Metv Galvus - cikakkun umarnin don amfani, sake dubawa game da masu ciwon sukari da likitoci

Kudus Galvus wani magani ne mai haɗe da ƙwaƙwalwar ƙwaƙwalwar ƙwayar cuta. An haɓaka shi don daidaita al'ada a cikin masu ciwon sukari tare da cutar ta biyu. Magungunan suna da karfin sarrafa metabolism na insulin da glucagon.

Medicalungiyar likitocin Turai ta yi imanin cewa Galvus Honey yana da tasiri sosai fiye da wanda ya riga shi, Galvus, wanda yake da shawara don amfani kawai don rashin haƙuri ga metformin.

Bayanin sigar sashi

A cikin cibiyar sadarwar kantin magani, ana ba da magani a cikin nau'ikan allunan mai rufi, kowane ɗayansu yana dauke da kayan aiki guda biyu: 50 MG na vildagliptin da 500, 850 ko 1000 mg na metformin. Magnesium stearate, hyprolose, hypromellose, talc, titanium dioxide, macrogol 4000 da baƙin ƙarfe ana amfani da su azaman matattara.

Kowane boka yana dauke da Allunan 10. An shirya faranti a cikin kwalaye na guda 3, kowane kunshin Galvus Met yana da umarnin.

• 50/500 mg - m Allunan tare da kaifi baki a cikin kwasfa da launin ruwan hoda shuɗi. An rage LLO a gefe guda kuma NVR a baya.
• 50/850 mg - kamannin kwamfutar hannu mai kama da juna, harsashi kawai yana launin toka-toka kuma alamar ta dace: SEH a gefe guda kuma NVR a ɗayan.
• 50/1000 mg - allunan da suka bambanta da nau'in da suka gabata a cikin wata inuwa mai cike da rawaya tare da ƙari na launin toka da raguwa: NVR - a gefen gaba da FLO - a baya.

Hanyar magunguna

Thearfin hypoglycemic na miyagun ƙwayoyi an gano shi ta nau'ikan abubuwa guda biyu na asali, kowane ɗayan yana da nasa hanyar aiwatarwa. Complexarfinsu masu rikitarwa yana ba ka damar dogara da sarrafa glycemia yayin rana.

1. Vildagliptin - mai hanawa na dipeptidyl peptidase-4 (DPP-4) - yana inganta halayyar sel zuwa insulin, yana haɓaka haɓakar sa. An bayar da wannan sakamakon ta hanyar ƙarfafawa ta nau'in glyptin na samar da sunadarai masu mahimmanci ga ƙwayar cuta - nau'in peptide glucagon-G1P (GLP-1) da glucose-polypeptide-insulinotropic glucose-HIP.
2. Metformin, wani rukuni na rukunin hydrochloride biguanide, yana ba da izini a cikin glycemic indices ta rage ƙimar karɓar carbohydrates a cikin ƙananan hanji, rage samar da glycogen a cikin hanta da kuma inganta amfani da shi a cikin kyallen takarda na ciki. Kwayar zata iya haifar da hauhawar jini.

Tare da amfani da baka na maganin, vildagliptin da metformin suna shiga cikin jini ta bangon hanji, suna isa yanayin warkewa a cikin mintuna 25-30 kuma a ko'ina aka rarraba kan gabobin da kyallen takarda. Hanyoyin tafiyar matakai na metabolite na Galvus Met suna faruwa a cikin hanta. Kayan samfuran lalata abubuwa masu ɗauke da ƙwayoyin cuta tare da fitsari. Matsakaicin lokacin wanda rabin abin da ake amfani da shi an nuna shine kimanin awanni uku.

A yayin jiyya mai rikitarwa tare da kwayoyi guda biyu a farashin yau da kullun na metformin 1500-3000 mg da vildagliptin 50 mg, rarraba fiye da aikace-aikacen 2, an yi rikodin raguwa a cikin sukarin jini sama da shekara guda. A lokaci guda, glycosylated kwalliyar haemoglobin ta ragu da 0.7%, idan aka kwatanta da ƙungiyar kulawa da ta karɓi metformin kawai.

A cikin masu ciwon sukari da ke kan hadaddun jiyya na Galvus Metom, ba a rubuta mahimmancin gyaran nauyi ba. Fiye da makonni 24 na amfani da miyagun ƙwayoyi, an bayyana raguwa mai yawa a cikin karfin jini a cikin marasa lafiya masu hauhawar jini da nau'in ciwon sukari na 2. Laifukan cututtukan cututtukan cututtukan jini sun yi adadi mafi ƙaranci.

Lokacin da aka wajabta Galvus Meta yayin kulawa tare da insulin (a cikin kashi na raka'a 41) a cikin masu ba da agaji da ke cikin binciken, matakin glycosylated haemoglobin ya faɗi da 0.72%. Hypoglycemia a cikin ƙungiyar gwaji da ƙungiyar placebo ba ta bambanta da yawan lokuta ba.

Tare da yin amfani da daidaituwa na amfani da glimepiride (daga 4 mg / rana) tare da Galvus Met, an kuma rage yawan raguwar haemoglobin glycosylated - ta 0.76%.

Fasali na pharmacokinetics

Karshen

Idan kun dauki Allunan kafin abinci, sinadaran da ke aiki suna karuwa cikin sauri, suna zuwa matsakaicinsu bayan mintuna 105 bayan shigowa. Lokacin amfani da miyagun ƙwayoyi tare da abinci, yawan sha yana rage kadan.

Cikakken bayanin bioavailability na miyagun ƙwayoyi ya isa sosai - 85%. Rarraba metabolite tsakanin plasma da erythrocytes yana da daidaituwa, yana da rauni yana ɗaure wa furotin na jini - kawai 9.3%.

Babban hanyar kawar da miyagun ƙwayoyi shine biotransformation, 69% na kashi a cikin jiki ya juya ya zama mai aiki na Lay151 na pharmacologically marasa aiki. Ficewar vildagliptin yana faruwa ne ta hanyar kodan (85%) da hanji (23%).

Wakilan kabilu daban-daban, na mace ko na mace, na nau'ikan sikelin jiki daban-daban suna nuna kusan magungunan maganin guda ɗaya ne.

Tare da ƙarancin hepatic a cikin m ko matsakaici na tsari, bioavailability na vildagliptin ya ragu zuwa 20%, a cikin mummunan yanayin yana ƙaruwa da 22%.

Tare da ilimin cututtukan koda, matsakaici, matsakaici da mummunan siffofin AUC, vildagliptin yana haɓaka 1.4 zuwa sau 2.

Sakamakon vildagliptin akan magunguna na yara ba a yi nazari ba.

Metformin

A sashi na 500 MG, bioavailability na metformin shine 50-60% idan an sha shi kafin abinci. Tare da kara sashi, mai nuna alama yana ƙaruwa gwargwado. Idan kun sha miyagun ƙwayoyi a layi daya tare da abinci, bioavailability yana raguwa.

Tare da kashi ɗaya, metabolite a zahiri ba a ɗaura shi ga furotin plasma (don kwatantawa, shirye-shiryen sulfonylurea sun haɗa 90%). Tare da yin amfani da dogon lokaci, magungunan a hankali sun shiga cikin sel jini.

Guda guda inra na rigakafin magungunan ga masu sa kai masu lafiya sun nuna raunin koda na al'ada a cikin wannan tsarin. Babu wani metabolites da aka samo a cikin hanta. A cikin masu ciwon sukari, har zuwa kashi 90% na magungunan da aka dauka suna dauke da kodan ne a cikin sa'o'i 24.

Bambance-bambancen jima'i ba su shafar magungunan magunguna ba. Masu ciwon sukari na kabilu daban-daban sun yi tasirin sakamako na metformin.

Ba a yi nazarin fasalolin sha, rarraba da kuma kawar da miyagun ƙwayoyi a cikin marasa lafiya da cututtukan hanta ba. Tare da ilimin cututtukan koda, rabin rayuwar yana ƙaruwa. Sakamakon raguwar ƙarfin koda a cikin marasa lafiya masu tsufa, ana lura da irin wannan sakamakon. Babu bayanai game da tasirin maganin a kan sakamakon magani a cikin yara.

Wanda aka nuna don maganin

Haɗin haɗin an tsara shi don bi da masu ciwon sukari tare da nau'in ciwon sukari na 2. Dangane da Galvus Meta, akwai magungunan warkewa iri iri.

1. Monotherapy - don daidaita sukari, suna amfani da magani ɗaya - Galvus Met.
2. Rarraba amfani da abubuwa masu aiki na Metformin da Vildagliptin azaman magunguna masu zaman kansu.
3. Hade jiki tare da magungunan sulfanylurea.
4. Tsarin sau uku tare da ƙari na insulin zuwa Galvus Meta.
5. A matsayin magani na farko-farko da aka yi amfani da shi a farkon farawar magani, lokacin da abinci mai ƙarancin carb da ɗaukar nauyin tsoka ba ya haifar da sakamakon da ake so.

Maganin Galvus mai kyau ga mata masu juna biyu da masu shayarwa

Gwaje-gwajen kan dabbobi masu juna biyu, wanda aka gudanar da allurai na vildagliptin sau 200 fiye da yadda aka saba, ya nuna cewa maganin bai keta alfarmar tayi ba kuma bashi da tasirin cutar kwayar cuta. Yin amfani da Galvus Meta a cikin sashi na 1/10 ya nuna irin wannan sakamako.

Ba a yi nazarin tasirin magani a jikin tayin ɗan adam ba, saboda haka, ba a shardanta mata masu juna biyu ba. Metformin ya shiga cikin madara mai nono; babu bayanai akan shigarwar vildagliptin.

Gabaɗaya, ba a amfani da Galvus Met don shayarwa.

Ga wanda hypoglycemic wakili ne contraindicated

Ilimin halittar jini wanda ba a ba shi maganin metabolite ba:

• Kayan aiki daban-daban, rashin jituwa ga kowane bangare na maganin;
• Ciwon sukari na nau'in 1 - tare da cutar-da yake dogara da wannan nau'in, ana buƙatar insulin;
• Bayan 'yan kwanaki kafin a fara aikin, X-ray da kuma gwajin radiisotropic, zazzabin cutar baƙi;
• Acetonemia cuta ce ta rayuwa wanda ake kira bayyanar jikin ketone a cikin ruwayoyin halittu, musamman wannan na faruwa ne tare da hyperglycemia;
• Cutar cututtukan fitsari (a cikin mawuyacin hali ko marassa lafiya), hanyoyin da suke tsokanar rashin ruwa a jiki - kazantar jiki sakamakon zawo ko yawan amai, zazzabi, kamuwa da cuta (sepsis, cututtukan tsarin numfashi);
• Rashin ƙwayar hanta da ke hade da yanayin da ke rage aikinta (cirrhosis, hepatitis);
• Cutar zuciya, bugun zuciya, gajeriyar numfashi;
• Alcoholism a matsayin cuta ko maye giya;
• Abincin hypocaloric, lokacin da har zuwa 1000 kcal / rana ya shiga jiki .;
• Duk lokacin haila da lactation;
• Yara - aminci da tasirin magani ba a kafa su ba.

Yadda ake amfani da maganin

Ya kamata a hadiye kwamfutar hannu gaba daya, ba tare da taunawa ko narkewa ba, a wanke shi da isasshen ruwan a zazzabi mai dadi. Idan kun ɗauki kwaya tare da abinci, haɗarin cutar zai iya raguwa.

Yawan allurai na Galvus Meta sun dogara da matakin biyan diyya na sukari, sakamakon magani na baya tare da analogues, da tsawon lokacin cutar. A kowane hali, tsarin kulawa likita ne.

Idan an wajabta magungunan a karon farko, a matsayin ƙari ga abinci mai inganci da aiki na yau da kullun, ƙayyadaddun zai zama 50/500 MG (alamomi na farko shine vildagliptin, na biyu shine metformin). A nan gaba, tare da isasshen sakamako na warkewa, wanda aka ƙaddara ta hanyoyin dakin gwaje-gwaje, za a iya daidaita sashi matakin.

Lokacin da mai haƙuri ya riga ya saba da magungunan (ya ɗauki su daban ko a sauran haɗuwa), suna ba da shawarar ɗayan zaɓi - 50/850 MG ko 50/1000 MG.

A cikin shekaru masu girma ko tare da haɓakar cututtukan koda, mafi ƙarancin yawanci ana bada shawara.

Don kimanta sakamakon maganin Galvus Metom, ya zama dole don bincika matakin sugars (duka a gida, tare da glucometer, kuma a cikin dakin gwaje-gwaje) a kai a kai.

Side effects

Ba'a yin rikodin abubuwan da ba a so ba sau da yawa, amma wajibi ne don nazarin jerin abubuwan kafin amfani da masu ciwon sukari.

1. Gastrointestinal fili - cutawar dyspeptik, ƙwannafi, bugun ƙwayar cuta, ƙanshin ƙarfe a bakin, ƙarancin shan Vitamin B12.
2. CNS - asarar daidaituwa, ciwon kai, hannaye da rawar jiki.
3. Hankalin hanta da bile - hepatitis da dysfunction hanta.
4. Tsarin Musculoskeletal - haɗin gwiwa da ciwon tsoka.
5. Fata - blisters, busa, fata bushe.
6. Metabolism - lactic acidosis (karuwa a cikin taro na uric acid, amsawar acidic na yanayin).
7. Allergy - fatar fata, itching, urticaria; a cikin matsanancin halayen - huhun angioedema Quincke na kumburi (kumburi da fuska da gabobin ciki) da tashin hankalin anaphylactic (faduwar gaba a hawan jini, wanda ya inganta ta hanjin kwayoyi).

   
   

Wani lokacin yawan rashin ƙarfi na haɓakawa tare da yawan zafin gumi, da rawar jiki. A alamomin farko, kuna buƙatar shan rabin gilashin shayi mai zaki ko ruwan 'ya'yan itace, ku ci alewa.

Umarni na musamman

Lokacin da yake rubuta magani, mai ciwon sukari yana buƙatar nazarin umarnin kansa. Umarni na musamman zai taimaka wajen nisantar da illa.

• Galvus Met ba shine maganin insulin ba, yana da mahimmanci, da farko, ga masu ciwon sukari da ke fama da ciwon sukari da ke dogaro da insulin.
• A cikin jiyya tare da miyagun ƙwayoyi, ana buƙatar saka idanu akai-akai game da sukari na jini (duka dakin gwaje-gwaje da mutum, ta amfani da glucometer).
• Kowane wata, hanyoyin dakin gwaje-gwaje suna tantance yanayin ƙodan, hanta, da kuma tattarawar lactic acid.
• A lokacin jiyya, Galvus Metom ba a yarda da shan giya ba - wannan na iya ba da gudummawa ga ci gaban lactic acidosis.
• Rashin shan bitamin B12 mara kyau, wanda ya haifar da amfani da magani, na iya tsokani cutar rashin jijiyoyi da jijiyoyin jini.
• Yara, masu juna biyu da masu shayarwa Galvus Met ba su yarda ba.
• Abubuwan da ke aiki da metabolite suna hulɗa tare da kwayoyi da yawa, lokacin da suke tsara yanayin kulawa, ya kamata a sanar da likita game da duk magungunan da aka dauka.
• Sakamakon Galvus Meta akan halayen psychomotor da kuma matakin tattara hankali ba a yi nazari ba. Lokacin aiki tare da inji da injuna yayin jiyya tare da miyagun ƙwayoyi, dole ne mutum yayi hankali sosai.

Yawan damuwa

Idan shawarar da aka ba da shawarar ta wuce sau da yawa, myalgia, hypoglycemia, rikicewar dyspeptik, edema na ƙarshen, lactic acidosis (daga wuce haddi na metformin) haɓaka. Alamomin yawan abin sama da ya wuce ya bace bayan katse magani.

Tare da irin wannan bayyanar cututtuka, an soke maganin, an wanke shi tare da jijiyoyin ciki kuma ana yin magani na alama. Amfani da hemodialysis, metformin kawai za'a iya cire shi gaba daya, vildagliptin an cire wani sashi.

Karfe Galvus - analogues

Idan muka kwatanta abun da ke ciki da sakamakon jiyya, to gwargwadon abubuwan aiki masu inganci da ingancin warkewa, ana amfani da analog ɗin:

• Metva na Met;
• Sofamet;
• Trazenta;
• Methadiene;
• Tsarin Pliva.

Shawarar ajiya da farashin magani

Dangane da umarnin, Galvus Met ya dace don amfani a cikin watanni 18 daga ranar da aka sake shi, ƙarƙashin batun ajiya mai dacewa. Dole ne a zubar da maganin da ya ƙare. Wuri mai duhu da bushewa wanda ba ya isa ga hankalin yara ya dace da ajiya, tare da yanayin zazzabi har zuwa 30 ° C.

An sake sayan magani. Don Galvus Met, sashi yana ƙaddara ta sashi:

1. 50/500 MG - matsakaici na 1457 rubles;
2. 50/850 MG - matsakaici na 1469 rubles;
3. 50/1000 MG - matsakaici na 1465 rubles.

Ko da tare da amfani guda ɗaya na yau da kullun, ba duk masu ciwon sukari sun gamsu da wannan farashi ba, mafi yawan korafe-korafe daga masu fansho tare da ƙarancin albashi. Koyaya, samfuran kamfanin Switzerland na Novartis Pharma ana rarrabe su koyaushe ta hanyar ingancin su, kuma basa cikin ɓangarorin kasafin kuɗi na wakilai na hypoglycemic.

Galvus Met - sake dubawa game da masu ciwon sukari da likitoci

A cikin ɗakunan tattaunawar maganganu, endocrinologists suna ba da amsa game da sakamakon maganin Galvus Metom. Ba'a ba da shawarar yin shi don matsalolin oncological ba, tunda DPP-4, enzyme wanda ke hana ci gaban neoplasms, Galvus Metom yana hana shi. A cikin cututtukan cututtukan ƙwayar ƙwayar cuta, ana ba da umarnin insulin yawanci. Nazarin marasa lafiya game da Galvus Mete sun haɗu, babban batun jayayya shine ingancin farashin.

Bayanai game da miyagun ƙwayoyi Galvus Met hade hypoglycemic illa a kan insulin da glycogen a cikin jiki ya dogara da umarnin hukuma, amma an ba da shi don dalilai na bayanai kawai kuma ba zai iya zama jagora don ganewar asali ko magani na kai ba.