Galvus shine wakili na hypoglycemic wanda aka tsara don sarrafa glycemia a cikin nau'in ciwon sukari na 2. Ainihin kayan aiki mai maganin shine vildagliptin. An fito da miyagun ƙwayoyi a cikin nau'in Allunan. Dukkanin likitocin da masu ciwon sukari sun sami kyakkyawan sakamako daga Galvus.
Yana da ƙarfi yana sarrafa metabolism na insulin da glucagon. Antungiyar Antidiabetic Turai ta Turai ta ce Galvus a cikin maganin monotherapy yana da kyau a yi amfani da shi kawai lokacin da metformin ya ba da haƙuri ga mai haƙuri. Ga masu ciwon suga da ke fama da cutar insulin da ke dauke da cuta ta 2, Galvus yana taimakawa wajen rage yawan poplites da kuma yawan allurar da yake ciki.
Abubuwan da ke tattare da magunguna
Hormones ana kiranta homon da hanjin ke samarwa yayin da abinci mai gina jiki ya shiga ciki. Wadannan kwayoyin halittar suna insulinotropic, suna shigo da rufin insulin, saboda kashi 60% na samarwarsa ya kasance daidai da tasirin abubuwan incretins. An gano wannan sabon abu a cikin 1960, lokacin da suka koya don tantance taro insulin a cikin plasma.
Glucan-kamar peptide-1 (GLP-1) yana ɗaya daga cikin shahararrun, tun da yake an rage yawan haɗuwa da nau'in ciwon sukari na 2. Wannan ya haifar da sabon rukuni na kwayoyi waɗanda ke ƙara yawan abubuwan da ke cikin waɗannan kwayoyin halittu ko dai ta hanyar allurar roba ta GLP-1, kamar Baeta ko Victoza, ko ta hanyar magana kamar Galvus ko kuma anavia Janavia. DPP-4 inhibitors ba kawai ƙara haɗuwa da abubuwan homonu biyu kawai ba, amma yana hana lalata su.
Wanda ya dace da Galvus
Ga masu ciwon sukari da nau'in cuta na 2, ana iya amfani da maganin:
- Don monotherapy, a hade tare da abinci mai ƙarancin carb da isassun nauyin ƙwayoyin tsoka;
- A cikin hadaddun jiyya a layi daya tare da metformin, idan sakamakon da aka samo daga magani ɗaya bai isa ba;
- A matsayin madadin Galvus-like magunguna dangane da metformin da vildagliptin;
- A matsayin ƙari ga sauran wakilai na hypoglycemic, idan tsoffin magunguna na baya ba su da tasiri;
- A matsayin ilmin likita sau uku tare da insulin da metformin, idan abinci, motsa jiki da insulin tare da metformin ba su da tasiri.
Umarnin don amfani
Sashin maganin yana karewa ne ta hanyar maganin cututtukan endocrinologist daban-daban, la'akari da matakin cutar da kuma lafiyar lafiyar gaba daya na masu ciwon sukari. Amfani da allunan ba a haɗa shi da abincin da za a yi karin kumallo ba, babban abin sha shine a sha maganin da isasshen ruwa. A gaban sakamakon da ba a tsammani ba don cutar ta mahaifa, zai fi kyau a yi amfani da magani tare da abinci.
Idan an shigar da nau'in ciwon sukari na 2, Galvus za'a iya sanya shi nan da nan. Ba tare da la'akari da tsarin kulawa ba (hadaddun ko monotherapy), ana ɗaukar allunan cikin adadin 50-100g / rana. Ana ɗaukar matsakaicin ƙa'ida (100 MG / rana) a cikin matakan matsanancin ciwon sukari. A yayin jiyya, tare da sauran wakilai na hypoglycemic, an tsara 100 MG / rana.
Wani yanki na 50 g / rana. wanda aka ɗauka sau ɗaya, yawanci da safe, ya kamata a raba kashi na 100 MG zuwa kashi 2 - daidai, da safe da maraice. Idan ba'a rasa lissar Galvus ba, kwaya ya kamata a ɗauka a kowane lokaci, amma dole ne a kiyaye iyakokin gaba ɗaya.
Idan tare da monotherapy zaka iya ɗaukar 100 MG / rana, to, tare da ƙwaƙƙwarar magani, fara da 50 mg / rana, misali, tare da metformin: 50 mg / 500 mg, 50 mg / 850 mg, 50 mg / 100 mg.
Tare da diyya mai ƙoshin ƙwayar cuta wanda bai cika ba, an tsara magunguna na hypoglycemic madadin (metformin, insulin, kalaman sulfonylurea, da sauransu) ƙari.
Idan koda na koda da hanta suna aiki tare da cin zarafi, an rage mafi girman magunguna zuwa 50 MG / rana., Tun da Galvus ya rataye ƙodan, yana haifar da ƙarin nauyi akan tsarin ɓarin ciki.
Yawan yawan bayyanar cututtuka
Idan ƙimar yau da kullun ba ta wuce 200 mg / rana ba, ana canja wurin masu ciwon sukari na Galvus ba tare da sakamako ba. Ana lura da yawan yawan haɗari tare da alamun da suka dace lokacin da aka cinye shi da yawa akan 400 MG / rana. Myalgia (ciwon tsoka) ana nuna shi sau da yawa, ba sau da yawa - paresthesia (a cikin laushi da tsari transistor), kumburi, zazzabi, ƙwayar lipase yana ƙaruwa sau biyu kamar VGN.
Idan ƙimar Galvus ta wuce sau uku (600 mg / day), to akwai haɗarin kumburi, ƙwaƙwalwar ƙwayar cuta da haɓaka matakin ALT, CPK, myoglobin da furotin na C-mai kunnawa. Duk sakamakon gwajin, kamar alamu, yana ɓacewa lokacin da aka soke Galvus.
Galvus: analogues
Dangane da sashin tushen aiki, magungunan Vildaglympin da Galvus Met za su kasance iri ɗaya ne ga Galvus, kuma Janavia da Onglisa sun zo daidai da lambar ATX-4. Nazarin kwayoyi da kuma nazarin masu haƙuri sun nuna cewa waɗannan kwayoyi suna da alaƙa da juna.
Abubuwan Bala'i
Amfani da Galvus na dogon lokaci zai iya hade da sakamako masu illa:
- Ciwon kai da asarar daidaituwa;
- Remarfin makamai da ƙafafu;
- Rashin cutar dyspeptic;
- Peeling, blister da rashes na fata na asalin rashin lafiyar;
- Take hakkin rudani na hanjin motsi;
- Rashin kariya
- Rushewa da aiki mai yawa;
- Ciwon kansa, cututtukan cututtukan hanta da sauran cututtukan hanta da cututtukan fata;
- Chills da kumburi.
Ga wanda Galvus ya ba da izini
Contraindications don amfani da Galvus zai kasance da yawan cututtuka da yanayi.
- Kowane ɗan haƙuri ga abubuwan da ke cikin miyagun ƙwayoyi, halayen rashin lafiyan mutum;
- Renal da excretory tsarin tabarbarewa;
- Halin da ke haifar da mummunan aiki na kodan (zazzabi, kamuwa da cuta, baƙin ciki, amai);
- Cututtuka na zuciya da jijiyoyin jini;
- Matsalar numfashi;
- Ketoacidosis na ciwon sukari, coma, da kakanni, lokacin da aka fassara ciwon sukari cikin insulin;
- Lactic acidosis, karuwar taro na lactic acid;
- Haihuwa da lactation;
- Nau'in cuta guda 1;
- Tsarin tsari ko giya;
- Abincin mai tsauri sosai tare da adadin kuzari na 1000 Kcal / rana;
- Haramcin shekaru: har zuwa shekaru 18 na haihuwa, ba a ba da umarnin metabolite ba, bayan shekaru 60 - tare da taka tsantsan;
- Kafin aikin (kwana 2 kafin da bayan), a ranar gabatarwar wakilan bambanci ko gwajin rediyo;
- Ofaya daga cikin mahimmancin contraindications wa Galvus shine lactic acidosis, sabili da haka, tare da hanta ko gazawar renal, ba a sanya magani ba.
A cikin masu ciwon sukari na tsufa, yin jaraba ga metformin yana yiwuwa, wannan yana ƙaruwa da yawan rikitarwa, don haka an wajabta Galvus ne kawai a ƙarƙashin kulawar likita.
Siffofin Galvus lura da wasu nau'ikan masu ciwon sukari
Babu wani abin dogaro da bayanai game da tasirin kwayoyi kan lafiyar mahaifiyar da tayin, saboda haka, a lokacin daukar ciki ba a sanyata. Increasedarin yawan yawan sukari a cikin mace mai ciki na kara haɗarin kamuwa da cututtukan cututtukan haihuwata har ma da mutuwar yaro. A cikin ciwon sukari a cikin mata masu juna biyu, glycemia yawanci al'ada ce ta insulin.
Bincike ya nuna cewa koda kashi na Galvus, wanda ya wuce al'ada sau 200, bai tsokanar canje-canje ba cikin yanayin kiwon lafiyar matar mai ciki ko tayin. An yi rikodin sakamako iri ɗaya tare da yin amfani da metformin da Galvus a cikin rabo 10: 1.
Ba a yi bincike game da yiwuwar metabolite ya shiga cikin madarar nono ba, saboda haka, tare da shayarwa, ba a kuma sanya maganin Galvus ba.
Kwarewar maganin Galvus na yara masu ciwon sukari tare da nau'in cuta na 2 (yawan irin wannan marasa lafiya yana ƙaruwa da sauri a yau), musamman, raunin ingancinsa da mummunan sakamakonsa, ba a yi nazari sosai ba.
Saboda haka, ana sanya allurar ciki a cikin nau'in ciwon sukari na 2 daga shekara 18.
Masu ciwon sukari na tsufa (bayan shekaru 60) dole ne su tsayar da sarrafa duka matakan Galvus da mahimman sigoginsu, saboda idan kun ji mummunan rauni, nan da nan ku sanar da likita. A wannan zamanin, haɗarin rikice-rikice da sakamakon da ba a so, yana ƙaruwa, kamar yadda ake haifar da jaraba.
Shawara ta musamman
Dole ne a sanar da masu ciwon sukari game da duk sakamakon yiwuwar sabon maganin da zai haifar masa.
Galvus wakili ne na maganin antidi, amma ba wai maganin insulin bane. Saboda haka, amfani da shi yana buƙatar saka idanu akai-akai game da aikin hanta. Hakanan za'a iya bayanin wannan ta hanyar gaskiyar babban aikin Galvus yana haɓaka ayyukan aminotransferases. A waje, wannan ba a bayyana shi a takamaiman bayyanar cututtuka, amma canje-canje a cikin aikin hanta har zuwa ci gaban hepatitis ba makawa. A kowane hali, masu ba da lafiya na masu ciwon sukari daga ƙungiyar sarrafawa sun nuna irin wannan sakamakon. A alamun farko na m pancreatitis (ciwan ciki mai zafi na ciki), yakamata a soke maganin nan take. Ko bayan maido da lafiyar hanta, Galvus baya sake yin saiti.
Magungunan Galvus da ke fama da ciwon suga da ke da nau'in cuta ta 2 ana wajabta su ne kawai tare da shirye-shiryen insulin.
Akai-akai da damuwa da yawan zubar da jijiyoyi na rage karfin Galvus. A cewar masu ciwon sukari, yawancin lokuta jikinsu yana motsa jiki tare da asarar daidaituwa da tashin zuciya. Saboda haka, tuƙi abin hawa ko yin m abubuwa a cikin irin wannan yanayi ba da shawarar ba.
Kafin jarrabawar kowane nau'in, Galvus da analogues dinsu sun tsaya na kwana biyu. Abubuwan da suka bambanta da aka yi amfani dasu a cikin maganin yawanci suna dauke da aidin. Saduwa da vildagliptin, yana haifar da ƙarin kaya akan hanta da tsarin motsa jiki. A ƙarshen asalin lalacewa a cikin ayyukan su, lactic acidosis na iya faruwa.
Yankin farko na raunin zuciya (rarrabuwa na NYHA) tare da daidaitattun ƙwayoyin tsoka baya buƙatar daidaita sashi na Galvus. Kashi na biyu ya ƙunshi iyakance aikin tsoka don hana ƙarancin numfashi, rauni, da tachycardia, tunda a cikin kwanciyar hankali babu irin waɗannan cututtukan da aka rubuta.
Don hana haɗarin hauhawar jini, tare da haɗuwa da magani tare da shirye-shiryen sulfonylurea, an zaɓi ƙaramar sashi mai tasiri.
Sakamakon Cutar Magunguna
A cikin hadaddun farji tare da ƙari na metformin, glibenclamide, pioglitazone, ramipril, amlodipine, digoxin, valsartan, simvastatin, warfarin zuwa Galvus, babu wani mahimman sakamako na asibiti da aka bayyana daga hulɗar su.
Gudanar da haɗin gwiwa tare da thiazides, glucocorticosteroids, sympathomimetics, hormones thyroid yana rage yiwuwar hypoglycemic na vildagliptin.
Masu hana enzyme angiotensin-canza enzyme tare da amfani da layi daya suna ƙara haɗarin angioedema.
Galvus da irin waɗannan alamu ba a soke su ba, tun da edema ta wuce da kanta.
Magungunan ba ya canza saurin tafiyar matakai na rayuwa tare da amfani da layi daya na amfani da enzymes CYP3A4, CYP1A2, CYP2C8, CYP3A5, CYP2C9, CYP2C19, CYP2D6, CYP2E1.
Dokokin ajiya
A cikin cibiyar sadarwar kantin magani, ana sayar da Galvus ta hanyar takardar sayan magani. Ana iya rarrabe su ta hanyar yanke baki da alama mai gefe biyu: raguwar FB da NVR. A kan farantin karfe na iya zama allunan 7 ko 14 na 50 MG. A cikin kwali na kwali akwai daga blisters biyu zuwa goma sha biyu.
Ana adana magungunan a cikin yanayin zafin jiki har zuwa 30 ° C a wuri mai duhu, ba tare da yara ba. Tsayayyar rayuwar Galvus har zuwa shekaru 3. Allunan ƙarewa dole ne a zubar dasu.
Nazarin likitoci da marasa lafiya
Wannan wakili na bakin jini yawanci ana rubutashi da farko ga masu ciwon sukari kai tsaye bayan kamuwa da cuta. Sabili da haka, a cikin bita a kan ɗakunan tattaunawar suna da tambayoyi da yawa ga endocrinologist fiye da amsoshi.
Da yake tsokaci game da irin waɗannan rahotanni, likitocin sun lura cewa ciwon sukari cuta ce ta tsawon rayuwa. Babu Galvus, ko kowane wakili na maganin rigakafi da zai iya tsayar da mit ɗin glucose a matakin al'ada har abada. Halin kiwon lafiya na mai ciwon sukari yana raguwa koyaushe, ƙimar mummunan canje-canje kai tsaye ya dogara da matakin diyya na diyya. Babu kwaya ta mu'ujiza don masu ciwon sukari. Gyara kawai na abinci, sake fasalin tsarin rayuwa gabaɗaya tare da maganin kulawa zai iya rage ci gaban rikice-rikice tare da kula da ingancin rayuwa tare da ciwon sukari a matakin al'ada.
Ba duk masu fansho suna da damar zuwa Galvus ba a farashin 800 rubles. don 28 inji mai kwakwalwa., da yawa suna neman wanda zai maye gurbin sa, kodayake Januvia (1400 rubles) ko Onglisa (1700 rubles) suma basu dace da kowa ba. Kuma waɗanda ke ci gaba da amfani da sanarwa cewa sannu a hankali sukari yana farawa daga lalacewa kuma tasirin magani yana raguwa.
