Metglib 400 shine ingantaccen sabon wakilin jini na jiyya na jiyya ga marasa lafiyar masu cutar siga. Ba ya haifarda hypoglycemia, baya tasiri ɓoye insulin a cikin jiki. Shan maganin yana ba da kyakkyawan sakamako a cikin jiyya da sarrafa ciwon sukari.
Sunan kasa da kasa mai zaman kansa
INN - Glibenclamide + Metformin.
ATX
Lambar dangane da yadda aka tsara ATX shine A10BD02.
Saki siffofin da abun da ke ciki
Kwamfutar hannu 1 ta ƙunshi mg MG 400 na metformin hydrochloride da glibenclamide 2.5 MG. Allunan an rufe su tare da fim mai narkewa a cikin rami na hanji. Bugu da ƙari sun ƙunshi alli hydrogenphosphate dihydrate, sodium stearyl fumarate, povidone, microcrystalline cellulose.
Metglib 400 shine ingantaccen sabon wakilin jini na jiyya na jiyya ga marasa lafiyar masu cutar siga.
Aikin magunguna
Kayan aiki ya ƙunshi haɗakar magungunan hypoglycemic na kungiyoyi daban-daban na magunguna - metformin, glibenclamide. Dangane da biguanides, Metformin yana rage yawan adadin glucose. Yana da nau'ikan hanyoyin aikin akan jikin:
- raguwa a cikin yawan samar da glucose a cikin kyallen hanta;
- increasedara hankalin masu karɓar sel zuwa insulin;
- haɓaka hanyoyin amfani da sarrafa glucose a cikin ƙwayoyin tsoka;
- jinkirta sha na glucose a cikin abubuwan narkewar abinci;
- tashin hankali ko asarar nauyi a cikin masu ciwon sukari.
Metformin yana da tasiri mai kyau akan daidaitawar lipids na jini. Yana rage maida hankali kan yawan ƙwayoyin cuta, da farko saboda ƙarancin lipoproteins mai yawa. Yakan saukar da abubuwa marasa nauyi.
Glibenclamide wani fili ne wanda aka samo daga aji na sulfonylurea na biyu.
Tare da amfani da shi, adadin sukari na jini ya ragu, saboda yana ƙarfafa tsarin aikin insulin ta hanyar ƙwayoyin beta na pancreas. Wannan abun yana cika nauyin rage karfin sukari na Metformin. Saboda haka, raguwa mai tsari cikin haɓakar glucose na jini yana faruwa, wanda ke hana haɓakar sassan haɓaka da hana haɓaka yanayi mai haɓaka.
Metformin yana da tasiri mai kyau akan daidaitawar lipids na jini.
Pharmacokinetics
Bayan amfani na ciki, glibenclamide yana kasancewa cikakke daga narkewa. An ƙaddara mafi girman taro bayan sa'o'i 4. Kusan gaba daya sunadaran sunadarai ne a cikin plasma. An daidaita shi da sifa tare da bile, feces.
Metformin baya ɗaukar nauyin protein na plasma. A cikin rauni mara nauyi, yakan lalace, yana fitar da fitsari. Partangare na miyagun ƙwayoyi yana fitowa tare da feces.
Tare da cututtukan koda, adadin metformin a cikin jini yana tashi da ɗan kadan, saboda kodan basu da lokaci don fallasa shi. Cin abinci ba ya shafar wadatar magunguna daga yawancin biguanides.
Alamu don amfani
An ba da shawarar yin amfani da shi a cikin binciken cututtukan cututtukan cututtukan da ba na insulin-insarin 2 ba, idan har cewa maganin abinci da ilimin jiki ba su da tasiri ko bayan amfani da abubuwan ƙira na sulfonylurea. Hakanan za'a iya wajabta shi don maye gurbin magani na baya tare da abubuwan da suka shafi Metformin da abubuwan sulfonylurea, idan dai ana kula da ciwon sukari na mai haƙuri kuma babu wasu lokuta na yanayin rashin lafiyar.
An ba da shawarar yin amfani da shi a cikin nazarin cututtukan cututtukan da ba na insulin-da ke ɗauke da ciwon sukari na 2 ba.
Contraindications
Magungunan suna da irin waɗannan contraindications:
- Type 1 ciwon sukari.
- Babban hankalin jiki ga metformin, glibenclamide da sauran abubuwa masu alaƙa da sulfonylcarbamides.
- Yanayin mawuyacin hali wanda ke haifar da canji a cikin ayyukan kodan: ƙonewa, kamuwa da cuta, girgiza.
- Ketoacidosis, precoma da coma.
- Rashin hankali ga wasu sinadaran da ke girka Metglib.
- Rashin ƙarancin Rashin ƙarfi da sauran rikicewar ƙwayoyin cutar nephrological suna haifar da raguwa a cikin ɗaukarwar creatinine a ƙasa da 60 ml / min.
- Gudanar da sinadarai na kayan x-ray mai dauke da aidin.
- Yanayin tare da matsanancin iskar oxygen na kyallen takarda: karancin zuciya, huhu, bugun zuciya.
- Rashin hanta, gami da hepatitis.
- Cutar ƙwayar cuta ta Porphyria (cin zarafin matakai na narkewar metabolism, tare da haɓaka abun ciki na porphyrins na jini, wanda aka nuna ta ƙara ƙwayar fata zuwa hasken rana, da tashin hankali ko damuwa na kwakwalwa).
- Shan Miconazole.
- Tashin tiyata, raunin da ya ƙone da yawa.
- Yanayin buƙatar insulin far.
- M barasa guba.
- Lactic acidosis (gami da tarihi).
- Yarda da wani karamin abinci mai kalori tare da iyakance adadin kuzari na yau da kullun da bai wuce 1000 kcal ba.
- Mai haƙuri a ƙarƙashin shekaru 18.
Tare da kulawa
An tsara miyagun ƙwayoyi tare da taka tsantsan a cikin lamurran masu zuwa:
- zazzabi;
- barasa;
- kasawar rashin haihuwa;
- rashin aiki sosai na kashin baya;
- decompensated thyroid pathologies;
- shekaru sama da shekaru 70 (akwai haɗarin mummunar cutar hypoglycemia).
Yadda ake ɗaukar Metglib 400?
Umarni yana nuna cewa ana shan maganin. Ba za a iya ɗanɗana kwamfutar hannu ba, a ci shi, a ɗanɗar da shi cikin foda ko dakatarwa. Dole ne a hadiye shi duka sannan a wanke shi da isasshen adadin tsabta mai tsabta kuma har yanzu ruwa. Ba a yarda da amfani da wasu abubuwan sha don waɗannan dalilai ba saboda canji mai yiwuwa a cikin aikin hypoglycemic na Metglib.
Umarni yana nuna cewa ana shan maganin ta hanyar magana, ba za a iya cinya, a gauraya ba, an murƙushe shi cikin foda ko an yi shi daga dakatarwa.
Tare da ciwon sukari
Sashi na magani don ciwon sukari an yanke shi ne ta likita, gwargwadon yanayin mai haƙuri, metabolism metabolism. Don alƙawarin kashi, alamar glycemic tana da sakamako mai yanke hukunci.
Yawancin lokaci kashi na farko shine allunan 1 ko 2 a rana. Dole ne a ɗauke su tare da babban abincin. Nan gaba, sashi na iya karuwa zuwa daidaitaccen daidaituwar abubuwan glucose.
Matsakaicin adadin shine Allunan 6. A wannan yanayin, sun kasu kashi uku.
Sakamakon sakamako na Metglib 400
Abubuwanda zasu iya biyo baya na iya faruwa yayin magani:
- Akwai canje-canje a cikin abubuwan da ke tattare da jini da yanayin tsarin lymphatic, wanda aka nuna a cikin agranulocytosis, leukopenia da thrombocytopenia. Wadannan rikice-rikice ba su da yawa kuma sun ɓace bayan cire magunguna. Yana da matukar wuya cewa anemia hemolytic, huhu kasusuwa (rashin isassun kayan jikin mutum), pancytopenia (rashi ga dukkan abubuwanda aka kirkira jini).
- Wani lokacin girgiza anaphylactic na iya haɓaka. Akwai halayen hankali na kaifin ƙwaƙwalwa ga abubuwan da ake amfani da su na sulfonylurea.
- A wani bangare na metabolism, hypoglycemia, porphyria, raguwa a cikin shan ƙwayar bitamin B12, tare da amfani da tsawan magungunan Metformin, mai yiwuwa. Akwai haɗarin cutar megaloblastic.
- Tasteinɗar da ba ta da kyau a cikin kogon baki yana yiwuwa. A farkon jiyya, raguwar wani ɗan gajeren lokaci na sashin hangen nesa na faruwa ne sakamakon raguwar haɗarin glucose.
- Sau da yawa za'a iya samun tashin zuciya, zawo, amai, jin zafi a cikin ciki da raguwa (wani lokacin cikakken rashin sa'a) na ci. Wadannan bayyanar suna faruwa ne a farkon farfaɗo kuma suna wucewa da sauri. Yin amfani da miyagun ƙwayoyi a cikin allurai da yawa kuma jinkirin karuwa sosai yana rage yiwuwar haɓaka irin waɗannan alamun.
- Da wuya, lalatawar hanta da haɓaka aiki na enzymes hanta na iya faruwa. A wannan yanayin, kuna buƙatar dakatar da shan.
- Abubuwan da ke tattare da cututtukan cututtukan fata suna da wuya su bayyana - itching, kurji, urticaria. Allergic vasculitis, erythema, da dermatitis na iya ci gaba a wasu lokuta. An sami lokutan kara yawan fatar jiki zuwa hasken rana.
- Wani lokaci yana yiwuwa a ƙara maida hankali akan urea da creatinine a cikin ƙwayar magani.
- Da wuya, an sami raguwar matakan sodium jini.
Tasiri kan ikon sarrafa abubuwan inji
Sakamakon haɗarin haifar da hypoglycemia a matakin farko na magani, ya zama dole a guji aikin da ya shafi tuki da sarrafa kayan injin. Tare da haɗarin hypoglycemia, hankali na iya lalacewa.
Umarni na musamman
Ya kamata a gudanar da magani ne kawai a karkashin kulawar kwararrun. A lokacin warkewar hanya, dole ne a lura da duk shawarar likita a hankali: abinci mai dacewa, kulawa akai-akai na azumin glucose jini da kuma bayan cin abinci.
Haramun ne a sha maganin rage yawan abinci.
Yi amfani da lokacin daukar ciki da lactation
A lokacin gestation, alƙawarin yana ɗaure sosai. Dole ne mara lafiyar ya sanar da likita cewa tana shirin daukar ciki ko kuma ta zo. Idan ciki ya faru yayin shan maganin, yakamata a cire maganin nan da nan. Bayan sokewar Metglib, an wajabta mara lafiya ta hanyar insulin (gabatarwar insarin insulin don rage yawan sukari).
An ba da izinin ɗaukar nauyin sarrafa Metglib lokacin shayarwa. Wannan ya faru ne sakamakon karancin bayanai kan iyawar abubuwan da ke tattare da magungunan don shiga cikin madarar nono. Idan ya zama tilas a yi amfani da magunguna yayin shayarwa, an wajabta wa mara lafiya allurar insulin ko kuma a tura yaro zuwa hanyar dabarar wucin gadi.
Magungunan Metglib don Yara 400
Ba a sanya shi ba.
Yi amfani da tsufa
Ya kamata tsofaffi su kula sosai. Akwai haɗarin haɗarin hypoglycemia mai ƙarfi.
Aikace-aikacen aiki mara kyau
Tare da dysfunctions na koda, ya kamata a yi amfani da miyagun ƙwayoyi tare da taka tsantsan, saboda haɓaka matakan jini na abubuwan da suke aiki da shi mai yiwuwa ne. Ba a amfani da gazawar tashar jirgin ƙasa.
Tare da lalatawar koda, ya kamata a yi amfani da miyagun ƙwayoyi tare da taka tsantsan.
Amfani don aikin hanta mai rauni
Ba za a iya tsara shi don lalata lalata hanta ba.
Yawan adadin Metglib 400
Tare da yawan yawan zubar da jini, haɓakar jini na haɓaka. Zazzage jini zuwa matsakaici ya dakatar da yawan kuzari. Ya kamata ku canza sashi na maganin kuma ku daidaita abincin.
A cikin mummunan hypoglycemia, asarar hankali yana faruwa, paroxysm, rikicewar jijiyoyin jiki waɗanda ke buƙatar haɓaka kulawar likita ta gaggawa. Samun sauƙin yanayin yana buƙatar gabatarwar gaggawa na Dextrose a cikin jiki.
Tuhuma da rashin lafiyar jiki alama ce da ke nuna rashin lafiyar mutum cikin gaggawa. Don guje wa komawa daga baya, mutum yana buƙatar a ba shi abincin da ke ɗauke da carbohydrates masu saurin narkewa.
A cikin cututtukan hanta a cikin masu ciwon sukari, yawan karuwar glibenclamide yana ƙaruwa. Sabili da haka, irin waɗannan marasa lafiya suna buƙatar saka idanu sosai game da sashi na miyagun ƙwayoyi. Lokacin amfani da babban allurai na Metglib, dialysis bai dace ba.
Tunda Metformin yana cikin abun da ke ciki, yawan amfani da Metglib a cikin adadi mai yawa na iya haifar da lactic acidosis. Wannan yanayin haɗari ne da ke buƙatar likita na gaggawa. Lactate da metformin za a iya kawar dasu ta hanyar dialysis.
Lactate da metformin za a iya kawar dasu ta hanyar dialysis.
Yin hulɗa tare da wasu kwayoyi
Yayin yin jiyya, an haramta yin amfani da phenylbutazone lokaci guda. Yana haɓaka aikin ƙwaƙwalwar ƙwayar cuta na Metglib. Zai fi kyau a yi amfani da wasu magungunan anti-mai kumburi marasa amfani don maganin zafi da kumburi.
Kada kayi amfani da wasu abubuwa tare da sulfonylurea idan mai haƙuri ya rigaya yana ɗaukar Metglib. In ba haka ba, hypoglycemia mai tsanani na iya haɓaka.
Yin amfani da Bosentan yana ƙaruwa da haɗarin cutar guba mai guba kan hanta. Ana iya rage tasirin glibenclamide sosai.
Amfani da barasa
A lokacin warkarwa, yanayin disulfiram-mai yiwuwa ne (mai kama da wanda aka nuna ta hanyar ethanol tare da Antabus). Wannan magani bai dace da ethanol ba.
Barasa na iya ƙaruwa da yiwuwar haɓaka mummunan rashin jini da kuma cutar rashin ƙarfi na hypoglycemic coma. Sabili da haka, tare da maganin Metglib, an hana tinctures dauke da barasa.
Analogs
Analogues na kayan aiki sune:
- Glibenfage;
- Glibomet;
- Glucovans;
- Gluconorm;
- Gluconorm Plus;
- Forcearfin Metglib.
Magunguna kan bar sharuɗan
An sake shi ta hanyar takardar sayan magani.
Zan iya saya ba tare da takardar sayan magani ba?
Wasu kantin magunguna suna ba da izinin sayar da Metglib ba tare da takardar likita ba. Marasa lafiya waɗanda suka sayi magani ba tare da alƙawarin ƙwararrun likitoci suna cikin haɗari ba saboda suna iya haɓaka ƙarancin hypoglycemia.
Farashin Metglib 400
Matsakaicin farashin shirya kayan (Allunan 40) kusan 300 rubles.
Yanayin ajiya na miyagun ƙwayoyi
Adana a cikin busassun wuri, iska mai iska da isar da hasken rana. Yawan zazzagewar magani kada ya wuce + 25 ° C.
Ranar karewa
Ana iya adana maganin har tsawon shekaru 3 daga ranar da aka ƙera shi.
Mai masana'anta
Ana samarwa a Canonfarm Production, Rasha.
Ra'ayoyi game da Metglib 400
Likitoci
Irina, mai shekara 38, endocrinologist, Obninsk: "Na wajabta Metglib ga marasa lafiya da ke da cikakkiyar lada na nau'in ciwon sukari na 2. A farkon makonni, marasa lafiya suna shan Allunan guda 2 a rana, sannan satin yana ƙaruwa zuwa Allunan 3-4. Godiya ga wannan, yana yiwuwa a ci gaba da ƙimar glucose jini al'ada. kuma kada ku wuce su. "
Svetlana, mai shekara 45, endocrinologist, Moscow: "Metglib kyakkyawar kayan aiki ne don magance ciwon sukari da hana hauhawar cututtukan jini. An yarda da shi sosai ta hanyar haƙuri, shari'o'in cututtukan fata da sauran cututtukan sakamako ba a lura da su ba."
Marasa lafiya
Ivan, mai shekaru 50, Petrozavodsk: "Ingancin magani na cutar sankara wanda ba ya haifar da jin daɗi, rashin lafiya kuma a lokaci guda yana ba ku damar adana sukari na jini al'ada. Wasu magunguna ba su da wannan tasiri. Ci gaba ya inganta sosai bayan an fara jiyya."
Olga, mai shekara 42, Vologda: "Bayan shan Metglib, lafiyar ta ta inganta. Sauran masu ba da jini suna haifar da rashin jin daɗi. Magungunan suna taimakawa ci gaba da sukari na al'ada ba tare da jin dadi ba."
Polina, mai shekara 39, Kirov: "Wani magani mai rahusa kuma ingantacce yana inganta lafiya, yana rage matakan sukari. Sakamakon yana da sauri fiye da sauran magunguna. Babu wasu sakamako masu illa bayan fara maganin."
