Magunguna na diuretic na nau'in ciwon sukari na 2 ana amfani dasu sau da yawa don maganin da ke faruwa tare da ci gaban haɓakar ciwon sukari, ƙarancin ƙarfi ko lokacin da akwai buƙatar kawar da ƙafar kafa.
Zuwa yau, an samar da adadi mai yawa na magunguna daban-daban waɗanda zasu iya haɓaka adadin fitsari da aka fitar.
Zaɓin zaɓin na diuretic, idan ya cancanta, yakamata a gudanar da wannan binciken bisa ga sakamakon binciken, la'akari da yanayin jikin mai haƙuri.
Drugaya daga cikin magunguna gama gari shine indapamide.
Indapamide yana cikin rukunin thiazide-kamar diuretics. Wannan magani yana da tasirin vasodilating.
Ana amfani da diuretics azaman abubuwan haɗaɗɗun maganin cututtukan cututtukan ƙwayar cuta. Wadannan kwayoyi suna inganta tasirin masu hana ACE.
Taizide-kamar diuretics, wanda ya haɗa da Indapamide, suna da sakamako mai sauƙi a cikin ciwon sukari. Wadannan kwayoyi ba su da wani tasiri a kan yadda ake fitar da sinadarin potassium da matakin glucose da mai a cikin jini.
Shigar da Indapamide don ciwon sukari na 2 ba ya haifar da rashin aiki a cikin al'ada aikin kodan mai haƙuri.
Magungunan yana da tasirin nephroprotective a jikin mai haƙuri a kowane mataki na lalacewar koda, wanda ke haɗuwa da haɓakar ciwon sukari mellitus na nau'in insulin mai cin gashin kansa.
Abun da ke tattare da miyagun ƙwayoyi, bayanin janar da magani
Magungunan suna samar da miyagun ƙwayoyi a cikin nau'ikan allunan don maganin baka.
Magunguna a saman yana da murfin fim.
Babban sinadarin aiki mai karfi na maganin shine indapamide, kwamfutar hannu guda daya ta ƙunshi 2.5 MG na fili.
Baya ga abu mai aiki, ana gabatar da ƙarin mahaɗan sinadarai waɗanda ke da rawar taimako a cikin tsarin maganin.
Irin wadannan mahadi wadannan abubuwan sune:
- lactose monohydrate;
- povidone-K30;
- crospovidone;
- magnesium stearate;
- sodium lauryl sulfate;
- foda talcum.
Abun da keɓaɓɓen kwasfa na kwamfutar hannu ya haɗa da abubuwan haɗin sunadarai masu zuwa:
- Amasamai.
- Macrogol 6000.
- Talc.
- Titanium dioxide
Allunan suna da zagaye, siffar convex kuma suna fenti fari.
Magungunan magani yana cikin rukunin magungunan diuretic. Kayanta suna da kusanci da thiazide diuretics.
Bayan shan maganin, urinary excretion na sodium da chlorine daga jikin mutum yana ƙaruwa. Zuwa mafi ƙarancin tasiri yana shafar aiwatar da ƙwayar potassium da ion magnesium daga jiki.
Magungunan suna da ikon toshe tasirin alli na membranes da kuma haɓaka haɓakar bangon jijiyoyin jijiya, yana rage juriya na jijiyoyin ƙwayar jijiyoyin jiki.
Shan maganin yana taimakawa rage karfin tashin zuciya na hagu.
Yin amfani da miyagun ƙwayoyi ba ya shafar matakin maida hankali na jini a cikin jini kuma baya shafar metabolism na sugars.
Shan magani yana ba ka damar rage ƙarfin bangon jijiyoyin jiki zuwa tasirin norepinephrine da angiotensin II a kansa, kuma yana ba ka damar haɓaka aikin kwayar cutar prostaglandin E2 a cikin jiki.
Yin amfani da magani yana rage ƙarfin samuwar abubuwa masu lalacewa masu sassauƙa da ke cikin jiki.
Sakamakon mummunan sakamako na maganin yana tasowa mako guda bayan fara maganin kuma ya ci gaba har kwana guda bayan kashi ɗaya a kowace rana.
Pharmacokinetics na miyagun ƙwayoyi
Bayan shan maganin, an cire shi gaba daya daga cikin gastrointestinal fili a cikin tsarin jijiyoyin jini. A miyagun ƙwayoyi yana da babban bioavailability, wanda shine kusan 93%.
Cin abinci yana da tasiri a hankali saboda yawan shan miyagun ƙwayoyi a cikin jini, amma ba ya shafar adadin maganin da aka sha. Ana samun mafi yawan maida hankali a cikin jini 1-2 sa'o'i bayan shan magani a ciki.
Tare da sake yin amfani da miyagun ƙwayoyi, sauye-sauye a cikin taro a cikin jiki tsakanin allurai an rage su. Magungunan ya isa cikin daidaituwa a cikin jiki bayan kwanaki 7 na shan miyagun ƙwayoyi.
Rabin rayuwar miyagun ƙwayoyi yana daga 14 zuwa 24 hours. Magungunan suna da alaƙa da abubuwan gina jiki na plasma jini. Matsakaicin ɗaukar nauyin furotin kusan 79%.
Abubuwan da ke aiki na miyagun ƙwayoyi suna iya ɗaure tare da elastin na tsarin tsoka mai santsi waɗanda suke ɓangare na bangon jijiyoyin bugun gini.
Magungunan yana da ikon hayewa ta hanyar shinge nama, yana da ikon ƙetare shingen sifar. Lokacin shan magani, yana wucewa cikin madarar nono.
Metabolization na aiki mai aiki yana faruwa a cikin kyallen hanta. Fitar da bangaren aiki yana gudana ne a cikin hanyar metabolites ta kodan a cikin girman 60 zuwa 80%. Tare da jijiyoyin wuya, kusan 20% an fesa daga cikin hanjin.
Idan mai haƙuri yana da gazawar renal, magungunan ƙwayoyi ba su canzawa. Tara tarin kuɗi a cikin jiki baya faruwa.
Alamu da contraindications don shan magani
Babban nuni ga shan magunguna don ciwon sukari shine haɓakar mai haƙuri tare da hauhawar jini.
Kamar kowane na'ura na likita, Indapamide yana da contraindications da yawa don amfani.
An ba da izinin amfani da miyagun ƙwayoyi in babu wasu contraindications a cikin haƙuri.
Babban sabbin magunguna don amfani da magani sune kamar haka:
- mara lafiya yana da babban hankalin jijiyoyi ga magungunan da aka kirkira akan maganin sulfonamide;
- rashin haƙuri ga marasa lafiya da lactose;
- mara lafiya yana da galactosemia;
- idan mutum ya bayyana alamun wata cuta ta malabsorption na glucose ko galactose;
- gano wani mummunan nau'in rashin nasara na renal a cikin haƙuri;
- kasancewar alamun hypokalemia;
- kasancewar gazawar hanta mai tsanani;
- cutar koda
- lokacin haila da shayarwa;
- shekarun haƙuri har zuwa shekaru 18;
- Ana gudanar da aikin tiyata wanda a cikin lokaci guda ake gudanar da wakilai wadanda zasu iya tsawaita QT tazara.
Tare da taka tsantsan, ya kamata ku sha magani yayin gano matsala a cikin aikin kodan da hanta, idan akwai rashin lafiyar haƙuri a ma'aunin ruwa-electrolyte, idan akwai hyperparathyroidism a cikin jiki.
Bugu da kari, ya kamata a yi amfani da Indapamide a hankali lokacin da aka gudanar da maganin da ake amfani da magungunan antiarrhythmic.
Ana yin taka tsantsan lokacin amfani da miyagun ƙwayoyi don haɓakar ciwon sukari na mellitus a mataki na lalata.
Umarnin don amfani da allunan
Yarda da miyagun ƙwayoyi ana aiwatar dashi ba tare da la'akari da jadawalin abinci ba. Ya kamata a sami wadatattun allunan tare da shan ruwa mai yawa. Lokacin da akafi so don shan maganin shine safiya.
Matsakaicin warkewa na yau da kullun don magani shine 2.5 MG ko kwamfutar hannu guda ɗaya kowace rana. Idan bayan makonni 4-8 na farji ba a cimma sakamakon da ake so ba, to bai kamata a ƙara yawan kashi ba. Increaseara yawan sashi na iya yin barazanar haɓaka ci gaba a jikin wasu sakamako masu illa daga amfani da miyagun ƙwayoyi.
Idan babu sakamakon sakamako a magani, ana bada shawara don canza miyagun ƙwayoyi zuwa mafi inganci. A cikin taron cewa ana aiwatar da maganin ta amfani da kwayoyi biyu, sashi na Indapamide yana canzawa a 2.5 MG kowace rana.
Lokacin shan Indapamide a cikin mutum, wasu sakamako masu illa na iya faruwa waɗanda ke bayyane cikin rikice-rikice a cikin tsarin tsarin jiki daban-daban.
Yawancin sakamako masu illa na Indapamide don ciwon sukari sune:
- Tsarin narkewa. Wataƙila ci gaban zawo, maƙarƙashiya, bayyanar zafi a ciki. Sau da yawa ana jin tashin zuciya da bushewa a cikin kogon baki. Wataƙila bayyanar vomiting a cikin lokuta mafi wuya, haɓakar ƙwayar ƙwayar ƙwayar cuta yana yiwuwa.
- Tsarin juyayi na tsakiya. Wataƙila ci gaban yanayin asthenic, bayyanar ƙaruwar juyayi, ciwon kai da ciwon sukari, ƙaruwar bacci. A cikin lokuta mafi wuya, ƙara gajiya da rauni gaba ɗaya ya bayyana. Wani lokaci akwai jin zazzabin cizon sauro, ƙwayoyin tsoka, rashi da kuma damuwa na damuwa.
- A wani ɓangare na tsarin numfashi, haɓakar tari, pharyngitis, sinusitis kuma, a cikin mafi yawan lokuta, rhinitis yana yiwuwa.
- Tsarin zuciya. Wataƙila haɓakar ƙwayar orthostatic, canje-canje a cikin ƙwayoyin lantarki, yana yiwuwa ga mai haƙuri ya haɓaka arrhythmias a cikin zuciya da haɓaka ƙimar zuciya.
- Tsarin Urinary. Babban yuwuwar ci gaba da kamuwa da cututtukan cututtukan cututtukan cututtukan ƙwayar cuta da ƙwayar cuta.
- Fata. Zai yiwu ci gaban halayen halayen ya nuna ta hanyar fatar fata, itching fata da cututtukan cututtukan fata da ke fama da cututtukan fata.
Bayan waɗannan sakamako masu illa, thrombocytopenia, leukopenia, agranulocytosis, da kuma ƙaruwa na tsarin lupus erythematosus na iya haɓaka a jikin mai haƙuri.
Analogues na magani, nau'i na saki, farashi da yanayin ajiya
Ana amfani da miyagun ƙwayoyi a cikin nau'ikan allunan da aka sanyaya, kowane kwamfutar hannu ya ƙunshi 2.5 MG na miyagun ƙwayoyi.
Allunan 10 na kunshe acikin kayan kwano na musamman wanda aka yi da fim din polyvinyl chloride kuma an lullube shi da bangon aluminium. Uku kwano na musamman, da umarnin don amfani da miyagun ƙwayoyi, an saka su cikin fakiti.
An wajabta maganin da za a adana shi a cikin wuri mai duhu a zazzabi a cikin kewayon daga 15 zuwa 25 digiri Celsius. Kada a isa wurin adana magungunan.
Rayuwar shiryayye na miyagun ƙwayoyi shine shekaru 3. Bayan karewar lokacin ajiya, an haramta yin amfani da miyagun ƙwayoyi. An zubar da magani mai ƙarewa.
Baya ga Indapamide, an ƙirƙiri magunguna waɗanda sune alamun analogues ne.
Mafi mashahuri da kuma mashahuri sune alamun analog ɗin masu zuwa na miyagun ƙwayoyi:
- Arifon Repard - sanannen analog na Indapamide, baya tasiri metabolism na metabolism.
- Acripamide analog ne na Indapamide, wanda asalinsa asalin Rasha ne.
- Indap magani ne wanda aka kera a cikin Czech Republic.
- Noliprel magani ne wanda yake da tasiri sosai.
- Perinid shahararren magani ne wanda ya dace da yawan masu haƙuri.
Farashin Indapamide a cikin yankin Tarayyar Rasha yana da nauyin 12 zuwa 120 rubles, ya dogara da masana'anta da yankin da aka sayar da miyagun ƙwayoyi.
Gwanaye daga bidiyo a wannan labarin zai yi magana game da halayen magunguna na Indapamide.
