Kwanan nan, an yi amfani da wakilai masu amfani da hypoglycemic hypoglycemic (Buformin, Metformin, Fenformin, da dai sauransu) don magance ciwon sukari. Amfani da su yana da fa'ida bayyananniya. Yi la'akari da fasalin waɗannan mahadi, tasirin su da hanyoyin magance cutar sukari tare da taimakon su.
Yaya suke aiki
Anyi amfani da Biguanides don kamuwa da cutar tun daga shekarun 1970. Ba sa haifar da insulin insulin daga ciki. Sakamakon irin waɗannan magunguna yana faruwa ne saboda hana aikin gluconeogenesis. Mafi magunguna na yau da kullun wannan nau'in shine Metformin (Siofor).
Ba kamar sulfonylurea da abubuwan da ya samo asali ba, Metformin ba ya rage glucose kuma baya haifar da hypoglycemia. Wannan yana da mahimmanci musamman bayan azumin na dare. Magungunan yana iyakance yawan karuwa a cikin jini bayan cin abinci. Metformin yana ƙaruwa da ƙwaƙwalwar ƙwayoyin sel da ƙirar jikin mutum zuwa insulin. Bugu da kari, yana inganta kwararar glucose a cikin sel da kyallen takarda, yana rage jinkirin sha a cikin hanji.
Metformin shine babban wakilin kungiyar biguanide na kwayoyi
Tare da yin amfani da tsawan lokaci, biguanides suna da tasirin gaske akan metabolism mai. Suna rage jinkirin aiwatar da canza glucose zuwa kitse mai kitse, kuma a wasu halaye sun rage yawan abubuwan triglycerides, cholesterol a cikin jini. Ba a gano sakamakon biguanides yayin rashin insulin ba.
Ana amfani da Metformin sosai daga cikin gastrointestinal tract kuma yana shiga cikin jini, inda mafi girmansa ya kai awowi biyu bayan gudanarwa. Rayuwa ta rabin rabin lokaci har zuwa awa 4 da rabi.
Manuniya da contraindications
Wataƙila amfani da biguanides a hade tare da insulin. Hakanan zaka iya ɗaukar su a hade tare da sauran magunguna masu rage sukari.
Musamman Metformin an nuna shi musamman ga marasa lafiya da ciwon sukari da kuma kiba mai yawa.
Magungunan yana contraindicated a cikin irin waɗannan lokuta:
- ciwon sukari mai dogaro da insulin (sai dai idan an hada shi da kiba);
- dakatar da samar da insulin;
- ketoacidosis;
- gazawar koda, gajiya hanjin aiki;
- ciwan zuciya da rashin karfin numfashi;
- rashin ruwa, girgizawa;
- na kullum mai shan giya;
- lactic acidosis;
- ciki, shayarwa;
- karancin kalori (kasa da kilogram 1000 a rana);
- shekarun yara.
Ya kamata a yi taka tsantsan wajen sanya biguanides ga mutanen da suka wuce shekara 60 idan suna cikin aiki ta jiki. A wannan yanayin, akwai babban haɗarin haɓaka ƙwayar lactic acidosis coma.
Side effects da yawan abin sama da ya kamata
A cikin kusan 10 zuwa 25 bisa dari na lokuta, marasa lafiya waɗanda ke shan biguanides suna fuskantar tasirin sakamako kamar dandano mai ƙarfe a cikin bakin, asarar ci, da tashin zuciya. Don rage yiwuwar kamuwa da irin wannan alamomin, yana da mahimmanci a ɗauki waɗannan magunguna tare da ko bayan abinci. Ya kamata a ƙara yawan hankali a hankali.
A wasu halaye, ci gaban megaloblastic anemia, karancin cyanocobalamin yana yiwuwa. Da wuya, rashin lafiyar fitsari ta bayyana akan fatar.
Game da yawan abin sama da ya wuce, alamomin lactic acidosis na faruwa. Bayyanar cututtuka na wannan yanayin sune rauni, damuwa na numfashi, amai, tashin zuciya, da gudawa. Sanyaya daga ƙarshen ƙarshen, bradycardia, hypotension sanannen abu ne. Jiyya na lactic acidosis alama ce ta alama.
Likita ne kawai yakamata yakamata ayi magani kuma ka zabi kashi
Sashi
Dole a sanya sashi na miyagun ƙwayoyi kowane lokaci daban-daban. Kullum kuna da glucose a hannu. Hakanan yana da mahimmanci la'akari da jin daɗin rayuwa: sau da yawa sakamako masu illa suna haifar ne kawai saboda ƙimar da ba ta dace ba.
Jiyya tare da biguanides ya kamata farawa da ƙarancin kashi - ba fiye da 500-1000 g kowace rana ba (bi da bi, 1 ko 2 Allunan na 0.5 g). Idan ba'a lura da wani sakamako ba, to ana iya ƙara yawan kashi. Matsakaicin adadin magani a rana shine 3 grams.
Don haka, Metformin babban kayan aiki ne mai inganci don magani da rigakafin cutar sankara. Wajibi ne a bi umarnin don amfani da miyagun ƙwayoyi a hankali.
