Haɗaɗɗen shiri ya ƙunshi abubuwa masu aiki guda 2, tasirin magunguna masu ƙoshin lafiya, kuma an yi amfani da su don magance hauhawar jijiya.
Suna
Noliprel (Bi) Forte magani ne tare da ninki biyu na abubuwa masu aiki (Perindopril 4 mg + Indapamide 1.25 mg). Idan ya zama dole don amfani da matsakaicin allurai a cikin masu haɗarin haɗari (ciwon sukari, shan taba, hypercholesterolemia), Bi-Forte (Perindopril 10 mg + Indapamide 2.5 MG) an tsara.
Haɗaɗɗen shiri ya ƙunshi abubuwa 2 masu aiki waɗanda ke haɓaka tasirin magunguna.
ATX
C09BA04 Perindopril a hade tare da diuretics.
Saki siffofin da abun da ke ciki
Allunan mai rufe fim.
Abunda yake aiki: Perindopril 2 mg + Indapamide 0.625 mg.
Aikin magunguna
Yana taimakawa wajen daidaita yanayin systolic da hawan jini (BP) a cikin awanni 24. Cikakken sakamako yana tabbata bayan wata daya na cin abinci na yau da kullun. Kammalawa na shugabanci ba ya haifar da ci gaban alamun cirewa
Magungunan yana rage saurin hanyoyin gyaran myocardial, yana rage juriya na jijiyoyin mahaifa ba tare da shafar matakin lipids da gulukon jini ba.
Perindopril yana hana ayyukan enzyme, wanda ke fassara angiotensin I a cikin aiki mai aiki na enzyme angiotensin II, wanda yake da ƙarfi vasoconstrictor. ACE kuma yana lalata bradykinin, mai aikin vasodilator na ilimin halitta. Sakamakon vasodilation, juriya na jijiya yana raguwa kuma yana rage karfin jini.
Allunan mai rufe fim.
Indapamide mai diuretic ne daga rukunin thiazide. Ana gano tasirin diuretic da kaddarorin mai rauni ta hanyar rage juzu'in jan ragamar sodium ion a cikin kodan. Akwai karuwa a fitsari a cikin fitsari na sodium, wanda sakamakon juriya na jijiya yana raguwa kuma yawan jini wanda zuciya ke karuwa.
Haɗin amfani da perindopril da indapamide yana haɓaka tasiri na jiyya don hauhawar jini, rage haɗarin hypokalemia (sakamako na gefen shan diuretics).
Pharmacokinetics
Magungunan magunguna na abubuwan da ke aiki ba ya bambanta tare da haɗin su ko keɓaɓɓen amfani.
Lokacin ɗauka ta baka, kusan 20% na jimlar perindopril ana haɗuwa da su zuwa aiki mai aiki. Wannan darajar na iya raguwa lokacin amfani dashi tare da abinci. Matsakaicin abun ciki a cikin jini an yi shi awanni 3-4 bayan gudanarwa. Smallan karamin sashi na perindopril yana ɗaure wa garkuwar jini. An fitar dashi cikin fitsari.
Za'a iya jinkirta perindopril a cikin gazawar na koda, musamman ma a cikin tsofaffi marasa lafiya.
Indapamide yana narkewa daga ƙwayar gastrointestinal, bayan minti 60 matsakaicin abun ciki na metabolite mai aiki an tsaida shi a cikin jini. Kashi 80% na maganin yana dauke da albumin jini. Ana fitar da ita ta hanyar filta a cikin kodan tare da fitsari, kashi 22 cikin ɗari yana a cikin feces.
Alamu don amfani
Hauhawar jini (hauhawar jijiya).
An wajabta magunguna don hauhawar jini.
Contraindications
- rashin haƙuri ga thiazide diuretics, masu hana ACE;
- matakin potassium na jini kasa da 3.5 mmol / l;
- matsanancin rarar ɗan ƙasa tare da raguwa a cikin ƙimar tacewar ƙasa da ƙasa da 30 ml / min;
- atherosclerotic stenosis na arteries na duka kodan ko stenosis na artery na guda aiki koda;
- mummunan rauni na aikin hanta;
- kulawa na lokaci guda tare da kwayoyi tare da tasirin proarrhythmogenic;
- ciki
- lokacin shayarwa.
Yadda ake ɗauka
Kafin farawa, ya zama dole a karanta umarnin don amfani da tuntuɓi ƙwararrun likita.
Ana shan miyagun ƙwayoyi 1 kwamfutar hannu a baki sau 1 a kowace rana, zai fi dacewa da safe akan komai a ciki.
Zan iya raba kwayan
Kuna iya rabawa, kwaya tana da hadari a garesu.
Siffofin miyagun ƙwayoyi tare da kari "forte" ba su da haɗari kuma an rufe su da wani fim ɗin fim. Ba za a iya raba su ba.
Yadda za'a kula dashi don ciwon sukari na 2
Ba ya tasiri metabolism, tsaka tsaki na rayuwa. Ga marasa lafiya da ke fama da cutar siga, amfani mai yiwuwa ne gwargwadon tsarin da aka tsara.
Side effects
Gastrointestinal fili
Ciwon ciki, tare da tashin zuciya da amai; rikicewar saiti; bushe bakin bayyanar yellowness na fata; haɓaka samfuran awon na hanta da ƙwayar cuta a cikin jini; tare da lalata hanta, haɓakar encephalopathy yana yiwuwa.
Hematopoietic gabobin
Anemia (a cikin marasa lafiya da mummunan koda na cututtukan koda); raguwa a cikin adadin haemoglobin, platelet, leukocytes, granulocytes; rage hematocrit; hawan jini; amosanin gabbai na cutar kansa; saukar jini kasusuwa.
Ga marasa lafiya da ke fama da cutar siga, amfani mai yiwuwa ne gwargwadon tsarin da aka tsara.
Tsarin juyayi na tsakiya
Ciwon kai, tsananin rauni, rauni, gajiya, haushi, hawaye, rashin kwanciyar hankali, raunin yanayin audit da nazarci na gani, rashin bacci, karuwar yanayin jijiyoyin jiki.
Daga tsarin numfashi
Haɗarin ciki wanda ke bayyana tare da fara amfani, yana jurewa tsawon lokacin shan miyagun ƙwayoyi kuma ya ɓace bayan cirewa; wahalar numfashi airway spasm; da wuya - fitowar mucous daga hanci.
Daga tsarin urinary
Rage aiki na renal; bayyanar furotin a cikin fitsari; a cikin wasu halaye, lalacewar na koda; canji a matakan electrolyte: raguwar potassium a cikin jini, tare da hypotension.
Cutar Al'aura
Fatar fata, ƙaiƙayi na nau'in cutar urticaria; Harshen Quincke na edema; vasculitis basur; da wuya - erythema multiforme.
Umarni na musamman
Amfani da barasa
Yin amfani da haɗin gwiwa tare da abubuwan da ke haifar da ethanol na iya taimakawa wajen haifar da mummunan raguwar hauhawar jini, rushewar jijiyoyin jiki. Ba'a bada shawarar amfani da ma'asumi ba.
Tasiri kan ikon sarrafa abubuwan inji
A farkon shan miyagun ƙwayoyi, ya kamata ku yi hankali lokacin tuki motoci da yin aikin da ke buƙatar hankali da saurin amsawa.
Tare da nakasa aikin hanta
Zai iya haifar da ci gaban cututtukan cholestatic jaundice tare da karuwa mai yawa a cikin ayyukan hanta enzymes hanta. Lokacin da wannan yanayin ya faru, wajibi ne a soke maganin kuma a nemi likita.
A cikin marasa lafiya da ke fama da cutar cirrhosis, babu buƙatar daidaita sashi.
Tare da gazawar koda
A gaban cututtuka na tsarin urinary tare da alamar lalacewa a cikin aikin tacewa, haɓaka abun ciki na creatinine, uric acid da urea a cikin jini, haɓakar abun cikin potassium mai yiwuwa ne.
A cikin marasa lafiya da ke fama da cutar cirrhosis, babu buƙatar daidaita sashi.
Tare da raguwa game da keɓantar da keɓaɓɓen kasa da 30 ml / min. Ya kamata a cire magunguna daga tsarin kula da warkewa.
Yayin ciki da lactation
An hana yin amfani da in babu karatu kan tasirin kwayoyi kan tayin. Mata a cikin sati na biyu da na uku yakamata suyi taka tsantsan.
A cikin tsufa
Kafin fara shiga, ya zama dole don saka idanu kan alamomin aikin renal (creatinine, urea), enzymes hanta (AST, ALT), electrolytes. Maganin yana farawa da ƙarancin allurai kuma an zaɓi shi daban-daban don yin la'akari da raguwar hauhawar jini.
Alkawarin Noliprel ga yara
An contraindicated ga yara da matasa a karkashin 18 saboda rashin bayanai game da amincin a cikin wannan rukuni na marasa lafiya.
Yawan damuwa
Alamar yawan yawan yawan zubar jini: tashin hankali, tashin zuciya, amai, ciwon mara, tashin zuciya, raunin zuciya.
Kulawa ta gaggawa: lavage na ciki, gudanar da carbon wanda aka kunna, gyaran jini electrolytes. Tare da hypotension, ya kamata a ba mai haƙuri matsayi na sama tare da kafafu da aka ɗaga.
Mata a cikin sati na biyu da na uku yakamata suyi taka tsantsan.
Yin hulɗa tare da wasu kwayoyi
Tare da kulawa
Lokacin da aka haɗaka tare da maganin rigakafi ko maganin hana haihuwa, haɓaka sakamako akan hauhawar jini tare da haɓakar hauhawar jini na iya faruwa.
Glucocorticosteroids yana rage tasirin antihypertensive.
A bango daga ɗaukar shan, yana yiwuwa a inganta sakamakon rage ƙarfin sukari na insulin da abubuwan asali na sulfonylurea.
Haɗuwa tare da glycosides na zuciya yana buƙatar kulawa da hankali na matakan potassium da ECG, da kuma gyaran hypovolemia.
Tare da nazarin bambancin X-ray, rigakafin bushewar ruwa ya zama dole.
Tare da yin amfani da lokaci ɗaya na wasu kwayoyi (Erythromycin, Amiodarone, Sotalol, Quinidine), haɗarin arrhythmias yana ƙaruwa.
Ba a shawarar haɗuwa da haɗin guiwa ba
Ba a yarda raba shi tare da shirye-shiryen lithium ba saboda yawan haɗarin da ke tattare da zubar lithium.
Tare da rage aikin aikin koda, haɗi tare da diuretics, wanda ke taimakawa jinkiri ga abubuwan lantarki, da kuma infusions na potassium chloride ya kamata a guji.
Tare da gudanarwa na baka na lokaci guda tare da NSAIDs a kan tushen rashin ruwa, zai iya haifar da babban cutar cututtukan cututtukan koda.
Analogs
Ko-Perineva, Ko-Parnawel, Perindapam, Perindid.
Magunguna kan bar sharuɗan
An sake shi ta hanyar takardar sayan magani.
Farashin Noliprel
Kudin kunshin ɗaya na miyagun ƙwayoyi (30 Allunan), waɗanda aka ƙididdige su a wata na magani, yana farawa daga 470 rubles.
Yanayin ajiya na miyagun ƙwayoyi Noliprel
Kada a kai yara. Babu buƙatar yanayin ajiya na musamman da ake buƙata.
Ranar karewa
Shekaru 3
Neman bita akan Noliprel
Likitocin zuciya
Zafiraki V.K., Krasnodar: "Kyakkyawan haɗuwa, wanda ya nuna kansa ba kawai dangane da rage karfin jini ba, har ma dangane da rage abubuwan da suka shafi jijiyoyin jini, tare da raunin zuciya."
Nekrasova GS, Krasnodar: "Mafi kyawun zaɓi ga marasa lafiya da hauhawar jini."
Marasa lafiya
Kauna, Moscow: "Magungunan suna da kyau, yana taimaka."
Alexander, Oryol: "Matsalar al'ada ce."
