Nau'in na 2 na ciwon sukari mellitus cuta ce ta kowa da yawa, wanda aka nuna ta cin zarafin metabolism. Babban hanyar magani shine motsa jiki, maganin rage cin abinci, maganin ƙwayoyi. Ofaya daga cikin magungunan da aka wajabta don ciwon sukari na 2 shine glibenclamide.
Babban bayani game da miyagun ƙwayoyi
Glibenclamide sanannun magani ne na rage sukari wanda aka yi amfani dashi a cikin ƙasashe daban-daban, musamman a Rasha, tun farkon shekarun 70s. Shi wakili ne na abubuwan da suka samo asali na sulfonylurea (ƙarni na biyu). Ana amfani da miyagun ƙwayoyi don magance cututtukan type 2.
Magungunan da aka gabatar sun nuna ƙarin kaddarorin amfani ga jiki. A cikin shekaru 45 da suka gabata, ingantattun magungunan antidiabetic da kwayoyi tare da wata hanyar aiwatarwa daban sun bayyana a kasuwar magunguna. Amma Glibenclamide har yanzu likitoci sun wajabta shi kuma ba sa asararsa.
Ba kamar magabata ba, magungunan sun fi juriya da aiki. An wajabta shi a cikin rashin sakamako na rashin magani da juriya ga wasu kwayoyi.
Propertiesungiyoyin magunguna da abubuwan da aka tsara
Sakamakon magani shine hypocholesterolemic, hypoglycemic. Yana ƙara yawan adadin insulin da ake buƙata ta hanjin ƙwayar hanji, tahanyar farkawa aikin beta sel na ɗarikar islet. Abubuwan yana toshe tashoshin potassium waɗanda ke dogaro ne (tashoshin ATP).
Starfafa wasu kwayoyin halitta tare da insulin yana faruwa kuma, sakamakon haka, abubuwa masu rai suka shiga jini da ruwa mai shiga tsakani.
Baya ga babban aikin, kayan yana da tasirin thrombogenic kuma yana rage cholesterol. Yana bayar da saurin rushewa da narkewa cikin narkewa. Yin jingina ga ƙwayoyin plasma na faruwa kusan gaba ɗaya (98%). Magungunan yana metabolized a cikin hanta. Matsakaicin maida hankali a cikin jini ya isa cikin awa 2.
Amfanin yana aiki tsawon sa'o'i 12. Rabin rayuwar bayan maganin baka shine sa'o'i 7, ƙare cikin kwanaki 2-3. An cire shi gaba daya tare da bile da fitsari .. Tare da rage yawan aiki hanta, an cire hankali a hankali, kuma tare da gazawar renal matsakaici, akasin haka, yana ƙaruwa.
Sunan mai aiki a cikin Latin shine glibenclamide. Takaddar saki: Allunan tebur zagaye. Kowane ya ƙunshi 5 MG na kayan aiki.
Manuniya da contraindications
Nuna don amfani: cututtukan da ba su da insulin-insulin, sun bayar da cewa babu wani sakamako na gyaran glucose ta hanyar maganin marasa magani.
Contraindications don amfani sun haɗa da:
- rashin haƙuri ga abu mai aiki;
- aikin lalata hanta;
- metabolism tare da hali na acidification na jiki;
- precoma ko mai ciwon sukari;
- ciki
- aikin koda mai rauni;
- lokacin lactation;
- kammala maimaita rashin nasarar magani;
- ciwon sukari mai dogaro da insulin (DM 1);
- mutane yan kasa da shekara 18.
Umarnin don amfani
An gudanar da canjin zuwa glibenclamide daidai, an tsara maganin tare da allunan 0.5 a kowace rana. Tsofaffi mutanen da ke da dysfunctions na jiki ana bada shawara don ƙara sashi na hankali a hankali.
Gaskiya ne gaskiya ga mutanen da ke yin nauyin kilo 50. A kowace rana, kashi shine 2.5-5 MG na magani (har zuwa kwamfutar hannu 1). Idan ya cancanta, ƙara kashi a hankali. Tsarin yau da kullun ya kasance har zuwa allunan 3.
Ana shan magani kafin abinci. A cikin ƙwaƙwalwar fiye da kwamfutar hannu 1, ana bada shawara don bin ƙimar 2: 1 (safiya: maraice). Amincewa ana aiwatar da ita a lokaci guda ba tare da fashewa mai kaifi ba. A lokacin jiyya, ana kula da yanayin metabolism.
Tare da taka tsantsan, yakamata a yi amfani da maganin ta ƙayyadaddun masu haƙuri:
- tsufa;
- mutane masu ƙarancin aikin hanta;
- marasa lafiya da rage yawan aikin thyroid;
- tare da alamun cututtukan cerebral sclerosis.
Shan barasa yayin jiyya cikin tsari na tsari na iya shafar ambigually - don haɓaka ko rage ƙarfin tasirin maganin. Dye E124 yana haifar da rashin lafiyan a cikin marasa lafiya masu saurin kamuwa. Idan wata cuta (ko data kasance) ta faru, ya zama dole a sanar da likita. Marasa lafiya bai kamata su daina shan magani ba ko kuma su daidaita maganin ba tare da tuntuɓar likitan su ba.
Side effects da yawan abin sama da ya kamata
Daga cikin illolin da aka lura:
- karin nauyi;
- amai, tashin zuciya, nauyi a cikin narkewa, narkewa;
- pruritus, rash, anemia;
- aikin lalata hanta;
- haɓaka cikin sigogin ƙirar ƙwayoyin cuta;
- raunin gani;
- hypoglycemia;
- halayen rashin lafiyan;
- thrombocytopenia, leukocytopenia, erythrocytopenia, granulocytopenia;
- rauni sakamako diuretic.
Yawan shaye-shaye (tsawan ƙarami ko ƙara yawan lokaci a kashi) a cikin lamura da yawa suna haifar da hauhawar jini.
Alamarsa sune:
- gumi
- pallor na fata;
- karancin magana da azanci;
- palpitations, jin sanyi;
- tare da jihar ci gaba - hypoglycemic coma.
A cikin yanayi mai tsanani, ya zama dole a kurkura ciki kuma a sa allura na glucose. Idan ya cancanta, ana gudanar da glucagon. Za'a iya kawar da cutar sikari da ƙarfi ta hanyar cin sukari.
Yin hulɗa tare da wasu magunguna da analogues
Magungunan da ke haɓaka tasirin Glibenclamide sun haɗa da: Miconazole, maganin rigakafi na tetracycline, maganin anabolic steroid, antidepressants, insulin da kwayoyi masu yawa masu kamuwa da cutar sankara, maza na maza.
Magungunan da ke taimakawa rage tasirin sun hada da: hormones thyroid, corticosteroids, nicotinates, glucagon, beta-andrenoblockers, hormones na mace, diuretics, barbiturates.
Magungunan da za su iya tasiri a kan glibenclamide (haɓaka ko, a taƙaice, ƙananan) sun haɗa da: Clonidine, Reserpine, H2 receptor blockers, pentamidine.
Magunguna na irin wannan aikin:
- cikakken kwatanci shine Maninil (abu mai aiki iri daya ne);
- rukuni na kwayoyi tare da glimepiride - Amapirid, Amaril, Glibetic, Glimax, Diapride;
- shirye-shirye tare da Gliclazide - Glidia, Glicada, Gliclazide, Diagnizid, Panmicron-MV;
- kudade tare da Glipizidom - Glynez, Minidiab.
Abubuwan bidiyo daga Dr. Malysheva game da samfuran da ke rage sukari a cikin ciwon sukari kuma ana iya amfani dashi azaman ƙari ga magunguna:
Ra'ayoyin masu haƙuri
Daga sake dubawa game da marasa lafiya da ke shan Glibenclamide, zamu iya yanke shawara cewa farashin maganin yana da araha kuma yana rage sukari sosai, amma bayan amfani dashi, tasirin sakamako yana haifar da sauƙin yanayin tashin zuciya da rashin ci.
Na yi rashin lafiya tare da ciwon sukari na tsawon shekaru 12. An tsara magunguna daban-daban, amma Glibenclamide ya tabbatar da cewa ya fi dacewa. Da farko an bi da su tare da Metformin - babu wani sakamako na musamman akan daidaita sukari koda bayan haɓaka sashi. Bayan sallama Glibenclamide. Abubuwan da ke haifar da sakamako a cikin nau'i na asarar ci da tashin zuciya sun kasance a farkon watan, to, komai ya koma daidai. Matsakaicin sukari tare da amfani da maganin ya ragu kuma yana kiyayewa cikin 6. A lokacin rana Ina jin al'ada, kuma yana jin daɗi.
Irina, ɗan shekara 42, Samara
Mahaifiyata kwanan nan ta gano nau'in ciwon sukari na 2. Likitan halartar nan da nan ya wajabta wa Glibenclamide kuma ya rubuta takardar sayan magani. Kimanin mako guda bayan an yi amfani da shi, sai na fara jin tashin zuciya da rashin ci. Amma, kamar yadda ta ce, wannan ba mai mahimmanci ba ne idan aka kwatanta da gaskiyar cewa ana sa glucose a 6-7. Yayin magani, ya zama dole don sarrafa sigogin hanta ban da matakin glucose. Amma inna, tare da Glibenklemin, suna da kyau.
Sergey, dan shekara 34, Yekaterinburg
Ciwon sukari na kusan shekara 6 da haihuwa. A zahiri, ba za a iya daidaita glucose ba. Dole ne in dauko magani. Ina jin sakamakon kawai daga Glibenklemin - an rage sukari zuwa 6.5. (A koyaushe ina amfani da mitir). Kafin wannan, ba zan iya samun irin wannan alamar na dogon lokaci ba, a ƙasa sukari 7 bai ragu ba. A karshe na dauko magani na. Da farko na ɗan ɗan yi mini nauyi, amma daga baya na daidaita abincin da nake ci. Daga cikin sakamako masu illa: tashin zuciya lokaci-lokaci, lokaci-lokaci - zawo da asarar ci.
Oksana, mai shekara 51, Nizhny Novgorod
Farashin asalin magani ya tashi daga 90 zuwa 120 rubles. Ana bayar da maganin ne kawai ta hanyar takardar sayan magani.
Glibenclamide magani ne mai daidaitacce don rage matakan glucose. An tsara shi da ƙwazo ta hanyar likitoci kuma ba sa asararsa, duk da kasancewar magungunan sabon samfurin.
