Wasu masu ciwon sukari suna iya tunanin cewa basu taɓa shan metformin ba. Amma wannan ba zai yiwu ba, tunda rabin waɗannan marasa lafiya an tsara su da magungunan tushen metformin hydrochloride daga kwanakin farko bayan bayyanar cututtuka na nau'in ciwon sukari na 2, idan gyaran salon ba ya kawo sakamakon da ake so. Allunan kuma an tsara su tare da metformin na duniya sunan wasu a wasu yanayi (cutar sikila, prophylaxis of cardiovascular situation and oncology), amma, a kowane hali, za'a iya siye su kawai ta hanyar sayan magani.
Idan kana da metformin akan fam, zabi Metformin Teva. Wannan cancanci analog na Faransanci na asali Glucophage ya cika dukkan ka'idoji na magungunan maganin cututtukan cututtukan zamani.
Metformin Teva da takwaransa na asali
Kamfanin hada magunguna na Isra'ila TEVA Pharmaceutical masana'antu, Ltd. a cikin garin Petah Tikva (kazalika da wakilan ofisoshinsa a Poland, Italiya da sauran ƙasashe) suna samar da ƙwayoyin halitta dangane da ainihin kayan abu (metformin hydrochloride), tare da sashi ɗaya (500, 850 da 1000 mg), tare da ɗaukar guda ɗaya da kuma narkar da fitarwar bangaren aiki, kamar na Faransa. Yanayin samarwa da kayan aiki daidai suke da zagayen samarwa a masana'antar da ke samar da metformin na asali.
Hanyar amfani da shirya faɗar baki ta asali da analog daidai ce.
Generic Metformin Teva yana da sauƙin araha: fakitin ainihin Glucofage farashin yana da nauyin 330 rubles, kwatankwacin sigar farashi na kwayoyin - 169 rubles. A ciki zaku iya samun blisters da yawa tare da farin zagaye ko m (dangane da kashi) Allunan tare da layi mai rarraba da kuma zane mai zane. Fadinsu ya yi laushi, ba tare da lalacewa ba. Hakanan ana iya samun Metformin-MV-Teva a sashi na 500 MG tare da damar tsawan lokaci. Rayuwar shiryayye na allunan shine shekaru 2.5-3, magani ba ya buƙatar yanayi na musamman don ajiya.
Abubuwan Magunguna na Magunguna na Metformin Teva
Pharmacodynamics
Babban sashi na maganin shine metformin hydrochloride, wanda rukuni ne na abubuwan da ake amfani da su na biguanide wadanda ke daidaita tasirin glycemic na azumin da sukari bayan jini. Hanyar aiwatar da miyagun ƙwayoyi ya dace.
- Magungunan yana hana samar da glycogen a cikin hanta ta toshe hanyoyin gluconeogenesis da glycogenolysis;
- Magungunan yana rage juriya da kyallen takarda zuwa insulin, inganta haɓakawa da aiki da glucose a cikin tsokoki;
- Kayan aiki yana rage ƙimar yawan shan glucose ta bangon hanji.
Biguanide yana haɓaka aikin samar da glycogen endogenous.
Hakanan yana rage karfin tsarin jigilar glucose a jikin membrane.
An kafa shi ta hanyar gwaji cewa magungunan kwantar da hankali na magunguna suna inganta haɓakar lipid na jini: suna rage yawan jimlar cholesterol, triglycerol da ƙananan lipids mai yawa.
Pharmacokinetics
- Baƙon Matsakaicin matakin T max na miyagun ƙwayoyi tare da cikakken bioavailability har zuwa 60% ana rikodin 2.5 sa'o'i bayan shigowar cikin jijiyoyin. Tare da tsarin kulawa na yau da kullun, ana ganin yawan ƙwayar magunguna a cikin jini bayan kwana ɗaya ko biyu, kuma ya kai 1 μg / ml. Shan magani tare da abinci yana rage jinkirin narkewar metabolite.
- Rarraba. Abun da ake amfani da shi na yau da kullun baya shiga cikin sunadarai; V D (matsakaicin rarraba rarraba) ba ya wuce lita 276. Ba'a gano matakan metabolites a cikin jikin ba; canzawa, ana cire shi ta hanta.
- Kiwo. Manuniya na sharewar hepatic na metformin (daga 400 ml / min.) Nuna cewa yana da tabbacin cirewar sa ta hanyar gurɓatar da duniya. Rabin rayuwa a cikin zangon karshe na shakatawa shine sa'o'i 6.5. Tare da lalatawar yara, raguwa ta raguwa, wannan yana tsoratar da tarawar metformin a cikin jini. Har zuwa 30% na miyagun ƙwayoyi suna cire hanji a cikin asalin ta.
Alamu
Metformin Teva magani ne na farko; an wajabta shi ne ga manya da yara fiye da shekaru 10 don sarrafa nau'in ciwon sukari na 2 a duk matakai na ci gaban cutar.
An tsara miyagun ƙwayoyi idan canjin yanayin rayuwa (abinci mai ƙarancin carb, aiki na jiki, iko da damuwa na hankali) ba ya sarrafa glycemia sosai.
Magungunan ya dace duka don maganin kashe ƙwayar cuta da kuma magani mai wahala, tunda metformin an haɗu da shi tare da insulin kuma tare da madadin magunguna na maganin antidiabetic tare da tsarin aikin daban fiye da biguanides.
Contraindications
Baya ga hankalin mutum ga abubuwan da ke tattare da tsari, ba a sanya maganin ba:
- Tare da ketoacidosis mai ciwon sukari, coma, precoma;
- Marasa lafiya tare da dysfunctions na koda (CC a ƙasa 60 ml / min.);
- Marasa lafiya cikin rawar jiki, tare da bushewar ruwa, mummunan cututtuka na yanayin kamuwa da cuta;
- Idan cutar (m ko na kullum form) tsokani oxygen yunwa da kyallen takarda;
- A lokacin bincike ta amfani da alamun bambanci dangane da aidin;
- Tare da lalatawar hanta, gami da maye giya (m ko na kullum).
Saboda ƙarancin ingantaccen tabbaci na aminci, Metformin Teva yana cikin mata masu juna biyu, uwaye masu shayarwa, da yara 'yan ƙasa da shekaru 10.
Motar motoci da hanyoyin hadaddun masu cutar sukari yayin aikin jiyya tare da Metformin Teva ba contraindicated ba ne idan sun dauki maganin a matsayin maganin monotherapy. Tare da kulawa mai rikitarwa, dole ne a la'akari da damar wasu kwayoyi.
Shawarwarin don amfani
Magungunan Metformin Teva ya ba da shawarar shan shi gaba ɗaya tare da isasshen ruwa. Ana iya samun sakamako mafi girma tare da amfani da allunan kai tsaye kafin abinci ko lokacin cin abinci. Likita ya zabi tsarin kashewa da kuma daukar matakin la’akari da matakin cutar, yawan yin lafuzza, da yawan masu cutar sankara, yanayin da mutum yake yiwa maganin.
Manya
Tare da monotherapy ko magani mai rikitarwa, sashin farawa bai wuce shafin 1 / 2-3r ba / rana. Gyara tsarin yana yiwuwa bayan sati 2, lokacin da zaku iya tantance tasirin maganin. Increaseara mai sauƙi a hankali zai taimaka wa jiki tsira tsawon lokacin daidaitawa tare da ƙarancin sakamako mara kyau. Matsakaicin marginal na miyagun ƙwayoyi don wannan rukuni na masu ciwon sukari shine 3 g / day. tare da amfani da sau uku.
Lokacin maye gurbin analogues na hypoglycemic analogues tare da magani, ana jagorantar su ta hanyar tsarin kulawa na baya. Don samfuran saki masu jinkirta, zaku buƙaci tsayar da sauyawa zuwa sabon jadawalin.
Tare da haɗin allunan tare da allurar insulin, ana fara ɗaukar metformin tare da mafi ƙarancin kashi (500 mg / 2-3 r / rana.).
An zaɓi sashi na insulin daidai da tsarin abinci da glucometer.
Cutar Malaria
A cikin “masu kwarewa” masu ciwon sukari, karfin kodan suna rauni, sabili da haka, lokacin zabar tsarin kulawa, dole ne a la'akari da yanayin su kuma ana nuna kulawa a kai a kai.
Yara
Yaran da ke fama da ciwon sukari sama da shekaru 10 ana wajabta su 500 MG / rana. Ana ɗaukar kwamfutar hannu sau ɗaya, da maraice, yayin cikakken abincin dare. Yin titration yana yiwuwa bayan sati 2. Matsakaicin ƙa'idar wannan rukunin shine 2000 MG / rana, an rarraba fiye da allurai 3.
Side effects da yawan abin sama da ya kamata
Metformin Teva shine ɗayan amintattun magungunan antidiabetic. An tabbatar da wannan binciken ta hanyar bincike da yawa da kuma shekaru masu yawa na aikin asibiti. A lokacin daidaitawa, 30% na masu ciwon sukari suna korafi game da rikicewar dyspepti: tashin zuciya, amai, ɗanɗano mai ƙarfe daga lokaci zuwa lokaci, ana rage ci, kowane abinci yana ƙarewa a cikin ɓacin rai.
Titin hankali na yawan kashi yana rage rashin jin daɗi kuma a tsawon lokaci alamun ya ɓace. Wani fasalin Metformin Teva shine mafi ƙarancin ƙarin abubuwan haɗi a cikin abun da ke ciki. Yawancin lokaci su ne ke haifar da sakamako mara kyau.
Ko da ƙaruwa 10-karuwa a cikin warkewa don dalilai na gwaji bai tsokani ƙwayar cuta ba. Madadin haka, an lura da alamun lactic acidosis. Mayar da ayyukan aikin da ya shafa ta hanyar jiko da maganin hemodialysis.
Matsayin mai amfani
Babu sake dubawa mara kyau game da Metformin Teva. Masu ciwon sukari sun lura da kasancewarsa, inganci da amincinsa, ba ƙasa da takwarorinsu masu tsada.
Kamfanin kamfanoni da yawa na Teva Pharmaceutical Industries Ltd shine jagora a masana'antar harhada magunguna ta duniya: bara kawai, ribar da take samu ya wuce dala biliyan 22. Kamfanin yana da alhakin duk kasuwannin 80 wanda samfuransa suke ciki. Shekaru sama da 20 tana yin aiki tare da masu cin abincin Rasha, suna ba su kusan nau'ikan samfuran 300.
Tun daga 2014, wani shuka yana aiki a cikin Yaroslavl wanda ke samar da allunan biliyan 2 a kowace shekara don Rasha da kasashe makwabta. Kamfanin Teva LLC yana a matsayin wani ɓangare na aiwatar da dabarun saka hannun jari na duniya.
