Ana amfani da Noliprel 0.625 don rage karfin jini. Magungunan yana cikin rukunin samfuran haɗuwa kuma ya ƙunshi kayan aiki da yawa. Sakamakon tsarin aikin waɗannan abubuwan, an sami kyakkyawan sakamako cikin sauri.
Sunan kasa da kasa mai zaman kansa
Perindopril + indapamide.
ATX
C09BA04.
Saki siffofin da abun da ke ciki
Ana samar da miyagun ƙwayoyi a cikin allunan. Haɗaɗɗan abubuwa guda 2 masu aiki suna nuna kaddarorin antihypertensive:
- perindopril erbumin 2 mg;
- indapamide 0.625 mg.
Ana samun maganin a cikin fakitoci dauke da allunan guda 14 ko 30.
Ana amfani da Noliprel 0.625 don rage karfin jini.
Aikin magunguna
Magungunan yana cikin rukunin masu hana ACE, amma kuma ya ƙunshi diuretic, wanda ƙari kuma yana taimakawa kawar da alamun cutar hauka. Saboda haɗuwa, abubuwan haɗin aiki suna haɓaka aikin juna. Tsarin perindopril yana hana aikin enzyme da ke tattare da aiwatar da canji na angiotensin I zuwa angiotensin II. Dangane da wannan, abun da ke ciki shine mai hana inzarin angiotensin-mai canza enzyme ko ACE.
An kwatanta Angiotensin II ta ikon iya rage lumen tasoshin jini. Saboda wannan, matsin lamba yana ƙaruwa. Idan tsarin juzu'i na juyawar angiotensins ya yi rauni, sannu sannu sannu ake kewaya jini, an kuma dawo da tsarin jijiyoyin jiki. Bugu da ƙari, enzyme angiotensin mai rikodin ma yana da alhakin lalata bradykinin, wanda babban aikin shi shine ƙara ƙwanƙwasa jijiyoyin jiki da jijiyoyin jiki.
Wannan yana nufin cewa tasirin aikin ACE yana ba da gudummawa ga maido da tsarin jijiyoyin zuciya. Bugu da ƙari, sauran hanyoyi na perindopril an lura:
- yana shafar cortex na adrenal, yayin da yawan haɓakar babban aikin hormone mineralocorticosteroid, aldosterone, ya ragu;
- yana da tasirin kai tsaye akan enzyme na tsarin renin-angiotensin, wanda ke ba da gudummawa ga daidaituwa na hawan jini, tare da maganin Noliprel, aikin renin a cikin jini yana ƙaruwa;
- yana rage juriya na jijiyoyin jiki, wanda sakamakon sakamakon tasoshin ne a cikin kyallen takarda da kodan.
Godiya ga sinadaran da ke aiki, Noliprel yadda yakamata yana rage matsin lamba kuma yana inganta aikin CVS.
Yayin gudanar da mulkin Noliprel, ba a lura da ci gaban bayyanuwar abubuwa marasa kyau ba, musamman, gishiri ba ya kasancewa a jiki, wannan yana nuna cewa an fitar da ruwan cikin gaggawa. Bugu da ƙari, sakamakon perindopril ba ya haifar da ci gaban tachycardia. Godiya ga wannan bangaren, an sake dawo da aikin myocardial. Wannan shi ne sabili da daidaituwa na tsoka da ya kwarara a cikin jini a tsakiyansu da elasticity na ganuwar tasoshin jini. Koyaya, akwai karuwa a fitowar zuciya.
Wani sashin aiki mai aiki (indapamide) yana kama daya a cikin kaddarorin zuwa thiazide diuretics. Karkashin tasirin sa, yawan fitarwar ion alli na raguwa. A lokaci guda, ƙwaƙƙwaran aikin cire potassium da ion magnesium daga jiki yana ƙaruwa. Koyaya, uric acid an keɓe shi. Karkashin tasiri na indapamide, ana sake rushe tsari na sake samar da ions sodium ions. A sakamakon haka, hankalinsu ya ragu. Accelearin amfani da hanzarin cire ƙwayar chlorine.
Wadannan hanyoyin suna ba da gudummawa ga karuwar yawan fitsari. A lokaci guda, ana cire ƙwayar ƙwayar cuta a hankali, hawan jini yana raguwa. Ana iya ɗaukar Indapamide a cikin adadi kaɗan, amma har ma a wannan yanayin akwai raguwar hauhawar jini, kodayake, irin waɗannan allurai ba su ba da gudummawa ga bayyanuwar aikin diuretic ba.
Tare da maganin Noliprel, ingantaccen tasirin yana ci gaba na tsawon awanni 24 masu zuwa. Koyaya, an lura da haɓakawa a cikin yanayin janar na haƙuri tare da hauhawar jini bayan makonni da yawa. Amfanin Noliprel shine rashin alamun cirewa a ƙarshen far.
An lura cewa haɗarin indapamide da perindopril yana ba da sakamako mafi kyau (saurin sauri da tasiri mafi tasiri a cikin karfin jini) fiye da lokacin amfani da kowane abu daban. Noliprel ba ya shafar abun ciki. Bugu da kari, maganin da ake tambaya yana da tasiri don hauhawar jini a kowane irin tsananin. An sauƙaƙe wannan ta hanyar kasancewar perindopril a cikin abun da ke ciki.
Pharmacokinetics
Tare da haɗuwa da abubuwa masu aiki guda 2, ƙwayoyin magunguna ba su canzawa. Don haka, perindopril yana tunawa da sauri. Bayan minti 60, ganima na wannan abun ya kai matsayin, tunda matakin taro ya hau zuwa iyakar babba. Perindopril yana metabolized. Koyaya, kawai mahaɗin guda ɗaya ke aiki tare da babban ɓangaren magungunan.
A lokacin abinci, sha na perindopril jinkirin da sauri. Kodan tana da alhakin fitar ta. Game da rushewar wannan sashin, ana riƙe sashi mai aiki a cikin jikin mutum, wanda ke haifar da karuwa a cikin taro.
Indapamide yana kama da wannan a cikin kundin magungunan magungunan zuwa perindopril. Hakanan ana sha da sauri. Bayan minti 60, matsakaicin maida hankali akan wannan abun ya kai. Rabin rayuwar tipamide ya bambanta daga 14 zuwa 24 awanni. Don kwatantawa, an cire perindopril daga jiki a cikin awanni 17, amma an daidaita yanayin daidaitawar bai wuce kwanaki 4 ba.
Idan akwai rauni na aiki na fyaɗe, sinadaran da ke aiki suna tarawa a jikin mutum.
Alamu don amfani
Babban tsananin hauhawar jini.
Contraindications
Restuntatawa akan nadin Noliprel:
- rashin jituwa na yanayin mutum na kowane bangare a cikin abun da ke ciki, amma mafi yawan lokuta ana nuna mummunar amsawa ga abubuwa masu aiki, a Bugu da kari, ba a amfani da maganin don nuna rashin damuwa ga wasu kwayoyi na ƙungiyar sulfonamide (diuretics), ACE inhibitors;
- rauni na zuciya a matakin lalacewa;
- hali na laryngeal edema;
- hypokalemia;
- karancin maganin lactase, cututtukan malabs-galactose malabsorption, galactosemia.
Yadda ake ɗaukar Noliprel 0.625?
Don kauce wa rikitarwa da hana sakamako masu illa, kazalika don cimma sakamako mafi kyau a cikin mafi ƙarancin lokacin da zai yiwu, an wajabta magunguna da safe. An bada shawara don ɗaukar magani a kan komai a ciki. Yawan shawarar da aka bada shawarar shine kwamfutar hannu 1 a kowace rana. Matsayin jiyya a matakin farko shine tsawon wata 1.
Idan a ƙarshen wannan lokacin ba a sami sakamako mai kyau ba (raguwar matsin lamba), za'a sake nazarin sashi na samfuran. A wannan yanayin, ana iya ba da umarnin Noliprel Forte wanda ke ɗauke da irin wannan adadin abubuwan da ke aiki wanda shine 2 sau kashi na Noliprel.
Yaya za a kula da ciwon sukari na 2?
Babban halin da ake ciki don lura da marasa lafiya a cikin wannan rukunin shine ɗaukar mafi ƙarancin kashi a cikin makon farko. Don haka, zaku iya fara hanya tare da kwamfutar hannu 1 na Noliprel. A hankali, idan ya cancanta, yawan maganin yana ƙaruwa. Koyaya, a wannan yanayin, ana sanya manyan alamomin jini, hanta, da kodan akai-akai don guje wa rikitarwa.
Sakamakon sakamako na Noliprel 0.625
Haɓakawa a cikin gabobin hangen nesa, ji, rashin ƙarfi, hyperhidrosis. A wani ɓangaren tsarin jijiyoyin zuciya, an nuna angina pectoris, ƙarancin yawanci: infarction myocardial, raguwa mai ƙarfi a cikin karfin jini.
Gastrointestinal fili
Amai, tashin zuciya, jijiya a cikin ciki, canji na ɗanɗano, wahala a cikin jijiyoyin wuya, abincin mai haƙuri ya ɓace, narkewar ya rikice, zawo ya bayyana. Wani lokacin kumburi yakan tsiro (rauni a cikin hanji). Commonlyarancin da aka saba, ana kamuwa da cutar cututtukan ƙwayar ƙwayar ƙwayar cuta tare da Noliprel.
Hematopoietic gabobin
Haɗin, kuma a lokaci guda, kaddarorin jini yana canzawa. Misali, anemia, thrombocytopenia, da sauransu na iya haɓaka.
Tsarin juyayi na tsakiya
Mai haƙuri yakan canza yanayi. Akwai matsaloli tare da bacci, farin ciki, ciwon kai, hankali yana cikin damuwa. Karancin yau da kullun shine canji a cikin tunani.
Daga tsarin urinary
Cutar rashin lafiyar koda.
Daga tsarin numfashi
Karancin numfashi, bronchospasm, tari (mafi yawa bushewa), rhinitis, eosinophilic ciwon huhu.
Cutar Al'aura
Vasculitis, tare da cututtukan jini, cututtukan mahaifa, cututtukan hanji da Quincke.
Tasiri kan ikon sarrafa abubuwan inji
Yakamata a yi taka tsantsan yayin tuki motocin yayin jiyya tare da Noliprel. Wannan buƙatar yana faruwa ne saboda gaskiyar cewa a ƙarƙashin rinjayar kayan aikin aiki, rikicewar gani na iya haɓaka. A cikin rashin halayen mutum marasa kyau ga miyagun ƙwayoyi a cikin tambaya, yana halatta a shiga kowane irin ayyukan da ke buƙatar ƙara kulawa.
Yakamata a yi taka tsantsan yayin tuki motocin yayin jiyya tare da Noliprel.
Umarni na musamman
Irin wannan yanayin na rayuwa kamar idiosyncrasy da wuya ya inganta.
A mafi yawan halayen, ba a ba da magani ba idan gazawar na koda saboda ci gaban ƙirar koda. Rashin lafiyar wannan sashin jiki yakan haifar da asali daga cututtukan zuciya. Wannan an sauƙaƙe wannan ta hanyar cututtukan ƙwayar cutar yara.
Tare da hypotension na jijiya, babu buƙatar dakatar da shan ƙwayoyi. A wannan yanayin, matsin lamba an daidaita shi ta hanyar gabatar da mafita na sodium chloride.
An buƙata don bincika matakin potassium a cikin plasma a kai a kai.
Yiwuwar ci gaba da inganta ƙwayar cuta ta neutropenia yana ƙaruwa a cikin marasa lafiya tare da wasu cututtuka, alal misali, tare da rashin isasshen aikin renal, cirrhosis.
Shan Noliprel tare da maganin rashin nutsuwa (maganin kwari) yana kara hadarin girgiza kwayar cutar kwayar kwayoyi.
A kan asalin yanayin maganin cutar motsa jiki na gaba daya, raguwar matsin lamba na iya faruwa idan mai haƙuri ya dauki maganin.
Yi amfani da lokacin daukar ciki da lactation
Ba a sanya magani ba. Wannan ya faru ne saboda gaskiyar cewa lokacin shayarwa, tare da madarar uwa, abubuwan da ke aiki suna shiga jikin jariri. Bugu da kari, yayin daukar ciki, yana da matukar yuwuwar cewa tayin zai bunkasa cutar.
Yi amfani da tsufa
Kan aiwatar da kawar da abubuwa masu aiki ana sassauta shi. Ana iya buƙatar daidaita sashi na abu.
Nadin yara Noliprel 0.625
Ba'a amfani dashi ƙarƙashin shekara 18 years.
Aikace-aikacen aiki mara kyau
A kan tushen mummunar lalacewar wannan sashin, Noliprel ba a sanya shi ba. Rashin lalacewa na weaker ba dalili bane na karban magunguna. A wannan yanayin, babu buƙatar sake karanta sashi.
Amfani don aikin hanta mai rauni
A cikin yanayi mai laushi zuwa matsakaiciyar cuta, ana iya amfani da miyagun ƙwayoyi. Ba a cika yin amfani da adadin maganin ba. Gabanin tushen ƙarancin aiki na hanta, ba a amfani da maganin da yake tambaya.
Tare da yawan abin sama da ya wuce, alamu na nuna damuwa yana bayyana: rashin barci, farin ciki, da sauransu.
Yawan adadin Noliprel 0.625
Babban cutar shine rashin lafiyar jiki. A kan tushen rage matsin lamba, alamomin da ke faruwa suna faruwa: rushewa, tashin zuciya, tsananin farin ciki, amai, amai. Wataƙila cin zarafin sani, canji a cikin abun da ke cikin sodium da potassium a cikin jiki: raguwa, ƙaruwa.
Don cire bayyanar da ba ta dace ba, ya kamata ku tsabtace ciki, saboda wannan, an cire adadin ƙwayar cutar daga jikin mutum. Koyaya, wannan matakin zai samar da sakamako da ake so kawai idan an karɓi Noliprel kwanan nan. Bugu da kari, an wajabta maganin sihiri, ana aiwatar da maganin kulawa da nufin dawo da ma'aunin ruwa-electrolyte.
Yin hulɗa tare da wasu kwayoyi
Tare da kulawa
Ana buƙatar kulawa ta musamman ga yanayin jiki yayin shan Noliprel da irin waɗannan kwayoyi:
- Baclofen;
- NSAIDs;
- maganin cututtukan cututtukan mahaifa da cututtukan jini;
- GCS;
- sauran magunguna waɗanda aikinsu da nufin rage karfin jini;
- magungunan hypoglycemic;
- Allopurinol;
- sauran diuretics;
- Metformin;
- salts na salula;
- Cyclosporin;
- iodine dauke da abubuwa wanda aka yi amfani dashi wajen gudanar da binciken kayan masarufi ta amfani da hanyar bambanci
Ba a ɗaukar Noliprel lokaci guda tare da abin sha mai ɗauke da giya.
Ba a shawarar haɗuwa da haɗin guiwa ba
Ba a amfani da Noliprel lokaci guda tare da shirye-shiryen da ke ɗauke da lithium. Kada a tsara kwayoyi waɗanda ke haifar da ci gaban arrhythmias, hypokalemia, cardiac glycosides.
Amfani da barasa
Ba a ɗaukar Noliprel lokaci guda tare da abin sha mai ɗauke da giya, saboda a wannan yanayin haɗarin hypotension yana tasowa, nauyin a kan hanta yana ƙaruwa.
Analogs
Amfani da Noliprel:
- Perindopril da indapamide;
- Noliprel A;
- Indapamide / Perindopril-Teva;
- Ko-perineva.
Magunguna kan bar sharuɗan
Magunguna masu sayan magani.
Zan iya saya ba tare da takardar sayan magani ba?
A'a.
Farashin Noliprel 0.625
Matsakaicin matsakaici shine 600-700 rubles.
Yanayin ajiya na miyagun ƙwayoyi
Babu takamaiman shawarwari don adana Noliprel. Koyaya, dole ne a yi amfani da allunan a cikin watanni 2 bayan amincin akwatin ɗaukar hoto.
Ranar karewa
Magungunan sun riƙe kaddarorin na tsawon shekaru 3.
Mai masana'anta
Servier, Faransa.
Neman bita akan Noliprel 0.625
Likitocin zuciya
Zhikhareva O. A., Samara
Magungunan suna da tasiri. Haka kuma, an lura da ingantattun canje-canje a cikin marasa lafiya a matakin farko na hauhawar jini, da kuma a cikin mafi tsananin siffofin. Na yi la'akari da hasara na dogon lokaci na aiki, amma idan ya cancanta, zaku iya ƙara yawan kashi, amma wannan ya cika da rikitarwa.
Zafiraki V.K., Tula
Magungunan yana taimakawa wajen daidaita yanayin mai haƙuri tare da hauhawar jini, kuma bugu da ƙari yana hana ci gaba da cututtuka na tsarin zuciya. Farashin yana matsakaici, kunshin ya ƙunshi adadin allunan da suka dace da tsarin kulawa na wata-wata, wanda ya dace kuma yana baka damar adana kuɗi.
Marasa lafiya
Veronica, ɗan shekara 49, Penza
Na dauki Noliprel na dogon lokaci (ba tare da bata lokaci ba), saboda matsin lamba na yakan hauhawa, kuma lokacin da alamun tashin hankali ya gushe, hawan jini na har yanzu yana matakin babban matakin al'ada. Kamar yadda na karɓi, na lura cewa mura yana fitowa a bangon bayan rashi na sauran alamun mura. Bayan binciken, ya juya cewa wannan shine yadda magungunan ke aiki, dole in daina shan shi kuma in sami wanda zai maye gurbinsa.
Eugenia, mai shekara 29, Vladimir
Noliprel ta dauko mama. Ta gwada magunguna daban-daban, amma koyaushe akwai matsaloli, musamman, maganganu marasa kyau na jiki. Bayan ɗaukar Noliprel, sannu a hankali yanayin ya zama al'ada, matsin lamba baya ƙaruwa. Haka kuma, wannan magani baya wanke alli, wanda yake da mahimmanci a cikin tsufa.
