sulfonylurea yakan haifar da raguwa a cikin kashinsu don rage haɗarin cututtukan hawan jini. Inje na miyagun ƙwayoyi ba ya shafar sashi na wasu kwayoyi.
Muhimmin wuraren aikace-aikacen:
- bai kamata a gudanar da maganin ba bayan karin kumallo ko abincin dare;
- An haramta yin amfani da allurar ciki ko na ciki na Bayet;
- kada kuyi amfani da almalin sirinji tare da maganin laka, haka ma canza launi;
- miyagun ƙwayoyi na iya haifar da halayen kamar amai, pruritus, fitsari ko redness, zawo, da sauran raunin narkewa da damuwa.
Musamman marasa lafiya
Mutanen da ke da ciwon sukari galibi suna da wasu cututtukan ƙwayar cuta. A wannan yanayin, ya kamata ku mai da hankali musamman wajen amfani da maganin Bayeta.
Rukunin marasa lafiya da ke buƙatar kulawa ta musamman sun haɗa da:
- Samun keta a cikin aikin kodan. Marasa lafiya tare da sassauya mai sauƙi ko matsakaici na lalacewa na koda bazai buƙatar daidaita sashin Bayet ba.
- Samun keta hakkin hanta. Kodayake wannan dalilin ba zai canza canji a cikin taro na exenatide a cikin jini ba, yin shawarwari tare da ƙwararren likita ya zama dole.
- Yara. Ba a yi nazarin tasirin maganin a jikin gungun matasa ba har zuwa shekaru 12. A cikin matasa shekaru 12-16 bayan gabatarwar mafita (5 μg), sigogi na pharmacokinetic sun yi kama da bayanan da aka samo a cikin binciken tsofaffin marasa lafiya.
- Ciki Sakamakon mummunan sakamako masu amfani da miyagun ƙwayoyi akan haɓakar tayin, an ba shi contraindicated don amfani da uwaye masu tsammani.
Yawan sha da yawa da hulɗa tare da wasu magunguna
Bayyanar alamun bayyanar kamar matsanancin amai, tsananin tashin hankali, ko raguwa sosai a cikin glucose na jini na iya nuna yawan shan magani (ya wuce adadin da aka iya yarda da maganin sau 10).
Jiyya a wannan yanayin ya kamata don sauƙaƙe bayyanar cututtuka. Tare da bayyanar bayyanar cututtuka na hypoglycemia, ya isa ya cinye carbohydrates, kuma idan akwai alamun ciwo mai tsanani, ana iya buƙatar gudanar da jijiyar ciki.
Yayin aikin jiyya tare da inyections na Bayeta, tare da wasu magunguna, mahimman abubuwan da za a yi la’akari da su sun hada da:
- Magungunan da suke buƙatar shan hanzari a cikin narkewa yakamata yakamata a ɗauki 1 sa'o'i kafin gudanarwar Byet ko a cikin irin wannan abincin lokacin da ba a buƙatar allura.
- Ingancin Digoxin yana raguwa tare da gudanar da aikin na Byet lokaci guda, kuma lokacin fitowar sa ya karu da awa 2.5.
- Idan ya zama dole don rage karfin jini tare da Lisinopril na miyagun ƙwayoyi, ya zama dole a lura da tsaka-tsakin lokaci tsakanin shan allunan da allurar ta Bayet.
- Lokacin ɗaukar Lovastatin, rabin rayuwar sa yana ƙaruwa 4 hours.
- Lokacin cire warfarin daga jiki yana ƙaruwa da 2 hours.
Ra'ayoyin game da miyagun ƙwayoyi
Daga sake dubawar marasa lafiya, ana iya kammala game da tasiri na Byeta da haɓakawa a cikin aiki bayan an yi amfani da shi, kodayake mutane da yawa suna lura da tsadar magungunan.
Cutar sankara ta bayyana shekaru 2 da suka gabata. A wannan lokacin, ƙoƙarin rage sukari ta hanyar shan magunguna daban-daban bai yi nasara ba. Wata daya da suka gabata, likitan da ke halartar ya ba ni umarnin rage yawan magungunan Bayet. Na karanta sake dubawa ta yanar gizo kuma na yanke shawara game da magani. Sakamakon ya ba da mamaki matuka. A cikin kwanaki 9 na gudanarwa, matakin sukari ya ragu daga 18 mmol / L zuwa 7 mmol / L. Bugu da kari, na sami damar rasa karin kilo 9. Yanzu ba na jin bushewa da ɗanɗano mai faɗi a bakina. Kadai rashin amfani da magani shine babban farashin.
Elena Petrovna
Har tsawon wata daya Baffa. Sakamakon haka, na sami damar rage matakan sukari da yawa raka'a kuma in rasa nauyi da 4 kilogiram. Na yi farin ciki da cewa ci ya ragu. Likita ya ba da shawarar ci gaba da ba da maganin har tsawon wata, amma har ya zuwa yanzu na yanke shawarar bin dokanin abincin da na koma ga magungunan da suka gabata. Farashinsa haramun ne a gare ni, saboda haka ba zan iya saya ba duk wata.
Ksenia
Abubuwan bidiyo akan amfanin da ya dace na alkalami mai sihiri:
Zan iya maye gurbin maganin?
Babu kwatankwacin maganin analog na maganin Bayet a kan kasuwar magunguna. Akwai "Baeta Long" kawai - foda don shirye-shiryen dakatarwar da aka yi amfani dashi don yin allura.
Wadannan kwayoyi suna da irin wannan tasirin, kamar Baeta:
- Victoza. Kayan aiki an yi nufin shi ne don gudanar da aiki da subcutaneous kuma yana samuwa a cikin nau'in sirinji almara. Amfani da shi daga marasa lafiya masu fama da ciwon sukari na 2 na iya rage matakan sukari da rasa nauyi.
- Januvia - Akwai shi a cikin kwamfutar hannu. Yana daya daga cikin mafi arha hanyoyin da suke da irin wannan sakamako akan jikin.
An ba da magani na Baeta a cikin kantin magani tare da takardar sayan magani. Farashinsa ya sauya kusan 5200 rubles.
