Atorvastatin-Teva magani ne na hypoliplera. Hanyar aiwatar da ayyukan rage ƙwayoyin lipid shine rage matakin "mummunan" cholesterol, da kuma adadin triglycerides da kuma lipoproteins na ƙarancin ƙima. Bi da bi, suna ƙara haɗuwa da yawan ƙwayoyin lipoproteins mai ɗimbin yawa da kuma "mai kyau" cholesterol.
Atorvastatin-Teva yana samuwa a cikin nau'ikan farin allunan da aka shirya fim. Rubutun guda biyu ana lullube su a farfajiya, ɗayansu shine “93”, na biyu kuma ya dogara da sashi na ƙwayoyi. Idan sashi yakai 10 MG, to kuwa rubutun "7310" aka zana shi, idan 20 MG, to "7311", idan 30 MG, to "7312", idan kuma 40 MG, to "7313".
Babban kayan aiki na Atorvastatin-Teva shine alli na atorvastatin. Hakanan, tsarin maganin ya haɗa da ƙarin ƙarin, abubuwa masu taimako. Waɗannan sun haɗa da, alal misali, lactose monohydrate, titanium dioxide, polysorbate, povidone, alpha-tocopherol.
Tsarin aikin Atorvastatin-Teva
Atorvastatin-Teva, kamar yadda muka ambata a farko, wakili ne mai rage zafin nama. Duk karfinsa yana nufin hanawa, watau hana ayyukan enzyme a karkashin sunan HMG-CoA reductase.
Babban aikin wannan enzyme shi ne tsara yadda ake kirkiro cholesterol, tunda samuwar gabanta, mevalonate, daga 3-hydroxy-3-methyl-glutaryl-coenzyme A. ya fara faruwa. Ana aika cholesterol, tare da triglycerides, zuwa hanta, inda ya haɗu da ƙarancin lipoprote mai yawa. . Kwayar halitta da aka kirkira ta shiga cikin jini jini, sannan tare da wanda yake dashi yanzu ana mika shi ga sauran gabobin da kyallen takarda.
Convertedarancin wadataccen lipoproteins masu yawa suna canzawa zuwa ƙarancin lipoproteins mai yawa ta hanyar tuntuɓar takamaiman masu karɓar su. Sakamakon wannan hulɗa, haɗarin su yana faruwa, watau lalata.
Magungunan yana rage adadin cholesterol da lipoproteins a cikin jinin marasa lafiya, yana hana tasirin enzyme da haɓaka adadin masu karɓa a cikin hanta don ƙananan lipoproteins mai yawa. Wannan yana ba da gudummawa ga mafi girmanwa da kuma zubar da su. Hakanan an rage aikin samarda abinci mai guba na atherogenic lipoproteins. Bugu da kari, tarawar babban sinadarin lipoprotein cholesterol yana ƙaruwa kuma triglycerides ya ragu tare da apolipoprotein B (furotin mai ɗaukar jini).
Amfani da Atorvstatin-Teva yana nuna sakamako mai zurfi a cikin lura da ba kawai atherosclerosis ba, har ma da sauran cututtukan da ke da alaƙa da ƙwayar lipid, wanda sauran hanyoyin rage ƙwayar lipid ba su da tasiri.
An gano cewa hadarin kamuwa da cututtuka masu alaƙa da zuciya da jijiyoyin jini, kamar bugun zuciya da bugun jini, yana raguwa sosai.
Pharmacokinetics na Atorvastatin-Teva
Wannan magani yana cikin sauri. Kimanin sa'o'i biyu, ana yin rikodin mafi girman magungunan a cikin jinin mai haƙuri. Baƙon abu, wato, ɗaukar ciki, na iya canza saurin sa.
Misali, zai iya yin jinkiri yayin shan Allunan tare da abinci. Amma idan shaye-shayen hakan yayi saurin rage shi, to hakan ba zai haifar da tasirin Atorvastatin ta kowace hanya - cholesterol yana ci gaba da raguwa gwargwadon sigar. Lokacin da ya shiga cikin jiki, miyagun ƙwayoyi suna shan canje-canje na tsarin a cikin gastrointestinal tract. An ɗaure ta da ƙarfi ga furotin plasma - 98%.
Babban canje-canje na rayuwa tare da Atorvastatin-Teva yana faruwa a cikin hanta saboda bayyanar da ke nunawa da isoenzymes. Sakamakon wannan tasiri, an kirkiro metabolites masu aiki, waɗanda ke da alhakin hanawar HMG-CoA reductase. 70% na duk sakamakon maganin suna faruwa daidai saboda waɗannan metabolites.
Atorvastatin an cire shi daga jiki tare da cututtukan hepatic. Lokacin da yawan maganin a cikin jini zai zama daidai da rabi na asali (wanda ake kira rabin rayuwa) shine 14 hours. Tasirin enzyme yana kimanin kwana ɗaya. Babu fiye da kashi biyu na adadin da aka yarda da za a iya ƙaddara ta hanyar nazarin fitsari mara haƙuri. Ga marasa lafiya da kasawar koda, yakamata a tuna cewa a lokacin hemodialysis Atorvastatin baya barin jiki.
Matsakaicin ƙwayar cutar ta wuce matsayin ta kashi 20% a cikin mata, kuma an rage rage ƙarfin ta da 10%.
A cikin marasa lafiya da ke fama da lalacewar hanta sakamakon shan barasa mai saurin motsa jiki, matsakaicin maida hankali yana ƙaruwa sau 16, kuma yawan fitarwar yana sauka sau 11, sabanin yadda aka saba.
Manuniya da contraindications don amfani
Atorvastatin-Teva magani ne da aka yi amfani da shi sosai a aikin likita na zamani.
Kulawa na kowane daga cikin cututtukan da ke sama da kuma cututtukan cututtukan da ake aiwatarwa yayin aiwatar da abincin da ke taimakawa ƙananan cholesterol (mafi girma a cikin kayan lambu da 'ya'yan itatuwa, ganyaye, ganye, berries, abincin teku, kaji, ƙwai), kazalika da rashin sakamakon daga farko amfani da magani.
Akwai alamu da yawa da ya tabbatar da ingancinsu sosai:
- atherosclerosis;
- na farko hypercholesterolemia;
- heterozygous da iyali da kuma wadanda ba familial hypercholesterolemia;
- nau'in hypercholesterolemia hade (nau'in na biyu bisa ga Fredrickson);
- dagagge triglycerides (nau'in na huɗu bisa ga Fredrickson);
- rashin daidaituwa na lipoproteins (nau'in na uku bisa ga Fredrickson);
- Iyalin hypercholesterolemia na hyzygous.
Hakanan akwai wasu contraindications don yin amfani da Atorvastatin-Teva:
- Cutar cututtukan hanta a cikin aiki mai aiki ko a cikin lokacin ɓacin rai.
- Anara yawan matakan samfuran hepatic (ALT - alanine aminotransferase, AST - aspartate aminotransferase) sun fi sau uku, ba tare da dalilai bayyananne;
- Rashin hanta.
- Haihuwa da lactation.
- 'Ya'yan ƙananan shekaru.
- Bayyanar bayyanar cututtuka yayin ɗaukar kowane ɓangare na maganin.
A wasu halayen, waɗannan kwayoyin ya kamata a tsara su da tsananin taka tsantsan. Wadannan lamura kamar:
- yawan wuce haddi na giya;
- ilimin hanyoyin kwantar da hankali na hanta;
- rashin daidaituwa na hormonal;
- rashin daidaituwa na electrolytes;
- cuta cuta na rayuwa;
- karancin jini;
- m cutar raunuka;
- cututtukan da ba a kula da su ba;
- babban aiki da raunin rauni;
Bugu da kari, taka tsantsan lokacin shan miyagun ƙwayoyi ya kamata a yi amfani da shi a gaban pathologies na tsarin tsoka.
Umarnin don amfani da miyagun ƙwayoyi
Sashi na maganin yana ƙaddara ta hanyar farkon cutar ta buƙatar magani, matakin cholesterol, lipoproteins da triglycerides. Hakanan, amsawar marasa lafiya ga aikin ci gaba ana la'akari dashi koyaushe. Lokacin shan maganin ba ya dogara da cin abinci ba. Ya kamata ku ɗauki kwamfutar hannu guda ɗaya ko fiye (dangane da maganin likita) sau ɗaya a rana.
Mafi sau da yawa, amfanin Atorvastatin-Teva yana farawa tare da kashi 10 na MG. Koyaya, irin wannan sashi ba koyaushe yake tasiri ba, sabili da haka ana iya ƙara yawan kashi. Matsakaicin izini shine 80 MG kowace rana. Idan har yanzu ana buƙatar haɓakar kashi na ƙwayar, to, tare da wannan tsari, ya kamata a aiwatar da saka idanu akan bayanan furotin na yau da kullun kuma ya kamata a zaɓi farji daidai da su. Canza hanyar magani ya zama dole ba sau ɗaya a wata.
Babban burin maganin shine rage cholesterol zuwa al'ada. Matsakaicin yawan cholesterol a cikin jini shine 2.8 - 5,2 mmol / L. Ya kamata a tuna cewa ga marasa lafiya da ke fama da gazawar hanta, yana iya zama dole a rage kashi ko kuma a daina amfani da maganin gaba daya.
Sakamakon sakamako na miyagun ƙwayoyi
Yayin amfani da Atorvastatin-Teva, halayen cutarwa daban-daban daga bangarori da tsarin gabobin jiki na iya haɓaka. Wasu sakamako masu illa sun fi yawa.
Tsarin tsakiya da na jijiyoyin jijiyoyi: rikicewar bacci, ciwon kai, raunin ƙwaƙwalwa, rauni, raguwa ko gurbata hankali, ƙwaƙwalwa.
Gastrointestinal fili: ciki na ciki, amai, gudawa, hakar gas mai yawa, maƙarƙashiya, ƙoshin ciki, tafiyar matakai mai kumburi a cikin hanta da hanji, kumburin ciki wanda ke da alaƙa da barkewar ciki, gajiya.
Tsarin Musculoskeletal: jin zafi a cikin tsokoki, musamman ma a cikin tsokoki na baya, kumburi da ƙwayoyin tsoka, raunin haɗin gwiwa, rhabdomyolysis.
Bayyanar bayyanar cututtuka: ta hanyar nau'in fatar fata a cikin nau'in urticaria, itching, amsawar rashin lafiyar nan da nan a cikin yanayin girgiza anaphylactic, kumburi.
Tsarin Hematopoietic: raguwa a cikin adadin platelets.
Tsarin metabolic: raguwa ko haɓaka a cikin glucose jini, karuwa a cikin aikin enzyme wanda ake kira creatine phosphokinase, edema na ƙasan babba da na ƙarshen, hauhawar nauyi.
Wasu: rage ƙarfin aiki, jin zafi a cikin kirji, isasshen aikin ƙididdigar mutum, ƙashin kai, ƙara gajiya.
Don wasu cututtukan cuta da yanayi, ya kamata a tsara Atorvastatin-Teva tare da taka tsantsan, misali:
- Almubazzaranci;
- Pathology na hanta;
- Testsara gwaje-gwajen aikin hanta ba gaira babu dalili;
Hakanan ana buƙatar taka tsantsan yayin shan wasu magungunan anticholesterolemic, maganin rigakafi, immunosuppressants, da wasu bitamin.
Yin hulɗa tare da wasu magunguna
Atorvastatin-Teva yana da ɓarna tare da haɓakar cutar myopathy - rauni mai rauni na tsoka, kamar duk magunguna na ƙungiyar HMG-CoA reductase inhibitors. Tare da yin amfani da magunguna da yawa, haɗarin haɓaka wannan cutar na iya ƙaruwa sosai. Waɗannan magunguna ne kamar su fibrates (ɗaya daga cikin rukunin magungunan anticholesterolemic), maganin rigakafi (erythromycin da macrolides), magungunan antifungal, bitamin (PP, ko nicotinic acid).
Wadannan rukunoni suna aiki a kan wani enzyme na musamman da ake kira CYP3A4, wanda ke taka muhimmiyar rawa a Atorvastatin-Teva metabolism. Tare da wannan nau'in maganin haɗin gwiwa, matakin atorvastatin a cikin jini na iya ƙaruwa saboda hanawa da enzyme da aka ambata, tunda magungunan ba su metabolized da kyau. Shirye-shirye na rukunin ƙwayar wuta, alal misali, Fenofibrate, yana hana aiwatar da canji na Atorvastatin-Teva, wanda yawan sa a cikin jini shima yana ƙaruwa.
Atorvastatin-Teva kuma na iya haifar da haɓakar rhabdomyolysis - wannan mummunan ilimin cuta ne wanda ke faruwa a matsayin sakamako na dogon lokaci na myopathy. A cikin wannan tsari, ƙwayoyin tsoka suna cikin lalacewa mai yawa, ana lura da rarraba su a cikin fitsari, wanda zai haifar da gazawar ƙirar koda. Rhabdomyolysis mafi yawan lokuta yana haɓaka tare da yin amfani da Atorvastatin-Teva da kuma ƙungiyoyin magunguna na sama.
Idan kun tsara ƙwayar magani a cikin matsakaicin adadin izini na yau da kullun (80 MG kowace rana) tare da Digoxin cardiac, to, akwai karuwa a cikin taro na Digoxin kusan kashi ɗaya cikin biyar na kashi da aka ɗauka.
Yana da matukar muhimmanci a haɗa amfani da Atorvastatin-Teva tare da magungunan hana haihuwa waɗanda ke kunshe da estrogen da abubuwan da ake amfani da shi, tun da akwai haɓaka matakin hormones mata. Yana da mahimmanci ga mata masu haihuwa.
Na abinci, ana ba da shawarar a hankali don rage amfani da ruwan 'ya'yan itacen innabi, tunda ya ƙunshi abubuwa fiye da ɗaya waɗanda ke hana enzyme, a ƙarƙashin rinjayar wanda babban metabolism na Atorvastatin-Teva ke faruwa kuma matakinsa a cikin jini yana ƙaruwa. Ana iya siyan wannan magani a kowane kantin magani tare da takardar sayan magani.
An ba da bayani game da magungunan Atorvastatin a cikin bidiyo a cikin wannan labarin.
