Synthesized daban-daban ta jiki a cikin adrenal bawo ko wani dakin gwaje-gwaje steroid, glucocorticoid an yi niyya don toshe kafofin watsa labarai masu kumburi.
Magani ya ƙaddara rarrabewar glucocorticoids bisa ga hanyar aikace-aikacen, aiki, ƙarfin aiki, dangane da hanyar gudanarwa.
Ana buƙatar glucocorticosteroids na Artificially don hana mayar da hankali na kumburi, ƙarancin da aka tsara don rashin lafiyan jiki ko azaman magani na immunosuppressive.
Abubuwan steroids na halitta
A ƙarƙashin tasirin tsarin juyayi na tsakiya da ƙwayar ƙwayar cuta, ƙwayar cuta ta haɓaka ta haɓaka a cikin adrenal cortex, da nufin riƙe yanayin gaba ɗaya yayin damuwa, haɓaka aiki na yau da kullun, da kuma kawar da cutar kumburi. Lokaci daban-daban na rana yana shafar fitar da takamaiman ƙwayoyin cuta.
Cortisol
Wadannan nau'ikan steroid na halitta an rarrabe su:
- cortisol (hydrocortisone) ana yin sa ne yayin damuwa, da nufin farkawa da ƙarfin adaɓin jiki don tsayayya da yanayin damuwa. Rashin damuwa akai-akai yana haifar da wuce haddi na cortisol, wanda ke ba da gudummawa ga tara nauyin jiki mai yawa, adon mai a kafadu da kugu, rashin damuwa, tashin hankali na bacci, cututtukan kasusuwa da aikin haihuwa. Rtarancin cortisol na jini yana haifar da asarar nauyi, rage karfin jini, rawar jiki daga ƙarshen, damuwa;
- cortisone An haɗa shi daidai da cortisol, amma a cikin adadi kaɗan. Manufarta ita ce ƙarfafa matakan tafiyar matakai, haɓaka aikin tsoka. Wannan yana rage aikin tunani, kariya ta jiki, aikin narkewa.
Aara yawan al'ada ko ƙara gajerun abu na cortisol mai yiwuwa ne ga jiki: yayin ɗaukar yaro a cikin mata, bayan rauni ko kamuwa da cuta, tsawaita damuwa, tsananin motsa jiki.
Ana lura da babban kwayar hormone a cikin jini da safe, kimanin awanni 8, a hankali yana ragewa yayin rana, ya kai ƙaramin ƙarfe 3 na safe.
Bred a cikin dakin gwaje-gwaje
Don lura da wasu cututtuka, taimako a cikin yanayi mai wahala, da kuma sarrafa tafiyar matakai na rayuwa, glucocorticoids aka samo asali daga wucin gadi. Ayyukansu sunyi kama da na halitta, ana amfani dasu don isasshen samar da hormone a cikin jiki.
Tsara shirye-shiryen glucocorticoid dangane da manufarsu da tasirinsu a jiki. Kamfanonin magunguna sun wakilci hormone a cikin fassarori daban-daban, wanda ya bambanta a cikin abubuwan da ke tattare da wakilan masu taimakawa, da kuma batun babban abu.
Allunan Allunan
Noncoorcoated glucocorticoids:
- cinzankari. Yana da tasirin vasoconstrictor, yana tasiri metabolism da metabolism na BZHU. An gabatar dashi azaman dakatarwa ko mafita don allura. Ana amfani dashi don kumburi, don sauƙaƙa halayen halayen da ƙaiƙayin fata. Ya ƙunshi magunguna: Beloderm, Betazone, Betaspan, Diprospam, Celederm, Celeston;
- maganin riga-kafin. Ana amfani dashi don sauƙaƙa mummunan rashin lafiyar, yanayin girgiza, yana da matsakaicin ƙarfin aiki. Rarraba glucocorticoids na wannan rukunin ta hanyar hanyar aikace-aikacen ya kasu kashi: na baka, allurar, parenteral. Magunguna sun gabatar da shi: Prednisolum, Medopred, Decortin;
- sabbinna. Amfani da shi azaman abu mai haɓakawa don leukocytes da macrophages nama. Ana aiwatar da jiyya ta hanyar magana ta baki da ta ɓata, yana aiki tare da cututtukan endocrine. Magunguna tare da hormone: Medrol, Metipred.
Don glucocorticoids na roba mai haske sun hada da:
- dexamethasone. Zai iya shiga cikin tsarin jijiya ta tsakiya, yana ba da rigakafi da tasirin rigakafi. Akwai cikin injections, allunan, saukad da ido. A miyagun ƙwayoyi ne hormonal, sabili da haka, marasa lafiya suna fuskantar matsala a cikin tsarin hormonal, matakan metabolism, da canji a cikin yanayin tunanin. An ƙunshi magunguna: Dexazone, Dexamed, Mexidex;
- triamcinolone. An haɗa shi don lura da cututtukan cututtukan cututtukan cututtukan zuciya, cututtukan fata, gouty da arthritis, hypercalcemia a cikin mummunan neoplasms. An gabatar dashi a baki, allurar, shawa, siffofin gida. Babban kayan magungunan: Kenalog, Berlicort, Polcortolone, Triacort.
Amfani da fatsilayin corticosteroids
Samun tasiri na gida ko gaba ɗaya akan jiki, ana iya samun kwayoyi masu amfani da glucocorticoids a cikin nau'ikan allunan, maganin shafawa, saukad da, injections. Babban aikinsu shine sauƙaƙe bayyanar gida game da rashin lafiyan jiki, kawar da fifikon kumburi, da kuma samar da tasirin immunostimulating. Dangane da hanyar aikace-aikacen, glucocorticoids an rarrabasu cikin rukuni 2: tasirin gida da sakamako.
Maganin shafawa na Betamethasone
Kungiya 1 - watsawar gida:
- don aikace-aikacen fata (maganin shafawa, foda, cream): Mometasone, Betamethasone, Fluocinolone Acetonide;
- saukad da idanu, kunnuwa: Betamethasone;
- inhalation: budesonide, flunisolid, fluticasone propianate;
- allurar cikin ciki: Betamethasone;
- Gabatarwa zuwa kashin jijiya: Hydrocortisone.
Kungiyoyi 2 - glucocorticoids:
- Hydrocortisone (miyagun ƙwayoyi masu aiki (LS) - Cortef);
- Prednisone;
- Prednisone;
- Methylprednisolone;
- Dexamethasone;
- Triamcinolone;
- Betamaratani.
Glucocorticosteroids yana hana ɗaure na immunoglobulin zuwa ƙwayoyin mast, yana hana bayyanar cututtuka. Ana amfani da magungunan Hormonal idan akwai wani rashin lafiyar mai taushi: Harshen Quincke, ƙarar anaphylactic, urticaria. Wani lokaci ana amfani dashi don kawar da rashin lafiyan gida.
Tare da ikon kawar da rigakafi, ana amfani da glucocorticoids cikin nasara transplantology. Rage ayyukan kariya na jikin mutum yana hana ƙin karɓar kyallen takarda.
Ta hanyar dakatar da aikin phospholipase, an sami tasirin rigakafin cutar corticosteroids. Rage fitowar fitowar ruwa saboda kumburin cibiyar sadarwa yana haifar da raguwar alamun bayyanar edematous. Ana murmurewa saboda karuwar microcirculation a cikin rauni.Ko da kuwa rarrabuwar, na halitta da na roba glucocorticoids suna da magani iri ɗaya, sakamakon warkewar su shine:
- canji (tare da karancin hormone);
- pathogenetic (anti-mai kumburi, anti-shock, immunosuppressive, anti-rashin lafiyan sakamako);
- m (tsanantawa na samar da corticoliberin, alhakin bayyanuwar damuwa) aiki.
Tasirin sakamako
Magunguna na asali na asali suna da sakamako masu kyau a cikin jiyya kuma suna ɗaukar sakamako masu illa.
Yana da mahimmanci a gudanar da hanya a ƙarƙashin tsananin kulawa na likita, ba tare da magani na kai ba.
Wadanda ba a ke so su bayyana ne kamar kara yawan glucose a cikin jini, kasancewar sukari a cikin fitsari. Maganin ciwon sukari na steroid mellitus sakamakon haɗuwa da kwayoyin homones a cikin metabolism na carbohydrates yana da haɗari musamman.
Rashin halayen steroids a cikin ƙwayoyin gina jiki yana haifar da rushewar ƙwayar tsoka. Rage kayan ƙirar collagen yana haifar da tsufa na fata, yana rage turgor. Supparfafawar ƙwayar furotin yana shafar samuwar sabon ƙwayar nama, wanda yake da mahimmanci lokacin da ake warkar da raunuka da yanke.
Tasirin glucocorticoids akan metabolism mai yana haifar da rarraba asymmetric na adipose nama a cikin jiki. Marasa lafiya suna da karancin kasancewar ƙwayoyin mai a cikin ƙwaƙwalwar ƙwayar cuta a cikin wata gabar jiki, amma faɗin yalwata a wuyansa, fuska, kirji.
Amfani da ɗan gajeren lokaci na steroids ba ya haifar da nazarin halittar jini na zuciya.
Haphazard na amfani da magunguna na asali na asali na asali yana ba da gudummawa ga bayyanuwar hauhawar jini, cututtukan zuciya.
Abubuwan da ke haifar da cutarwa na iya haɗawa da rashin bacci, da ƙwaƙwalwar ƙwayar cuta, sanyin hanji a cikin marassa lafiya, ƙwayar gastrointestinal, jinkirin haɓaka yara, osteoporosis. Bayyanar bayyanar gida da wuya lura da candidiasis na nasopharynx, ƙonewa, tari, zubar jini na mucous membranes yana yiwuwa.
Bidiyo masu alaƙa
Lakcar a kan mahimmancin glucocorticosteroids a magani:
Cikakken cikakken bayani na glucocorticoids yana ba da cikakken hoto game da amfani da magungunan da ke ɗauke da steroids. Halittuwar da aka samu ta hanyar kwantar da hankali suna ɗaukar aikin da aka ba da umarni a cikin yaƙi da ƙwarewar kamuwa da cuta ko microflora na pathogenic. Sesananan allurai na abu suna ba da gudummawa ga ingantacciyar hanyar cutar ba tare da rikitarwa daga sauran tsarin jiki ba.
